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Citation: Kashyap D, Tuli HS, Sharma AK. Cordyceps: A Natural Himalayan Viagra with Promising Aphrodisiac
Potential. Austin Andrology. 2016; 1(2): 1010.
Austin Andrology - Volume 1 Issue 2 - 2016
Submit your Manuscript | www.austinpublishinggroup.com
Tuli et al. © All rights are reserved
Austin Andrology
Open Access
treatment of cordycepin, an active ingredient of Cordyceps extract,
in an experiment upon Male Sprague-Dawley rats have shown dose-
dependent elevation in epididymal weight, sperm motility, and
movement, well-arranged spermatogonia, densely packed cellular
material, along with increased number of mature spermatozoa in
the seminiferous lumen [23]. e results further demonstrate that
supplementation of Cordyceps mycelium improves sperm quality as
well as quantity in subfertile boars which further supports the role
of Cordyceps in the enhancement of aphrodisiac properties [24]. In
another study, Cordyceps extract has been noticed to strengthen the
accessory genital glands of mice along with modulation of androgen
secretion [25]. is genus has also been suggested to positively
inuence the reproductive functions in yang vacuity of kidney
mice model by improving adenine-induced testis morphology. e
mice, when treated with Cordyceps which were receiving adenine
at the same time, have shown improved testis morphology along
with improvement in the rate and time of their matched female’s
pregnancy. In addition to this, numbers as well as the average body
weight of their newborn mice were also found to be increased [26].
is mushroom also lightened the BPA-induced reproductive
damage by activating the antioxidant defense system which involves
testicular superoxide dismutase (SOD), glutathione peroxidase
(GSH-PX), and glutathione (GSH), along with a reduction in serum
malondialdehyde (MDA). is medicinal fungus was further found
to elevate the levels of serum luteinizing hormone and testosterone in
comparison to the BPA-treated group [27]. In conclusion, the genus
of this sac fungus has the potential to modulate reproductive activity
and restore the impaired reproductive function by directly aecting
the release of sexual hormones such as testosterone from Leydig cells
and estrogen and progesterone from granulosa or theca cells. As the
cumulative observations from literature support the therapeutic role
of Cordyceps, therefore, this fungus with medicinal importance could
be introduced to improve sex or reproductive impairment.
References
1. Kashyap D, Mondal R, Tuli HS, Kumar G, Sharma AK. Molecular targets of
gambogic acid in cancer: recent trends and advancements. Tumor Biol. 2016;
3: 208–215.
2. Kashyap D, Tuli HS, Sharma AK. Ursolic acid (UA): A metabolite with
promising therapeutic potential. Life Sci. 2016; 146: 201-213.
3. Dharambir Kashyap HST, Sharma A, Kumar M, Sak K. Molecular targets of
natural metabolites in cancer: recent trends and advancements. J Biol Chem
Sci. 2016; 3: 208–215.
4. Kashyap D, Mittal S, Sak K, Singhal P, Tuli HS. Molecular mechanisms of
action of quercetin in cancer: recent advances. Tumor Biol. 2016.
5. Tuli HS, Kashyap D, Sharma AK, Sandhu SS. Molecular aspects of melatonin
(MLT)-mediated therapeutic effects. Life Sci. 2015; 135: 147–157.
6. Kashyap D, Sharma A, Tuli HS, Punia S, Sharma AK. Ursolic Acid and
Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inammatory
Activities. Recent Pat Inamm Allergy Drug Discov. (2016).
Editorial
Natural dietary supplements with promising therapeutic eects
are emerging collaterally as decisive agents against multiple clinical
and pathological manifestations [1–3]. Findings from several studies
on phytochemicals, contributing to their remarkable role in prevention
and cure of cancer, cardiovascular, neuro-degeneration, and sex or
reproduction-related disorders without or with minimal side eects
[4–7]. Cordyceps is among the category of such medicinally important
genus of ascomycete fungi (sac fungi) having worldwide distribution
of approximately 400 species, that parasitizes on the insects and
other arthropods mainly from Lepidoptera order, thus called
entomopathogenic fungi [8–13]. Firstly this mushroom came into
limelight during 1993 sports championship, when few of the winner
athlete’s committed that they were utilizing Cordyceps mushroom
based ingredients in their diet. Its life cycle starts with infection to
the insect, mainly in the early months of winter thereaer, fungus
emerges out from the insect’s body in March-April which justies its
name i.e. winter worm summer grass [14]. In the last few decades,
the pharmacological potential of this fungus has been extensively
implicated in the treatment of various lethal diseases including
diabetes, and cancer [11]. In addition to the above mentioned
medicinal values, Cordyceps genus is also known as Himalayan
Viagra due to its positive eects on sexual stamina enhancement [15].
