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Abstract

Rosa canina L. fruits (Rosaceae) are used to treat diabetes in Anatolia traditionally. In this study, the ethanol extract of R. canina fruits and its fractions were screened for their antioxidant, hypoglycaemic and antidiabetic activities. The ethanol extract that was administered for 7 days possessed a remarkable hypoglycemic effect at 250 mg/kg dose in streptozotocin (STZ) induced diabetic rats. Then it was fractionated through successive solvent extractions to yield CHCl 3 Fr., EtOAc Fr., n -BuOH Fr. and R-H 2 O Fr. respectively. These fractions were administrated to normal plus glucose hyperglycemic rats. Additionally the subacute antidiabetic activities of the fractions were studied in diabetic rats for 7 days. The experimental data indicated that R-H 2 O Fr. Possessed significant antidiabetic activity (50-62%) in diabetic rats. Also, a minor hypoglycemic effect was observed in normoglycemic plus glucose-hyperglycemic animals treated with R-H 2 O Fr. (15%). In vitro antioxidant experiments revealed that EtOAc Fr. Showed the highest radical scavenging activity on DPPH (79.5±0.4%), whereas CHCl 3 Fr. exhibited the maximum reducing power. The highest total phenolic content was observed in CHCl 3 Fr. (18.5±0.6% gallic acid equivalent g/g fraction) but no correlation was observed between the antidiabetic activity of fractions and their phenolic contents. Our findings support the traditional usage of R. canina fruits as a folk remedy in the treatment of diabetes in Turkey.

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... The constituents of dog rose fruit (hips) are endowed with vitaminisant, astringent, colagogue, choleretic, diuretic, antidiarrhoea, antioxidant properties, etc. (Yi et al., 2007). In addition, Orhan et al. (2009) reported that the rose hips also have antidiabetic properties. Several authors reported that the nutritive and therapeutical value of the mature dog rose fruit (Cynosbati fructus) is due to their content of sugars, organic acids, pectins, flavonoids, tannins, carotenoids (β-carotene, licopene, and isomeres of rubixanthin), vitamins (especially vitamin C, but also vitamins B1, B2, K, PP, D, and E), macro-and microelements etc. (Pârvu, 2000;Demir şi Ozcan, 2001;Tiţă, 2003; 160 Scientific Bulletin. ...
... Series F. Biotechnologies, Vol. XIX, 2015ISSN 2285-1364, CD-ROM ISSN 2285-5521, ISSN Online 2285-1372, ISSN-L 2285-1364Stănescu et al., 2004Arsenescu et al., 2008;Orhan et al., 2009). The dog rose seeds contain oil and minerals; the fatty acids within the dog rose oil are mainly represented by the linoleic, oleic, linolenic, palmitic, stearic, and arachidonic acid, (Ozcan, 2002). ...
... The dog rose seeds contain oil and minerals; the fatty acids within the dog rose oil are mainly represented by the linoleic, oleic, linolenic, palmitic, stearic, and arachidonic acid, (Ozcan, 2002). The varied content of the fruit (hips) confers the next properties: antiscorbutic, anti-inflammatory, even anti-mutagene; it also increases the biosynthesis of colagene, stimulates the immune system, improves the body resistance to sustained effort, (Pârvu, 2000;Tiţă, 2003;Kiliçgun and Dehen, 2009;Orhan et al., 2009). Some properties of the dog rose hips are attributed to some hypothetical compounds of silicium. ...
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The aim of the present research was to make a comparison between two Bulgarian commercial forms of Rosa canina L. for herbal preparations in terms of the possible benefits by oral intake. The plant samples were investigated for their antioxidant activity and the bioactive substances. The total phenolic content of the extracts was evaluated as well. Four reliable methods (DPPH, ABTS, FRAP and CUPRAC assays) for antioxidant activity assessment were applied. The highest results were recorded by the FRAP assay.The plant Rosa canina is known as wealthy source of carotenoids and organic acids, therefore fat soluble β-carotene, lycopene and lutein in addition to water soluble malic, citric, fumaric and ascorbic acids were evaluated by HPLC-methods. According the conducted assays the tested samples have similar composition. Lutein concentration in both tested extracts was calculated as 6.9 μg/g DW. Lycopene and β-carotene were determined to be 13.91 and 12.18 μg/g DW and 27.14 and 22.83 μg/g DW, respectively. HPLC determination of organic acids showed that the amount of citric acid in the extracts was 7343 and 6583 μg/g DW and fumaric acid content in both samples was 30 μg/g DW. The size of the plant particles used for the extraction seems to contribute significantly to the exhibited activity.
