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Alopecia switch to herbal medicine

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... ey stated that glycyrrhizin compounds derived from compounds belonging to the phytosterol group inhibit 5α-reductase in the formation of dihydrotestosterone compounds that cause alopecia and have advantages in the treatment of Androgenetic alopecia (AGA) [9]. Epigallocatechin gallate, a compound contained in green tea, according to [10], showed significant results with increased hair growth. [11] showed, in clinical trials, that procyanidin B2 compounds contained in apple extract can increase hair growth and scalp quality, as well as increase the density, weight, and keratin content of hair. ...
... Based on the results of the analysis in Table 2, several compounds found were the same in each fraction and in accordance with the research of [10,11] flavonoids, terpenoids, and phenylpropanoids. e analysis of the data on the spectrum of the compounds contained is seen in Figure 3. ...
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Alopecia is a health condition in which the hair loses its function in some or all of the body. Alopecia occurs due to various genetic, environmental, and nutritional factors. One of the methods developed to treat alopecia is through inhibition of the enzyme 5-α-reductase, which converts testosterone into its more potent metabolite, dihydrotestosterone (DHT). In ethnomedicine, the leaves of Merremia peltata are used by the people of Sulawesi as a remedy for baldness. Therefore, in this study, an in vivo study was conducted on rabbits to investigate the antialopecia activity of the ethanolic extract of M. peltata leaves. The purified M. peltata leaf extract was fractionated using vacuum liquid chromatography with several solvents to produce fractions F1–F5. Each fraction was then retested in vivo in rabbits, and its content was then analyzed by LC-MS. An in silico study was then carried out using minoxidil as a comparison ligand; 17 compounds derived from M. peltata leaves were identified as antialopecia compounds through prediction of molecular interactions and molecular dynamics simulation and prediction of absorption, distribution, metabolism, excretion, and toxicology (ADME-Tox). The assay results showed that fractions F2 and F3 had a better effect on hair growth compared to the positive control, and the test compound obtained from the LC-MS analysis, bufotalinin, had a strong binding energy to the receptor in the molecular docking interaction study: −5.99 kcal/mol compared to −4.8 kcal/mol for minoxidil. Molecular dynamics simulation analysis with complex stability parameters based on solvent-accessible surface area (SASA), principal component analysis (PCA), root mean square deviation (RMSD), and root mean square fluctuation (RMSF) showed that bufotalinin has good affinity for androgen receptors. ADME-Tox prediction for bufotalinin showed good results for the parameters of skin permeability, absorption, and distribution. Therefore, bufotalinin, a steroid compound, is a potential androgen receptor antagonist and could be useful in the treatment of alopecia.
... What chemicals in plants have biological activity in promoting hair growth? From a variety of literature review, Semwal et al. (2011) found there are dozens of phytochemical suspected effects on hair growth, including saponin, alkaloids, ecliptine, wedelic acid, luteolin, triterpine, glycosides, β-sitosterol, hentriacontanol, vitamin A, vitamin C, iron calcium oxalic, malic acid, α pinene, β pinene, fatty acid, sterol compounds, polyphenols, steroids, volatile oil and essential oil [12]. ...
... What chemicals in plants have biological activity in promoting hair growth? From a variety of literature review, Semwal et al. (2011) found there are dozens of phytochemical suspected effects on hair growth, including saponin, alkaloids, ecliptine, wedelic acid, luteolin, triterpine, glycosides, β-sitosterol, hentriacontanol, vitamin A, vitamin C, iron calcium oxalic, malic acid, α pinene, β pinene, fatty acid, sterol compounds, polyphenols, steroids, volatile oil and essential oil [12]. ...
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Traditional hair care using ingredients from plants has been practiced for a long time by local people in many countries, including Indonesia. However, biological-pharmaceutical scientific research has only flourished in the last two decades. This article presents the results of research conducted by students and researchers in Indonesia. There are dozens of types of plants in Indonesia that are known to have the potential to be developed as hair growth-promoting drugs. Even so, there are still many weaknesses in the research process that must be overcome so that the validity of the information on the efficacy of these plants in overcoming the problem of hair loss can be relied on.
... [1,2] Traditionally, there are many types of method to treat hair loss (alopecia) in different system of medicine including herbal medicine. [3] Referring to pharmacological works in the last five years, there were various herbs reported to show hair growth promoting activities in test animals. Among the examples are as follows. ...
