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How Nutrition, Proper Speciﬁc Hydration, and
Inﬂammation aﬀect Body Flora
By Dr. Keith Kantor
Inﬂammation and Flora Balance.
Gut ﬂora (gut microbiota, or gastrointestinal microbiota) is the complex community of
microorganisms that live in the digestive tracts of humans and other animals, including
The gut microbiota has a signiﬁcant role in human health and disease. Dysbiosis of the
intestinal ecosystem contributes to the development of certain illnesses that can be reversed
by favorable alterations by probiotics. The published literature was reviewed to identify
scientiﬁc data showing a relationship between imbalance of gut bacteria and development of
diseases that can be improved by biologic products. The medical conditions vary from
infectious and antibiotic-associated diarrhea to obesity to chronic neurologic disorders. A
number of controlled clinical trials have been performed to show important biologic eﬀects in
a number of these conditions through administration of prebiotics, probiotics, and synbiotics.
Controlled clinical trials have identiﬁed a limited number of prebiotics, probiotic strains, and
synbiotics that favorably prevent or improve the symptoms of various disorders including
inﬂammatory bowel disease, irritable bowel syndrome, infectious and antibiotic-associated
diarrhea, diabetes, nonalcoholic fatty liver disease, necrotizing enterocolitis in very low birth
weight infants, and hepatic encephalopathy. Studies have shown that probiotics alter gut
ﬂora and lead to elaboration of ﬂora metabolites that inﬂuence health through 1 of 3 general
mechanisms: direct antimicrobial eﬀects, enhancement of mucosal barrier integrity, and
immune modulation. Restoring the balance of intestinal ﬂora by introducing probiotics for
disease prevention and treatment could be beneﬁcial to human health. It is also clear that
signiﬁcant diﬀerences exist between diﬀerent probiotic species. Metagenomics and
metatranscriptomics together with bioinformatics have allowed us to study the cross-talk
between the gut microbiota and the host, furthering insight into the next generation of
biologic products. (19)
In humans, the gut ﬂora is established at one to two years after birth, and by that time the
intestinal epithelium and the intestinal mucosal barrier that it secretes have co-developed in
a way that is tolerant to, and even supportive of, the gut ﬂora and that also provides a barrier
to pathogenic organisms. (2,3,6,8)
Human gut microorganisms beneﬁt the host by collecting the energy from the fermentation of
undigested carbohydrates and the subsequent absorption of short-chain fatty acids (SCFAs),
acetate, butyrate, and propionate. Intestinal bacteria also play a role in synthesizing vitamin
B and vitamin K as well as metabolizing bile acids, sterols, and xenobiotics. (3,4,8)
The systemic importance of the SCFAs (small chain fatty acids) and other compounds they
produce are like hormones and the gut ﬂora itself appears to function like an endocrine
Imbalance of the gut ﬂora has been associated with a host of inﬂammatory and autoimmune
conditions. Extensive modiﬁcation and imbalances of the gut ﬂora is associated with obesity.
However, in certain conditions, some species are thought to be capable of causing disease
by causing infection/inﬂammation or increasing cancer risk for the host.
Probiotic bacteria are used to treat or prevent a broad range of human diseases, conditions,
and syndromes. In addition, there are areas of medical use that have been proposed for
future probiotic applications. Randomized double-blind studies have provided evidence of
probiotic eﬀectiveness for the treatment and prevention of acute diarrhea and antibiotic-
induced diarrhea, as well as for the prevention of cow milk–induced food allergy in infants
and young children. Research studies have also provided evidence of eﬀectiveness for the
prevention of traveler's diarrhea, relapsing Clostridium diﬃcile–induced colitis, and urinary
tract infections. There are also studies indicating that probiotics may be useful for prevention
of respiratory infections in children, dental caries, irritable bowel syndrome, and inﬂammatory
bowel disease. Areas of future interest for the application of probiotics include colon and
bladder cancers, diabetes, and rheumatoid arthritis. The probiotics with the greatest number
of proven beneﬁts are Lactobacillus rhamnosus strain GG and Saccharomyces boulardii.
Inﬂammation eﬀects Flora balance in many ways one of them being the insulin mechanism.