... The ferric-reducing antioxidant power (FRAP) and Troloxequivalent antioxidant capacity (TEAC) of the crude extracts showed high contents of carotenoids and total phenolics. The crude extracts rich in ascorbic acid exhibited about 51 % Winther et al. [25] Ameye and Chee [26] Deliorman et al. [34] Larsen et al. [36] Yilmaz and Ercisli [6] Orhan et al. [38] R. multiflora Thunb Antiinflammatory Guo et al. [ Rosa canina Cardiovascular Andersson et al. [40] inhibition against the lipid peroxidation induced by 2, 2 0azobis (2, 4-dimethylvaleronitrile) and 85 % inhibition in 2, 2 0 -azobis (2-amidinopropane) hydrochloride (AAPH) assay at a concentration of 250 lg/ml . The crude extracts showed a large inhibitory effect in the ferric ion-induced lipid peroxidation and caused 83.7 % inhibition at a concentration of 25 lg/ml dried powder. ...
... Orhan et al. [38] administered the ethanol extract of R. canina hips to streptozotocin-induced diabetic rats at 250 mg/kg dose for 7 days. A hypoglycemic effect was observed which supported the traditional usage of rose hips as a folk remedy in the treatment of diabetes in Turkey. ...
Article
The search for nutrient-dense food source is a top-priority in today’s food-challenged world of multi-billion population. Food insecurity has become especially critical in developing countries, though potential sources of functional foods are being wasted right before our eyes. Rose hips, the fruits of rose plants (Rosa sp.) have been discovered to be rich in polyphenols (triterpene acids, flavonoids, proanthocyanidins, catechin), essential fatty acids, galactolipid, folate, vitamin A, C and E, mineral (Ca, Mg, K, S, Si, Se, Mn and Fe), among other bioactive components. The extracts have proven to possess antioxidant, anti-inflammatory, immunomodulation, anticancer, cardioprotective, antidiabetic, neuroprotective, and antimicrobial properties. The extracts have been validated beneficial against non-alcoholic fatty liver disease, osteoarthritis, rheumatoid arthritis, obesity, cancer, kidney stone, depression, dermal issues. The mechanisms of therapeutic actions involved intervention in COX-2, iNOS, NF-kappaB, PPAR-γ, p38 MAPK, Bak, Caspase-3, Ca⁺⁺ channel blockade pathways. Apart from the Rosaceae family-characteristic allergenicity due to LTPs, the rose hips are free of other side effects. This holistic review, based on recent findings is excited to report rose hips as an emerging ‘functional food’ that deserves to be integrated to food platter without delay.
... The dog rose (Rosa canina L.) is a pentaploid (2n=35), xeromesophytic, thorny shrub normally ranging in height from 3 to 5 m, native to Europe, North-East Africa and Western Asia from 0 to 1200 m altitude, (Pârvu, 2000;Tiţă, 2003;Petrova et al., 2007;Kiliçgun and Dehen, 2009). The dog rose hips (Cynosbati fructus) comprise several biologically active compounds, such as: sugars, organic acids, pectins, flavonoids, tannins, carotenoids, fatty acids, vitamins (particularly the vitamin C, and also the vitamins B 1 , B 2 , K, PP, E), macro-and microelements etc, (Pârvu, 2000;Demir and Ozcan, 2001;Tiţă, 2003;Stănescu et al., 2004;Arsenescu, 2008;Orhan et al., 2009). The seeds are rich in oil and mineral substances. ...
