The East Luoguhe intrusion in Mohe County, Heilongjiang Province, located in the northern end of the Great Hinggan Range, is mainly composed of monzogranite-porphyry, syenogranite-porphyry and quartz monzonite-porphyry, with minor dioritic microgranular enclave. The intrusion belongs to I-type granite, with affinity to high-K calc-alkaline series. The SHRIMP zircon U-Pb age of the granite-porphyry is 129. 8 ±2. 2Ma, indicating that the intrusion formed in Early Cretaceous. Its SiO2 and Al2O3 contents range 68. 03% -74. 32% and 13. 06% -14. 55% , respectively. The Na 2O/K2O ratios range 0. 45 - 0. 86, ASI values from 0. 94 to 1. 11 ( mostly <1. 1) , and the Mg* index from 18 to 42( mostly < 30). The REE content is between 160.00 x 10-6and235. 15 x 10 -6, with δEu of 0. 31 - 0. 52 ( average 0. 41 ) and ( La/Yb ) N ratios of 8. 99 - 17. 87 ( average 13. 82 ) . The East Luoguhe intrusion is characterized by low-Sr (118 x 10 -6 -268 x 10 -6) , high-Y ( 16. 9 x10-6-26. 1 x 10 -6, generally >18 x10-6), and low Sr/Y ratios (5. 62-13. 81). The intrusion is enriched in Rb, Th, U, K, Zr, Hf and LREE (e. g. La, Ce, Nd and Sm) , but strongly depleted in Ba, Sr, P and Ti, with notable depletion of Nb and Ta. The geochemical signatures above are similar to those of post-collisional granitoids, suggesting that the East Luoguhe intrusion can be classified into the group of post-collisional granites. The intrusion has low initial 87Sr/86 Sr ratio ( 0. 702486 - 0. 707269, average 0. 705434 ) , clear negative εND ( t) value ( -3.45 - -2.64, average - 3. 01 ) , young Nd-model age (969 - 1131Ma, average 1018Ma) , and extremely low δ18O ratio ( - 8. 1%o to 4. 1%o for K-feldspar). And the 206Pb/204 Pb ( 18. 5939 - 18. 6721, average 18. 6426 ) , 207Pb/204 Pb ( 15. 6019 15.6058, average 15. 6035) and 208Pb/204Pb (38. 4058 -38. 5249, average 38. 4613 ) ratios for K-feldspar are relatively high. The Nd-Sr-Pb-O isotope systematics shows that the intrusion originated from partial melting of a source with remarkable mantle-derived components. The source is likely the juvenile crust formed during the convergence of Rodinia supercontinent at the transition from Mesoproterozoic to Neoproterozoic. Given that the Paleo-Asian Ocean was finally closed at the end of Late Paleozoic, followed by closing of the Mongol-Okhotsk Ocean during Permian-Middle Jurassic, the East Luoguhe intrusion of Early Cretaceous age must be formed in the collision regime between the Siberia and Mongol-Sinokorea continents, especially in a tectonic transition setting from compression to extension.