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A Comparative Study on Seven-Year Results of "All-On-Four™" Immediate-Function Concept for Completely Edentulous Mandibles: Metal-Ceramic vs. Bar-Retained Superstructures

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Abstract

The study aims to document the clinical outcomes over a 7-year period of two techniques used for the rehabilitation of edentulous mandibles according to the “All-on-Four™” concept: (1) fixed complete-arch prostheses fabricated with metal-ceramic implant-supported fixed prosthesis with a titanium framework and all-ceramic crowns and (2) bar-retained implant-supported removable prosthesis with acrylic resin prosthetic teeth. The study was performed on 32 patients who received immediately loaded “All-on-Four™” fixed mandibular prostheses. (Fixed prostheses with ceramic superstructures, n:16; bar-retained removable acrylic prostheses, n:16). The patients were evaluated for up to 7 years after prosthesis completion. The endpoints included the evaluation of prosthodontic complications, bone resorption, plaque accumulation, bleeding on probing, periodontal probing depth and an oral health impact profile (OHIP). Bone loss remained under 1.2 mm in all of the implants, and no difference was observed between two groups. Plaque accumulation increased gradually in both groups, and the bar-retained acrylic-bearing implants showed significantly higher values during the first 5 years. Immediate improvement was assessed by the OHIP score in both groups. The observed bone loss and the subjective outcomes showed equivalent levels of clinical success for bar-retained and ceramic superstructures over a 7-year period. The higher level of plaque accumulation observed around implants with bar-retained superstructures requires that patients with acrylic superstructures be highly motivated to maintain their personal oral hygiene. Further studies are needed to clarify the occurrence of prosthodontic complications and assess their economic aspects.
ORIGINAL ARTICLE
A comparative study on 7-year results of ‘‘All-on-Four
TM
’’
immediate-function concept for completely edentulous mandibles:
metal-ceramic vs. bar-retained superstructures
Mustafa Ayna
1
Aydin Gu
¨lses
2
Yahya Acil
3
Received: 28 September 2016 / Accepted: 21 February 2017
The Society of The Nippon Dental University 2017
Abstract The study aims to document the clinical out-
comes over a 7-year period of two techniques used for the
rehabilitation of edentulous mandibles according to the
‘All-on-Four
TM
’ concept: (1) fixed complete-arch pros-
theses fabricated with metal-ceramic implant-supported
fixed prosthesis with a titanium framework and all-ce-
ramic crowns and (2) bar-retained implant-supported
removable prosthesis with acrylic resin prosthetic teeth.
The study was performed on 32 patients who received
immediately loaded ‘‘All-on-Four
TM
’ fixed mandibular
prostheses. (Fixed prostheses with ceramic superstruc-
tures, n:16; bar-retained removable acrylic prostheses,
n:16). The patients were evaluated for up to 7 years after
prosthesis completion. The endpoints included the evalu-
ation of prosthodontic complications, bone resorption,
plaque accumulation, bleeding on probing, periodontal
probing depth and an oral health impact profile (OHIP).
Bone loss remained under 1.2 mm in all of the implants,
and no difference was observed between two groups.
Plaque accumulation increased gradually in both groups,
and the bar-retained acrylic-bearing implants showed
significantly higher values during the first 5 years.
Immediate improvement was assessed by the OHIP score
in both groups. The observed bone loss and the subjective
outcomes showed equivalent levels of clinical success for
bar-retained and ceramic superstructures over a 7-year
period. The higher level of plaque accumulation observed
around implants with bar-retained superstructures requires
that patients with acrylic superstructures be highly moti-
vated to maintain their personal oral hygiene. Further
studies are needed to clarify the occurrence of
prosthodontic complications and assess their economic
aspects.
Keywords Acrylic dentures Bleeding on probing Bone
loss Plaque accumulation Probing depth Immediate
loading All-on-Four
TM
Introduction
The ‘‘All-on-Four
TM
’ concept, which exploits the load-
bearing capacity of the mandible allows basically for two
different types of superstructures [13]: 1. a metal-ceramic
implant-supported fixed prosthesis with a titanium frame-
work and all-ceramic crowns and 2. a metal-acrylic resin
implant-supported fixed prosthesis with a titanium frame-
work and acrylic resin prosthetic teeth. In addition, bar-
retained removable acrylic superstructures can be used as
an alternative to the metal-acrylic resin implant-supported
fixed prosthesis [4].
When selecting a superstructure type, the dental pro-
fessional primarily needs to consider the patients’ prefer-
ences and economic status. There is a considerable
difference in the cost of different types of superstructures
(laboratory costs in Germany are approximately 1700 USD
[acrylic]; 3400 USD [bar-retained]; 5500 USD [ceramic]);
thus, it would be useful to perform a comparative evalua-
tion of these methods [5]. Unfortunately, a limited number
of studies have been conducted on the clinical outcomes of
&Aydin Gu
¨lses
aydingulses@gmail.com
1
Center for Dental Implantology, 47051 Duisburg, Germany
2
Christian Albrechts University, Department of Oral and
Maxillofacial Surgery, 24105 Kiel, Germany
3
Christian Albrechts University, Department of Oral and
Maxillofacial Surgery, 24105 Kiel, Germany
123
Odontology
DOI 10.1007/s10266-017-0304-7
different types of superstructures and there is a need for
long-term comparative studies in this area.
In a recent study [5], patients who received ceramic were
compared with those who received acrylic superstructures
over a period of 5 years. However, clinical results for bar-
retained removable acrylic superstructures mounted on four
interforaminal implants according to the ‘‘All-on-Four
TM
’’
concept have not been investigated thus far.
The purpose of the present study was to document the
long-term clinical outcomes of the use of two techniques
for the rehabilitation of completely edentulous mandibles
according to the ‘‘All-on-Four
TM
’ concept: 1. the use of
fixed complete-arch prostheses that are fabricated with
metal-ceramic implant-supported fixed prosthesis with a
titanium framework and all-ceramic crowns and 2. a bar-
retained implant-supported removable acrylic prosthesis
with acrylic resin prosthetic teeth.
Materials and methods
Between February 2006 and February 2007, patients with
edentulous mandibles were screened for participation in a
trial where they would receive implant-based fixed den-
tures. To participate, patients had to fulfill the following
criteria: Atrophy of the edentulous mandible (class C and D
according to Misch and Judy [6]) with the rehabilitation
option of ‘All-on-4
TM
’ concept. Opposing natural dentition
or implant-based prosthesis. An interforaminal bone width
C5 mm and bone height C8 mm. Completely healed, at
least 6 months postextraction socket(s). The exclusion
criteria were as follows: General systemic contraindica-
tions against implant surgery (psychiatric disorders, preg-
nancy, metabolic bone diseases, etc.). The presence of
systemic diseases which may jeopardize the success of
implant integration (uncontrolled diabetes, osteoporosis,
etc.). The use of drugs which may negatively affect the
osseointegration process (bisphosphonates, corticosteroids,
etc.). Active inflammation or neighboring pathologies in
the areas intended for implant placement. Radiation ther-
apy to the head and/or neck region in the preceding
12 months. Requirement of bone augmentation during
implant placement. Clinically significant parafunction.
Poor oral hygiene and/or compliance. Eligible patients,
which have to pay for their surgical and prosthetic treat-
ments, were informed orally and in writing about the goals
and the duration of the study (observation period of
7 years) and the pertinent risks and benefits of the proce-
dure and of the respective superstructures. Thirty-two
patients were assigned to different superstructure groups
(ceramics or bar-retained acrylic resin) of their own choice;
the primary decision criterion was the substantial differ-
ence in price between the techniques.
Surgical procedure
Standard dental records and radiographs were taken as if
the patient were to receive an immediate mandibular
denture after extractions. A finished complete mandibu-
lar denture was fabricated by the dental laboratory for
later modification as a provisional fixed restoration
according to the manufacturer’s guided-surgery protocol.
CBCT scans (iCat
, Imaging Sciences International,
LLC, http://www.i-cat.com) using the double-scan tech-
nique were taken with the patient wearing this appliance
and occlusal registration. The CBCT data were con-
verted into DICOM images and imported into the
NobelClinician software for guided-surgery treatment
planning. The completed plan was digitally sent to the
manufacturer for surgical guide fabrication. In addition,
preoperative pictures, capturing the patient’s smile, high
lip line, and resting line were recorded. The vertical
dimension was ensured.
All procedures were performed by the same dental
surgeon (M.A.) under local anesthesia [articaine chloro-
hydrate (72 mg/1.8 ml) with epinephrine (0.018 mg/
1.8 ml) 1:100,000]. All of the patients received four Nobel
Speedy
TM
implants according to the ‘‘All-on-Four
TM
’’
protocol in the edentulous mandibles [13] (Fig. 1). A
mucoperiosteal flap was raised at the ridge crest with
relieving incisions on the buccal aspect in the molar area.