... Citing recent results of other authors' research, Kiliçgun and Dehen (2009) stated that the hips display an anti-inflammatory, antioxidant and anti-mutagen effect. Moreover, the research done by Orhan et al., (2009) evinced that the dog rose hips have also antidiabetic properties (probably due to their content of monosaccharids, oligosaccharids and pectins). ...
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There were studied 36 genotypes of Rosa canina L. belonging to 25 native populations from the counties ofBacău, Neamţ and Vrancea. The analyzed genotypes displayed a high variability of fruit density/individual (shrub), andalso of the shape, size, colour and biomass, and of the content of vitamin C in fruits. There were identified genotypes ofgreat perspective in this species’ amelioration as it concerns the fruit density/plant, a lower density of stem prickles, thefresh biomass/hip, and the content of vitamin C in the ripe fruits.
... From this family Rosa canina has been suggested as a strong anti-diabetic natural remedy in traditional medicine. In addition, a number of studies reported the hypoglycemic and antidiabetic activities of Rosa canina fruits extract (8)(9)(10)(11)(12). The results of a clinical trial about the impact of the administration of aqueous extract of Rosa canina fruits on patients with type 2 diabetes indicated the reduction of fasting blood glucose and serum total cholesterol/high density lipoprotein-chlosterol without any side effect in patients (8). ...
... The results of a clinical trial about the impact of the administration of aqueous extract of Rosa canina fruits on patients with type 2 diabetes indicated the reduction of fasting blood glucose and serum total cholesterol/high density lipoprotein-chlosterol without any side effect in patients (8). Also, a significant hypoglycemic effect was observed in streptozotocin (STZ)-induced diabetic rats (9). In another study, the intraperitoneal administration of hydroethanolic extract of Rosa canina fruits to alloxan-induced diabetic rats, decreased serum levels of glucose, low density lipoproteinchlosterol, triglyceride, total cholesterol, urea, uric acid, creatinine, and alkaline phosphatase, and at once increased serum high density lipoprotein-chlosterol levels (10). ...
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Background and purpose: Because of the high prevalence, diabetes is considered a global health threat. Hence, the need for effective, cheap, and comfortable therapies are highly felt. In previous study, a novel oligosaccharide with strong anti-diabetic activity in the crude extract of Rosa canina fruits, from the rosacea family, was identified. The present study was designed to ensure its efficacy using in vivo and in vitro studies. Experimental approach: Crude extract and its purified oligosaccharide were prepared from corresponding herb. Adult male Wistar rats were randomly divided into four groups of 10 each, as follows: group 1, healthy control rats given only sterile normal saline; group 2, diabetic control rats received sterile normal saline; group 3, diabetic rats treated with crude extract of Rosa canina (40% w/v) by oral gavage for 8 weeks; group 4, diabetic rats treated with purified oligosaccharide of Rosa canina (2 mg/kg) by oral gavage for 8 weeks. After treatment, body weight, fasting blood glucose, serum insulin levels and islet beta-cell repair and proliferation were investigated. The possible cytoprotective action of oligosaccharide was evaluated in vitro. The effect of oligosaccharide on apoptosis and insulin secretion in cell culture media were examined. Real-time PCR was used to determine the expression level of some glucose metabolism-related regulator genes. Findings / results: In the animal model of diabetes, the insulin levels were increased significantly due to the regeneration of beta-cells in the islands of langerhans by the purified oligosaccharide. In vitro cell apoptosis examination showed that high concentration of oligosaccharide increased cell death, while at low concentration protected cells from streptozotocin-induced apoptosis. Molecular study showed that the expression of Ins1 and Pdx1 insulin production genes were increased, leading to increased expression of insulin-dependent genes such as Gck and Ptp1b. On the other hand, the expression of the Slc2a2 gene, which is related to the glucose transporter 2, was significantly reduced due to insulin concentrations. Conclusion and implications: The purified oligosaccharide from Rosa canina was a reliable anti-diabetic agent, which acted by increasing insulin production in beta-cells of the islands of Langerhans.
