In this paper, a closed loop control approach for controlling the vibration of buildings under earthquake excitations is introduced. An active hybrid control combining base isolation and active tuned mass damper (AMD) installed on the lowest floor of a base-isolated frame building is investigated. The Active control force is controlled by the mean of a proportional–integral–derivative (PID) controller, incorporated with a negative feedback error closed loop. The difference between the base displacement and equilibrium position of the structure is used to evaluate the error and feed the PID controller. A simulation is carried out on a six degrees of freedom base-isolated frame structure using MATLAB. The performances of the proposed active hybrid control system are tested under El Centro, Northridge, and Loma Pietra earthquakes.Compared results with base-isolated structure and base-isolated structure equipped with a passive and active tuned mass damper (TMD)/ (ATMD) showed that the active hybrid control system is more efficient. A reduction of 70% in base displacement, velocity and 15% in base acceleration is obtained.