It has been traditionally being practiced as nutritious food for the
enhancement of sexual performance and the restitution of impairment
in sexual function amongst Chinese population [16]. Proved in the
study using normal mouse Leydig cells, that Cordyceps treatment
stimulated the steroidogenesis in a dose-dependent relationship and
at a concentration of 3 mg/ml, signicantly stimulated testosterone
production determined by radioimmunoassay (RIA) (p >0.05) [17–
19]. Further results indicated that Cordyceps signicantly elevated
plasma testosterone levels both in immature and mature mice aer
3 and/or 7 days of treatment (p < 0.05) [20]. Also, in MA-10 mouse
Leydig tumor cells, Cordyceps stimulated steroidogenesis through
both PKA and PKC signal transduction pathways, therefore could be
utilized to modulate sexual ecacy [21,22]. Moreover, utilizing the
Editorial
Cordyceps: A Natural Himalayan Viagra with Promising
Aphrodisiac Potential
Kashyap D1, Tuli HS2*, Sharma AK2
1Department of Histopathology, Postgraduate Institute of
Medical Education and Research (PGIMER), Chandigarh,
Punjab, 160012, India
2Department of Biotechnology, Maharishi
Markandeshwar University, Mullana-Ambala, Haryana,
133207, India
*Corresponding author: Hardeep Singh Tuli,
Assistant Professor, Department of Biotechnology,
Maharishi Markandeshwar University, Mullana
(Ambala), Haryana, India
Received: October 15, 2016; Accepted: October 21,
2016; Published: October 24, 2016
Austin Andrology 1(2): id1010 (2016) - Page - 02
Tuli HS Austin Publishing Group
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7. Cordyceps Species - Cordyceps Trusted Reviews. http://cordycepsreviews.
com/cordyceps-sinensis-information/cordyceps-species/
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cordycepin on A549 human lung cancer cell line. Turkish J Biol. 2015; 39:
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9. Tuli HS, Sandhu SS, Sharma AK, Gandhi P. Anti-angiogenic activity of the
extracted fermentation broth of an entomopathogenic fungus, Cordyceps
militaris 3936. Int J Pharm Pharm Sci. 2014; 6.
10. Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential
of Cordyceps with special reference to Cordycepin. 3 Biotech. 2013; 4: 1–12.
11. Tuli HS, Sandhu SS, Sharma AK, Kashyap D. Cordycepin: A bioactive
metabolite with therapeutic potential. Life Sci. 2013; 93: 863–869.
12. Tuli HS, Sharma AK, Kashyap D. Cordycepin: A Cordyceps Metabolite with
Promising Therapeutic Potential, in: Fungal Metab. Springer International
Publishing Cham. 2015: 1–22.
13. Sung GH, Hywel-Jones NL, Sung JM, Luangsa-ard JJ, Shrestha B, Spatafora
JW. Phylogenetic classication of Cordyceps and the clavicipitaceous fungi.
Stud Mycol. 2007; 57: 5–59.
14. Mongkolsamrit S, Kobmoo N, Tasanathai K, Khonsanit A, Noisripoom
W, Srikitikulchai p, et al. Life cycle, host range and temporal variation of
Ophiocordyceps unilateralis/Hirsutella formicarum on Formicine ants, J.
Invertebr Pathol. 2012; 111: 217–224.
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of Cordyceps with special reference to Cordycepin. 3 Biotech. 2013; 4: 1–12.
16. Sharma A, Tuli HS, Sharma SS. Optimization of Extraction Conditions and
Antimicrobial Potential of A Bioactive Metabolite, Cordycepin from Cordyceps
Militaris 3936. 2014.
17. Huang BM, Hsu CC, Tsai SJ, Sheu CC, Leu SF. Effects of Cordyceps
sinensis on testosterone production in normal mouse Leydig cells. Life Sci.
2001; 69: 2593–2602.
18. Hsu CC, Huang YL, Tsai SJ, Sheu CC, Huang BM. In vivo and in vitro
stimulatory effects of Cordyceps sinensis on testosterone production in
mouse Leydig cells. Life Sci. 2003; 73: 2127–2136.
19. Wong KL, So EC, Chen CC, Wu RSC, Huang BM. Regulation of
steroidogenesis by Cordyceps sinensis mycelium extracted fractions with
(hCG) treatment in mouse Leydig cells. Arch Androl. 2007; 53: 75–77.
20. Huang YL, Leu SF, Liu BC, Sheu CC, Huang BM. In vivo stimulatory effect
of Cordyceps sinensis mycelium and its fractions on reproductive functions in
male mouse. Life Sci. 2004; 75: 1051–1062.
21. Chen YC, Huang YL, Huang BM. Cordyceps sinensis mycelium activates
PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse
Leydig tumor cells. Int J Biochem Cell Biol. 2005; 37: 214–223.
22. Hsu CC, Tsai SJ, Huang YL, Huang BM. Regulatory mechanism of Cordyceps
sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS Lett. 2003;
543: 140–143.
23. Sohn SH, Lee SC, Hwang SY, Kim SW, Kim IW, Ye MB, et al. Effect of
long-term administration of cordycepin from Cordyceps militaris on testicular
function in middle-aged rats. Planta Med. 2012; 78: 1620–1625.
24. Lin WH, Tsai MT, Chen YS, Hou RCW, Hung HF, Li CH, et al. Improvement of
sperm production in subfertile boars by Cordyceps militaris supplement. Am J
Chin Med. 2007; 35: 631–641.