... Rosehip has traditionally been administered for the treatment of colds, infectious diseases and inflammatory diseases (16). In support of its traditional uses, various studies have reported that rosehip exhibited bioactivity, including antioxidant (17,18), anti-inflammatory (19)(20)(21)(22), hepatoprotective (23), anti-diabetic (17) and anti-obesity (24) effects. Therefore, rosehip may be considered a functional food that promotes health. ...
... Rosehip has traditionally been administered for the treatment of colds, infectious diseases and inflammatory diseases (16). In support of its traditional uses, various studies have reported that rosehip exhibited bioactivity, including antioxidant (17,18), anti-inflammatory (19)(20)(21)(22), hepatoprotective (23), anti-diabetic (17) and anti-obesity (24) effects. Therefore, rosehip may be considered a functional food that promotes health. ...
Article
Rosehip, the fruit of Rosa canina L., has traditionally been used to treat urate metabolism disorders; however, its effects on such disorders have not been characterized in detail. Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro. In addition, the serum urate lowering effects of the rosehip hot water extract in a mouse model of hyperuricemia (male ddY mice, which were intraperitoneally injected with potassium oxonate) were investigated. Furthermore, the influence of rosehip hot water extract on CYP3A4 activity, which is the most important drug‑metabolizing enzyme from a herb‑drug interaction perspective, was investigated. Rosehip extracts of hot water, ethanol and ethyl acetate inhibited XO activity [half maximal inhibitory concentration (IC50) values: 259.6±50.6, 242.5±46.2 and 1,462.8±544.2 µg/ml, respectively]. Furthermore, the administration of 1X rosehip hot water extract significantly reduced the levels of serum urate at 8 h, which was similar when compared with the administration of 1 mg/kg allopurinol. Rosehip hot water extract only marginally affected CYP3A4 activity (IC50 value, >1 mg/ml). These findings indicate that rosehip hot water extract may present as a functional food for individuals with a high urate level, and as a therapeutic reagent for hyperuricemic patients.
... [3,17,18] Phytochemical analyses by previous researchers have shown that V. album contains a wide variety of pharmacological active principles of medical and toxicological importance. [3,4,[18][19][20][21][22][23] However, the potency of V. album decoction depends on the host plant, [24] geographical regions and environmental conditions of source. [17] Although there are several previous reports on the hypoglycemic potency of V. album, the present study sought to carry out, on comparative basis, the capacities of aqueous and ethanolic leaf extracts of V. album to ameliorate hyperglycemia in concurrence with the effects of the two types of extract on body and visceral organ weights of experimental animals. ...
... Glibenclamide, like other second generation sulphonylurea anti-diabetic drugs, act by stimulating pancreatic β-cells to secrete insulin that in turn promotes cellular uptake of glucose. [27,28] Previous studies have shown that blood glucose lowering effects of plant extracts may be facilitated by insulin mimicry, [10,29,30] stimulation of insulin biosynthesis/secretion, [31] neutralization of free radicals, [11,21,26,32] progressive regeneration of the β-cells sequel to damage by diabetogenic agents. [5,33,34] Also, there are extra-pancreatic mechanisms involving the suppression of gluconeogenic enzymes, promotion of glycogen biosynthesis, [35][36][37][38] and reduction of intestinal glucose absorption [39] but with concomitant enhanced glucose uptake by peripheral tissue. ...
... In a study conducted in Turkey, the ethanol extract of R. canina fruits and its fractions were screened for their antioxidant, hypoglycemic and antidiabetic activities. A remarkable hypoglycemic effect at the dose of 250 mg/kg of the ethanol extract was reported in streptozotocin induced diabetic rats [17]. Anderson et al. [18] also investigated the possible metabolic effects of rose hip powder by administering as dietary supplement to obese C57BL/6J mice. ...
... The results suggest that R. canina may reduce fasting blood glucose and total cholesterol/HDL-C ratio in type 2 diabetic patients without any hepatic, renal or gastrointestinal adverse effects. Although the hypoglycemic effects of R. canina fruit were reported in diabetic rat [17][18], the fasting blood glucose lowering effects observed in present study is in contrast to previous clinical trial conducted on obese patients in which 40 gram per day R. canina fruit intake did not influence blood glucose levels during 6 weeks study [20]. These contradictory results may be due to limitations of that study; as that study was cross-over and conducted on total 31 diabetic and non diabetic obese patients [20]. ...
