DataPDF Available

Poster - New topical treatment of symptomatic internal hemorrhoids in a general practice setting

Authors:
New Topical Treatment of Symptomatic Internal
Hemorrhoids in a General Practice Setting
Maja Miskulin1,2, Zdenka Lalic3, Albina Dumic4, Ivan Miskulin2,
Damir Sebo2, Aleksandar Vcev2,4
1Department of Public Health, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
2Institute for Integrative Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
3APIPHARMA Ltd., Zagreb, Croatia
4Department of Internal Medicine, Family Medicine and Medical History, Faculty of Medicine Osijek, Josip Juraj Strossmayer
University of Osijek , Osijek, Croatia
0
0,2
0,4
0,6
0,8
1
1,2
1,4
1,6
Status before
the therapy Status after 1
month of
therapy
Status after 2
months of
therapy
Status after 3
months of
therapy
Figure 2. Intensity of Each Analyzed
Symptom Among the Participants
During the Follow up Period
(Friedman’s test; p<0.001)
Bleeding Prolapse Pain Itching
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Patients
with 4
symptoms
Patients
with 3
symptoms
Patients
with 2
symptoms
Patients
with 1
symptom
Patients
without
symptoms
Figure 1. Participants According to the
Number of the Symptoms Before and
After the Therapy
Before the therapy After the therapy
Introduction
Oral usage of flavonoid-based drugs can be
successfully applied in the conservative
treatment of internal hemorrhoids;however, its
efficiency inaform of topical preparations has
not been demonstrated yet.The aim of the
present study was to determine the efficiency
of ointment with propolis extract (containing
minimally 115 mg/kg of flavonoid galangin) in
relief and suppression of the symptomatic
internal hemorrhoids grade 1and 2(bleeding,
prolapse, pain, and itching).
Methods
This prospective cohort epidemiological study
that included 46 participants of both genders,
mean age 53.6±14.3 years, was conducted in
the general practice setting in Osijek, Croatia
and lasted for three months. A specially
designed questionnaire was used to collect
demographic data and data concerning the
hemorrhoid disease symptoms and to evaluate
the intensity of the latter data according to the
scale defined in the research protocol.
Results
The study showed statistically significant
improvements in the intensity of all the
symptoms connected with the internal
hemorrhoids grade 1and 2(p<0.001)during
the follow up period (Figure 2.), as well as
statistically significant differences in proportions
of participants with and without of the each of
the analyzed symptoms before and after the
therapy (p<0.001). After three months of
therapy with ointment containing propolis
extract 82.7% patients (38/46)had none of the
analyzed symptoms (Figure 1.).
Conclusions
Ointment with propolis extract efficiently
affected all the analyzed symptoms of the
hemorrhoid disease thus having avery
significant place within the conservative
treatment of hemorrhoids.
Key words
hemorrhoids,topical treatment, propolis,
flavonoid, Croatia
9th European Congress for Integrative Medicine
ECIM 2016 Global Summit on Integrative Medicine and Healthcare
ResearchGate has not been able to resolve any citations for this publication.
ResearchGate has not been able to resolve any references for this publication.