Excess inﬂammation can cause carbohydrate and sugar cravings leading to poor insulin
regulation, stimulating the opiate receptors in the brain, triggering addictive behaviors along
with detrimental health consequences, such as cancer, and obesity. (6,7)
Contributing Factors to poor ﬂora balance include:
Age - Adults have been shown to suﬀer from poor ﬂora balance more than children, although
there are children who do suﬀer with poor ﬂora balance. Some research points to those who
were born via C-section have less exposure to healthy ﬂora, therefore putting them at risk
later on in life. (9)
Diet - Consuming a diet RICH in Processed foods will eventually lead to an imbalanced gut
ﬂora. Processed sugar feeds Candida and "bad" bacteria (including the pathogen you are
trying to destroy with the antibiotic).
Here is a list of processed foods that should be avoided:
Saccharin / Sweet and Low
Sucralose / Splenda.
Acesulfame Potassium / Sunett and Sweet One
Aspartame / NutraSweet, Equal and Sugar Twin.
Neotame / This is the newest of the sweeteners available on the market and was produced
by the industrial giant Monsanto. Its chemical structure is similar to that of aspartame and
one of its metabolites, too, is formaldehyde. In addition to this, it contains another chemical
called 3-dimethylbutyl, which is listed as a harmful chemical by the Environmental Protection
Agency. One of its brand names is Sweetos.
Artiﬁcial sweeteners have long been promoted as diet and health aids. But breaking
research shows that these products may be leading to the very diseases they were said to
help prevent: scientists have discovered that, after exposure to artiﬁcial sweeteners, our gut
bacteria may be triggering harmful metabolic changes. (12)
The ﬁndings showed that many -- but not all -- of the volunteers had begun to develop
glucose intolerance after just one week of artiﬁcial sweetener consumption. The composition
of their gut microbiota explained the diﬀerence: the researchers discovered two diﬀerent
populations of human gut bacteria -- one that induced glucose intolerance when exposed to
the sweeteners, and one that had no eﬀect either way. Dr. Elinav believes that certain
bacteria in the guts of those who developed glucose intolerance reacted to the chemical
sweeteners by secreting substances that then provoked an inﬂammatory response similar to
sugar overdose, promoting changes in the body's ability to utilize sugar. (13)
A saturated fat is a fat in which the fatty acids all have single bonds. Double bonds can
react with hydrogen to form single bonds. (14)
Palm and palm kernel oil
Artiﬁcial (synthetic) preservatives BHA, BHT, TBHQ, MSG (which is also disguised as
“yeast extract” in foods on labeling
The above, upon daily consumption will be more likely to show signs of poor gut health.
Nutrient deﬁciencies will also eﬀect ﬂora balance. Those who are malnourished will have a
higher content of yeast in their stomach and mouth, a suppressed immune system, poor
digestion, autoimmune conditions and higher risk of disease. (15)
Altering the numbers of gut bacteria, for example by taking broad-spectrum antibiotics, may
aﬀect the host's health and ability to digest food. Antibiotics can cause antibiotic-associated
diarrhea (AAD) by irritating the bowel directly, changing the levels of gut ﬂora, or allowing
pathogenic bacteria to grow. Another harmful eﬀect of antibiotics is the increase in numbers
of antibiotic-resistant bacteria found after their use, which, when they invade the host, cause
illnesses that are diﬃcult to treat with antibiotics. (10)
The Program/ nutrition plan will help reduce inﬂammation while balancing ﬂora.
This program consists of a diet rich in Omega 3 fatty acids, low in processed sugar and ﬂour,
optimal high quality proteins, dye free and chemical pure whole foods are used as much as
This program/ nutrition plan incorporates healthy fats, antioxidants, ﬁber and optimal macro
This program/nutrition plan will help optimize gut ﬂora balance, and immune system.
Speciﬁc foods and a hydroxide rich water that can help ﬁght inﬂammation and promote gut
ﬂora balance include:
Hydroxide rich water
Heart healthy nut and seed butters like sunﬂower butter (actual nuts and seeds may be
painful if colitis is a health issue),
Heart healthy oils like coconut oil, extra virgin olive oil,
All natural protein sources,
Antioxidant rich produce, including avocado, berries, cruciferous vegetables like cabbage,
broccoli, cauliﬂower and dark leafy greens.
Come up with a supplementation plan for your gastrointestinal health.
Working with your doctor or qualiﬁed health professional, add probiotics to your supplement
Probiotics are microorganisms that are believed to provide health beneﬁts when consumed.
With regard to gut ﬂora, probiotics are typically non-digestible, ﬁber compounds (11) that
pass undigested through the upper part of the gastrointestinal tract and stimulate the growth
or activity of advantageous gut ﬂora by acting as substrate for them.
