Professional Misconduct by NAM Committee on Food Allergy

Technical Report (PDF Available) · January 2017with 1,453 Reads
DOI: 10.13140/RG.2.2.23522.94405
A preview of the PDF is not available
  • Article
    Full-text available
    Injecting allergens causes the development of allergies. Known for more than a hundred years. Researchers and vaccine developers ignored that fact and caused the food allergy epidemic with food allergen contaminated vaccines. Eating allergens protects against allergy. Known for more than a hundred years. Researchers ignored that fact, recommended allergen avoidance and made the allergy problem worse. Now they are turning around and recommending early allergen introduction. However, they still refuse to stop injecting food allergen contaminated vaccines. The root cause of food allergy. Allergic asthma and most autism cases are related to food allergen contaminated vaccines. The mechanism is described.
  • Article
    Full-text available
    Flawed assumptions have been used to analyse vaccine safety related to autoimmune diseases. These assumptions are demonstrated to be false. Thus the rise in autoimmune diseases can be explained and are due to flawed vaccine designs.
  • Article
    Full-text available
    Peanut protein patch applied to HEALTHY skin is a treatment for peanut allergy. One of the ways peanut protein applied to skin works, is the generation of regulatory T cells (Tregs) specific to peanut. Tregs regulate/moderate the immune system's reaction to peanut exposure. One of the causes for type 1 diabetes (T1D) is a reduction in the number of Tregs in the pancreas. This allows CD8+ T cells to attack the islet cells, unrestrained, causing T1D. Chicken protein contaminated vaccines are the most likely source of the proteins that train the CD8+ T cells to attack the islet cells. We need chicken protein specific Tregs to restrain them. The potential solution is to create chicken protein specific Tregs by topical chicken protein. Tregs are trained to home to a part of the body. Eating/drinking chicken protein generates Tregs that home to the gut. Topical chicken protein generates Tregs that home to the skin. The CD8+ T cells that attack islet cells are trained to home to the skin. But it turns out the pancreas attract these cells by producing the same chemical attractant as the skin. Therefore skin homing Tregs produced by topical chicken protein will also home to the pancreas just like the CD8+ T cells.
  • Article
    Full-text available
    A simple picture is currently portrayed about the influenza vaccine. The reality is far more complex. Influenza vaccines cause anti-influenza allergy, aeroallergen allergy and allergic asthma. Anti-influenza allergy causes vaccine ineffectiveness due to IgE neutralizing vaccine antigens. Allergy to influenza, increases morbidity and mortality when a person is eventually infected by the strain due to inevitable vaccine failure (wrong strain chosen by WHO, antigenic drift between wild and vaccine strains, IgE mediated antigen neutralization, etc.). When the vaccine works, it provides temporary immunity at the expense of allergy, autoimmunity, cancer and loss of long term protection against influenza. When the flu vaccine "works", it makes the population more dependent on WHO making the right strain selection every time and no antigenic drift between wild and vaccine strains. We are creating a more vulnerable population (allergic asthma to HA and no natural influenza protection) that is dependent on an unreliable vaccine. Influenza vaccine is therefore contributing to increasing influenza related morbidity and mortality. We need a new influenza control policy redesigned from scratch to address the big picture.
  • Article
    Full-text available
    Since vaccinologists are themselves ignorant of vaccine mechanisms, how can we expect epidemiologists to understand the mechanisms? So most epidemiological studies ignore mechanism of adverse event causation. If you ignore mechanism, you cannot design the study with appropriate controls. So the results of such epidemiological studies have to be discarded due to confounding. Proven mechanism involved in cow's milk contaminated vaccines causing folate receptor antibody related autism is described.
