Article

Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency

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Abstract

Introduction: Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses. The pathogenesis of chronic rhino sinusitis remains poorly defined. It was recently proposed that Vitamin D deficiency may explain some part of this pattern. The aim of study is to evaluate the effect of vitamin D supplement in patients diagnosed as chronic rhino sinusitis with vitamin D deficiency. Materials and Methods: Prospective study was performed on 57 patients diagnosed as chronic Rhinosinusitis and vitamin D deficiency. Patients received vitamin D3 tablet (1000 IU) daily for one month. Before and after drug intake all patients were asked to fill in a questionnaire in which they rated their overall symptoms. Results: (75.4%) of patients cured from smell disturbance, (22.8%) of patients cured from headache, (21.1%) cured from nasal obstruction and only 7% of patients cured from nasal discharge. (64%) of patients improve (not cured) from nasal obstruction symptoms, (63%) of patients not cure from nasal discharge. Conclusions: Vitamin D supplement shows significant improvement in symptoms of chronic Rhinosinusitis mainly smell disturbance, Vitamin D could be use as adjuvant treatment for Chronic Rhino sinusitis.

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... They found that a low-level vitamin D3 was more in female patients. This may be due to clothing style in our community that cause less exposure to sun light [8][9][10][11]. ...
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Vitamin D deficiency continues to be a worldwide problem, especially in developing countries. The aim of this study was to investigate potential risk factors for vitamin D deficiency. Girls (n = 89) aged 13 to 17 y were enrolled in the study. Study subjects were stratified into 3 groups: Group I included girls living in a suburban area; Group II girls lived in an urban area, and Group III girls lived in an urban area and wore concealing clothes for religious reasons. At the end of winter (in April) serum 25-hydroxyvitamin D [25(OH)D] levels were measured and dietary data were collected using questionnaires. Vitamin D deficiency was defined as a serum 25(OH)D concentration < 25 nmol/L, and insufficiency as a 25(OH)D concentration between 25 and 50 nmol/L. The lumbar and femur neck bone mineral densities (BMD) were measured using dual X-ray absorptiometry (DEXA). Overall, 39 girls (43.8%) had vitamin D insufficiency and 19 (21.3%) had vitamin D deficiency. In group III (wearing covered dress) the serum 25(OH)D concentrations (28.13 +/- 12.53 nmol/L) were significantly lower than in the other 2 groups, and within this group, 50% of girls were vitamin D deficient. The lumbar and femur neck BMD of girls with lower 25(OH)D levels did not differ from those with adequate vitamin D levels. We conclude that vitamin D deficiency is an important problem in Turkish adolescent girls, especially in those who follow a religious dress code; therefore, vitamin D supplementation appears to be necessary for adolescent girls.
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In the 1960s, the prevalence of asthma and allergic diseases began to increase worldwide. Currently, the burden of the disease is more than 300 million people affected. We hypothesize that as populations grow more prosperous, more time is spent indoors, and there is less exposure to sunlight, leading to decreased cutaneous vitamin D production. Coupled with inadequate intake from foods and supplements, this then leads to vitamin D deficiency, particularly in pregnant women, resulting in more asthma and allergy in their offspring. Vitamin D has been linked to immune system and lung development in utero, and our epidemiologic studies show that higher vitamin D intake by pregnant mothers reduces asthma risk by as much as 40% in children 3 to 5 years old. Vitamin D deficiency has been associated with obesity, African American race (particularly in urban, inner-city settings), and recent immigrants to westernized countries, thus reflecting the epidemiologic patterns observed in the asthma epidemic. Providing adequate vitamin D supplementation in pregnancy may lead to significant decreases in asthma incidence in young children.
Sinusitis and polyposis Ballenger's Otorhinolaryngology, Head and neck surgery
  • P Andrew
  • W Davied
Andrew P, Davied W: Sinusitis and polyposis. In James B, John JB. (Ed): Ballenger's Otorhinolaryngology, Head and neck surgery, 16th ed. ch. 26, spain, BC Decker Inc, 2003, pp276-77.
Ballenger's Otorhinolaryngology, Head and neck surgery
  • P Andrew
  • W Davied
Andrew P, Davied W: Sinusitis and polyposis. In James B, John JB. (Ed): Ballenger's Otorhinolaryngology, Head and neck surgery, 16th ed. ch. 26, spain, BC Decker Inc, 2003, pp276-77.