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Clinical Implications of a General Psychopathology Factor: A Cognitive–Behavioral Transdiagnostic Group Treatment for Community Mental Health

American Psychological Association
Journal of Psychotherapy Integration
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Implicaciones clínicas de un factor general de psicopatología: un grupo de diagnóstico cognitivo-conductual Tratamiento para la salud mental comunitaria La investigación sobre la estructura subyacente de la psicopatología ha encontrado que un solo factor psicopatológico general puede ser la base de todos los trastornos mentales. Este hallazgo es consistente con décadas de investigación que muestran que los mismos factores de riesgo están asociados con muchos trastornos diferentes. Revisamos estos hallazgos y discutimos una implicación primaria: que los médicos podrían utilizar potencialmente el mismo tratamiento para individuos con diferentes trastornos mentales y comórbidos. Este enfoque transdiagnóstico no es un concepto nuevo, pero estos tratamientos están recibiendo un renovado interés. Se ha demostrado que los tratamientos transdiagnósticos recientemente desarrollados son efectivos en entornos de investigación, pero estos tratamientos no satisfacen varias necesidades de salud mental de la comunidad. En consecuencia, proporcionamos un fundamento basado en la evidencia para un tratamiento grupal cognitivo-conductual de inscripción continua y totalmente transdiagnóstico que se basa en la investigación sobre la estructura de la psicopatología. Concluimos con sugerencias para investigaciones futuras que integran investigación científica básica, investigación sobre tratamientos y práctica clínica.
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... Practically, although the PVI involves eight aspects and differences across classes in various aspects exist, we recommend that future intervention strategies employ universal transdiagnostic treatment protocols. We made this recommendation because universal therapy makes theoretical and pragmatic sense 20,80 . From a theoretical standpoint, the general p-factor implies that numerous different disorders share common risk factors 81 . ...
... From a theoretical standpoint, the general p-factor implies that numerous different disorders share common risk factors 81 . Interventions targeting different disorders comprise the same evidence-based modules (e.g., psychoeducation, setting treatment goals, and cognitive restructuring), suggesting that they treat the constituents of the pfactor and possibly the p-factor itself 80 . From a practical perspective, transdiagnostic treatment protocols are being tested with several notable successes 80,82 . ...
... Interventions targeting different disorders comprise the same evidence-based modules (e.g., psychoeducation, setting treatment goals, and cognitive restructuring), suggesting that they treat the constituents of the pfactor and possibly the p-factor itself 80 . From a practical perspective, transdiagnostic treatment protocols are being tested with several notable successes 80,82 . Certain therapies originally developed for specific disorders have been applied in transdiagnostic interventions due to their demonstrated effectiveness across various conditions 83 . ...
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Accumulating research on mental health emphasizes the general factor of psychopathology (p-factor) that unites various mental health issues. This study develops a psychopathological vulnerability assessment for youths, evaluating its psychometric properties and clinical utility. An umbrella review conceptualized multifactor psychopathological vulnerability, leading to a 57-item pool. A total of 11,224 individuals participated in this study. The resulting 22-item psychopathological vulnerability index (PVI) fitted the unidimensional Rasch model, demonstrating a person separation reliability of 0.78 and a Cronbach’s alpha of 0.84. Cut-off points of 11 and 5, derived from latent class analysis, were used to distinguish vulnerable and high-protection populations. The PVI’s concurrent and predictive hit rates ranged from 36.00% to 53.57% in clinical samples. The PVI concretized the vulnerability–stress model for identifying at-risk youths and may facilitate universal interventions by integrating the theoretical foundations of bifactor S-1 models with key symptoms from network models for theoretically grounded approaches.
... That is, some mental disorders are more highly correlated with each other. Studies about the structure of psychopathology result in the incorporation of disorder clusters in research and the growth of transdiagnostic treatment (17,18). According to an existing psychopathology structure model (i.e., "three factor model"), mental disorders can be organized into three broad clusters (or higher-order factors): internalizing disorders (e.g., depression, generalized anxiety disorder, panic disorder, and post-traumatic stress disorder), externalizing disorders (e.g., conduct disorder, alcohol dependence, cannabis dependence, other drug dependence, and tobacco addiction), and thought disorders [e.g., obsessive-compulsive disorder (OCD), mania, and schizophrenia] (19)(20)(21). ...