Article
Background: Rosa canina L. (rose hip) has been traditionally used to treat diabetes mellitus in Iran. However, no scientific human study has determined its efficacy in diabetic patients. Objective: This study was conducted to evaluate the efficacy and safety of R. canina fruit aqueous extract in type 2 diabetic patients. Methods: Sixty patients with type 2 diabetes, aged 35 - 60 years with fasting blood glucose levels between 130 to 200 mg/dL and HbA1c between 7 - 9% despite using conventional oral hypoglycemic drugs were divided randomly to two groups. Two groups of 25 and 23 patients completing the trial received 750 mg R. canina fruit extract and 750 mg toast powder as placebo two times a day respectively for three months. Fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) as primary outcomes and postprandial blood glucose (PBG), lipid profile and hepatic and renal function tests as secondary outcomes were determined at baseline and at endpoint of treatment. The patients were asked to note down any gastrointestinal or other side effects during the study. Results: The FBG level decreased significantly (P = 0.002) in R. canina group after 3 months compared to the baseline. In addition total cholesterol/HDL-C was significantly (P = 0.02) decreased in the R. canina group compared to the baseline. Other blood parameters were not significantly changed during the study compared with placebo and baseline. No serious side effects were reported in both groups during the study. Conclusion: Rosa canina 3-month administration to type 2 diabetic patients may reduce fasting blood glucose and total cholesterol/HDL-C without any side effect.
... Previous study on fruits of R canina demonstrated that this medicinal plant possesses hypoglycemic effect in animal model of diabetes mellitus. 27 One of the main causes of diabetes mellitus is defined as deficiency of pancreatic b-cell viability and performance. The finding of current study exhibited that enhancement of pancreatic b-cell proliferation plays a pivotal role in managing diabetes mellitus and its complications by this medicinal plant. ...
Article
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NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages. Rosa damascena Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract of R. damascena on animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase (p < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels. R. damascena significantly reduced the elevation of final body weight, liver fat accumulation, TG, TC, LDL-C concentrations and hepatic enzymes (p < 0.05). Histopathological examination of hepatic tissue confirmed the therapeutic effect of R. damascena. Improvement of total antioxidant power activity, total thiol content, MPO enzyme activity, and also lipid peroxidation were also considered in treated animals (p < 0.05). HPLC analysis showed that phenolic compounds including gallic acid, quercetin and syringic acid are the main bioactive compounds of R. damascena hydroalcoholic extract. In conclusion, R. damascena dietary supplementation has a therapeutic effect in NAFLD. Improvement of oxidative stress associated damage in liver tissue is among the main pharmacological mechanisms involved in therapeutic activity of the plant.
... The fruits of R. canina, commonly known as rose hip, which is consumed as a strong antidiabetic natural drug in folklore medicine of different countries especially Iran and Turkey, exhibited the hypoglycemic effect in type 1 diabetic rats. Reinforcement of antioxidant function and scavenging free radicals are among the main contributors in the antidiabetic potential of rose hip (Orhan et al., 2009). Rose hip and is active constituent, trans-tiliroside, significantly ameliorated glucose tolerance and insulin resistance associated obesity in mice with diet-induced obesity (Ninomiya et al., 2007;Andersson et al., 2011). ...
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Diabetes mellitus is the most common endocrine disorder and a major cause of morbidity and mortality. Traditional medicines worldwide suggest a wide range of natural remedies for the prevention and treatment of chronic disorders, including diabetes mellitus. This mechanistic review aims to highlight the significance of medicinal plants traditionally used as dietary supplements in Persian medicine in adjunct with restricted conventional drugs for the prevention and treatment of diabetes mellitus. Mounting evidence suggests that these natural agents perform their protective and therapeutic effect on diabetes mellitus via several cellular mechanisms, including regeneration of pancreatic β cell, limitation of glycogen degradation and gluconeogenesis, anti-inflammatory, immunoregulatory, antiapoptosis, antioxidative stress, as well as modulation of intracellular signaling transduction pathways. In conclusion, traditional medicinal plants used in Persian medicine can be considered as dietary supplements with therapeutic potential for diabetes mellitus and maybe potential sources of new orally active agent(s).