The mental nerve was exposed to exactly identify the
neurovascular bundle. The implants and abutments were
placed in one position at a time, starting with the posterior
ones. A special guide (edentulous guide, Nobel Biocare
AB, Goteborg, Sweden) was used to assist implant and
abutment placement. This guide was placed into a 2 mm
osteotomy made at the midline of the jaw and the titanium
band is bent so that the occlusal centerline of the opposing
Fig. 1 Surgical phase—insertion of implants and placement of 30
multi-unit abutments
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123
jaw was followed. By doing this, it was possible to guide
the implants to be placed in the center of the opposing
prosthesis and at the same time find the optimal position
and inclination for best implant anchorage and prosthetic
support.
Two distal implants in the posterior region which are
tilted anterior to the mental foramen were inserted at an
angulation of 30
–45
. The use of the All-on-4
surgical
guide assists in ensuring that the distal screw access holes
were located at the occlusal face of the first molar, the
second premolar, or the first premolar.
The insertion of the implants followed standard proce-
dures, except that under preparation was used to achieve an
insertion torque of at least 35 Ncm before final seating of
the implant. After closing and suturing the flap with 3-0
nonresorbable suture, the abutments were accessed by
means of a punch if needed, and impression copings were
placed. The implant sizes were 4 913 mm mesial and
4915 mm distal, with the longer distal implants provid-
ing bicortical anchoring. All implants were immediately
loaded within 24 h.
Antibiotics (amoxicillin 875 mg ?clavulanic acid
125 mg) were given 1 h prior to surgery and two times a
day for 6 days thereafter. Antiinflammatory medication
(ibuprofen, 600 mg) was administered for 5 days.
Immediate prosthetic procedure
For both groups, a rounded titanium bar with two distal
extensions on both sides was welded on to the implant
abutments. A high-density acrylic resin prosthesis was then
manufactured at the dental laboratory and mounted within
24 h post-surgery (Fig. 2). All centric and lateral contacts
were evaluated with articulating paper 40 microns and
adjusted to obtain a correct occlusal contact. Cantilever
length was determined according to 1.5-2 x A-P-spread
rule [7], which allows a 10–12 mm posterior cantilever
extended to the first molar regions.
Final prosthetic procedure
Three months later, for the patients who were slated to
receive a bar-retained acrylic resin implant-supported
removable prosthesis, a chrome-molybdenum bar with a
quadrilateral shape and two distal extensions with ball
attachments was fabricated using CAD/CAM technology,
and an acrylic removable prosthesis with acrylic resin
prosthetic teeth was prepared (Fig. 3).
For the patients who were slated to receive ceramic
superstructures, 3 months later, a metal-ceramic implant-
supported fixed prosthesis with a titanium framework that
Fig. 2 a,bImmediately loaded
provisional acrylic prosthesis
with a rounded titanium bar
which was welded on the
abutments with two distal
extensions on both sides
Fig. 3 a,bThree months later,
a chrome-molybdenum bar with
a quadrilateral shape with two
distal extensions with ball
attachments and a rubber ring
retention was fabricated using
CAD/CAM technology
Odontology
123
was fabricated using CAD/CAM technology (Fig. 4) and
connected to the implants with abutment screws to 15N
(Fig. 5).
Outcome parameters
Measurement of bone resorption Bone crest levels
around the implants were measured with a standard
right-angle parallel technique, based on single digital
X-rays. The radiographs were scanned at 600 dpi
(Trophy RVG UI USB Sensor, KODAK 5.0 software,
Carestream, Stuttgart, Germany), and image analysis
software was used to assess bone level (UTHSCSA
Image Tool version 3.00 for Windows, University of
Texas Health Science Center, San Antonio, Texas
USA). The linear distance between the implant neck
and the most coronal bone-to-implant contact at the
mesial and distal aspect was measured for each implant
[5,8,9] immediately after implant insertion and 1, 3, 5
and 7 years after, and the bone loss was calculated
using the bone level immediately after implantation as
a reference.
PPD was measured in mm at six peri-implant sites at 1,
3, 5 and 7 years postoperatively. BOP was measured at
four sites every year. The deepest pocket was consid-
ered in the analysis, and any bleeding on probing was
recorded as affirmative.
Plaque accumulation was evaluated using the plaque
Index according to Mombelli et al. [10]. The exami-
nation was performed every year during the follow-up
period.
The impact of the reconstruction on the quality of life
was assessed using the German version of the OHIP
[1116], which was applied before surgery, immedi-
ately after implantation and at 1, 5 and 7 years after
denture integration. OHIP considers 14 metrics in seven
domains using a five-point verbal rating scale ranging
from ‘‘never’’ (coded 0) to ‘‘very often’’ (coded 4).
Statistical analysis
The data were analyzed using the software package SPSS
20. The following non-parametric methods were used: the
Wilcoxon test for differences over time, Mann–Whitney
Utest for group differences and for discrete parameters.
The level of significance was set at p\0.05. The Spear-
man correlation coefficient was calculated to analyze the
relationship between scale variables.
Results
One patient in the ceramic superstructure group was lost to
follow-up during the observation period due to relocation
and was excluded from the study group.
A total of 32 patients between 66 and 83 years of age
(mean 71.00 ±4.07 years) were enrolled in the study.
The female/male ratio was 19:13. None of the patients
were smokers as a part of the study design. There were
no statistically significant differences in the demo-
graphics and the baseline data between the two groups.
(Table 1) Totally, 128 implants were placed and none of
the implants failed during the observation period. In
addition, no biological complications such as fistula
formation, pain, infection or soft-tissue inflammation
were found. The survival rate of the prosthesis was
100%.
An analysis of the difference in the insertion torque
between patients with bar-retained and ceramic super-
structures (Table 2) revealed significantly higher values in
region 45 for patients in the former group. Moreover, the
straight implants (regions 32 and 42) were inserted with
Fig. 4 Metal-ceramic implant-supported fixed prosthesis with a
titanium framework fabricated using CAD/CAM technology
Fig. 5 Metal-ceramic implant-supported fixed prosthesis was con-
nected to implants with abutment screws to 15N
Odontology
123
significantly less torque than the angulated implants in
regions 35 and 45 (p\0.0001, Table 2).
Outcome parameters
In both groups, a uniform, albeit slight, a progression of
bone loss was observed over the 7-year observation period
that remained well within the limits for ‘success’, as
defined by the 2007 Pisa consensus [17](\2 mm). In
addition, bone loss was significantly more pronounced
around the distal implants in regions 35 and 45
(p\0.0001). There were no significant differences
between the groups in terms of the bone loss between the
ceramic and bar-retained superstructures (Table 3).
