Screening of Anti-hyperglycemic Activity of Kigelia africana on Alloxan-Induced Diabetic Rats

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... Treatment of diabetic rats with methanol extract (200-400 mg/kg) of the plant produced a significant reduction in serum levels of triglyceride and cholesterol in a dose-dependent manner which was found comparable to standard drug glibenclamide. [47] Daily administration of the defatted methanol extract (for 21 days) of flower of K. africana in streptozotocin-induced diabetic rat causes statistically significant (P < 0.001) reduction in the level of blood glucose in a dose-dependent manner from 288.45 ± 2.30 mg/dL to 152.48 ± 2.7 mg/dL and 298.29 ± 3.50 mg/dL to 138.43 ± 3.5 mg/dL at the doses of 250 and 500 mg/kg, respectively. Glibenclamide (10 mg/kg) was used as a standard drug. ...
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African plant Kigelia africana (Lam.) Benth. belonging to the family Bignoniaceae is widely distributed in the South, Central, and West Africa. Tree of K. africana is approximately 20 m long, either evergreen or deciduous depending on the rainfall condition in different part of the world. Due to its huge sausage or cucumber-like fruit, K. africana is commonly referred to as sausage or cucumber tree. Different parts of K. africana have been used for various medicinal purposes in different parts of the world. In India, K. africana is well known as Balmkheera. A very famous slogan is used in different parts of Uttar Pradesh (India) for K. africana as “Balamkheera jo bana de pet ko heera.” Different parts of this plant used by ethnic groups throughout the world for the treatment of common skin diseases such as fungal infections, psoriasis, eczema, boils, leprosy, syphilis, skin cancer gynecological complaints, constipation, tapeworm infection, jaundice, ulcers, sores, pneumonia, malaria, diabetes, and waist pain. Pharmacological activities of different extracts as well as isolated compounds of the plant are reported as analgesic, antipyretic, anti-inflammatory, hepatoprotective, antidiabetic, antibacterial, antifungal, nematocidal, antiamebic, antiviral, antitrypanosomal, antiamebic, antimalarial, antidiarrheal, anticancer, antioxidant, aphrodisiac, and wound healing activity have been studied using different methods. In the present article, data have been collected on the ethnopharmacology and pharmacology of K. africana up to June 2017.
... One of the major chemical constituents of K. africana are naphthoquinones, which are shown in Fig. 2. Due to its unique phytochemical diversity, K. africana has been reported to possess various biological activities (Table 2). A methanol extract (250, 500 mg/kg) of K. africana flower has been reported as showing antidiabetic po- 133) During an experimental period of 21 d, K. africana extract successfully normalized the glycemic level and lipid profile of the rats. In addition, K. africana leaf extract (100-400 mg/kg) has been tested for its antidiabetic potential in an alloxan induced diabetic rat model. ...
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Diabetes mellitus is the seventh leading cause of death globally. Ninety percent of the diabetic population suffers from type-2 diabetes, which still needs an effective, safe and economical oral hypoglycemic therapy. Plants are rich sources of various therapeutic molecules. More than 400 medicinal plants of interesting phytochemical diversity have been reported for their antidiabetic potential. Naphthoquinones are a group of phytochemicals, which have a wide range of pharmacological potential, including antidiabetic activity. Naphthoquinones exert their antidiabetic effects through various mechanisms such as the inhibition of α-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2 translocations, enhanced peroxisome proliferator-activated receptor gamma (PPARγ) ligand activity, and by normalizing carbohydrate metabolizing enzymes in the liver. Moreover, naphthoquinone inhibits adipogenesis by both upstream and downstream regulation to control obesity, which is one of the important risk factors for diabetes. Naturally occurring naphthoquinones, as well as their plant sources, are therefore of interest for exploring their antidiabetic potential. The present review aims to overview the antidiabetic potential of naphthoquinones and their plant resources in Thailand. Graphical Abstract Fullsize Image
... Similarly, methanolic extract from the leaves was found to significantly decrease (P<0.01) serum glucose level in alloxan-induced diabetic rats after the 21 days of oral treatment (Priya et al., 2014). The ethanolic extract, together with compounds catalpol, specioside and minecoside (10 μM) isolated from the n-butanol fraction exhibited significant stimulation of GLUT4 translocation to cell surface from intracellular compartments (Khan et al., 2012). ...
... Moreover, the most pronounced decrease in serum glucose was observed on 21st day at a dose of 400 mg/kg. However, at a dose of 100 mg/kg, the extract failed to lower the blood glucose to a significance level as compared with diabetic control rats (Priya et al., 2014). ...
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