... [25] Other botanicals that commonly used for treatment of AGA, that allegedly able to reduce free testosterone are lauric and myristic acid. [26] Overall, from a variety of literature review, Semwal et al. [3] stated there are dozens of substances suspected effect on hair growth, including saponin, alkaloids, ecliptine, wedelic acid, luteolin, triterpine, glycosides, βsitosterol, hentriacontanol, vitamin A, vitamin C, iron calcium oxalic, malic acid, α pinene, β pinene, fatty acid, sterol compounds, polyphenols, steroids, volatile oil and essential oil. ...
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Current technologies and therapies of hair disorders are not yet satisfying people suffer from hair loss, so that efforts in seeking effective medicine for promoting hair growth are still continues. This study intended to investigate and confirms the effects of crude corms extract of pisang kepok (Musa balbisiana) given topically on rabbit hairs growth. Four healty, male rabbits, aged 4-5 months, weighing 1.5 kg – 2 kg were used for the study. Six areas (2 cm x 2 cm each) on the dorsal aspects of animals were shaved. The first shaved area treated topically with nothing (normal control). The second and third areas treated consecutively with gel without banana corms extract (as negative control) and reference formulations (as positive control). The last three areas treated with gel containing corms extract of pisang kepok with the concentration of 2%, 4% and 8% respectively. All treatments were given once daily for 21 days. The length of hairs were assessed on day 7, 14 and 21, while the hair mass was measured on day 22. The results showed herbal topical gel containing crude corms extract of pisang kepok significantly increase the animal hairs length and mass in comparison to the normal and negative control. Therefore it can be suggested that herbal gel containing corms extract of M. balbisiana is potent to be use as the topical formulations for hair growth.
... Some of the herbal treatments that are effective for treating alopecia are shown in the data gathered in 2.1. Because they encourage quicker hair development, herbs like bhringraj and hibiscus have been shown to be the most popular herbal treatments for hair loss [19][20][21] . These remedies have been widely used by locals belonging to South Indian states. ...
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This article describes herbal remedies and herbal products for alopecia. It mainly states the use of herbal preparations for the treatment of hair loss and also describes their advantages over synthetic products and drugs. As the use of herbal blends have least side effects, maximum efficacy, and are economically and easily prevalent, they can act as naturopathic medicines in treating various types of hair loss. Hair loss can be due to different reasons such as genetic tendency, extreme stress, nutritional deficiency, environmental triggers, exposure to chemicals etc. Hence use of synthetic compounds can show unfavorable outcomes such as scaling, dermatitis, pruritus and other skin related problems and to overcome such effects herbal products which are made by extraction of natural compounds mainly herbs are preferred as they play a role in patient compliance and show more than one mode of action for the treatment of alopecia. The article basically gives the description of various herbal products, remedies and also herbal products with nutrient supplements available with their brand name, manufacturing details along with their cost, indications which can be beneficial to treat hair loss.
... UDR contains about 1 % of phytosterols (β-sitosterol, campesterol, ergosterol, stigmasterol, etc.), fatty acids, lectins, lignans, polysaccharides, amino acids, trace elements, etc. [12,13]. Due to the content of phytosterols, UDR extracts have antiandrogenic action (inhibit 5-α-reductase, block androgen receptors), so their effectiveness in the treatment of androgenic alopecia in cutaneous use has been confirmed [14][15][16][17][18]. ...
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Due to the content of phytosterols, extractive preparations of Urtica dioica roots are able to show antiandrogenic effect in the case of external therapy of men and women with androgenic alopecia. Oil extracts (OE) are characterized by several advantages when applied to the skin of the scalp compared to water-alcohol extracts. For the development of OE technology from Urtica dioica roots, it is important to choose the optimal extraction parameters, which are based on the quantitative determination of phytosterols in the extractant and the studied samples of extracts. The aim of the work is to choose the optimal parameters for obtaining OE from Urtica dioica roots based on quantitative determination of phytosterols content in experimental samples of OE by gas capillary chromatography. Materials and methods. Objects of the research – Urtica dioica root, refined corn oil, refined sunflower oil, samples of oil extracts. Determination of phytosterol content in experimental samples was carried out by gas capillary chromatography (chromatograph “Crystal 2000”, manufacturer – research and production company “Analytics”). Results. 5 different compounds of steroid structure (stigmasterol, β-sitosterol, etc.) were identified in sunflower oil by gas liquid chromatography, and 10 (campesterol, 2-α stigmasterol, β-sitosterol, Δ5-avenosterol, etc.) were identified in sunflower oil. The quantitative content of β-sitosterol in the sum of sterols of corn oil was significantly higher compared to the content of this substance in sunflower oil and amounted to 59.33 %. Optimal technological parameters were established considering the peculiarities of extraction with oil extractant and quantitative determination of the amount of phytosterols and β-sitosterol in experimental samples of OE. The total content of plant sterols in OE, including considering their amount in the extractant, was in the range of 7880 mg/kg; the amount of β-sitosterol was 4638 mg/kg. Conclusion. The choice of optimal parameters for obtaining OE from UDR based on determination of phytosterol yield by gas capillary chromatography was experimentally substantiated, namely: extractant – corn oil, raw material-extract ratio – 1: 5, extraction time – 6 h, extraction method – maceration
... Vegetables oils, as indicated by many authors, contained majority or at least some of the phytochemicals that were found to show hair growth promoting activities. Semwal et al. (2011) stated there are more than ten substances suspected effect on hair growth, including saponin, alkaloids, ecliptine, wedelic acid, lauric and myristic acids, luteolin, triterpine, glycosides, β-sitosterol, hentriacontanol, vitamin A, vitamin C, iron calcium oxalic, malic acid; α pinene, β pinene, fatty acid, sterol compounds, polyphenols, steroids, volatile oil and essential oil. Moreover, according to Begum et al. (2014), hair growth is coordinated by hormones and It commands the follicle to undergo appropriate changes during this process. ...
