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Neural Energy Density Assessment of Cognitive Processing by Multiple Sclerosis Patients following Liquid Cooling Therapy: A research and development case study

Thesis

Neural Energy Density Assessment of Cognitive Processing by Multiple Sclerosis Patients following Liquid Cooling Therapy: A research and development case study

Abstract and Figures

This capstone report outlines the development of neurophysiological procedures to monitor the enhanced cognitive processing by multiple sclerosis patients following short term body cooling therapy. The approach included use of topographic electroencephalographic (TEEG) measures of cerebral function, a visual discrimination task administered by computer, and the use of a NASA developed liquid cooling garment (LCG). TEEG was used to determine changes in cortical function associated with cognition. The visual discrimination task was used to produce stimulus gated event related potentials of each patient’s task performance neural activity. The LCG was used to provide cooling of the patient to lower their body temperature by the amount needed to improve cognition. During the study period testing, analytical and display procedures for TEEG monitoring were developed, that extend the state of the art and provide a valuable tool for the study of cerebral circulatory and neural activity during cognition. It is expected that the analysis of cognitive TEEG test sequences will facilitate studies of learning and memory disorders, dementias and other encephalopathies. The near real time capability of the recording equipment will facilitate monitoring of patients with a variety of neurological disorders and will allow researchers to obtain immediate feed-back of results to optimize experimental conditions during the recording session.
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