The purpose of this paper is to outline and describe the development and implementation of a mindfulness-based music intervention (MBM) for decreasing depression and anxiety in patients with a cancer diagnosis. The development of the intervention is based on a translation of mindfulness practices, research, and function of particular musical elements within mindfulness practice. Initial client responses and comments about the MBM intervention are also provided. The use of mindfulness-based interventions is a prevalent offering for cancer patients in oncology settings often addressing the distress of depression and anxiety. Mindfulness helps decrease symptoms of anxiety and depression by decreasing mental rumination through acceptance of present-moment experience. Music listening and playing can facilitate mindfulness, whereby music assists with improving attention and memory, and increasing positive emotions, acceptance, and motivation. Development and limitations of the outlined intervention, recommendations for future studies, and additional clinical applications are explored.