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Hair loss is a dermatologic disorder, and the surge for discovering natural products anti hair loss with less side effects is continuous. This study aimed to promote hair growth of a safety ointment on rabbits. The ointment was formulated by a mixture of oils of Ricinus communis as active and Butyrospermum parkii as an excipient, two species well known for their uses in hair maintenance. Eight healthy, male and female rabbits weighting 1.5-1.8 kg were divided in four groups. The ointment was applied to the rabbits previously shaved on the flank area at the rate of twice treatments daily for 28 days. Hair length was measured each two days while the hair mass was assessed on day 29. In addition, quality of this ointment was evaluated by specific microbiological control, stability by observation of some appearance parameters along the experiment and safety by in vivo skin irritation test. PKR ointment with yellowish color obtained had an excellent consistency, was homogeneous, with an interesting odor and pH= 4.1. After 28 days of ointment application, results showed for the male a cumulative growth length round to 20 mm i.e. average daily growth of 0.714 mm/day against 15.5 mm i.e. average daily growth of 0.553 mm/day for female. On Day 29, hair mass also increased in treated groups. The ointment did not show any microbial contamination, it remained stable over time with a good pH and non irritative. The ointment could be used as potential topical formulation hair grower in replace to synthetic cosmetics. Qualité, sécurité et activité d'une pommade formulée à partir des huiles de Butyrospermum parkii et Ricinus communis sur la croissance des poils chez le lapin. Résumé : La chute des cheveux est un trouble dermatologique pour lequel la recherche sur des produits naturels avec des effets supportables est continue. Cette étude vise à promouvoir une pommade de qualité pour la croissance des poils chez les lapins. La pommade a été formulée par un mélange des huiles de Ricinus communis comme actif et de Butyrospermum parkii comme excipient, deux espèces bien connues pour leurs utilisations dans l'entretien des cheveux. Huit lapins sains, mâles et femelles, pesant entre 1,5 et 1,8 kg ont été répartis en 4 groupes. La pommade a été appliquée deux fois par jour sur les lapins préalablement rasés sur les flancs pendant 28 jours. La longueur des poils a été mesurée tous les deux jours tandis que la masse des poils a été évaluée au 29ème jour. Les tests de contrôle microbiologique, de stabilité et d'innocuité ont été également réalisés. La pommade jaunâtre de pH= 4,1 présentait une excellente consistance, une bonne homogénéité et une agréable odeur. Après 28 jours, les résultats ont montré pour le mâle une longueur de croissance cumulée de 20 mm soit une croissance journalière moyenne de 0,714 mm/jour contre 15,5 mm soit une croissance journalière moyenne de 0,553 mm/jour pour la femelle. Au jour 29, la masse des poils a également augmenté dans les groupes traités. La pommade n'a montré aucune contamination microbienne, elle est restée stable avec un bon pH et était non irritant. Cette pommade pourrait être utilisée comme potentiel produit capillaire en remplacement des cosmétiques synthétiques.
... Unfermented extract of C. sinensis contains high amounts of catechin, epicatechin and epigallocatechin gallate with oligomeric catechin tanning agents, flavonoids, purine alkaloids and caffic acid derivative. 4,21 Pharmacological properties of C. sinensis have been considered by folk medicine recently. Previous studies suggested this plant for reduction of cardiovascular disease risk and cancer. ...