Research has shown that treatment with some probiotic strains of bacteria may be eﬀective
in irritable bowel syndrome and chronic idiopathic constipation. (16,17)
This treatment is designed to improve problems related to leaky gut, a condition in which
damaged intestinal walls release undigested food particles into the bloodstream. Leaky gut is
associated with a range of inﬂammatory and immune responses including Irritable Bowel
Disease, Crohn’s Disease, Colitis, asthma and diabetes. (18)
The Program/ nutrition plan will work best in additional to a support team; it is ideal for those
who are under supervised clinical treatment and therapies of qualiﬁed health professionals.
Certain lifestyle trends and habits may contribute to gut health.
Poor nutrition, environmental toxin exposure, nutrient deﬁciencies, and stress are all
contributing factors to poor ﬂora balance.
Try to detoxify your cosmetics, cleaning products, and food utensils, containers, etc. Look
for all natural cosmetics, avoiding parabens, dyes, titanium, etc. Move towards, stainless
steel, ceramic, and glass kitchenware.
The goal of a sound nutrition program, working to reduce inﬂammation and maintain a
healthy gut ﬂora balance includes incorporating these essential nutrients daily:
Vitamin D - from the Sun, fatty ﬁsh like salmon and sardines and if you choose to
supplement a simple baseline is 1000IU per 25 lbs. of body weight.
Vitamin K2 - grass fed butter, egg yolks.
Magnesium - spinach, Swiss chard, halibut, salmon and pumpkin seeds.
If you decide to go with a supplement, I recommend taking from 200 mg to 500 mg
per day in a form like magnesium citrate, chloride or glycinate, which are absorbed
much better than the cheaper magnesium oxide form.
Vitamin C as well as other antioxidants like selenium and vitamin E are very
important and used heavily when the body is dealing with an infection or are trying to
heal tissues. Some sources of these antioxidants include citrus fruits, peppers,
sunﬂower butter, spinach, and avocado.
Foods to include in daily nutrition: Omega 3 fatty acids from wild caught salmon,
avocados, and cruciferous vegetables like Brussel Sprouts, cabbage, and broccoli.
Foods to Avoid: coﬀee, sport drinks/juice, candy and gluten.
Proper Hydration through Hydroxide Rich Water for Flora
Balance and Combatting Inﬂammation
Acidity and inﬂammation go hand in hand. By chemical deﬁnition, acidity is a problem of too
much hydrogen (H+). Too much acidity in the body can stem from diet, disease, exercise,
and other life style factors. It is generally recognized that excess acidity in the body creates
inﬂammation which leads to other disease conditions. Acidity causes a lack of oxygen and a
lower pH condition in which pathogens ﬂourish.
Hydroxide (OH-) is a natural hydrogen hunter that does not merely buﬀer the body against
excess hydrogen but eliminates by combining with it to form harmless water. That water can
then be used for hydration or eliminated through urination. Here is the formula of the
elimination reaction: OH- + H+ = H2O.
Most alkaline waters attempt to help the body buﬀer acidity by providing alkaline minerals.
But this does not address the underlying problem of excess hydrogen and instead only helps
the body maintain pH balance. Potential hydrogen (pH) balance helps the body but it does
not ﬁx the issue. The main goal of most alkaline waters is pH balance but this misses the
A water rich in hydroxide seeks to eliminate acidity by eliminating the excess hydrogen. Most
alkaline waters contain some hydroxide if they claim either to contain negative ions or have
gone through ionization. The problem is most alkaline waters rely more on alkaline minerals
to buﬀer the excess hydrogen than they use the hydroxide to eliminate hydrogen. This is why
it is imperative to ﬁnd a hydroxide rich water because elimination is far more eﬀective in
restoring balance to the body than mere buﬀering.
Beneﬁts of a hydroxide rich water:
Hydroxide eliminates acidity rather than just buﬀering the acidity.
Hydroxide produces no toxic by-products. It produces only water which can be used for
hydration or eliminated through urination.
By eliminating excess acidity (hydrogen), it frees up the body’s own oxygen to use for
other biological processes.
Hydroxide restores completely the acid-alkaline balance beyond just pH balance.
Hydroxide helps reduce inﬂammation by eliminating acidity and not just buﬀering it.
Drastically reducing inﬂammation has been shown in many studies to help the health gut
ﬂora and maintain a proper balance needed to help the immune system and various
diseases, as mentioned above.
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