Content uploaded by Peter Petrovich Gariaev
Author content
All content in this area was uploaded by Peter Petrovich Gariaev on Sep 09, 2016
Content may be subject to copyright.
A preview of the PDF is not available
DNA Decipher Journal | March 2016 | Volume 6| Issue 1 | pp. 01-11 Gariaev, P. P., Vladychenskaya, I. P. & Leonova-Gariaeva, E. A., PCR Amplification of Phantom DNA Recorded as Potential Quantum Equivalent of Material DNA
Abstract
In this article, we describe the method and application of PCR amplification of phantom DNA
recorded using modulated secondary broadband electromagnetic radiation (MBER) of LHN-303
Laser as potential equivalent of material DNA. As examples, we report two experiments applying
the herein described method. We appeal to and invite other research groups to verify our method
and results independently.
ResearchGate has not been able to resolve any citations for this publication.
In the earlier article I introduced the notion of Hamiltonian cycle as a mathematical model for musical harmony and also proposed a connection with biology: motivations came from two observations. The number of
icosahedral vertices is 12 and corresponds to the number of notes in 12-note system and the number of triangular faces of icosahedron is 20, the number of aminoacids. This led to a group theoretical model of
genetic code and replacement of icosahedron with tetraicosahedron to explain also the 21st and 22nd amino-acid and solve the problem of simplest model due to the fact that the required Hamilton's cycle does not exist. This led also to the notion of bioharmony.
This article was meant to be a continuation to the mentioned article providing a proposal for a theory of harmony and detailed calculations. It however turned out that the proposed notion of bioharmony was too restricted: all icosahedral Hamilton cycles with symmetries turned out to be possible rather than only the 3 cycles forced by the assumption that the polarity characteristics of the amino-acids correlate with the
properties of the Hamiltonian cycle. In particular, it turned out that the symmetries of the Hamiltonian cycles are the icosahedral symmetries needed to predict the basic numbers of the genetic code and its extension to include also 21st and 22nd aminoacids. One also ends up with a proposal for what harmony is leading to non-trivial predictions both at DNA and amino-acid level.
The article is devoted to detailed aplications of TGD inspired view about Quantum Mind. Mag-netic body carrying dark matter and forming an onionlike structure with layers characterized by large values of Planck constant is the key concept. Magnetic body is identified as intentional agent using biological body as sensory receptor and motor instrument. EEG is identified as a communication and control tool of the magnetic body and a fractal hierarchy of analogs of EEG is predicted. Living system is identified as a kind of Indra's net with biomolecules representing the nodes of the net and magnetic flux tubes connections between then. The reconnection of magnetic flux tubes and phase transitions changing Planck constant and therefore the lengths of the magnetic flux tubes are identi-fied as basic mechanisms behind DNA replication and analogous processes and also behind the phase transitions associated with the gel phase in cell interior. The model of DNA as topological quantum computer is discussed as an application. A general model for qualia is introduced. The identification of the correlates of the fundamental qualia as quantum number increments for a subsystem is in a complete analogy with the identification of quantum numbers as characterizers of physical states. A general classification of qualia based on thermodynamical notions is discussed and a mechanism generating sensory qualia is proposed. Also the question whether some qualia could correspond also to those of magnetic body is raised. The capacitor model for sensory receptor based on the idea that sensory qualia are generated in the analog of di-electric breakdown introducing a flow of large number of particles with quantum numbers characterizing the quale. A model for the cell membrane as sensory receptor and as qualia chart with lipids serving as its pixels is developed. Although sensory rorgans are assumed to define the seats if the fundamental qualia, also neurons would define sensory homunculi not necessarily responsible for sensory mental images at our level of self hierarchy. Cell membrane is assumed to be a quantum critical system taken to mean that it is near to a vacuum extremal of so called Kähler action. This explains large parity breaking in living matter (chiral selection) very difficult to understand in standard model. The model explains the peak frequencies of visible light for photoreceptors and predicts that biophotons and bunches of EEG photons result as decay products of same dark photons with energies mostly in visible range. The model of nerve pulse relies on the hypothesis that axonal membrane defines a Josephson junction. The ground state of the axon corresponds to a propagating soliton sequence for the phase difference over the membrane mathematically analogous to a sequence of coupled gravitational pen-duli with a constant phase difference between neighboring penduli. Nerve pulse is generated as one kicks one of the oscillating penduli. The model of nerve pulse explains the generation of EEG. The resonance frequencies of EEG can be understood as sums and differences of the harmonics of cyclotron frequencies of biologically important dark ions and of Josephson frequency.
