... Awareness of the importance of sensing safety can mean that defenses, such as obsessions, addictions, avoidance, attempts at mastery, or health risk behaviors (Maunder and Hunter, 2016), can be understood as reasonable, meaningful, and purposeful attempts to sense safety in response to real, perceived, or anticipated danger (Sampson, 1990). It also explains how perceptions of supportive relationships are a vital part of health , and how shattered assumptions about life (Janoff-Bulman, 1985), hopelessness and meaninglessness (Newcomb and Harlow, 1986), uncertainty (Brosschot et al., 2018), or loss of cultural safety (Curtis et al., 2019) impact whole person health and wellbeing. The Sense of Safety Theoretical Framework described in this paper integrates a number of well described theories-including Attachment Theory (Bowlby, 1984;Maunder and Hunter, 2001;Bowlby, 1979), Maslow's Theory of Motivation (Maslow, 1943), Allostatic Load Theory (McEwen, 2007;Lupien et al., 2009), Polyvagal Theory (Porges, 2011), Social Safety Theory (Slavich, 2020), Generalized Unsafety Theory of Stress (Brosschot et al., 2018), Theory of Human Security (Blatz, 1973) and Interpersonal Theory (Sullivan, 1953). ...