The probing pocket depth (PPD) increased consistently
and significantly over time in both groups. There was a
Table 1 Demographics and
baseline data Total Bar-retained acrylic Ceramics
Number of patients (n, %) 32 16 (50.0%) 16 (50.0%)
Males/females (n, %) 13/19 (40.6/59.4%) 7/9 (43.8/56.3%) 6/10 (37.5/62.5%)
Age (years) 66–83 (71.00 ±4.070) 66–80 (71.50 ±3.86) 66–83 (72.06 ±4.35)
Table 2 Evaluation of insertion
torque values Insertion torque (N) Total Bar-retained acrylic Ceramics
Region 32 40–59 (47.7 ±5.2) 40–58 (45.5 ±6.0) 40–59 (48.4 ±4.3)
Region 42 42–63 (50.2 ±5.7) 43–63 (51.5 ±6.5) 45–55 (48.8 ±4.6)
Region 35
¥
51–80 (66.1 ±6.3) 51–80 (67.0 ±7.1) 64–69 (65.2 ±5.3)
Region 45
¥
56–79 (69.3 ±5.9) 56–79 (71.4 ±6.2)* 57–73 (67.1 ±5.1)
According to the guidelines of all on 4
TM
treatment protocol, an insertion torque of 35–45 Ncm should be
achieved. Greater torque values in region 35 and 45 could be attributed to the fact that the implants placed
at these sites were 15 mm in length and bicortical anchorage has been achieved, which resulted in higher
torque values
*p\0.05 and ** p\0.01, comparison of region 32 vs. 35 and 42 vs. 45 ¥ p\0.0001
Table 3 Peri-implant bone loss
(mm) throughout 7 years of
function
Total Bar-retained acrylic Ceramics
Bone loss in region 32
After 1 year 0.1–0.6 (0.30 ±0.31) 0.2–0.4 (0.29 ±0.06) 0.1–0.6 (0.32 ±0.13)
After 3 years 0.2–0.8 (0.47 ±0.15) 0.2–0.6 (0.46 ±0.09) 0.2–0.8 (0.48 ±0.17)
After 5 years 0.3–0.8 (0.60 ±0.15) 0.3–0.8 (0.59 ±0.16) 0.4–0.8 (0.60 ±0.14)
After 7 years 0.4–0.9 (0.66 ±0.14) 0.4–0.9 (0.66 ±0.14) 0.4–0.9 (0.66 ±0.15)
Bone loss in region 35*
After 1 year 0.2–0.8 (0.65 ±0.15) 0.2–0.7 (0.53 ±0.16) 0.3–0.8 (0.55 ±0.15)
After 3 years 0.3–0.9 (0.75 ±0.16) 0.3–0.9 (0.64 ±0.15) 0.3–0.9 (0.66 ±0.15)
After 5 years 0.4–1.0 (0.80 ±0.17) 0.4–1.0 (0.74 ±0.16) 0.4–1.0 (0.76 ±0.18)
After 7 years 0.5–1.2 (0.59 ±0.17) 0.5–1.2 (0.80 ±0.17) 0.5–1.1 (0.81 ±0.18)
Bone loss in region 42
After 1 year 0.2–0.6 (0.37 ±0.14) 0.2–0.6 (0.40 ±0.11) 0.2–0.6 (0.35 ±0.11)
After 3 years 0.3–0.8 (0.49 ±0.14) 0.3–0.8 (0.52 ±0.15) 0.3–0.7 (0.46 ±0.13)
After 5 years 0.3–0.9 (0.59 ±0.15) 0.4–0.9 (0.63 ±0.14) 0.3–0.8 (0.55 ±0.13)
After 7 years 0.3–0.9 (0.62 ±0.15) 0.4–0.9 (0.65 ±0.15) 0.3–0.9 (0.60 ±0.15)
Bone loss in region 45*
After 1 year 0.3–1.0 (0.59 ±0.19) 0.3–0.9 (0.59 ±0.18) 0.3–1.0 (0.58 ±0.21)
After 3 years 0.4–1.0 (0.70 ±0.16) 0.4–0.9 (0.73 ±0.13) 0.4–1.0 (0.67 ±0.19)
After 5 years 0.5–1.1 (0.84 ±0.16) 0.6–1.0 (0.86 ±0.13) 0.5–1.1 (0.82 ±0.19)
After 7 years 0.6–1.2 (0.91 ±0.16) 0.7–1.1 (0.93 ±0.14) 0.6–1.2 (0.89 ±0.20)
Comparison of region 32 vs. 35 and 42 vs. 45 after 1, 3, 5 and 7 years * p\0.0001
Odontology
123
tendency towards shallower pockets for the ceramic
superstructures, which was mostly not significant
(Table 4).
Bleeding on probing (BOP) measurements around the
implants in region 35 showed statistically significant higher
values in the group with bar-retained superstructures
throughout the observation period over the group with
ceramic superstructures. Higher BOP values were also found
for implants in regions 42 and 32, especially in the first year
for the group with bar-retained superstructures (Table 5).
The plaque index showed that the plaque accumulation
was higher in the group with the bar-retained superstruc-
tures (Table 6).
There was a dramatic subjective improvement, as
assessed by the Oral Health Impact Profile (OHIP) score in
both groups. There were no differences in the OHIP scores
between patients with bar-retained dentures and ceramic
dentures (Fig. 6).
Complications
Bar-retained group
The following mechanical complications were recorded:
fractures of the extensions of the provisional acrylic
removable prosthesis (n:1) and dislodgement of the acrylic
teeth the provisional acrylic removable prosthesis (n:3).
The complications were resolved by repairing the pros-
thesis and adjusting the occlusion in situ. No mechanical
problems were observed in patients with definitive acrylic
prostheses, except for the attrition of the acrylic teeth.
Ceramics group
An acrylic tooth dislodged for one patient during the use of
provisional acrylic bridges and was repaired in situ. Some
problems were observed for patients with definitive cera-
mic superstructures. In one patient, the prosthesis around
the right premolar area dislodged at the end of the 7-year
period. The denture had to be removed and repaired in the
laboratory. Loosening of the multi-unit abutment screw
was observed in one patient at the implant region 32 and
was resolved by re-tightening the abutment screw.
All prostheses were easily mended and served well after
revision. No further mechanical complications were reg-
istered during the follow-up of this study.
Discussion
There have been numerous reports [2,1820] that bar-
retained acrylic superstructures function well if carefully
designed and manufactured and if good implant support is
provided; however, these superstructures are also some-
times associated with prosthetic problems. A literature
Table 4 The evaluation of the
probing pocket depth Total Bar-retained acrylic Ceramics
PPD in region 32 ¥ ¥ ¥
After 1 year 1.0–3.0 (2.00 ±0.50) 1.0–3.0 (2.03 ±0.53) 1.0–2.5 (1.96 ±0.49)
After 3 years 1.0–4.0 (2.50 ±0.60) 1.0–4.0 (2.62 ±0.69) 1.0–3.0 (2.37 ±0.50)
After 5 years 1.5–4.5 (3.01 ±0.61) 1.5–4.5 (3.12 ±0.69) 1.5–3.5 (2.90 ±0.52)
After 7 years 1.5–4.5 (3.23 ±0.62) 1.5–4.5 (3.31 ±0.68) 1.5–3.5 (3.15 ±0.56)
PPD in region 42 ¥ ¥ ¥
After 1 year 1.0–3.0 (2.26 ±0.59) 1.0–3.0 (2.43 ±0.60) 1.0–3.0 (2.09 ±0.55)
After 3 years 1.0–4.0 (2.54 ±0.65) 1.0–4.0 (2.65 ±0.72) 1.0–3.0 (2.43 ±0.57)
After 5 years 1.5–4.5 (3.06 ±0.63) 1.5–4.5 (3.21 ±0.70) 1.5–3.5 (2.90 ±0.52)
After 7 years 2.0–5.0 (3.23 ±0.60) 2.0–5.0 (3.40 ±0.68) 2.0–4.0 (3.06 ±0.47)
PPD in region 35 ¥ ¥ ¥
After 1 year 2.0–4.0 (2.87 ±0.50) 2.0–4.0 (2.93 ±0.54) 2.0–4.0 (2.81 ±0.47)
After 3 years 2.0–4.5 (3.10 ±0.57) 2.0–4.5 (3.18 ±0.65) 2.0–4.5 (3.03 ±0.49)
After 5 years 2.5–4.5 (3.56 ±0.56) 2.5–4.5 (3.56 ±0.57) 2.5–4.5 (3.56 ±0.57)
After 7 years 2.5–5.0 (3.70 ±0.59) 2.5–5.0 (3.68 ±0.57) 2.5–5.0 (3.68 ±0.57)
PPD in region 45 ¥ ¥ ¥
After 1 year 2.0–4.5 (2.96 ±0.59) 2.0–4.5 (2.96 ±0.64) 2.0–4.0 (2.96 ±0.56)
After 3 years 2.0–4.5 (3.34 ±0.54) 2.5–4.5 (3.40 ±0.55) 2.0–4.0 (3.28 ±0.54)
After 5 years 2.5–5.5 (3.81 ±0.60) 2.5–5.5 (3.87 ±0.69) 2.5–4.5 (3.75 ±0.51)
After 7 years 3.0–5.5 (4.07 ±0.55) 3.0–5.5 (4.15 ±0.59) 3.0–4.5 (4.00 ±0.51)
Increase over time: ¥ p\0.0001
Odontology
123
survey revealed several problems with bar-retained
implant-supported prostheses: bar fracture, retention clip
activation or O-ring replacement, abutment screw failure
and fracture of the retention clip [2123]. In the current
study, no mechanical problems were observed for the
group with definitive bar-retained acrylic prostheses,
except for the fracture of the extension of the provisional
acrylic prosthesis, which could be repaired in situ. An
O-ring replacement was performed every year for all of the
patients who were treated with bar-retained superstruc-
tures, even if no loss was observed in the retention clips.
Prosthetic problems were rarely observed in both groups in
this study; however, in the literature, it has been suggested
that [23] a significant shortcoming of acrylic removable
superstructures was the substantial increase in susceptibil-
ity to various prosthodontic complications with long-term
use. In addition, it has been proclaimed that mechanical
problems related to the bar-retained acrylic superstructures
could be resolved more cheaply than those related to the
ceramic superstructures, considering that acrylic super-
structures could be mostly repaired in situ, whereas the
denture had to be removed and repaired in the laboratory in
the ceramic group. In the ceramic superstructure group, we
have observed a dislodgement of the prosthesis around the
right premolar area in one patient at the end of the 7-year
period, and the denture had to be removed and repaired in
the laboratory. Further studies with long-term results are
needed to compare the economic aspects of prosthetic
complications between acrylic and ceramic superstructures.
