At the agricultural research station Agroscope in Zurich-Reckenholz (Switzerland), a large lysimeter facility was built in 2009. Totally 72 lysimeters, each with 1 m2 surface area and a depth of 150 cm, were monolithically excavated at three agricultural sites differing in soil type. All lysimeters can be operated from a walkable basement. Twelve of the lysimeters are weighable and are instrumented with tensiometers, temperature sensors, suction cups and FDR probes in four depths (10, 30, 60, and 90 cm), each with two replicates. The other 60 lysimeters are non-weighable. Seepage water is measured by tipping counters. All lysimeters are used for agronomic experiments. The main focus is on water flows and nitrate leaching under different cropping systems, soil tillage intensities, fertilization regimes, and soil types. All treatments are replicated three times. The results of the first seven experimental years (2009-2015) show that water flows of the lysimeters are subject to large annual variations, depending on climatic conditions and crops grown. Annual seepage volumes fluctuated between 116 mm and 754 mm. Results on nitrate leaching are shown by the example of an experiment on the ploughing-in time of a cover crop. Ploughing up in spring led to reduced N leaching compared to ploughing up already in autumn. Tracer experiments with bromide show that the mass transport through the soil profile takes about 0.5 to 1.5 years. A large lysimeter facility has large advantages and offers many opportunities, but is also a challenge in terms of financial and human resources.