Mendelian laws provide the universal founding paradigm for the mechanism of genetic inheritance through which characters are segregated and assorted. In recent years, however, parallel with the rapid growth of epigenetic studies, cases of inheritance deviating from Mendelian patterns have emerged. Growing studies underscore phenotypic variations and increased risk of pathologies that are transgenerationally inherited in a non-Mendelian fashion in the absence of any classically identifiable mutation or predisposing genetic lesion in the genome of individuals who develop the disease. Non-Mendelian inheritance is most often transmitted through the germline in consequence of primary events occurring in somatic cells, implying soma-to-germline transmission of information. While studies of sperm cells suggest that epigenetic variations can potentially underlie phenotypic alterations across generations, no instance of transmission of DNA- or RNA-mediated information from somatic to germ cells has been reported as yet. To address these issues, we have now generated a mouse model xenografted with human melanoma cells stably expressing EGFP-encoding plasmid. We find that EGFP RNA is released from the xenografted human cells into the bloodstream and eventually in spermatozoa of the mice. Tumor-released EGFP RNA is associated with an extracellular fraction processed for exosome purification and expressing exosomal markers, in all steps of the process, from the xenografted cancer cells to the spermatozoa of the recipient animals, strongly suggesting that exosomes are the carriers of a flow of information from somatic cells to gametes. Together, these results indicate that somatic RNA is transferred to sperm cells, which can therefore act as the final recipients of somatic cell-derived information.
Clearly, the fossil record from the Cambrian period is an invaluable tool for deciphering animal evolution. Less clear, however, is how to integrate the paleontological information with molecular phylogeny and developmental biology data. Equally challenging is answering why the Cambrian period provided such a rich interval for the redeployment of genes that led to more complex bodyplans.
0.2.1 TGD as a Poincare invariant theory of gravitation................ 1 0.2.2 TGD as a generalization of the hadronic string model.............. 2
Die Meistersinger is, by Wagner's standards, quite a cheerful opera. The action turns on comedy's staple, the marriage plot: get the hero and the heroine safely and truly wed with at least a presumption of happiness ever after. There are cross-currents and undercurrents that make Meistersinger's libretto subtle in ways that the librettos of operas usually aren't. But for once Nietzsche is nowhere in sight and nobody dies; the territory is closer to The Barber of Seville than to The Ring. Yet, in the first scene of Act 3, the avuncular Hans Sachs, whose benevolent interventions smooth the lovers' course, delivers an aria of bitter reflection on the human condition. It comes as rather a shock: Madness, Madness! Madness everywhere. Each thinks he is giving himself pleasure. So 'what got into Sachs?' is a well-known crux for Wagner fans, and one the opera doesn't resolve. (By Scene 2 of Act 3 Sachs is back on the job, arranging for Walther to get his Eva and vice versa.) Sachs isn't, of course, the first to wonder why we are so prone to making ourselves miserable, and the question continues to be pertinent. We have just seen the last of a terrible century with, quite possibly, worse to come. Why is it so hard for us to be good? Why is it so hard for us to be happy? One thing, at least, has been pretty widely agreed: we can't expect much help from science.
Noncontextual hidden variables theories, assigning simultaneous values to all quantum mechanical observables, are inconsistent
by theorems of Gleason and others. These theorems do not exclude contextual hidden variables theories, in which a complete
state assigns values to physical quantities only relative to contexts. However, any contextual theory obeying a certain factorisability
conditions implies one of Bell's Inequalities, thereby precluding complete agreement with quantum mechanical predictions.
The present paper distinguishes two kinds of contextual theories, ‘algebraic’ and ‘environmental’, and investigates when factorisability
is reasonable. Some statements by Fine about the philosophical significance of Bell's Inequalities are then assessed.
Planarian flatworms are a popular system for research into the molecular mechanisms that enable these complex organisms to regenerate their entire body, including the brain. Classical data suggest that they may also be capable of long-term memory. Thus, the planarian system may offer the unique opportunity to study brain regeneration and memory in the same animal. To establish a system for the investigation of the dynamics of memory in a regenerating brain, we developed a computerized training and testing paradigm that avoided the many issues that confounded previous, manual attempts to train planaria. We then used this new system to train flatworms in an environmental familiarization protocol. We show that worms exhibit environmental familiarization, and that this memory persists for at least 14 days - long enough for the brain to regenerate. We further show that trained, decapitated planaria exhibit evidence of memory retrieval in a savings paradigm after regenerating a new head. Our work establishes a foundation for objective, high-throughput assays in this molecularly-tractable model system that will shed light on the fundamental interface between body patterning and stored memories. We propose planaria as a key emerging model species for mechanistic investigations of the encoding of specific memories in biological tissues. Moreover, this system is likely to have important implications for the biomedicine of stem cell-derived treatments of degenerative brain disorders in human adults.