... Recently, this plant has been the focus of several studies due to its human health nutraceutical properties [8][9][10][11][12][13][14][15][16] . The beneficial health effects observed might result from specific compounds extracted from the fruit such as polyphenols, carotenoids, vitamin E, flavonoids, vitamin C with antioxidant potential 8,11,15,16 . ...
Article
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Rose hips have been used as medicinal and aromatic plants for a long time throughout Turkey. The plant has been the focus of many recent studies due to its potential effects on treatment and prevention of several diseases. However, there are few in vitro studies concerning its composition and antioxidant capacity. The aim of the present study was to determine bioactive content including ascorbic acid, total phenolics, total flavonoids, total carotenoids and antioxidant activity of Rosa canina biotypes growing wild in Sivas province located eastern Anatolia. The results revealed that fruits of Rosa canina biotypes rich in terms of Vitamin C which ranged from 360 to 482 mg/100 g fresh weight base. The total phenolic content varied from 340 to 464 mg/100 g fresh weight. The biotype S-07 had the highest total flavonoids content (241 mg quercetin equivalent/100 g fresh weight) and the lowest value attributed to biotype S-01 as 151 mg/quercetin equivalent/100 g fresh weight. The antioxidant activity of the biotypes was between 14.2-30.7 μg Trolox/ml sample. The results revealed that there was enough diversity among Rosa canina biotypes for bioactive content and promising biotypes with high bioactive content are ready material for future breeding activities.
... хлороформената фракция не корелира с показаната антидиабетна активност 48 . В своето изследване Andersson et al. (2011) целят проучването на метаболитните ефекти, които се наблюдават при консумация на шипково брашно от мишки (C57BL/6J), подложени на богата на мазнини диета. ...
Article
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Botanical, chemical and pharmacological characterization of hip fruits was made on the base of the published various local and foreign studies. Rose hip fruits were evaluated as a rich source of biologically active substances, such as vitamins (A, B, C), macroelements (Na, K, Ca, P), essential fatty acids, polyphenols, and polysaccharides. Due to the diverse chemical composition rose hip fruit extracts have exhibited gastroprotective effect, antioxidant, immunomodulatory, anti-microbial, and anti-inflammatory activity. Special attention was paid to the relationship between heterogeneous chemical composition and exhibited biological activity. The aim of current review is to introduce a wide range of readers with the useful properties of rose hip medicinal plant. This overview has been compiled with the vision to promote the application of a well-studied in some aspects, but underexploited food source in the functional beverages and additives. The creation of such products aims to support and complement with traditional medicine in the prevention and treatment of socially significant diseases.
... Rosa canina extract with the concentration of 0.001 mg/mL significantly increased proliferation of βTC6 cell line compared with control cells. These results were supported by Orhan et al.[133], who found that R-H 2 O fraction of Rosa canina fruits reduced blood glucose level significantly in streptozotocin (STZ)-induced diabetic rats (50–62%) and demonstrated the hypoglycemic effect of Rosa canina in an animal model of diabetes mellitus. Moreover, histopathological studies of organs from STZ-induced diabetic rats revealed that low doses of Rosa canina extract (250 mg/kg body weight) significantly increased the number of islets in comparison with diabetic rats of the control group and improved the histology of necrotic islets of pancreas[134]. ...
Article
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Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species ofRosain the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.
... Principe [8]'e göre, gelişmiş ülkelerde reçete ile satılan ilaçların yaklaşık % 25'i bitkisel kökenlidir ve şifalı bitkiler hem tedavide hem de ilaç yapımında önemli yer tutmaktadır [9]. Gülgiller (Rosaceae) familyası içerisinde yer alan kuşburnu (Rosa canina L) bitkisi de soğuk algınlığı, grip [10], romatizma [11], diyabet [12], öksürük [13] gibi çeşitli hastalıklarının tedavisinde kullanılan şifalı bitkilerden birisidir. Fenolik bileşikler ve C vitamini bakımından zengin olan bu bitki [14,15,10], çeşitli araştırmacılar tarafından antioksidan olarak kabul edilmektedir [16]. ...