It is obvious that the success of a dental prosthesis is
highly dependent on fulfilling the cosmetic and functional
demands of the patients. Measurement of occlusal forces is
a useful tool in comparing the functional aspects of dif-
ferent superstructures. We have used OHIP instrument to
assess subjective treatment outcomes, and found no sta-
tistically significant differences between two groups.
However, objective parameters such as occlusal force
measurements and comparative evaluation of the cosmetic
results via analysis of the lip support, cephalometric anal-
ysis, etc. were not included in the ‘‘Material and method’’
of the present study.
There are reports in the literature of patients who were
treated with bar-retained implant-supported overdentures
and experienced difficulties in maintaining good oral
hygiene, even when they were highly motivated to do so
[21,2427]. Similar to the aforementioned findings, in the
present study, the difference in plaque accumulation, as
evaluated by the plaque index of Mombelli et al. [10],
between ceramic and bar-retained acrylic-bearing implants
was significant throughout the observation period, and the
highest plaque indexes were found for patients with bar-
retained superstructures. Clinicians should be made aware
of this result, and patients with poor oral hygiene motiva-
tion should be informed of the risk of plaque accumulation
and instructed in oral hygiene maintenance. The observa-
tion of higher BOP values in the removable superstructure
group could also be attributed to higher plaque accumula-
tion, which depends on the maintenance of a patient’s
personal oral hygiene [28].
Conclusion
In the current article, equivalent results were obtained for
bar-retained and ceramic superstructures over a 7-year
period. The higher level of plaque accumulation observed
around implants with bar-retained superstructures requires
Table 5 Evaluation of the BOP values
Total Bar-retained acrylic Ceramics
BOP in region 32
After 1 year 37.5% 68.75%* 6.25%
After 2 years 43.75% 56.25% 31.25%
After 3 years 37.5% 62.5% 12.5%
After 4 years 40.63% 56.25% 25.0%
After 5 years 31.25% 43.75% 18.75%
After 6 years 21.88% 37.5% 6.25%
After 7 years 21.88% 37.5% 6.25%
BOP in region 42
After 1 year 43.75% 68.75%* 18.75%
After 2 years 34.38% 56.25% 12.50%
After 3 years 37.50% 75.00% 0.00%
After 4 years 31.25% 43.75% 18.75%
After 5 years 28.13% 50.00%* 6.25%
After 6 years 25.00% 37.50% 12.50%
After 7 years 25.00% 25.00% 25.00%
BOP in region 35
After 1 year 53.13% 75.00%* 31.25%
After 2 years 37.50% 75.00%* 0.00%
After 3 years 37.50% 50.00% 25.00%
After 4 years 43.75% 75.00%* 12.50%
After 5 years 28.13% 31.25% 25.00%
After 6 years 46.88% 68.75%* 25.00%
After 7 years 21.88% 43.75%* 0.00%
BOP in region 45
After 1 year 12.50% 25.00% 0.00%
After 2 years 34.88% 43.75% 25.00%
After 3 years 18.75% 37.50% 0.00%
After 4 years 28.13% 43.75% 12.50%
After 5 years 25.00% 37.50% 12.50%
After 6 years* 31.25% 43.75% 18.75%
After 7 years* 34.38% 25.00% 43.75%
Comparison of bar-retained acrylic resin and ceramic suprastructures
*p\0.05
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123
Fig. 6 OHIP scores for both
groups during the observation
period (preoperative and at the
end of 1st, 3rd 5th and 7th years
postoperatively) showing no
significant differences between
groups
Table 6 Evaluation of the
plaque accumulation (PA)
according to Mombelli and co-
workers
Total Bar-retained acrylic Ceramics
PA in region 32
After 1 year 0.0–3.0 (1.06 ±0.98) 0.0–3.0 (1.75 ±0.77)* 0.0–2.0 (0.37 ±0.61)
After 2 years 0.0–3.0 (1.37 ±1.00) 2.0–3.0 (2.18 ±0.40)* 0.0–2.0 (0.56 ±0.72)
After 3 years 0.0–3.0 (1.50 ±1.01) 1.0–3.0 (2.18 ±0.75)* 0.0–2.0 (0.81 ±0.75)
After 4 years 0.0–3.0 (1.46 ±1.01) 0.0–3.0 (1.87 ±0.95)* 0.0–3.0 (1.06 ±0.92)
After 5 years 0.0–3.0 (1.31 ±0.93) 1.0–3.0 (1.93 ±0.68)* 0.0–2.0 (0.68 ±0.70)
After 6 years 0.0–3.0 (1.34 ±0.90) 1.0–3.0 (1.93 ±0.77) 0.0–2.0 (0.75 ±0.57)
After 7 years 0.0–3.0 (1.25 ±0.95) 0.0–3.0 (1.87 ±0.88) 0.0–1.0 (0.62 ±0.50)
PA in region 42
After 1 year 0.0–3.0 (1.31 ±1.09) 0.0–3.0 (1.93 ±1.06)* 0.0–2.0 (0.68 ±0.70)
After 2 years 0.0–3.0 (1.21 ±0.94) 1.0–3.0 (1.93 ±0.57)* 0.0–2.0 (0.50 ±0.63)
After 3 years 0.0–3.0 (1.53 ±1.01) 0.0–3.0 (2.25 ±0.77)* 0.0–2.0 (0.81 ±0.65)
After 4 years 0.0–3.0 (1.40 ±0.94) 1.0–3.0 (2.06 ±0.68)* 0.0–2.0 (0.75 ±0.68)
After 5 years 0.0–3.0 (1.21 ±1.00) 1.0–3.0 (1.93 ±0.77)* 0.0–2.0 (0.50 ±0.63)
After 6 years 0.0–3.0 (1.28 ±0.99) 0.0–3.0 (1.75 ±1.06)* 0.0–2.0 (0.81 ±0.65)
After 7 years 0.0–3.0 (1.18 ±0.82) 1.0–3.0 (1.62 ±0.61)* 0.0–2.0 (0.75 ±0.77)
PA in region 35
After 1 year 0.0–3.0 (1.37 ±0.83) 1.0–3.0 (1.87 ±0.61)* 0.0–2.0 (0.87 ±0.71)
After 2 years 0.0–3.0 (1.18 ±0.89) 0.0–3.0 (1.75 ±0.85)* 0.0–1.0 (0.62 ±0.50)
After 3 years 0.0–3.0 (1.21 ±0.94) 0.0–3.0 (1.81 ±0.75)* 0.0–2.0 (0.62 ±0.71)
After 4 years 0.0–3.0 (1.34 ±0.97) 1.0–3.0 (2.00 ±0.63)* 0.0–2.0 (0.68 ±0.79)
After 5 years 0.0–3.0 (1.25 ±0.91) 0.0–3.0 (1.56 ±0.96) 0.0–2.0 (0.93 ±0.77)
After 6 years 0.0–3.0 (1.62 ±0.87) 1.0–3.0 (2.18 ±0.65)* 0.0–2.0 (1.06 ±0.68)
After 7 years 0.0–3.0 (1.25 ±0.91) 1.0–3.0 (1.87 ±0.71)* 0.0–2.0 (0.62 ±0.61)
PA in region 45
After 1 year 0.0–3.0 (0.84 ±0.91) 0.0–3.0 (1.31 ±1.01)* 0.0–1.0 (0.37 ±0.50)
After 2 years 0.0–3.0 (1.03 ±0.96) 0.0–3.0 (1.37 ±1.08) 0.0–2.0 (0.68 ±0.70)
After 3 years 0.0–3.0 (1.15 ±0.80) 0.0–3.0 (1.37 ±1.02) 0.0–2.0 (0.93 ±0.44)
After 4 years 0.0–3.0 (1.25 ±0.87) 0.0–3.0 (1.62 ±0.95)* 0.0–2.0 (0.87 ±0.61)
After 5 years 0.0–3.0 (1.31 ±1.02) 0.0–3.0 (1.81 ±1.16)* 0.0–2.0 (0.81 ±0.54)
After 6 years 0.0–3.0 (1.09 ±1.08) 0.0–3.0 (1.43 ±1.26) 0.0–2.0 (0.75 ±0.77)
After 7 years 0.0–3.0 (1.34 ±0.70) 0.0–3.0 (1.25 ±0.85) 0.0–2.0 (1.43 ±0.51)
Comparison of bar-retained acrylic resin and ceramic suprastructures, *p\0.05, were used to demonstrate
the values which were statistically significant
Odontology
123
that patients with acrylic superstructures be highly moti-
vated to maintain their personal oral hygiene. Further
studies are needed to clarify the occurrence of
prosthodontic complications and assess their economic
aspects.