  • Article
    Full-text available
    The safety studies most often referred by vaccine regulators when making claims about the safety of aluminum in vaccines, have ignored the immunotoxicity of aluminum. Vaccinologists admit that they neither understand the general immunological mechanisms involved in vaccination nor do they understand the mechanisms involved in aluminum adjuvant action. Thus vaccine regulators have no scientific basis to make vaccine safety claims. Given this situation one would expect that vaccine regulators would be very cautious about making vaccine safety claims. Instead, they collude with vaccine makers to actively hide vaccine safety problems and mislead the public. The dual role of immunotoxicity and neurotoxicity of aluminum in autism is also covered. Cow's milk contaminated aluminum adjuvanted vaccines cause the synthesis of folate receptor antibodies. These antibodies block folate uptake causing cerebral folate deficiency and autism. The folate deficiency in turn, causes aluminum accumulation in the brain, resulting in neurotoxicity and exacerbation of autism.
  • Article
    Full-text available
    Shingrix vaccine is contaminated with Chinese Hamster Ovary (CHO) cell proteins. Cancer immunology research has demonstrated that immunization with homologous xenogeneic proteins (such as vaccines contaminated with animal proteins that resemble human proteins) results in autoimmunity. Immunotoxicology experts have recommended the use of bioinformatics and autoimmune serology to study the safety of vaccine antigens to assess the risk of autoimmunity. No such safety studies have been performed for Shingrix.
  • Article
    Full-text available
    Autism patients are known to have higher genetic susceptibility to cancer. However, cancer rates are lower in autism patients. Cancer cells need folate for rapid growth. So they express more folate receptor alpha (FRA) proteins on their surface that helps transport folate. Thus treatments that target these FRA proteins with antibodies are an experimental cure for cancer. 75% of autism patients test positive for folate receptor alpha antibodies (FRAA).⁠ This explains why autism patients have lower rates of cancer. FRA proteins are present in cow's milk. Casein and casamino acids are cow's milk derived proteins used in the manufacture of vaccines. So numerous vaccines are contaminated with cow's milk proteins. Such cow's milk contaminated vaccines can cause the synthesis of FRAA which can protect against cancer and cause the development of autism.
  • Conference Paper
    Nobel Laureate Charles Richet demonstrated over a hundred years ago that injecting a protein into animals or humans causes immune system sensitization to that protein. Subsequent exposure to the protein can result in allergic reactions or anaphylaxis. This fact has since been demonstrated over and over again in humans and animal models. Many vaccines and injections contain food proteins. Many studies since 1940 have demonstrated that food proteins in vaccines cause sensitization in humans. Allergens in vaccines are not fully disclosed. No safe dosage level for injected allergens have been established. As a result, allergen quantities in vaccines and injections are not regulated. Allergen quantities in vaccine excipients are also not regulated. It has been demonstrated that a smaller quantity of allergen is needed to cause sensitization than elicitation. It is well recognized that many currently approved vaccines have enough allergen to cause anaphylaxis. Therefore, they contain more than enough allergen to cause sensitization. Children today have fewer childhood infectious diseases. They have less exposure to helminths. C-section birth rates have increased in the last few decades by 50%. C-section births are known to result in sub-optimal gut microbiome in the newborn. All the above result in an immune imbalance biased towards atopy. Vaccine schedules today include 30-40 shots. Up to five shots may be simultaneously administered in one sitting. Vaccines contain adjuvants such as pertussis toxins and aluminum compounds that also bias towards allergy. Adjuvants also increase the immunogenicity of injected food proteins. This combination of atopic children and food protein injection along with adjuvants, contributes to millions developing life-threatening food allergies. Given the scale and severity of the food allergy epidemic, urgent action is needed to change vaccine policy concerning vaccine specifications, manufacture, vaccine package insert documentation requirements, the Vaccine Adverse Event Reporting System (VAERS) and the National Vaccine Injury Compensation Program. Many researchers have called for the removal of food proteins from vaccines and re-evaluation of adjuvants such as aluminum compounds. In the interim, food allergy warnings can be included in vaccine package inserts. Simultaneous administration of multiple vaccines can be stopped to avoid the combined negative effects of multiple food proteins and adjuvants. I would like to acknowledge informative discussions with Dr. Polly Matzinger, National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID) and Dr. Calman Prussin, NIH/NIAID.
