This paper presented the development of a novel flexible inflatable Manipulation arm. Both straight beams and rotational joints are made of air-inflated membrane units. In order to minimize the actuation moment, a rotational joint with creases, analogous to spacesuit elbow, was developed. Besides, a tendon driven system was also developed to actuate the arm rotation. Biaxial tension and shear tests were conducted on the flexible PVC fabric of the inflatable arm, and the elastic constants of the membrane materials were obtained according to the orthotropic assumption. Moreover, a finite element model was created to simulate the rotational performance of the inflated arm. The simulation results are compared with those obtained for cylindrical joints with no creases, and the former configuration results in a much lower actuation torque, which well satisfies the design goal for the rotational joint. Furthermore, a prototype of the inflatable arm was designed and made to perform an experimental investigation, and the accuracy of the numerical simulation was validated by the test data. © 2016, Shanghai Jiao Tong University Press. All right reserved.