Acknowledgements The authors would like to thank Dr. Cengiz Han
Acikel from the Gulhane Military Medical Academy, Department of
Biostatistics, for conducting the statistical analysis of the current
study.
Contributions MA has performed the surgical interventions. AG,
MA and YA have written and edited the paper.
Compliance with ethical standards
Conflict of interest The authors declare that they have no conflict of
interest.
Consent Written informed consent was obtained from the patient for
publication of this case report and any accompanying images.
Disclosure The authors claim to have no financial interest, either
directly or indirectly, in the products or information listed in the
paper.
Approval This study was approved by the Ethics Review Committee
(NEAH/12.15.2015#498).
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... 25,26 Reviewing the literature revealed that there are clinical studies comparing the effects of mandibular four implant supported fixed prosthesis and bar overdenture on peri-implant tissues. [27][28][29][30][31][32] To the best of the authors' knowledge, only two clinical studies have compared an All-On-Four screwretained prosthesis to overdenture retained by unsplinted implants. 33,34 Hence, the objective of this study was to compare the clinical, radiographic, and prosthetic results of an All-On-Four maxillary hybrid prosthesis and a bar-clip retained maxillary overdenture after one year of follow-up in patients with mandibular hybrid prostheses. ...
... This might be attributed to the diminished cleaning ability of aged people, which makes plaque buildup worse. 27 Another factor might be patients' difficulty removing the prosthesis to practice sufficient oral hygiene in HP group. 30 While the presence of bar in BO group hindered the accessibility around the implants and complicated the oral hygiene. ...
... Ayna et. al. 27 discovered insignificant differences in marginal bone loss between All-On-Four implant hybrid prostheses and bar-clip retained overdentures. The hybrid prostheses, however, showed slightly greater bone resorption values than the bar-clip overdentures. ...
... This study has clearly shown that the advanced criteria for "success" in dental implantology [14], including bone resorption, were fulfilled throughout the sample after 5 years of observation for both groups. The results regarding the bone loss and inflammatory parameters in both groups were similar and parallel to those reported on the maxillary All-on-4 concept in the literature [15][16][17]. However, a slight superiority of the monolithic zirconia structures regarding the PPD and marginal bone loss could be observed. ...
Article
Full-text available
The aim of the current study was to present the clinical and radiological outcomes of monolithic zirconia superstructures compared to the metal–ceramic ones in the All-on-4 concept for the prosthetic rehabilitation of the maxillae. A total of 30 patients were subdivided into groups according to their superstructure type (metal–ceramic (n = 15) or monolithic zirconia (n = 15)). All implants were functionally loaded within 24 h after insertion with provisional acrylic superstructures. Prosthetic complications, marginal bone loss, plaque accumulation, probing pocket depth, bleeding on probing, and bite force were documented over a period of 5 years. Marginal bone loss around the implants of the ceramic group remained well over the five years (1.21 ± 0.23 mm). However, marginal bone loss was significantly lower around the implants in the monolithic zirconia group (0.22 ± 0.14 mm) (p < 0.001). Bleeding on probing, plaque accumulation, and probing pocket depth values were correlated with marginal bone loss. Among all evaluated parameters, no differences could be detected in terms of the angulation of the implants. Detachment or chipping was observed in seven cases in the metal–ceramic superstructure group. In all cases, dentures were removed and repaired in the laboratory. In the monolithic zirconia group, chipping was detected after one year in two cases, after two years in four cases, and after five years in one case and could be managed by polishing in situ. Monolithic zirconia superstructures presented superior results regarding the parameters evaluated.
... However, if the material has a high modulus of elasticity, fracture or mechanical complications versus bending and deformations are lower [14] . In this regard, while some researchers suggest a metal substructure due to its rigid structure, others suggest allacrylic resin prostheses and claim that this structure has the possibility of being used for a longer period [15] . Initially, prostheses on implants were made on a cast metal structure and later, thanks to technological advances, they were made on milled bars. ...
... With advancement of time probing depth (PD) significantly increased in both groups with median of 0.77 & 0.562 in group I and group II respectively. This goes in accordance with several studies that reported increase in probing depth in implants supporting "All on four" prosthesis (27) (28) . However, other studies reported shallow periodontal pockets and more stable soft tissues with no significant midfacial recession (29) (30) . ...
... 10 In addition, in some patients, the triangular arch of the mandible does not allow the appropriate distance between the implants, which may require a reduction in the number of implants. 11 For such a clinical situation, the "all on three" (ALL3) technique has been developed. While two angled implants placed posteriorly at an appropriate distance from the mental foramen provide proper load distribution, while a single anterior implant application reduces the possibility of overlapping the apex of the posterior implants and increases operational safety. ...
Article
Purpose This study aims to compare five implant-supported rehabilitation concepts of an edentulous mandible and determines the most biomechanically advantageous technique. Materials and methods Five models with implants in different configurations were created: All-on-4 concept (two anterior axial and two posterior distally curved implants), All-on-4v4 concept (four distal curved interforaminal implants), All-on-4W (two anterior mesial curved interforaminal implants and two posterior distally curved implants), the All-on-3 concept (one anterior axial and two posterior distally curved implants), and the treofil system (three interforaminal implants with titanium bar guide support). For this study, bone-level (4.3 × 13 mm) implants of Nobel Biocare and implants of the treofil system (5 × 13 mm) were used. Spherical loads were applied from the canine and molar regions to evaluate the tension, compression and von Mises stresses by applying 3D finite element analysis. Results Among the alternative concepts, treofil system were the most successful treatment option in biomechanical terms. On the other hand, All-on-3 concept was found to be the last method of choice. This was because of the high stresses on cortical and trabecular bones in most conditions. Conclusion The result of this study shows that the treophylline system is the most successful treatment option despite its technical details. Alternatively, classical All-on-4 and All-on-4v4 techniques are biomechanically successful treatment options.
... However, we cannot exclude that such type of analysis could be successfully implemented with a wider sample size. In fact, the study taken as a model (Ayna et al., 2018), while Li et al., also in a 7-year prospective study, reported bone loss of 1.2 mm for both axial and tilted implants (32 implants were assessed in both jaws) (Li et al., 2017). In this study, the implant type seemed to play no major role, as there was no significant difference in MBL between MKIV and NobelSpeedy implants along time. ...
Article
Full-text available
Purpose: To retrospectively assess clinical and radiographic outcomes of immediately loaded full-arch fixed prostheses supported by axial and tilted implants up to 15-year of function. Materials and methods: Patients with one completely edentulous arch received an immediate full-arch fixed prosthesis supported by two anterior axial and two posterior tilted implants. Definitive prosthesis consisting of a CAD-CAM titanium framework and acrylic teeth was delivered 6 months later. Patients were regularly followed to assess clinical parameters and marginal bone level (MBL) change. Multilevel regression analysis was performed to investigate factors affecting implant failure and MBL. Results: Six-hundred-ninety-two implants were placed in 72 maxillae and 101 mandibles. Seven maxillary implants (5 axial and 2 tilted) in 6 patients, and 12 mandibular implants (6 axial and 6 tilted) in 5 patients failed. Fifteen-year cumulative implant survival was 97.51% and 96.91% in maxilla and mandible, respectively (P=0.64). After 10 years the difference in MBL between axial and tilted implants was not significant in the maxilla (P=0.47, 65 patients), while it was in the mandible (P<0.001, 80 patients). Significant higher bone loss was reported in the mandible at both 5- and 10-year follow-up (P<0.001 and P=0.004, respectively). Mixed-effect multilevel linear regression evidenced a correlation between arch and bone loss at 5 and 10-year follow-up, while no correlation was found with age, gender, smoking, diabetes and history of periodontal disease. Conclusion: This long-term study suggests that the present technique can be considered a viable treatment modality for the immediate rehabilitation of both maxilla and mandible.
... 17,19 For the statistical analysis comparing survival of implants placed in the maxilla vs mandible, it was considered as a single study reporting on both arches. In the study by Ayna et al, 91 only the group of 16 patients with All-on-4 (Nobel Biocare) fixed rehabilitations was considered, while the group of patients rehabilitated with 16 removable overdentures supported by two axial and two tilted implants was excluded. In the study by Tallarico et al, 99 only the 20 patients rehabilitated according to the classical All-on-4 protocol (Nobel Biocare) were considered, while the other group, rehabilitated only with six axially placed implants, was excluded. ...