  • Article
    Full-text available
    Nobel Laureate Charles Richet demonstrated over a hundred years ago that injecting a protein into animals or humans causes immune system sensitization to that protein. Subsequent exposure to the protein can result in allergic reactions or anaphylaxis. This fact has since been demonstrated over and over again in humans and animal models. The Institute of Medicine (IOM) confirmed that food proteins in vaccines cause food allergy, in its 2011 report on vaccine adverse events. The IOM’s confirmation is the latest and most authoritative since Dr. Richet’s discovery. Many vaccines and injections contain food proteins. Many studies since 1940 have demonstrated that food proteins in vaccines cause sensitization in humans. Allergens in vaccines are not fully disclosed. No safe dosage level for injected allergens has been established. As a result, allergen quantities in vaccines and injections are not regulated. Allergen quantities in vaccine excipients are also not regulated. It has been demonstrated that a smaller quantity of allergen is needed to cause sensitization than elicitation. It is well recognized that many currently approved vaccines have enough allergen to cause anaphylaxis. Therefore, they contain more than enough allergen to cause sensitization. Children today have fewer childhood infectious diseases. They have less exposure to helminths. C-section birth rates have increased in the last few decades by 50%. C-section births are known to result in sub-optimal gut microbiome in the newborn. All the above result in an immune imbalance biased towards atopy. Vaccine schedules today include 30-40 shots. Up to five shots may be simultaneously administered in one sitting. Vaccines contain adjuvants such as pertussis toxins and aluminum compounds that also bias towards allergy. Adjuvants also increase the immunogenicity of injected food proteins. This combination of atopic children and food protein injection along with adjuvants, contributes to millions developing life-threatening food allergies. Given the scale and severity of the food allergy epidemic, urgent action is needed to change vaccine policy concerning vaccine specifications, manufacture, vaccine package insert documentation requirements, the Vaccine Adverse Event Reporting System (VAERS) and the National Vaccine Injury Compensation program. Many researchers have called for the removal of food proteins from vaccines and re-evaluation of adjuvants such as aluminum compounds. In the interim, food allergy warnings can be included in vaccine package inserts. Simultaneous administration of multiple vaccines can be stopped to avoid the combined negative effects of multiple food proteins and adjuvants.
  • Article
    Although anaphylaxis is an extremely rare vaccine-associated adverse event, it occurred in young children following administration of the 2011/12 seasonal split influenza vaccine, which contained 2-phenoxyethanol as the preservative. These children had high levels of IgE antibodies against influenza vaccine components. We herein investigated why these children were sensitized. One hundred and seventeen series of serum samples were obtained immediately before, and one month after the first and second immunizations with the HA split vaccine of 2011/12. Forty-two sequential serum samples were collected in the acute and convalescent phases (2 and 4 weeks) after natural infection with H1N1 Pdm in 2009. IgE antibodies developed following the vaccination of young children with seasonal split vaccines, whereas no significant IgE response was observed following natural infection with H1N1 Pdm 2009. The prevalence of IgE antibodies was not influenced by outbreaks of H1N1 Pdm. Repeated immunization with the HA split vaccine induced IgE sensitization against the influenza vaccine irrespective of the H1N1, H3N2, or B influenza subtypes. The reasons why anaphylaxis only occurred in recipients of the influenza vaccine containing 2-phenoxyethanol are still being investigated, and the size distribution of antigen particles may have shifted to a slightly larger size. Since the fundamental reason was IgE sensitization, current split formulation for the seasonal influenza vaccine needs to be reconsidered to prevent the induction of IgE sensitization. Copyright © 2015 Elsevier Ltd. All rights reserved.