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Bu çalışmada, profenofos insektisitinin genotoksik etkileri, Drosophila melanogaster’de somatik mutasyon ve rekombinasyon testi (SMART) ve insan periferal lenfosit hücrelerinde mikronükleus (MN) testi ile araştırılmıştır. Bu maddenin olası genotoksik etkilerinin giderilebilmesi için de kuşburnu (Rosa canina) bitkisine ait su ve etanol ekstreleri kullanılmıştır. SMART için D.melanogaster’in kanat preparatları incelendiği zaman, profenofosun artan konsantrasyonuna (0,025, 0,05, 0,075 ve 0,1ppm) bağlı olarak normal kanat fenotipinde mutasyon frekansının arttığı özellikle en yüksek uygulama grubunda (0,1 ppm) bu artışın pozitif etkili (+) olduğu gözlenmiştir (P0,05). Kuşburnu bitkisinin su (RCsu) ve etanol (RCeta) ekstreleri, profenofosun en yüksek konsantrasyonu (0,1 ppm) ile birlikte uygulandığı zaman (profenofos+ RCsu/RCeta) mutasyon frekansındaki artışın azaldığı ve bunun da istatistiksel olarak önemli olduğu gözlenmiştir (P
... Members of rosacea family have long been used for food, medical purposes and as decorative plants. Belonging to the Rosa variety from the rosacea family, Rosa canina L. (rosehip) is rich in sugars, vitamin C, phenols, antioxidants, macro and micro elements and many other biologic active components (Demir and Özcan 2001;Orhan et al. 2009;Chai and Ding 1995;Ercişli 2007). Besides this, it is also known that rosehip has a high phenolic matter content. ...
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Turkey is an important gene centre of rosehip populations and rosehip is naturally grown in the province of Adıyaman. This study has been conducted on rosehip fruits found in various altitudes in Adıyaman to determine the changes of their physico-chemical characteristics. The fruit weights of the genotypes used in the study ranged between 2.72 g–1.29 g, fruit width between 14.12–10.44 g and fruit length has ranged between 23.18 mm–18.62 mm. The rosehip genotypes to be processed to food are required to have a bulky fruit and a high amount of fruit flesh. The genotype with the highest fruit flesh ratio was found to have the lowest seed weight by 0.25 g, while the genotypes with the highest seed weight had this value ranging between 0.50–0.59 g. Rosehip genotypes dry matter ratio has ranged between 44.27 and 37.11%. While the a*, b*, C* and h° values of rosehip fruits had significant differences based on the genotypes, L* values had similarities. Genotypes had ranging WSDM contents of 33.56–22.50%, TA contents of 2.96–1.57%, pH values of 4.06–3.82, C vitamins of 782.34–352.16 mg/100 g, total phenol contents of 5.42–3.62 mg GAE/g DM and antioxidant activities of 113.60–56.80 µmol TE/g DM. The rosehip fruits containing high levels of fructose and glucose were found to be low in saccharose content. Fructose, glucose and saccharose contents of rosehip genotype fruits were found to be 22.93–16.86, 20.22–13.77 and 0–0.90 g/100 g DM, respectively. According to the outcomes of the study, physico-chemical characteristics of the rosehip fruits displayed significant differences, and these differences were affected by type, genotype and ecologic conditions.
... Morus nigra is eaten directly or as marmalade made from fruit and used for infection and aphthae by local people. It is also used for anemia (Özcan, 2003;Orhan et al., 2009); the ripe fruit is rub on the lips of children to treat herpes (Camejo-Rodrigues et al., 2003); used for eczema, hepatitis (Hayta et al., 2014), diabetes disease, oral wounds (Koca and Yıldırımlı, 2010) and cholesterol (Polat and Satıl, 2012). The leaves and shoots of Cistus laurifolius are boiled in water to drink and used for digestive problems. ...