Article
Purpose: To evaluate the performance of fixed complete dental prostheses supported by axial and tilted implants after at least 3 years of follow-up. Materials and methods: An electronic search plus a hand search up to April 2021 was undertaken. Clinical studies were selected using specific inclusion criteria, independent of the study design. The main outcomes were cumulative implant survival rate, marginal bone level changes, and complications, after ≥ 3 years of follow-up. The difference in outcomes between axial and tilted implants and between the maxilla and mandible was evaluated using meta-analysis and the Mantel-Cox test. Results: Out of 824 articles retrieved, 24 were included. In total, 2,637 patients were rehabilitated with 2,735 full prostheses (1,464 maxillary, 1,271 mandibular), supported by 5,594 and 5,611 tilted and axial implants, respectively. In a range between 3 and 18 years of follow-up, 274 implants failed. The cumulative implant survival rate was 93.91% and 99.31% for implants and prostheses, respectively. The mean marginal bone level change was moderate, exceeding 2 mm in only two studies. Marginal bone loss was significantly lower around axial compared with tilted implants (P < .0001), whereas it was not affected by arch (maxilla vs mandible; P = .17). Conclusion: Fixed complete dental prostheses supported by tilted and axially placed implants represent a predictable option for the rehabilitation of edentulous arches. Further randomized trials are needed to determine the efficacy of this surgical approach and the remodeling pattern of marginal bone in the long term.
Thesis
Over the last decade, the focus of clinical implant research shifted from predominately survival orientated to peri-implant health and patient-centred outcomes. A stable peri-implant bone level is a prerequisite to achieve long-term implant success. Peri-implant bone level is affected by patient-, implant-, and site-specific factors. In addition, the success of an implant treatment could also be determined by the improvement in Oral Health-Related Quality of Life (OHRQoL). The introduction (Chapter 1) scrutinizes and clarifies the current literature focusing on these factors. The existing literature gives an ambiguous effect of implant-related and site-specific factors on peri-implant bone stability, showing the need for more research. Chapter 2 presents the aims of this dissertation. This thesis's first two literature studies (Chapter 3 and 4) systematically assessed the available scientific evidence. The assessment focused on whether commonly used biological parameters correspond to long-term outcomes of implant survival and reported peri-implantitis prevalence. Additionally, it also examined whether long-term peri-implant bone loss is affected by implant surface roughness. The clinical studies in this thesis (Chapter 5, 6, and 7) aimed to evaluate the effect of implant related factors such as implant micro-design (implant surface roughness), macro-design (microthreads and implant-abutment connection), and site-specific factors (soft-tissue thickness) on long-term peri-implant bone stability and peri-implant health. Additionally, we paid attention to the Oral Health-Related Quality of Life in patients restored with mandibular implant-retained overdentures. Chapter 3 (Study I) is a critical review of the literature published between 2011 and 2017, regarding the biological peri-implant parameters bleeding on probing, probing pocket depth, and bone loss. The search algorithm highlighted 4,173 papers available for further analysis, 255 papers for full article reading, and 41 fulfilled the inclusion criteria. In these 41 articles, 15 different case definitions for peri-implantitis were used. The reported prevalence of peri-implantitis ranged between 0% and 39.7%, with an overall mean weighted implant survival rate of 96.9% (89.9% - 100%). Based on 8,182 implants, the overall weighted mean bone loss was 1.1 mm after a loading time ranging from 5 to 20 years. The mean bone loss did not correlate with the reported prevalence of peri-implantitis, and the diagnostic parameters mean probing pocket depth and mean bleeding on probing. Moreover, the reported peri-implantitis prevalence did not correlate with mean probing pocket depth. However, a strong correlation was found between the reported prevalence of peri-implantitis and bleeding on probing. The survival rate showed a substantial correlation with function time, showing minor implant loss over time. We concluded that the case definition for peri-implantitis varied significantly between studies, indicating that an unambiguous definition based on a specified threshold for bone loss is not agreed upon in the literature. Chapter 4 (Study II) scrutinized the literature on long-term peri-implant bone loss and the relation with implant surface roughness and patient-related factors such as smoking and history of periodontitis. Implant systems are categorised based on the surface roughness expressed in Sa-value; minimally rough (Sa value: 0.5 – 1 μm), moderately rough (Sa value: 1 – 2 μm), and rough (Sa value: > 2 μm). In implant dentistry's early days, only minimally rough and microporous titanium plasma-sprayed rough implant systems were available. However, over time several implant modifications were done by sandblasting, acid-etching, anodic oxidation, or hydroxyapatite coating resulting in a moderately rough implant system. These modifications improved the osteoconductive and osteoinductive properties of the implant. The surface of the moderately rough implant system showed better blot cloth stabilisation, enhanced production of biological mediators, stimulate osteogenic maturation leading to higher bone-to-implant contact, and increased bonding strength of the bone to the implant. On the other hand, rougher implant systems are linked to increased bacterial adhesion with a higher risk of being affected by peri-implantitis. The search yielded 2,566 studies and 156 were selected for further reading. Only 87 reported information about surface roughness of the implants and mean bone loss after at least five years of function. In these papers in total 15,695 implants were inserted in 6,755 patients. The average weighted survival rate for these implants was 97.3% after at least 5 years of function. If 3 mm bone loss was used as a threshold to quantify peri-implantitis, less than 5% of the implants were affected. Regarding implant surface roughness, the systematic review suggests that peri-implant bone loss around minimally rough implant systems was statistically significantly less than the moderately rough and rough implant systems. No statistically significant difference was observed between moderately rough and rough implant systems. The meta-analyses showed less average peri-implant bone loss around smoother surfaces. However, due to the heterogeneity of the papers and the multifactorial cause for bone loss, the impact of surface roughness alone seems somewhat limited and of minimal clinical importance. In addition, the meta-analysis showed that smoking and history of periodontitis increased the risk for bone loss. Chapter 5 (Study III) includes two prospective split-mouth studies. Both studies included edentulous patients in need of a two-implant-supported overdenture in the mandible. The first part of Study III described the effect of the site-specific factor ‘soft-tissue thickness’ on crestal bone remodeling and peri-implant health. Twenty-six patients received two moderately rough implants. According to the manufacturer's guidelines, the control implant was installed equicrestally. The test implant was placed below crestal level to ensure at least 3 mm space for biologic width establishment on the abutment part. Initially, 26 patients were treated with one equicrestally and one subcrestally placed implant. After 36 months, 24 patients were available for follow-up. The second part of Study III determined the effect of implant surface roughness on crestal bone remodeling. As concluded in Study II, crestal bone loss might be related to the implant surface roughness. The existing literature suggests higher survival rates for moderately rough implants compared to minimally rough implants. On the other hand, recent literature and the findings of Study II suggest that implants with a minimally rough surface yield less long-term crestal bone loss. An implant with a hybrid surface combines the benefit of a moderately rough implant body and a minimally rough implant neck. To determine the effect of implant surface roughness on crestal bone loss, 23 patients received two implants: an implant with a moderately rough surface (Sa value: 1.3 μm) and a hybrid implant with a minimally rough coronal neck of 3 mm (Sa value: 0.9 μm) combined with a moderately rough body (Sa value: 1.3 μm). Apart from the difference in implant surface roughness, the two implants were identical. After 36 months, 21 patients were available for follow-up. The implant survival rate was 100% after 36 months. No differences were observed in crestal bone remodeling between the hybrid and moderately rough implant. However, initial bone remodeling was affected by initial soft tissue thickness because the equicrestal implants had implant threads exposed above bone level. Anticipating the biological width re-establishment by adapting the vertical position of the implant in relation to the available soft tissue thickness may prevent that implant threads are not fully covered by peri-implant bone. However, long-term follow-up of the study is necessary to determine the influence of early implant surface exposure and implant surface roughness on crestal bone loss, biological parameters, and implant survival. Study III also included Oral Health-Related Quality of Life for edentulous patients restored with a two-implant-supported mandibular overdenture. This patient-centred outcome was assessed with the Oral Health Impact Profile-14 (OHIP-14). The study concluded that a two-implant-supported mandibular overdenture in comparison with a conventional removable denture yields a significant improvement in the quality of life. Chapter 6 (Study IV) presented the five-year follow-up of the first part of study III, determining the effect of soft tissue thickness on crestal bone remodeling and peri-implant health. Twenty-four patients were available for the five-year follow-up. The survival rate was 100%, and only one implant showed a mean bone level higher than 2 mm. During initial bone remodeling equicrestal placement yielded 0.68 mm additional surface exposure compared to subcrestal placement. Afterwards, bone level and peri-implant health were comparable in both treatment conditions and stable up to five years. Hence, Study IV concluded that adapting the vertical position of the implant concerning the soft tissue thickness prevents early implant surface exposure caused by initial bone remodeling. However, in a well-maintained population, this has no impact on long-term prognosis. In addition, the Oral Health-Related Quality of Life was assessed using the Oral Health Impact Profile-14 (OHIP-14), concluding a stable Oral Health-Related Quality of Life over