25. Yan LC. Hong-Jun W, Yan-Fang L, Ke-Yan S, Bo-Ping Z, Li-Qiang W.
Experimental Study on the Effects of Cordyceps Militaris Extract on the
Accessory Genital Glands and Serum Testosterone in Anamorph Mice.
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Citation: Kashyap D, Tuli HS, Sharma AK. Cordyceps: A Natural Himalayan Viagra with Promising Aphrodisiac
Potential. Austin Andrology. 2016; 1(2): 1010.
Austin Andrology - Volume 1 Issue 2 - 2016
Submit your Manuscript | www.austinpublishinggroup.com
Tuli et al. © All rights are reserved
... mushroom began to be in the spotlight in 1993, when some world athletics champions revealed part of their strategy for success, including a diet based on Cordyceps spp. ingredients (Kashyap et al., 2016). It works by an increase in cellular ATP increasing bioenergy and thus facilitating efficient oxygen utilization (Geng et al., 2017). ...
... Because Cordyceps spp. is a benchmark for a highly energetic source, its applications as a sexual stimulant and in sexual dysfunction are attractive (Zhu et al., 1998;Tuli et al., 2013a;Chen et al., 2017), even popularly known as the Himalayan Viagra (Kashyap et al., 2016). Cordyceps spp. ...
... In particular, the administration of cordycepin can increase the weight of the epididymis, sperm motility, and movement, and the number of mature sperm (Kashyap et al., 2016), namely, the quality and quantity of the sperm. Wang et al. (1998) demonstrate that PKC may be responsible for the C. sinensis-induced steroidogenesis in primary rat adrenal cell cultures. ...
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In recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-α, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthase activity, and stimulation of inflammatory response via mitogen-activated protein kinase pathway. Other pharmacological activities like antioxidant, anti-cancer, antihyperlipidemic, anti-diabetic, anti-fatigue, anti-aging, hypocholesterolemic, hypotensive, vasorelaxation, anti-depressant, aphrodisiac, and kidney protection, has been reported in pre-clinical studies. These biological activities are correlated with the bioactive compounds present in Cordyceps including nucleosides, sterols, flavonoids, cyclic peptides, phenolic, bioxanthracenes, polyketides, and alkaloids, being the cyclic peptides compounds the most studied. An organized review of the existing literature was executed by surveying several databanks like PubMed, Scopus, etc. using keywords like Cordyceps , cordycepin, immune system, immunostimulation, immunomodulatory, pharmacology, anti-cancer, anti-viral, clinical trials, ethnomedicine, pharmacology, phytochemical analysis, and different species names. This review collects and analyzes state-of-the-art about the properties of Cordyceps species along with ethnopharmacological properties, application in food, chemical compounds, extraction of bioactive compounds, and various pharmacological properties with a special focus on the stimulatory properties of immunity.
... It is usually called DongChongXiaCao (DCXC), means winter worm-summer grass. DCXC has over 30 bioactivities for the enhancement of endurance capacity and treatment of diabetes, liver cancer and kidney cancer, such as immunomodulatory, antitumor, antiosteoporotic, anti-inflammatory, and antioxidant activities through a variety of unique functional ingredients Lo et al., 2013;Kashyap et al., 2016;Wu et al., 2018). It is considered a beneficial traditional Chinese medicine. ...
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The fungus Ophiocordyceps sinensis is endemic to the vast region of the Qinghai-Tibetan plateau (QTP). The unique and complex geographical environmental conditions have led to the “sky island” distribution structure of O. sinensis. Due to limited and unbalanced sample collections, the previous data on O. sinensis regarding its genetic diversity and spatial structure have been deemed insufficient. In this study, we analyzed the diversity and phylogeographic structures of O. sinensis using internally transcribed spacer region (ITS) and 5-locus datasets by a large-scale sampling. A total of 111 haplotypes of ITS sequences were identified from 948 samples data of the fungus O. sinensis, with representing high genetic diversity, and 8 phylogenetic clades were recognized in O. sinensis. Both the southeastern Tibet and the northwestern Yunnan were the centers of genetic diversity and genetic differentiation of the fungus, and they were inferred as the glacial refugia in the Quaternary. Three distribution patterns were identified to correspond to the 8 clades, including but not limited to the coexistence of widely and specific local distributive structures. It also revealed that the differentiation pattern of O. sinensis did not fit for the isolation-by-distance model. The differentiation into the 8 clades occurred between 1.56 Myr and 6.62 Myr. The ancestor of O. sinensis most likely originated in the late Miocene (6.62 Myr) in the northwestern Yunnan, and the Scene A–C of the Qinghai–Tibetan movements may have played an important role in the differentiation of O. sinensis during the late Miocene–Pliocene periods. Our current results provide a much clearer and detailed understanding of the genetic diversity and geographical spatial distribution of the endemic alpine fungus O. sinensis. It also revealed that the geochronology resulting from paleogeology could be cross-examined with biomolecular clock at a finer scale.
... Recently aphrodisiac activity has been reported in O. sinensis, and termed as Himalayan Viagra (Kashyap et al., 2016). Wang et al. (1998) reported that O. sinensis contains a factor that stimulates corticosteroid production in animal model. ...
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