Article
Backgrounds: Androgenic alopecia is a common and unpleasant problem that directly influences the self-confidence and individual life quality. There are various treatment choices that currently are used by people suffering from androgenic alopecia. Drug therapies (e. g. minoxidil, finasteride, dutasteride, prostaglandin analogues, ketoconazole, Cyproterone acetate and spironolactone), Laser-light treatment, surgical treatment, cell mediated treatment and alternative treatments (vitamin, mineral and herbal components) are common therapeutic methods suggested for management of androgenic alopecia. Herbal medicines are now commonly used all over the world and this has increased global demand. Quality, safety and efficacy of these drugs have become a serious concern. Objectives: The aim of this review is evaluating the herbal or fungal medicines were used in androgenic alopecia and introducing the phytochemicals, biological effects, responsible constituents and the mechanism of this action. Results: The 23 medicinal fungi or plants with their possible mechanisms and active phytoconstituents, which were used in androgenic alopecia are described. Methods/design: In this review, most of the natural sources that used in the treatment of androgenic alopecia were collected from electronic databases including Web of Science, PubMed, Scopus and Google Scholar were searched for these plants. Data were gathered from 1970 to 2016. Conclusion: The summarized findings in this article could be inspiration to product new formulations for treatment of androgenic alopecia with more effective properties and fewer side effect.
... Among the result of the studies suggested that hair loss can be prevented by eating foods rich in biotin and cystein or using certain topical plant extracts or herbal oils [21][22][23]. Overall, from a variety of literature review, Semwal et al. (2011) stated there are dozens of substances suspected effect on hair growth, including saponin, alkaloids, ecliptine, wedelic acid, luteolin, triterpine, glycosides, βsitosterol, hentriacontanol, vitamin A, vitamin C, iron calcium oxalic, malic acid, α pinene, β pinene, fatty acid, sterol compounds, polyphenols, steroids, volatile oil and essential oil [24]. ...
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Plant extracts of cocor bebek, Kalanchoe pinnata (Lam.) Pers., containing various types of bioactive compound expected to have cosmetic benefits, however studies on its uses in haircare is lacking. Current study is a part of our effort in extending seeks of plant species growing in Indonesia that are potent to be use as hairgrowth promoting agents. Four healthy, adult, male New Zealand rabbits, aged 4-5 months, weighing 1.5 kg – 2 kg were used as test animals. The dorsal aspect of each rabbit were shaved and divided into six areas, with a size of 2 cm x 2 cm each. Each area of shaved skin were then administered with CMC gel containing substances set for treatment namely: CMC gel without cocor bebek extract (as negative control), 2% minoxidil (as positive control), and leaf extracts of cocor bebek of four levels of concentration i.e. 25% (v/v), 50% (v/v), 75% (v/v) and 100% (v/v) respectively. Topical administration of extract was done twice a day (morning and afternoon), for 21 days. Hair length was assessed using calliper on day 7, 14 and 21 by taking randomly 10 hairs from each treatment area, while the hair mass was measured using microbalance on day 22 by harvesting all hairs on each treatment area. The result showed CMC gel containing leaf extracts of K. pinnata remarkably increased hairs length of rabbits in a concentration-related manner. At the highest concentration, the effects even surpassed minoxidil. However, no treatment found to affect hair mass of the animals. It is inferred that plant extract of cocor bebek is potential to be use as a hair growth promoting agent.
... The essential oil content including 1, 8-cineole, α-pinene, methyl eugenol, terpineole, trans-carveole,cis-carveole, geraniol, methyl geranate, α-terpinyl acetate, neryl acetate, β-caryophyllene, myrcene, sabinene, myrcene, p-cymene, c-terpinene, linalyl acetate, car-3-ene, phellandrene, methyl eugenol, methyl butyrate, methyl benzoate, benzyl alcohol, isobutyl butyrate, myrtenylacetate, limonene, α-terpineol, linalool, eucalyptol, p-cymol, β-pinene, geraniol, camphene, butyl butyrate and myrtenol. [28] Hair-growth promoting activity of plant extracts of suruhan (Peperomia pellucida) Overall, from a variety of literature review, Semwal et al. [29] stated there are dozens of substances suspected effect on hair growth, including saponin, alkaloids, ecliptine, wedelic acid, luteolin, triterpine, glycosides, β-sitosterol, hentriacontanol, vitamin A, vitamin C, iron calcium oxalic, malic acid, α pinene, β pinene, fatty acid, sterol compounds, polyphenols, steroids, volatile oil and essential oil. ...
