The education stakeholders of the twenty-first century stress on the importance of thinking-based learning (TBL) where instructors are not only teaching students’ critical and creative thinking (CCT) but also teaching them strategically and visually how to use the forms of skilful thinking techniques in the content of learning. TBL highly emphasizes on the types of thinking techniques that directly lead students to obtain higher order thinking skills. To meet the challenges of the twenty-first century, current classroom pedagogy should infuse TBL techniques into their content of learning. Academics should also conduct uncompromising TBL professional development trainings for teachers on how to apply TBL techniques in their teaching, since (a) the improvement of students occurs with the empowerment of teachers’ abilities, (b) the majority of classroom instructors lack of adequate TBL skills, and (c) they find it difficult to identify where to apply the techniques in curriculum. This study aims to review TBL-related theories, applications, and practices in teaching and learning, emphasizing on the importance of TBL professional trainings to boost skilful thinking skills in school learning activities. Achieving these skills empowers teachers to infuse TBL into classroom activities and consequently enhance students’ skilful thinking skills across the globe.