time. Chapter 7 (Study V) determines the effect of implant neck (microthreaded versus non-microthreaded) as well as the type of connection (internal conical versus external flat-to-flat) on peri-implant bone stability and peri-implant health. According to the literature, peri-implant bone loss is minimized on implants with microthreaded neck design and internal type of abutment connection, albeit that many clinical studies are biased due to confounding factors. Twenty-five patients were treated with a maxillary implant-supported bar-retained overdenture on four different implant types. Each patient received one implant with an internal connection with microthreads (I MT), one with an internal connection without microthreads (I NMT), one with an external connection with microthreads (E MT), and one with an external connection without microthreads (E NMT). Other design features, as well as surgical and prosthetic protocol, were consistent. After at least 36 months, the survival rate was 96%. It was concluded that the implant-abutment connection type (internal vs external) and the implant neck design (microthreaded vs non-microthreaded) have no clinical effect on peri-implant bone remodeling, peri-implant bone level after the initial remodeling. Furthermore, it also had no clinical effect on peri-implant health parameters, at least when implants are installed according to soft tissue thickness. Chapter 8 is the general discussion and includes clinical and future research recommendations. In addition, it highlights the social relevance of the undertaken scientific work in conjunction with a personal reflection. This PhD thesis concludes that: 1. Various peri-implantitis definitions are used in the literature, and reporting of biological parameters is often incomplete. Consistent reporting of peri-implantitis is required for scientific purposes as well as for clinical practice. 2. The peri-implantitis prevalence based on various case definitions did not correlate with the diagnostic parameters ‘mean probing pocket depth’, ‘mean bleeding on probing’, and ‘mean bone loss’. The survival rate showed a substantial correlation with function time, but implant loss over time is low. 3. In the current literature, less than 5% of the implants showed bone loss above 3 mm after at least five years in function. This result was independent of surface or implant brand, suggesting that currently reported peri-implantitis prevalence is exaggerated. 4. Rough implant systems are more prone to crestal bone loss. However, the multifactorial cause for bone loss and the heterogeneity of the studies make it difficult to draw firm conclusions. Nevertheless, more papers show less bone loss in favour of minimally rough implant systems. 5. Co-factors such as smoking or a history of periodontal disease increase the risk of bone loss. 6. The implant neck design (microthreaded vs non-microthreaded) has no influence on peri-implant bone remodeling when implants are installed in relation to soft tissue thickness allowing the formation of a 3 to 4 mm biological seal. 7. The implant-abutment connection type (internal vs external) has no influence on peri-implant bone remodeling when implants are installed in relation to soft tissue thickness allowing the formation of a 3 to 4 mm biological seal. 8. Implant surface roughness (minimally rough vs moderately rough) influences peri-implant bone remodeling nor additional bone loss when implants are installed in relation to soft tissue thickness allowing the formation of a 3 to 4 mm biologic seal. 9. Peri-implant health parameters (probing pocket depth, bleeding on probing, and plaque score) are not affected by implant design, surface texture, or abutment-connection features when implants are installed in relation to soft tissue thickness. 10. Anticipating biologic width re-establishment by adapting the vertical position of the implant in relation to the available soft tissue thickness may prevent initial peri-implant bone loss. 11. In a well-maintained population, the effect of early implant surface exposure caused by initial bone remodeling on peri-implant bone stability and biological parameters seems to be limited. 12. Implant-supported mandibular overdentures significantly improve the quality of life, with little biological complications and a high survival rate of the implants.
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Introduction: This study aimed to evaluate peri-implant tissue health and patient satisfaction of vertical and inclined posterior implants for mandibular bar overdentures. Materials and methods: Thirty edentulous participants received four implants in the interforaminal area of the mandible. The patients were randomly assigned into two equal groups; (1) vertical group (control): all implants were inserted vertically parallel to each other. Inclined group (study): the anterior implants were placed vertically, and the posterior implants were tilted 30° distally. Hader bar attachment with two 7 mm-distal cantilevers (vertical group) and without cantilevers (inclined group) was used to connect the implants to mandibular overdentures. Peri-implant tissue health (Plaque [PL] and gingival [GI] indices, pocket depth [PD], and crestal bone loss [CBL]) were evaluated after denture insertion (T0), 6 (T6), and 12 (T12) months after insertion. Patient satisfaction was evaluated using a visual analog scale after 12 months. Results: At T12, the vertical group showed significantly higher PL, PD, and CBL than the inclined group for anterior (p < 0.037) and posterior (p < 0.017) implants. The vertical group showed significantly higher GI than the inclined group for anterior implants (p = 0.003), and the inclined group showed significantly higher GI than the vertical group for posterior implants (p = 0.016). The inclined group showed significantly higher scores for general satisfaction (p = 0.049), prosthesis as a part of you (p = 0.013), appearance (p < 0.001), stability (p = 0.002), ease of cleaning (p < 0.001), and comfort (p = 0.001) than the vertical group. Conclusion: Inclined posterior implants used to support mandibular bar overdentures are recommended than vertical implants, as it was associated with improved patient satisfaction and peri-implant tissue health.
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Abstract The objective of the present study is the evaluation of the comprehensive 5-year results of fixed mandibular dentures fabricated from metal-acrylic or metal-ceramics according to the 'All-on-4'™ protocol. Twenty-seven patients that received immediately loaded 'All-on-4'™ fixed mandibular dentures in 2005 were included in the study, and they were evaluated up to 5 years after denture integration. Endpoints were chosen in accordance with the 2007 Pisa consensus and included bone resorption, the Oral Health Impact Profile (OHIP), the Sulcus Fluid Flow Rate (SFFR), and prosthodontic complications. The initial situation in both groups was largely identical. Bone loss remained under 2 mm after 5 years in all implants and showed no group difference. The SSFR showed a gradual increase in both groups, and acrylic-bearing implants showed a substantially and significantly higher flow rate from the third year onward. The subjective improvement as expressed by the OHIP score was immediate and dramatic, and it showed no group differences. All acrylic restorations showed some extent of abrasion, and veneer fractures occurred in 4 patients (28.6%). Besides a single fracture of a fixation screw, there were no prosthetic complications in patients with ceramic suprastructures. According to bone loss and subjective outcome, acrylic and ceramic suprastructures apperared to be equivalent after 5 years; however, sulcus flow and prosthodontic complications suggest that the economic advantage of acrylic dentures may be specious. The rational choice of implant suprastructures requires comprehensive, long-term observation. Short-term economical benefits might be cancelled out in the long run.
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Background: Immediate implant function has become an accepted treatment modality for fixed restorations in totally edentulous mandibles, whereas experience from immediate function in the edentulous maxilla is limited. Purpose: The purpose of this study was to report on the medium- and long-term outcomes of a protocol for immediate function of four implants (All-on-4™, Nobel Biocare AB, Göteborg, Sweden) supporting a fixed prosthesis in the completely edentulous maxilla. Materials and Methods: This retrospective clinical study included 242 patients with 968 immediately loaded implants (Brånemark System® TiUnite™, Nobelspeedy™, Nobel Biocare AB) supporting fixed complete-arch maxillary all-acrylic prostheses. A specially designed surgical guide was used to facilitate implant positioning and tilting of the posterior implants to achieve good bone anchorage and large interimplant distance for good prosthetic support. Follow-up examinations were performed at 6 months, 1 year, and thereafter every 6 months. Radiographic assessment of the marginal bone level was performed after 3 and 5 years in function. Survival was estimated at patient level and implant level using the Kaplan–Meier product limit estimation with 95% confidence intervals. Results: Nineteen immediately loaded implants were lost in seventeen patients, giving a 5-year survival rate estimation of 93% and 98% at patient and implant level, respectively. The survival rate of the prosthesis was 100%. The marginal bone level was, on average, 1.52 mm (standard deviation [SD] 0.3 mm) and 1.95 mm (SD 0.4 mm) from the implant/abutment junction after 3 and 5 years, respectively. Conclusion: The high survival rates at patient and implant level indicates that the immediate-function concept for completely edentulous maxillae using the present protocol is viable in the medium- and long-term outcomes.
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Objectives: The aim of this prospective, randomized clinical trial was to evaluate the effect of a minimally invasive implant procedure for denture stabilization on patients' quality of life (QoL). Materials and methods: Thirty totally edentulous patients were selected for this study. All prostheses were adjusted and relined before randomization and allocation to treatment either with two small diameter implants (SDI) - retained overdenture (study group) or non-intervention group (control group). Quality of life was assessed using the Oral Health Impact Profile-EDENT (OHIP-EDENT) questionnaire before intervention and at one-year follow-up. Between-group comparisons were carried out using the non-parametric Mann-Whitney test. Results: Magnitude of change in the OHIP-EDENT total score at one-year follow-up was 25.4 ± 10.7 for the study group, revealing a statistically significant difference with the control group, that showed a change of 9.5 ± 8.3 (P = < 0.001). Conclusions: After one-year follow-up, patients wearing mandibular overdentures with two minimally invasive splinted SDI, experienced more improvements in perceived oral health-related quality of life, than patients having conventional treatment.