Article
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Efforts in seeking effective medicine for preventing hair loss and promoting hair growth are still continues worldwide. This study investigate effects of ethanolic plant extract of suruhan, Indonesian name for Peperomia pellucida (L.) Kunth., on rabbit hairs growth. Four healty, male rabbits, aged 4-5 months, weighing 1.5 kg-2 kg were used for the study. Six areas (2 cm x 2 cm each) on the dorsal aspects of animals were shaved and marked C-, C+, S1, S2, S3 and S4. Area C-and C+ are the shaved skin treated consecutively with CMC gel without suruhan extract (as negative control) and 2% minoxidil (as positive control). Area S1, S2, S3 and S4 are the shaved skin treated with gel containing suruhan extracts of 25% (v/v), 50% (v/v), 75% (v/v) and 100% (v/v) respectively. All treatments were given twice daily for 21 days. The length of hairs were assessed on day 7, 14 and 21, while the hair mass was measured on day 22. The results showed topical CMC gel containing ethanolic plant extracts of suruhan significantly increase the animal hairs length in a concentration-related manner. However, in comparison to both negative and positive controls, suruhan plant extracts show no significant effect on hair mass of the animals. It suggests that ethanolic plant extract of Peperomia pellucida is potent to be used as the topical formulations for hair growth.
... Various synthetic medicines are available for hair loss which do not treat permanently and also show severe sideeffects. Among them are minoxidil, finasteride and spironolactone used for AGA treatment, as well as minoxidil, anthralin (dithranol), corticosteroids and tretinoin used for AA therapy [14,97,133]. Minoxidil (2,4-diamino-6piperidinopyrimidine-3-oxide) was the first drug available for treating men and women scalp hair loss. ...
Article
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Currently available conventional therapies of hair loss using synthetic drugs are still imperfect and have a number of limitations. Their effectiveness as well as the safety of their use is often questioned. It has led to an increased interest in alternative treatments with fewer side-effects such as formulations containing herbs and/or their active constituents. For this purpose several electronic databases and hand-searched references were used to summarize current knowledge regarding topically used herbal products for the treatment of hair loss acquired on the basis of preclinical and clinical studies. Moreover, mechanism of their action, follicular penetration and possible adverse effect of herbal products will be also described.
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Alopecia refers to the scientific word for diminished hair growth or balding. It describes a disease in which hairs falls off from one or more parts of your body, most commonly the scalp. Losing your hair might be triggered by a variety of factors, including hereditary traits, external factors, chemical exposure, medication, dietary insufficiency, chronic tension, or prolonged sickness, among others. Alopecia is categorized into different types depending upon its pattern of diminished hair growth and its genesis. The pursuit of effective treatments has led to the exploration of both synthetic and herbal medications. This study examines the performance, mechanisms of action, tolerability profiles, and limits of synthetic and herbal remedies for alopecia. Synthetic medications such as minoxidil and finasteride are commonly prescribed and have demonstrated varying degrees of success in clinical trials. However, concerns regarding adverse effects and long-term efficacy persist. Conversely, herbal medications, including saw palmetto, ginseng, and pumpkin seed oil, have gained popularity due to their perceived natural origin and potentially fewer side effects. Nevertheless, the scientific evidence supporting their efficacy remains limited and often inconclusive. Additionally, challenges in standardization and regulation pose significant barriers to the widespread adoption of herbal treatments. This study aims to provide healthcare professionals and patients with a comprehensive overview of the current landscape of synthetic and herbal medications for alopecia, highlighting the need for further research to elucidate their therapeutic potential and optimize patient outcomes.
Article
Herbal cosmetics have growing demand on the earth market and are a precious gift of nature. Herbal formulations continuously have attracted gigantic concentration on the grounds that of their good endeavor and comparatively lesser or nil side effect with synthetic medications. Hair loss problem is of great significance to both men and women. Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetics, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. This hindrance could be solved by the use of natural medicines obtained from herbs. Various herbs are being used to preclude the hair loss and remorse of hairs. Herbs are starting material for any medicine research. Approximately about 80% residents recommended herbal drugs for their beneficial effects along with fewer side effects as compared synthetic drugs.
Article
Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1–5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.
Article
This article discusses the mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process. It was reported that the mechanisms involving (1) insulin-like growth factor-I (IGF-I), (2) vascular endothelial growth factor (VEGF), (3) epidermal growth factor (EGF), (4) fibroblast growth factor 2 (FGF-2), (5) endothelial nitric oxide synthase (eNOS), (6) Wnt/β-catenin signalling pathway, (7) prostaglandin E (PGE), (8) prostaglandin F (PGF) stimulate hair growth, whereas the mechanisms engaging (1) 5α-reductase and dihydrotestosterone (DHT), (2) transforming growth factor beta (TGF-β), (3) fibroblast growth factor 5 (FGF-5), (4) prostaglandin D2 (PGD2) inhibit hair growth. The knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss.
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