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Chondroid Syringoma of a Cheek
Abstract
Chondroid syringoma is an unusual, benign skin appendageal tumor originating from the eccrine and apocrine sweat glands resembling mixed tumors of the salivary glands. It develops as a slow-enlarging, small, cutaneous nodule or mass. The lesions are usually seen in older men on head and neck. This is a clinical report of a 46-year-old lady who presented with a slowly growing nodular protruding mass in a cheek. The clinical and histologic findings of the tumor are demonstrated. The clinician and the pathologist should take into account the tumor among differential diagnosis not to overlook the lesion. Total surgical excision is needed with a long-term follow-up.
... The cutaneous mixed tumor or chondroid syringoma (CS) is a rare skin appendageal benign neoplasm initially described in 1961 by Hirsch and Helwig [1]. It typically occurs in elderly patients with male preponderance, frequently in the head and neck region, and is considered a counterpart of mixed tumors of the salivary glands (pleomorphic adenoma) [2,3]. The common sites of occurrence include the nose, chin, scalp, cheek, upper lip, and forehead. ...
... Chondroid syringoma (CS)/cutaneous mixed tumor/ apocrine mixed tumor /eccrine mixed tumor or called 'pleomorphic adenoma of sweat gland' is a rare mixed skin tumor constituting 0.01%-0.1% of all primary skin tumors [1,2,7,8]. It was first described by Billroth while the term 'chondroid syringoma' was coined by Hirsch and Helwig [1,7]. ...
Cutaneous mixed tumor or chondroid syringoma is a rare benign, skin appendageal tumor prevalent in areas of the head and neck. It represents the cutaneous counterpart of the pleomorphic adenoma of salivary glands. Its clinical presentation often misguides the clinician to underdiagnose it as a reactive lesion. We report the case of a 94-year-old male admitted for excision of cutaneous carcinoma concurrently with a chondroid syringoma of the pinna provisionally misdiagnosed as a keloid.
... The malignant variants however predominantly involve the extremities as opposed to the benign ones which usually presents as asymptomatic slow growing mass on the head and neck region [1,2]. Common facial locations include cheek, orbit, scalp, chin, upper lip, nose, and forehead [1,[3][4][5]. Other regions of occurrence CS include the torso, and scrotum. ...
... Despite its largely asymptomatic nature, depending on its locations, it may presents with some localized symptoms as there has been reported case of intraorbital CS causing exophthalmos with pressure and ocular symptoms [6]. It mostly occurs in the middle-aged population and more prevalent in females than males [2,4,7]. ...
Chondroid syringoma (CS), used in place of pleomorphic adenoma of the skin is a rare, benign, skin appendageal tumor. The diagnosis of this rare condition is made on histopathological examination aided by its commonplace clinical presentation. The tumor commonly presents as asymptomatic, indolent lesion and slowly growing mass, typically located in the head and neck region. We present a case report of a CS located on the left cheek of a 33-year-old man believed to be the first case ever from a rural community in Ghana.
... The age range of reported cases is uniformly spread from 23 to 65 years of age with 42 years as the mean age of presentation [3]. It is more commonly seen in middle-aged or elderly men than women [7,18,19]. Nevertheless, it has also rarely been reported in young age [20]. ...
... The age range of reported cases is uniformly spread from 23 to 65 years of age with 42 years as the mean age of presentation [3]. It is more commonly seen in middle-aged or elderly men than women [7,18,19]. Nevertheless, it has also rarely been reported in young age [20]. ...
Chondroid syringoma is a cutaneous adnexal tumor originating from sweat glands origin. It is rare in occurrence and usually benign, having an incidence of 0.01 to 0.098%. As these tumors are uncommon, their diagnosis is missed many times and are misdiagnosed. Hence in any case of facial skin swelling increasing slowly in size, this entity should be kept in mind as one of the possibilities and differential diagnosis. Histopathological examination of the excision biopsy gives the definitive confirmatory diagnosis. Surgically excising the swelling locally along with a surrounding normal tissue cuff is the standard treatment given which prevents recurrence. Hereby we present a 35-year-old case of facial chondroid syringoma having a focal component of eccrine hidrocystoma, keratinous cyst as well as syringocystadenoma papilliferum on the chin that was clinically suspected to be an epidermoid cyst or mucocele.
... 3 Eighty percent of the tumors are seen in older patients with male predominance. 4 It usually involves head and neck region and presents as asymptomatic slow growing, firm subcutaneous or intra dermal nodule. Histopathology reveals differentiation towards the adnexal ductal epithelium with chondromyxoid differentiation in the stroma. ...
Chondroid syringoma is also known as mixed tumour of the skin. It is a rare, biphasic cutaneous neoplasm similar to pleomorphic adenoma of salivary glands. Because of its rarity, many cases are misdiagnosed in the initial stages as cysts or other cutaneous adnexal neoplasms and are often identified only after being sent for histopathological examination.Although it usually presents in middle and older aged patients, we are presenting three younger patients with Chondroid syringoma, located over the back, nose and cheek, respectively.
... Bone formation was seen in direct contact to stromal fibrocytes without intervening cartilage Both patients had provided written informed consent for publication of these cases report and any accompanying images in a scientific journal, after the authors explained the possible benefits to dental science. The CS is an uncommon eccrine sweat gland tumor that may originate from both secretory and ductal elements of the sweat glands (14,15 ...