  • Article
    Full-text available
    Ovalbumin coupled with liposomes (OVA-liposome) induced selective unresponsiveness of anti-OVA IgE antibody production in BALB/c mice, whereas OVA adsorbed with aluminum hydroxide (OVA-alum) induced a substantial amount of anti-OVA IgE antibody production. Ovalbumin-liposome and OVA-alum predominantly induced IgG2a and IgG1 anti-OVA production, respectively. These results suggest that OVA-liposome and OVA-alum induce type 1 and type 2 T helper (Th) immune responses, respectively. To further investigate this issue, we examined the cytokine production induced by these two distinct adjuvants. Spleen cells taken from mice immunized with either OVA-liposome or OVA-alum were cultured in vitro with OVA and the cytokine production from each culture was analyzed. It was demonstrated that spleen cells from mice immunized with OVA-liposome produced more interferon (IFN)-γ than those immunized with OVA-alum and, furthermore, interleukin (IL)-4 was produced only by spleen cells from mice immunized with OVA-alum. These results favor the notion that OVA-liposome and OVA-alum induce Th1 and Th2 cytokines, respectively. Interestingly, the production of IL-2, a Th1 cytokine, was higher in the OVA-alum-immunized group and the production of IL-10, a Th2 cytokine, remained at low levels in both groups after primary immunization; levels of IL-10 increased in the OVA-liposome-immunized group after secondary immunization. These results do not agree with the above notion and, thus, suggest that it may be important to consider the balance between IFN-γ-producing cells and IL-4-producing cells rather than that between Th1 and Th2 cells for the regulation of IgE antibody production.
  • Article
    The Vaccine Adverse Event Reporting System has received reports of allergic reactions following immunization with egg-free recombinant influenza vaccine, among patients with a self-reported egg allergy or previous allergic reaction to inactivated influenza vaccine. These results suggest that allergic reactions following influenza vaccination are not necessarily related to egg proteins. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
  • Article
    Full-text available
    In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors. © 2012 by the National Academy of Sciences. All rights reserved.
  • Article
    Full-text available
    The production of IgE specific to different viruses (HIV-1, Parvovirus B19, RSV), and the ability for IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Previous studies in our laboratory were the first to report the presence of IgE anti-varicella zoster virus (VZV) in an adolescent patient with shingles. However, the presence and long term persistence of IgE anti VZV antibodies has not been studied in adults. The presence of serum IgE in addition to IgE and IgG anti-VZV antibody in sera were studied in children (N=12) (0-16 y/o) and adults (N=9) (32-76 y/o) with either a past history of (wild type) chicken pox (N=7 children, 9 adults) or 5 years after vaccination with varicella zoster (N=2 children) (Varicella virus vaccine live, Oka/Merck), as well as in non-infected subjects (N=3 children). Of the patients who had a positive history of chicken pox 13 of 16 (81%) contained IgE anti-VZV antibodies; they were both serum IgEHi (>100 IU/ml) and IgELo (<100 IU/ml). Of the patients who were vaccinated, IgE anti-VZV antibodies were undetected. In contrast, serum from the patients without a history of chicken pox or vaccination did not make either IgE or IgG anti-VZV antibodies. This is the first demonstration of the existence of IgE anti-VZV antibodies, and its long-term persistence in serum of previously infected subjects. Future studies regarding the functional role of anti-viral IgE and its relationship to VZV are warranted.
  • Article
    Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF)-α and the interleukin (IL)-10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases.
  • Article
    The production of IgE specific to different viruses (HIV-1, Parvovirus B19, Parainfluenza virus, Varicella Zoster Virus), and the ability of IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Nevertheless, the presence and persistence of IgE anti-Influenza virus antibodies has not been studied. Total serum IgE and specific IgE and IgG anti-Influenza virus antibodies were studied in children (N = 3) (m/f 14-16 y/o) and adults (N = 3) (m/f, 41-49 y/o) 2-20 months after vaccination with Influenza virus (Flumist(®) or Fluzone(®)), as well as in non-vaccinated children (N = 2). (UniCAP total IgE Fluoroenzymeimmunoassay, ELISA, Immunoblot). We found that serum of vaccinated children and adults contained IgE and IgG anti-Influenza virus antibodies approaching two years post vaccination. Non-vaccinated children did not make either IgE or IgG anti-Influenza antibodies. Similar levels of IL-2, IFN-γ, IL-4, and IL-10 cytokines were detected in serum of vaccinated compared with non vaccinated subjects (p > 0.05), as well as between vaccinated adults compared with vaccinated children and non vaccinated subjects (p > 0.05). Vaccinated children and adults continue to produce IgE anti-Influenza virus antibodies long term post vaccination. The long term production of IgE anti-Influenza virus antibodies induced by vaccination may contribute to protective immunity against Influenza.