Vomiting, the basic protective reflexes against ingested toxins, or result from underlying diseases such as inevitable medication side effect or anatomic obstruction, however, in some situations, induced vomiting may be a therapeutic option as reported in bulimia nervosa as a weight control measure. Besides that, many types of researches demonstrate that induced vomiting for treating disease does not have serious negative effects. To well understand the therapeutic effect of induced vomiting, the paper firstly describe the anatomy of brain structures containing the vomiting reflex, including chemoreceptor trigger zone, vomiting center and the specific signal deliver process. Moreover, cardiovascular and respiratory functions changes are essential to the generation of vomiting. Furthermore, the brain-gut connections may play an important role in the vomiting reflex, its bidirectional interaction can be perturbed leading to acute physiological repercussions. In addition to that, vagal afferent activation is also indispensable. Effect of emesis can achieve via vagal fibers in variable methods. Additionally, induced vomiting can change the gastrointestinal homeostasis as well which lead to a recovery of the stomach’s function. Finally, this work will briefly illustrate the procedure of induced vomiting, as well as the side effects of induced vomiting and the corresponding control strategies. According to the known acknowledge about the induced vomiting as mentioned above, we draw a conclusion that induced vomiting may be a therapeutic option.