A 2500-year history of invasion, conquest, and resistance has left Afghanistan ethnically diverse and culturally rich. And yet, this storied history has bequeathed to the nation’s people a legacy of political fragmentation, economic impoverishment, and in recent times, even some international isolation. The last 40 years of relentless conflict, encompassing two superpower invasions and decades of a smoldering civil war, have placed entire generations of Afghans at risk for posttraumatic stress disorder and have pushed the nation into a cycle of poverty, reduced educational opportunity, and violence. It is the contention of this paper that several academic concepts–the neuroscience principle of propinquity, the scholarly disciplines of behavioral economics and game theory, and the blockchain technology promoted by “Satoshi Nakamoto”—can be woven together into a practical application to create business partnerships, jobs, and an entrepreneurial middle class for Afghanistan, thereby decreasing poverty and the fallout of crime and violence significantly. Based on these principles, a genuinely non-exploitative partnership structure can be built between United States and Afghan interests. The central role of military can be replaced by private sector players, to achieve through human security what could not be achieved through kinetic force. In such a diverse culture, and amidst the difficulties of Afghanistan’s geographical and topographical scenario, military dominance in Afghanistan has always failed, for thousands of years. Yet, that never would have been the true solution anyway. It seldom is. Afghanistan may utilize its vast mineral wealth as a starting place for trade, human security and national security, assisted but unexploited. And done in partnerships rather than as suppliers, they may then begin to extract the wealth of its human resources and find its future as a contributing and secure world citizen. The discussion below will sketch a broad outline of a possible path forward, employing twenty-first century innovative business structure to solve for the underlying long-standing impediments to security and prosperity. Like gravity, applications of these principles are true whenever humans compete for value or security. Anywhere self-interests have vetoed the common good, to the ultimate demise of both, these principles and guidelines that follow will prove useful for building the hope of a nation.