Pleomorphic adenoma, also known as benign mixed tumor, is the most common salivary gland tumor, mostly affecting major salivary glands, but also encountered concerning minor ones. The occurrence of this lesion in the skin, known with the term chondroid syringoma, is unusual and considered to be associated with eccrine or apocrine glands. The two lesions demonstrate almost identical histological features with microscopic characteristics of both epithelial and mesenchymal origin. In this article two cases of benign mixed tumor of the lip are presented and their surgical management and histological features are analyzed. Both cases involved the upper lip, one was located in the subcutaneous tissues and the other in the labial mucosa. The proximity of eccrine sweat gland tumors of the skin with the salivary glands of the oral mucosa makes it often difficult to discern the origin of benign mixed tumor. This report discusses the particular characteristics of each pathological entity, the clinical differential diagnosis and the treatment approach chosen accordingly.
Chondroid syringoma (CS) is a rare benign cutaneous neoplasm originating from the exocrine glands, representing ⁓0.01% of all primary skin cancers. This report presents three cases of CS: one located at the infraorbital rim and two in the cheek region. The diagnosis in all cases was confirmed through histopathological examination. Treatment involved surgical excision with multidisciplinary collaboration to ensure optimal patient care. These findings emphasize the importance of accurate histopathological diagnosis and coordinated specialist efforts for effective management of this uncommon tumor.
Skin mixed tumors are extremely rare clinically, lack characteristic manifestations, and are easily confused with other diseases. An Asian male came to our hospital's cosmetic and plastic surgery department because of a skin mass on the right side of his nose. After unanimous discussion by our doctors, the patient underwent subcutaneous tumor resection under local anesthesia and rotational flap transplantation to treat the disease and improve the shape of the nose. The surgery was a success. The patient was checked regularly, and the sutures were removed 1 week later. The patient's wound was normal after suture removal. During the 5-month follow-up, the patient's right nose showed no recurrence, the appearance was normal, and the scar was not obvious. The patient was satisfied.
Chondroid Syringoma is a rare benign mixed tumor characterized by gland elements in a cartilaginous stroma. These tumors most commonly occur in the skin of the head and neck district, affecting only rarely the periorbital area.
Below we present two cases of Chondroid Syringoma, the first on the upper lip, and the second in the orbital cavity. Both are characterized by an epithelial component in a cartilaginous stroma.
Coined in 1961 by Hirsch and Helwig, the term chondroid syringoma refers to a rare mixed tumour of subcutaneous tissue. Histologically, these tumours are almost identical to pleomorphic adenomas, arising from salivary glands. With the obvious difference being the presence of sweat gland tissue (syringoma) within a matrix of cartilage (chondroid). These mixed tumours remain scarce throughout the world, with an incidence of less than 0.098%. The vast majority of cases are reported in middle-aged and older adults, where they typically present as painless swellings in the head and neck, which gradually grow in size.
Chondroid syringoma - also known as mixed tumor of the skin - is a benign skin tumor often occurring in the head and neck region, that usually presents as a slow growing well-defined swelling in adults, with occasional commitment of the lips. The aim of this study was to report an illustrative case of chondroid syringoma in the lower lip of a 43-year-old male patient from Brazil. Physical examination revealed an asymptomatic hardened swelling of normal coloration, measuring 3.0 cm, located at the transition between the skin and semi-mucosa of the lower lip. Under the clinical hypothesis of a salivary gland tumor, an excisional biopsy was performed under local anesthesia. After histopathologic examination the final diagnosis was of chondroid syringoma of the lower lip. There is no evidence of recurrence one year after surgical procedure. Clinicians should consider chondroid syringoma when evaluating well-defined swellings of the lower lip.
Chondroid syringoma (CS) is an uncommon cutaneous tumor in the head and neck, with reported incidence rate from 0.01% to 0.1%. The CS of skin is a rare type of soft tissue tumor originating from the sweat glands. We report a documented case of CS occurring in the nasal dorsum in a 58-year-old man, which developed during the course of 1 year. The clinical, gross pathologic, and histologic findings of the tumor are described. The lesion was totally excised via transcutaneous approach and showed no evidence of recurrence after excision.
Pleomorphic adenoma (PA) is a rare tumor of the skin that may arise from either the apocrine or the eccrine glands. Only 4 cases of PA in the auricle have been reported. We experienced the case of a 40-year-old woman who had a slowly growing, nontender auricle mass for 3 years. Under a clinical diagnosis of an epidermal inclusion cyst, we performed a total excision of the tumor with the skin and with direct closure. No recurrence was found during the 18 months of postoperative follow-up. Histologic examination confirmed a diagnosis of PA. Hematoxylin-eosin stain showed tubules that were lined with 2 layers of epithelial cells. The stroma was composed of the myxoid and chondroid matrices. Immunohistochemical staining was positive for cytokeratin, epithelial membrane antigen, and gross cystic disease fluid protein, whereas it was negative for S-100 and carcinoembryonic antigen. These findings suggested that this tumor originated from the apocrine glands. Only a few cases of PA in the auricle have been reported in the literature, 2 of which occurred in the helical rim. Recurrence is rare if there is complete resection of the tumor along with the surrounding capsule. We report herein a rare case of PA that developed in the auricle.
Chondroid syringoma, or mixed tumor of skin, is an uncommon sweat gland tumor most often seen in the head-and-neck region of patients in the sixth or seventh decade. Tumors usually present as asymptomatic, slowly growing masses. Histologically, there are both epithelial and stromal components. The treatment of choice is local excision. Rare malignant examples have been reported, commonly involving the extremities. We present a case of cutaneous chondroid syringoma arising in the thigh of a 28-year-old female. The tumor grew over a 4-year period, increasing rapidly in size over the last few months with fixation and pigmentation of the overlying skin clinically mimicking a malignant neoplasm. Such cutaneous appendage tumors are uncommon, and surgeons may be unfamiliar with them.
- Sheikh