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To systematically review clinical studies on prosthodontic complication rates of implant fixed dental prostheses in edentulous patients after an observation period of at least 5 years. A literature search was conducted using different electronic databases. Specific terms were used for the database search, which spanned the years 1990 to 2008. The search was augmented by using the option of "related articles" as well as by hand searching of references and relevant journals. Relevant studies were selected according to predetermined inclusion and exclusion criteria. Agreement between reviewers was determined by using Cohen kappa coefficients. The initial database search yielded 8,216 relevant titles. Following the filtering process, 19 studies were finally selected. No study directly compared the incidence of prosthodontic complications of complete implant-supported metal-ceramic versus metal-acrylic resin fixed prostheses in the completely edentulous patient. Studies of metal-ceramic prostheses were scarce and short term. Metal-acrylic resin complete implant fixed prostheses presented with various prosthodontic complications after long-term function. The most frequent complications were veneer fracture and material wear.
Article
To evaluate the oral health-related quality of life (OHRQoL) of implant-retained overdenture users. 63 patients aged 50-90 years treated with at least one implant overdenture at the Complutense University (Madrid) in 2000-2010 were included. Of those, 42 answered the Oral Health Impact Profile (OHIP-14 sp) questionnaire. The additive method was used in the OHIP analysis. Data regarding sociodemographic background, overdenture features, and clinical factors were recorded. Sociodemographic and overdenture-related variables for the lost patients (n=21) were also gathered from their history files. Descriptive probes, Mann-Whitney and Kruskal-Wallis tests, and the Spearman correlation coefficient were applied (p ≤ 0.05). The predominant participants' profile was that of a 71-80-year-old woman wearing a mandibular overdenture with a bar retention system and a complete denture in the opposite jaw. 71.4% of the respondents suffered from some kind of impact on OHRQoL, showing an average score of 2.7 ± 3.0 (range: 0-13). 100% of respondents reported no impact for the "social disability" and "handicap" dimensions. The most prevalently affected domain was "physical pain", followed by "functional limitation" and "psychological discomfort". Variables such as the overdenture location or the retention system affected specific OHIP subscales (p ≤ 0.05). The greatest total score was achieved when the antagonist was a complete denture (p<0.01). Implant-retained overdentures provide a seemingly acceptable quality of life in the elderly population studied, irrespective of the influence of the location, retention system, and antagonist. Although further research is necessary, mandibular implant overdentures are more comfortable than maxillary ones. Ball-retained prostheses facilitate eating the most, whereas the presence of oral ulcers and/or candidiasis was only detected in the case of bars, thus impairing OHRQoL. A complete denture as antagonist decreases the patient overall satisfaction.
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Abstract In this study the microbiota associated with oral endosteal titanium hollow cylinder implants (ITI) was studied using microscopic, immunochemical and cultural methods. Samples from 5 edentulous patients with successfully incorporated implants serving as abutments for overdentures for more than one year were compared with samples from 7 patients with clinically failing implants. Unsuccessful sites were characterized by pocket probing depths of 6 mm or more, suppuration and visible loss of alveolar bone around the implant as visualized on radiographs. These sites harbored a complex microbiota with a large proportion of Gram-negative anaerobic rods. Black-pigmented Bacteroides and Fusobacterium spp. were regularly found. Spirochetes, fusiform bacteria as well as motile and curved rods were a common feature in the darkfield microscopic specimens of these sites. Control sites in the same patients harbored small amounts of bacteria. The predominant morphotype was coccoid cells. Spirochetes were not present, fusiform bacteria, motile and curved rods were found infrequently and in low numbers. The microbiota in control sites in unsuccessful patients and in site in successful patients were very similar. On the basis of these results, it is suggested that “periimplantitis” be regarded as a site specific infection which yields many features in common with chronic adult periodontitis.
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Immediate-function Brånemark System® implants (Nobel Biocare AB, Gothenburg, Sweden) have become an accepted alternative for fixed restorations in edentulous mandibles, based on documented high success rates. Continuous development is ongoing to find simple protocols for their use. The purpose of this study was to develop and document a simple, safe, and effective surgical and prosthetic protocol for immediate function (within 2 hours) of four Brånemark System implants supporting fixed prostheses in completely edentulous mandibles: the “All-on-Four” concept. This retrospective clinical study included 44 patients with 176 immediately loaded implants, placed in the anterior region, supporting fixed complete-arch mandibular prostheses in acrylic. In addition to the immediately loaded implants, 24 of the 44 patients had 62 rescue implants not incorporated in the provisional prostheses but incorporated in final prostheses later on. Five immediately loaded implants were lost in five patients before the 6-month follow-up, giving cumulative survival rates of 96.7 and 98.2% for development and routine groups, respectively. The prostheses' survival was 100%, and the average bone resorption was low. The high cumulative implant and prostheses survival rates indicate that the “All-on-Four” immediate-function concept with Brånemark System implants used in completely edentulous mandibles is a viable concept.
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The aim of this study was to verify quality of life related to oral health and satisfaction with dentures. Conventional mandibular complete dentures were converted to overdentures retained by two implants with immediate loading (bar-clip system, n = 16). The Brazilian short version of the Oral Health Impact Profile (OHIP-14Br) was used to evaluate the impact of oral health on quality of life. Satisfaction with the prostheses was obtained by means of a questionnaire addressing satisfaction with the present prostheses and through use of a visual analog scale (VAS). The results of the OHIP-14Br questionnaire were verified at 3 and 6 months after conversion from complete dentures to a mandibular overdenture. The satisfaction questionnaire for the mandibular prostheses obtained 43.75% satisfaction before conversion and 100% satisfaction at 1 week and 3 and 6 months after conversion. The satisfaction results of the prostheses, both maxillary and mandibular, were 68.75% before conversion, 93.75% at 1 week and 3 months after conversion, and 87.5% at 6 months. There was an immediate improvement in patients' satisfaction with the mandibular overdenture prostheses regarding stability and retention (Friedman test, P = .000) and quality of life (Friedman test, P = .001). The improvement seen justifies the immediate loading approach used in this study.
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To determine any difference in patient response to implant overdentures compared with conventional complete dentures alone. In a randomized, prospective, controlled study, 122 edentulous patients (Mean age 64; 39 men, 83 women) underwent baseline assessment of denture satisfaction and quality of life using the Oral Health Impact Profile-49 (OHIP-49) and a Denture Satisfaction Questionnaire. All patients were provided with new conventional complete dentures (CCDs) that they wore for 3 months, at which point they were reassessed using the same measures. Patients were randomly assigned either to continue with CCDs (CC group) or to have implant-retained overdentures (IODs) made (CI group). The CC group was assessed after a further 3 months (6 months after receiving CCDs). The CI group was assessed 3 months after receiving IODs. Significant improvements in satisfaction and quality of life were found in the patients 3 months after receiving CCDs (P < 0.05). No further improvements were found in the CC group at 6 months on any of the measures. The CI group showed significant additional improvements at 3 months following IODs on the functional limitation, physical pain, psychological discomfort, physical disability, social disability, psychological disability and handicap scales of the OHIP and on 10 of the 11 scales of the Denture Satisfaction Questionnaire (P < 0.05, ANOVA). The findings show that, controlling for expectancy bias and variability in baseline levels, IODs significantly increase patient satisfaction, dental function and quality of life over and above those achieved with good quality CCDs.
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Implant-supported mandibular overdentures have recently become a popular treatment alternative for edentulous patients desiring increased retention of complete dentures. The goal of this study was to evaluate and present treatment outcomes of mandibular overdentures retained by two unsplinted, early-loaded implants and compare these results with those for delayed-loaded implants. Twenty-six edentulous patients had two interforaminal implants placed with a one-stage protocol. The patients were each treated with a mandibular overdenture supported by ball abutments. In the test group, the overdenture was loaded 1 week after surgery and in the control group, the overdenture was loaded 3 months after surgery. Standardized clinical and radiographic parameters were recorded at surgery, and after 3, 6, 12, and 18 months, and 2, 3, 4, 5, and 7 years. Because two patients did not make the 7-year recall, only 24 patients (48 implants) were evaluated in this study. No implants were lost, and 1.31 ± 0.2 mm marginal bone resorption was noted for all implants after 7 years. Implant stability measurements, clinical peri-implant parameters and marginal bone levels exhibited no statistically significant differences between the two groups over 7 years. The results of this clinical trial show that there is no significant difference in the clinical and radiographic outcomes of patients treated with mandibular overdentures supported by TiUnite implants that are either early or delayed loaded.