In this chapter, more than a century of occupational therapy history has been reviewed, beginning with a description of important ideas and personalities prior to the 20th century that infl uenced the birth of the profession. For each of fi ve eras, a contextual backdrop was provided to describe the historical circumstances under which different events occurred, with the aim of emphasizing that professions, like individuals, are best understood in situational contexts. Occupational therapy began during a progressive era that was auspicious for bold ideas and new approaches.Although its fundamental principles were already being applied by professionals and nonprofessionals in different settings, it was not until an enthusiastic and ambitious consumer (George Barton) took the initiative to bring an interdisciplinary group of like-minded advocates together that the profession of occupational therapy was officially launched. Within weeks, a nation's preparations for caring for its wounded soldiers as it entered a great war provided a rare opportunity for the profession to organize around a patriotic cause and demonstrate its value. Because women were just emerging as a political force in the country and so few women held professional roles at the time, the recruits to occupational therapy were uncertain about how to manifest their opportunities. Occupational therapy had to compete with medical specialties, vocational educators, nurses, and others who believed that they were equally entitled to the use of curative occupations as part of their treatment regimens. For the entirety of their history, occupational therapists have been doers, often little interested in explaining or proving the theoretical ideas and practical benefi ts of their actions. This has placed the profession at a disadvantage to medicine and other disciplines, where sciencebased practice has become increasingly the norm. Yet, the inherent fl exibility of occupations as a therapeutic medium has continued to off er creative opportunities for benefi ting a wide range of patients and clients. Although once daunting health problems served by occupational therapists (e.g., tuberculosis [TB], HIV, and polio) have faded into the history books of biomedical success, occupational therapists have been able to mobilize in the service of emerging health problems and concerns deemed important by the public (such as dementia and autism spectrum disorders). Moreover, the cooperative nature of the therapeutic relationship has aff orded a bridge to connect the body and mind-providing occupational therapists with a rare, important, and enduring place in the lives of their patients-serving as healers as well as technologists, a role not easily appreciated by the casual observer. As occupational therapy moves ahead into the 21st century, one must ask if these themes will continue to shape the story of the profession. Will there continue to be role ambiguity and underappreciation for the importance of science and theory? Will therapists continue to reinvent new approaches for serving the emerging diseases of the 21st century, and will they capitalize on the unique position they have, but perhaps underuse, as technologists and custodians of meaning (Engelhardt, 1983)? Only the histories yet to be written will tell. © 2014 Lippincott Williams & Wilkins, a Wolters Kluwer business. All rights reserved.