Poster

BEST HOPE - Cohort of HIV newly diagnosed patients in Portugal

  • November 2016
  • Conference: XI Congresso Nacional de VIH/SIDA & XIII Congresso Nacional de Doenças Infeciosas e Microbiologia Clínica
  • At: Hotel Vila Galé, Coimbra
  • Affiliation: GAT
Authors:
Marta Pingarilho at Institute of Hygiene and Tropical Medicine
Marta Pingarilho
Pineda-Peña A.C.
Pineda-Peña A.C.
Pineda-Peña A.C.
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Sónia F Dias at National School of Public Health NOVA Lisboa
Sónia F Dias
  • National School of Public Health NOVA Lisboa
Victor Pimentel at Institute of Hygiene and Tropical Medicine
Victor Pimentel
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Abstract

BEST HOPE is a project to construct a cohort of newly diagnosed HIV patients in Portugal: BEST HOPE aims are: 1) to analyze the prevalence and characteristics of TDR in newly diagnosed HIV patients, and 2) to describe and analyze risk factors associated with HIV infection and transmission of drug resistance in Portugal.

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Drivers of HIV-1 transmission: The Portuguese case
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Background Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. Methods Demographic, clinical and genomic data were collected from 3599 HIV-1 naive patients between 2001 and 2014. Sequences obtained from drug resistance testing were used for subtyping, TDR determination and transmission clusters (TC) analyses. Results In Portugal, transmission of subtype B was significantly associated with young males, while transmission of subtype G was associated with older heterosexuals. In Portuguese originated people, there was a decreasing trend both for prevalence of subtype G and for number of TCs in this subtype. The active TCs that were identified (i.e. clusters originated after 2008) were associated with subtype B-infected males residing in Lisbon. TDR was significantly different when comparing subtypes B (10.8% [9.5–12.2]) and G (7.6% [6.4–9.0]) (p = 0.001). Discussion TC analyses shows that, in Portugal, the subtype B epidemic is active and fueled by young male patients residing in Lisbon, while transmission of subtype G is decreasing. Despite similar treatment rates for both subtypes in Portugal, TDR is significantly different between subtypes.
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