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Background Although a psychiatric history might be an independent risk factor for COVID-19 infection and mortality, no studies have systematically investigated how different clusters of pre-existing mental disorders may affect COVID-19 clinical outcomes or showed how the coexistence of mental disorder clusters is related to COVID-19 clinical outcomes. Methods Using a retrospective cohort study design, a total of 476,775 adult patients with lab-confirmed and probable COVID-19 between March 06, 2020 and April 14, 2021 in South Carolina, United States were included in the current study. The electronic health record data of COVID-19 patients were linked to all payer-based claims data through the SC Revenue and Fiscal Affairs Office. Pre-existing mental disorder diagnoses from Jan 2, 2019 to Jan 14, 2021 were extracted from the patients' healthcare utilization data via ICD-10 codes. Results There is an elevated risk of COVID-19-related hospitalization and death among participants with pre-existing mental disorders adjusting for key socio-demographic and comorbidity covariates. Co-occurrence of any two clusters was positively associated with COVID-19-related hospitalization and death. The odds ratio of being hospitalized was 1.26 (95% CI: 1.151, 1.383) for patients with internalizing and externalizing disorders, 1.65 (95% CI: 1.298, 2.092) for internalizing and thought disorders, 1.76 (95% CI: 1.217, 2.542) for externalizing and thought disorders, and 1.64 (95% CI: 1.274, 2.118) for three clusters of mental disorders. Conclusions Pre-existing internalizing disorders and thought disorders are positively related to COVID-19 hospitalization and death. Co-occurrence of any two clusters of mental disorders have elevated risk of COVID-19-related hospitalization and death compared to those with a single cluster.
... The authors emphasize that one of the benefits of this modular proposal is its flexibility regarding the order in which the skills are practiced and the time spent on each component. Moreover, to promote access to these treatments and improve their efficiency, they can be applied in group format (Meier & Meier, 2018 To sum up, published results which show the usefulness of both contextual and cognitive-behavioral transdiagnostic therapies also coincide in calling for an analysis of the differential efficacy and specificity of each therapy in the clinical change. Furthermore, of the contextual therapies, although BA and ACT understand the nature of the psychological problem in the same way, the focus of attention and the weight given to the different therapeutic tasks/resources is different in each one (Kanter et al., 2006;Levin et al., 2020). ...
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Studying the usefulness of contextual and cognitive transdiagnostic therapies calls for an analysis of both their differential efficacy and their specificity when acting on the transdiagnostic conditions on which they focus. This controlled trial compares the post-treatment and 3- and 6-month follow-up effects of Behavioral Activation (BA), Acceptance and Commitment Therapy (ACT) and Cognitive-Behavioral Transdiagnostic Therapy (TD-CBT) on emotional symptomatology, and analyses the role played by Experiential Avoidance, Cognitive Fusion, Activation and Emotion Regulation in the clinical change. One hundred twenty-eight patients who fulfilled diagnostic criteria for anxiety and/or depression (intention-to-treat sample) were randomly assigned to three experimental group-treatment conditions (BA, n = 34; ACT, n = 27; TD-CBT n = 33) and one control group (WL, n = 34). Ninety-nine (77.34%) completed the treatment (per-protocol sample). In the post-treatment, all therapies reduced anxiety and depression symptomatology. In the follow-ups, the reduction in emotional symptomatology was greater in the condition which produced greater and more prolonged effects on Activation. Activation appears to be the principal condition in modifying all the transdiagnostic patterns and BA was the most efficacious and specific treatment. The trial was registered at ClinicalTrials.gov NCT04117464. Raw data are available online http://dx.doi.org/10.17632/krj3w2hfsj.1 .
... That is, some mental disorders are more highly correlated with each other. Studies about the structure of psychopathology result in the incorporation of disorder clusters in research and the growth of transdiagnostic treatment (23,24). For example, according to an existing psychopathology structure model, i.e., "three factor model" (25), mental disorders can be organized into three broad clusters (or higher-order factors): "internalizing disorders" (people with internalizing disorders keep maladaptive emotions and cognitions to themselves or internalize problems, e.g., depression and anxiety), "externalizing disorders" (mental disorders characterized by externalizing behaviors, maladaptive behaviors directed toward an individual's environment, which cause impairment or interference in life functioning, e.g., antisocial and substance use disorders), and "thought disorders" (disturbance in cognition that adversely affects language and thought content, and thereby communication, e.g., schizophrenia and schizotypal personality All rights reserved. ...
