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EcoFoodFertility – Environmental and food impact assessment on male reproductive function. L.Montano, L. Iannuzzi, J. Rubes, C. Avolio, C. Pistos, A. Gatti, S. Raimondo, T.Notari, Andrology 2(Suppl.2):69, 2014 http://dx.doi.org/10.1111/andr.267
Abstract
Introduction: Over the past 60 years, several studies show a reduction in the concentration of sperm in many countries industrializzati.In some countries , especially industrialized , this trend shows differences of areas within the same country or even in the same region .
The EU project " EcoFoodFertility " affect 8 areas in Italy, Spain , Greece, Rep.Ceca.L ' male reproductive system is very sensitive to changes in endogenous and exogenous , and in particular , in the seminal fluid , it is possible to verify and quantify the presence of contaminants environmental and simultaneously measure the direct effects on sperm noxae very sensitive to the environment, therefore elective bioindicators of environmental damage on human health.
Materials and Methods: In this study, multi-disciplinary and multi- bodied males from 20 to 40 years old, non-smoking, non-drinking , non- drug , non-occupationally exposed , from 4 areas of high environmental impact, will be recruited from Italy ( Land of fires Campania ), Spain (area ind.Terrassa ), Greece ( Athens) and Czech Republic ( Silesia ) and 4 corresponding areas of low impact .
It will measure the levels of contaminants in the seed and in the blood ( heavy metals , polycyclic aromatic hydrocarbons Dioxins , PCBs and nanoparticles ) and it will correlate with conventional semen parameters , redox state , and especially with the index of DNA fragmentation spermatozoario . Similarly for blood lymphocytes will be made karyotyping and chromosomal stability by cytogenetic tests . We will also measure the antitransglutaminase and cytokines for food intolerances , especially gluten sensitive and celiac disease research .
Conclusions and objectives : The study, in addition to being able to give a knowledge of the state of bioaccumulation of environmental contaminants in homogeneous populations in areas with different environmental pressure index in both the countries themselves and between different countries, intends to investigate more clearly , how and how much environmental pollution directly affects the quality of semen , whether, how and what affects the development of food intolerances , such as eating styles and impact on reproductive function and, again, what and most reliable biomarker of cellular stress are associated with the bioaccumulation of contaminants environmental in blood and seme.In Finally, the role of diet and the possibilities offered by innovative formulations of nutritional sciences .
... Several serious concerns for general health, including reproductive ones, in "Land of Fires" were reported. Bio-monitoring studies indicated that trace toxics elements (e.g., Cr, Cd, Ni, Pb, Al) feature prominently in this area [41,42], including dioxins [43]. In response to such serious concerns, the EcoFoodFertility initiative [44] has been launched to better understand the environmental impact of toxicants on healthy humans [42,45]. ...
... Bio-monitoring studies indicated that trace toxics elements (e.g., Cr, Cd, Ni, Pb, Al) feature prominently in this area [41,42], including dioxins [43]. In response to such serious concerns, the EcoFoodFertility initiative [44] has been launched to better understand the environmental impact of toxicants on healthy humans [42,45]. It is a multicenter, multidisciplinary research connecting human lifestyle and dietary habits to the environmental consequences of exposure to toxicants. ...
... A stock solution (ICP multi-element standard solution Certipur ® , 1000 mg/L, Merck KGaA, Darmstadt, Germany) was used to prepare the standard solutions. The limits of detection (LOD) and quantification (LOQ) were calculated as the blank signal plus three or ten times its standard deviation, respectively [42]. ...
Air pollution is a problem shared by the entire world population, and researchers have highlighted its adverse effects on human health in recent years. The object of this paper was the relationship between the pollutants’ concentrations measured in the air and the quantity of pollutant itself inhaled by the human body. The area chosen for the study has a high environmental impact given the significant presence on the territory of polluting activities. The Acerra area (HI) has a waste-to-energy plant and numerous industries to which polluting emissions are attributed. This area has always been the subject of study as the numbers of cancer patients are high. A survey on male patients to evaluate the heavy metals concentrations in the blood was conducted in the two areas and then linked to its values aero-dispersed. Using the air quality data measured by the monitoring networks in two zones, one with high environmental impact (HI) and one with low environmental impact (LI), the chronicle daily intake (CDI) of pollutants inhaled by a single person was calculated. The pollutants considered in this study are PM10 and four heavy metals (As, Cd, Ni, Pb) constituting the typical particulates of the areas concerned. The CDI values calculated for the two zones are significantly higher in the HI zone following the seasonal pollution trend.
... Thus, spermatogenesis is a cycle extremely complex and vulnerable to endogenous and exogenous stress and that human semen can become an important "environmental and health marker".I nt h i sw a y ,t h eq u a l i t a t i v e assessment of human semen might be envisaged as a potential focus for future development of public prevention policies. Therefore, the use of reproductive biomarkers as environmental health risks was proposed as a promising/ innovative strategy for the early detection and prevention of environmental health [54]. ...
... Strikingly, an increased risk of sperm DNA fragmentation was associated to high levels of air pollution, in fact seems that the classical sperm parameters -motility, concentration, morphology-do not change related to high smog levels, while sperm DNA fragmentation appeared to be much more sensible [98]. In this direction, also in Campania Region (Southern Italy), preliminary data of EcoFoodFertility initiative [54], indicated an increased sperm DNA damage associated to environmental pressure, measured with two techniques. In fact, healthy, nosmoking, no-drinker, no professionally exposed to environmental stresses males (n = 175, mean age 30 AE 4) were enrolled in areas of High or Low environmental impact. ...
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