Introduction : The following compilation resulted from over forty years of experience as a doctor in the treatment of patients, since 1974 as an internist and house physician, since 1997 with the additional designation environmental medicine, 2008 to 2015 during the practical work in a clinic with focus on chronic Lyme disease and co-infections with patients that also had to suffer from other multisystem - Multi-infection diseases. The compilation is not complete. The literature collection is not strictly selected and not strictly well-ordered. Overlaps are possible. The presentation corresponds to the author’s experience horizon as a doctor in dealing with patients in South Germany. The procedures described were successful in practice. The scientific substantiation however has not been made until now. The interested skilled persons must find out for themselves what they have to believe. This should be a question of conscience. Summary : At levels of less than 80 nanometers, the real world of the observers graduelly moves into the world of quantum mechanics, the world of self-organization, immunology, symbiosis, life, and living cells. Some Virus types are not harmless. Bacteria change between an original form (frontal pathogen) and a cell wall defective form, a virus-like form (CWD) (stealth pathogen) with at least in part virus properties. There are only two indirect indications of fungi as co-infection in Lyme Borrelosis. Protozoa are single-cell organisms that form cell colonies and can live in biofilms. Biofilms are extra- and intra – cellular layers (films) from microorganisms, from bacteria, Virus species, archaea, protozoa, fungi and microalgae „Cities of Microbes“, symbiogenetic creatures. Toxins are chemical substances for organisms that are not processed properly. Nematodes have not yet been detected in Lyme-Borreliosis as co-infections. Between the correct and the missed diagnosis there is still an intermediate group, the „Cavete“ Diagnoses. Cavete Diagnoses are associated also with Lyme-Borreliosis, other pathogens and with the influence of toxins.