Preprint
Importance: A growing body of research focuses on the impact of pre-existing mental disorders on clinical outcomes of COVID-19 illness. Although a psychiatric history might be an independent risk factor for COVID-19 infection and mortality, no studies have systematically investigated how different clusters of pre-existing mental disorders may affect COVID-19 clinical outcomes or showed how the coexistence of mental disorder clusters is related to COVID-19 clinical outcomes. Objective: To explore how different pre-existing mental disorders and their co-occurrence affects COVID-19-related clinical outcomes based on real-world data. Design, Setting, and Participants: Using a retrospective cohort study design, a total of 476,775 adult patients with lab-confirmed and probable COVID-19 between March 06, 2020 and April 14, 2021 in South Carolina, United States were included in the current study. The electronic health record data of COVID-19 patients were linked to all payer-based claims data through the SC Revenue and Fiscal Affairs Office. Main Outcomes and Measures: Key COVID-19 clinical outcomes included severity, hospitalization, and death. COVID-19 severity was defined as asymptomatic, mild, and moderate/severe. Pre-existing mental disorder diagnoses from Jan 2, 2019 to Jan 14, 2021 were extracted from the patients healthcare utilization data via ICD-10 codes. Mental disorders were categorized into internalizing disorders, externalizing disorders, and thought disorders. Results: Of the 476,775 COVID-19 patients, 55,300 had pre-existing mental disorders. There is an elevated risk of COVID-19-related hospitalization and death among participants with pre-existing mental disorders adjusting for key socio-demographic covariates (i.e., age, gender, race, ethnicity, residence, smoking). Co-occurrence of any two clusters was positively associated with COVID-19-related hospitalization and death. The odds ratio of being hospitalized was 2.50 (95%CI 2.284, 2.728) for patients with internalizing and externalizing disorders, 3.34 (95%CI 2.637, 4.228) for internalizing and thought disorders, 3.29 (95%CI 2.288, 4.733) for externalizing and thought disorders, and 3.35 (95%CI 2.604, 4.310) for three clusters of mental disorders. Conclusions and Relevance: Pre-existing internalizing disorders, externalizing disorders, and thought disorders are positively related to COVID-19 hospitalization and death. Co-occurrence of any two clusters of mental disorders have elevated risk of COVID-19-related hospitalization and death compared to those with a single cluster.
... Other researchers are developing and testing new treatment methods that are designed to remediate the processes, e.g. negative emotionality, that all dimensions of psychopathology appear to share 82,83 . Tests of these new treatments may not only lead to better treatments with more widespread benefits, but will help us understand what underlies the general and specific factors of psychopathology. ...
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There is an ongoing revolution in psychology and psychiatry that will likely change how we conceptualize, study and treat psychological problems.­ Many theorists now support viewing psychopathology as consisting of continuous dimensions rather than discrete diagnostic categories. Indeed, recent papers have proposed comprehensive taxonomies of psychopathology dimensions to replace the DSM and ICD taxonomies of categories. The proposed dimensional taxonomies, which portray psychopathology as hierarchically organized correlated dimensions, are now well supported at phenotypic levels. Multiple studies show that both a general factor of psychopathology at the top of the hierarchy and specific factors at lower levels predict different functional outcomes. Our analyses of data on a large representative sample of child and adolescent twins suggested the causal hypothesis that phenotypic correlations among dimensions of psychopathology are the result of many familial influences being pleiotropic. That is, most genetic variants and shared environmental factors are hypothesized to non‐specifically influence risk for multiple rather than individual dimensions of psychopathology. In contrast, person‐specific experiences tend to be related to individual dimensions. This hierarchical causal hypothesis has been supported by both large‐scale family and molecular genetic studies. Current research focuses on three issues. First, the field has not settled on a preferred statistical model for studying the hierarchy of causes and phenotypes. Second, in spite of encouraging progress, the neurobiological correlates of the hierarchy of dimensions of psychopathology are only partially described. Third, although there are potentially important clinical implications of the hierarchical model, insufficient research has been conducted to date to rec­ommend evidence‐based clinical practices.
... In the p-factor literature, theory and model are intertwined (for good reason) but are generally conflated, likely because the lion's share of research on the p-factor uses a single type of model to examine it (i.e., the bifactor model). Although much research has extolled the virtues of the p-factor in terms of its ability to enhance research on the sources, correlates, and even treatment implications of psychopathology (Caspi & Moffitt, 2018;Conway, Forbes, et al., 2019;Lahey et al., 2017;Meier & Meier, 2018), we caution against the adoption of a theoretical model that is built on a methodological house of cards. For the field to move toward a more precise understanding of the p-factor, should it exist, it needs to grapple with the issues we raise in this commentary. ...
... In the p-factor literature, theory and model are intertwined (for good reason) but are generally conflated, likely because the lion's share of research on the p-factor uses a single type of model to examine it (i.e., the bifactor model). Although much research has extolled the virtues of the p-factor in terms of its ability to enhance research on the sources, correlates, and even treatment implications of psychopathology (Caspi & Moffit, 2018;Conway et al., 2019;Lahey et al., 2017;Meier & Meier, 2018), we caution against the adoption of a theoretical model that is built on a methodological house of cards. For the field to move towards a more precise understanding of the p-factor, should it exist, it needs to grapple with the issues we raise in this commentary. ...
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