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Huangfu Mi, Great Master of Medicine and Literature

Huangfu Mi, Great Master of Medicine and
Min Li, Yongxuan Liang*
School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, 100029, China
Huangfu Mi (215e282), courtesy name: Huangfu Shi-an,
sobriquet in his old age: Xuan Yan, given name Jing in his
childhood, was from Chaona, Anding (today’s Pingliang
County, Gansu Province). He lived in the Jin Dynasties
(265e316). Later, he moved to Xin’an (today’s Mianchi
County, Henan Province) with his uncle. Born into a poor
family, he had to do farm work in daytime and studied at
night. After hard working for years, he integrated the in-
tellectual achievements of hundreds of schools of thoughts,
and eventually became a prestigious scholar himself. Ac-
cording to legend, Zuo Si, an unknown writer, spent 10
years to complete writing the prose of San Du Fu (Praise-
worthy Three Cities), in which the three cities eChendu,
Jianye and Luoyang won applause for their prosperity. But
he thought “the words of the lowly carry little weight”, so
he went to ask Huangfu Mi to write a preface for him. After
reading the prose, Huangfu Mi heaped praise upon him and
willingly agreed. As expected, the prose gained a reputa-
tion far and wide. Scholars and noblemen were scrambling
to make and circulate its copies at the capital, which
caused paper in short supply and the price of paper was
rising steadily. From above we can see Huangfu Mi’s great
Although Huangfu Mi was so famous, he was indif-
ferent to fame and fortune, ready to lead a poor but
honest life. He regarded fame and wealth as dung and
dirt, but writings as life. He rejected outright the rec-
ommendations to be government official for several
times, even when the emperor of the Jin Dynasties
wanted to enlist him to serve in the central government
he refused politely.
Huangfu Mi was a prolific writer.
Praiseworthy Three Cities), Di Wang Shi Ji (Imperial
Century),Gao Shi Zhuan (Biography of Great Scholars),
Lie Nv Zhuan (Biography of Virtuous Women in Ancient
China), Xuan Yan Chun Qiu (Spring and Autumn by Xuan
Yan), and Zhen Jiu Jia Yi Jing (Systematic Classic of
Acupuncture and Moxibustion).Hehadmadegreat
achievements in medicine, history and literature. Ac-
cording to historical records, he suffered from hemi-
anesthesia due to wind with pain at the age of 42,
accompanied by atrophy of the right leg and poor
hearing, and then he decided to dedicate himself to
medicine, especially the study of acupuncture. Based on
his clinical experience, after he made a comparative
study of the previous classics on acupuncture, he finally
completed Huang Di San Bu Zhen Jiu Jia Yi Jing
(Huangdi’s Systematic Classic of Acupuncture and Mox-
ibustion in Three Parts), often shortened to The Sys-
tematic Classic of Acupuncture and Moxibustion or The
Systematic Classic. This is a most precious medical
The achievements of theoretical study of traditional
Chinese medicine and acupuncture were summarized in the
book in combination with the author’s personal clinical
experience. He drew materials from three medical
classicsdSu Wen (Plain Questions), Lin Shu (Miraculous
Pivot) and Ming Tang Kong Xue Zhen Jiu Zhi Yao (Essentials
of Acupoint Location and Treatment) and compiled one
book by cutting the superfluous. It has 12 volumes or 128
passages and covers the zang-fu organs, acupuncture and
meridians, acupoints, disease mechanisms, diagnosis and
treatment. He identified 349 acupoints, including 300 that
were on both sides of the body and 49 on only one side. In
addition, the names and locations of the acupoints and the
ways to locate them were also clarified in the book. The
* Corresponding author.
E-mail address: (Y. Liang).
Peer review under responsibility of Beijing University of Chinese
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author discussed in detail about the anatomical sites of the
acupoints, e.g. head, face, nape, shoulder, chest, back,
abdomen and four limbs, which helped to locate them
accurately. For easy clinical application, he elaborated
acupuncture therapies for over 100 disorders of internal
medicine, external medicine, gynecology, pediatrics and
ENT with the disease cause, pathogenesis, patterns, acu-
points, acupuncture treatment, contraindications and
prognosis in about 500 items. The book is still of significant
clinical value today.
Since its publication the book has been spoken highly by
practitioners of later generations. Wang Tao, a great
physician of the Tang Dynasty (618e907) said, “Physicians
have to study his precious book and observe his in-
During the Tang Dynasty, the Imperial Acad-
emy of Medical Sciences took his book as a compulsory
textbook for the medical students.
It was soon used as a
textbook in Korea and Japan too.
Huangfu Mi was a brilliant man of wide learning. He
dedicated his whole life to study of literature, history and
medicine with great achievements. He collected ancient
important acupuncture materials and compiled the
Huangdi’s Systematic Classic of Acupuncture and Moxibus-
tion in Three Parts, which plays the role of a bridge linking
the past and present. His great accomplishments and
neglect of fame and wealth deserve admiration.
Translated by Tingyu Fang
1. Fang XL. The Book of Jin. Book I. vols. 1e18. Beijing, China:
Zhonghua Book Company; 1974:1409e1411 [Chinese].
2. Wang T. Medical Secrets of an Official. Beijing, China: People’s
Health Publishing House; 1955:1077 [Chinese].
3. Ouyang X, Song Q. New Book of Tang. Book IV. vols. 37e49.
Beijing, China: Zhonghua Book Company; 1974:1245 [Chinese].
70 M. Li, Y. Liang
Full-text available
Qijiaoshengbai capsule (QJSBC) is a type of proprietary Chinese medicine, which is an effective treatment for leukopenia in clinical practice. The purpose of this study is to evaluate the efficacy of QJSBC in improving specific clinical indicators, in patients with leukopenia of various origins. A total of seven electronic databases were searched, up until an end date of April 30, 2021, and a selection of clinical indicators was noted. The primary indicators of concern were related to blood: white blood cells (WBC). Secondary indicators were hemoglobin (Hb), platelets (PLT), neutrophils (NEU), bone marrow suppression rate (BMSR), and effective rate (ER). The methodological quality of the included trials was analyzed using a risk of bias assessment, as per the Cochrane Manual. The meta-analysis was performed using RevMan 5.4. Results. Twenty-four randomized controlled trials involving a total of 2,692 participants were included in this review. We found that QJSBC had a positive effect on increasing WBC, HB, PLT, and NEU and improving BMSR and ER. Conclusion. When compared with conventional chemotherapy (CC), conventional radiotherapy (CR), combined chemotherapy and radiotherapy (CC + CR), or conventional treatment (CT), the use of QJSBC combined therapy can effectively improve the clinical outcome for patients with leukopenia. However, a larger sample size and a more standardized, high-quality study are required to validate these results.
New Book of Tang. Book IV. vols. 37e49
  • X Ouyang
  • Q Song
Ouyang X, Song Q. New Book of Tang. Book IV. vols. 37e49. Beijing, China: Zhonghua Book Company; 1974:1245 [Chinese].
The Book of Jin. Book I. vols. 1e18
  • X L Fang
Fang XL. The Book of Jin. Book I. vols. 1e18. Beijing, China: Zhonghua Book Company; 1974:1409e1411 [Chinese].
Medical Secrets of an Official. Beijing, China: People's Health Publishing House
  • T Wang
Wang T. Medical Secrets of an Official. Beijing, China: People's Health Publishing House; 1955:1077 [Chinese].