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Bayat rugs weaved with different madders can be used without fading their colors almost 100 years. The study aimed to record how to get madder by traditional methods from local plants, give stories of rug motives and present an overview of the medicinal uses of dyes plants collected in Afyonkarahisar, Inner-West Anatolia, Turkey. The study was conducted in both 11 villages and downtown of Bayat borough of Afyonkarahisar in 2013-2014. A total 150 women, aged between 17-25, were interviewed and observations were photographed. The rugs are completely 100% sheep wool and strings for weaving prepared traditionally by special spinning methods. The used plants to obtain the madders were determined. It was understood that in early August and September, plants give better colors and tones. These plants have also been used for medicinal purposes by the locals. Bayat people get non-fading colors from 11 plants ( Allium cepa L., Berberis crataegina L. , Papaver rhoeas, Papaver somniferum L., Malva silvestris L., Morus nigra L., Cistus laurifolius L., Quercus ithaburensis Decne. subsp. macrolepis (Kotschy) Hedge et Yalt, Rubia tinctorum L., Juglans regia L., Indigofera tinctoria L.) belonged to ten families. The plant organs used are root, shell, cupula, leaf, young shoot, and aerial parts of the plants. A natural mud is also used as alum in this region that provides to create dark colors, and prevents mixing the colors. It also inhibits fading the colors in the rugs’ texture. It was also recorded that different motives in Bayat Rugs have also interesting historical stories.
... They are used especially as medicine due to phenolic compounds, vitamins, anions, and cations they contain [11]. Rosehip, thanks to its polyphenol group compounds, is reported to be antioxidant, antidiabetic, anti-inflammatory, and effective in improving immunity system and lowering cholesterol [12][13][14][15]. These kinds of studies are mostly carried out on mammals as model animals. ...
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The objective of this study was to evaluate the effects of rosehip extracts on serum thyroid stimulating hormone (TSH) and thyroid gland activity [free and total triiodothyronine (FT3 and TT3) and free and total thyroxine (FT4 and TT4)] of common carp which were acutely and subchronically exposed (4 and 30 days) to 5, 10 and 20 ppm of dosage. According to the experimental results, the decrease of serum TSH levels in 5 ppm group and the increase of serum TSH levels in 10 and 20 ppm groups were significant (p<0.05) in acute phase when compared to control group. In sub-chronic phase, serum TSH levels were significantly decreased in 5, 10 and 20 ppm groups when compared to control group. In acute phase, FT3 and TT3 levels were significantly (p<0.05) decreased in 10 and 20 ppm groups and FT4 and TT4 levels were significantly (p<0.05) increased when compared with the control group. It can be concluded that rosehip extracts may have increased the metabolic activity in acute phase but decreased in sub-chronic phase.
... Diabetes, if not treated, is conscientious for much harm affecting various organs in the body. 1 Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion and/or insulin action, which results in hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism. 2 It is a disease mainly resulting from idiosyncrasy of carbohydrate metabolism. It is mainly described by absolute (type І) or relative (type ІІ) lack in insulin emission or receptor desensitization to insulin, ensuing in hyperglycemia. 3 Diabetes mellitus is associated with oxidative stress induced micro-and macrovascular complications. ...
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Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are responsible for induction of diabetes in human. In vitro techniques provide more accurate data and possible mechanism which are involved in diabetes disease. Now, a day's newer techniques such as diabetes induction with the help of viruses had been also introduced which are proving to be good tool in evaluation of antidiabetic drugs. This review could prove to be a good tool for the researchers who seek to do research on diabetes as it is providing vast resource about diabetic model under single umbrella.
... Rosa canina L. was used as antitussive, cold, diabetes. It was reported that Rosa canina L. showed anti-diabetic effect and antioxidant activity (Özcan, 2003;Orhan et al., 2009). Allium sativum L. was used as antihypertensive, ringworm; Hordeum vulgare L. was used as diuretic, kidnney stones; Allium cepa L. was used as cicatrizant, rheumatism; Morus alba L. was used in anemia, reducing; Glycyrrhiza glabra L. was used as digestive, high cholesterol. ...
... Alanine aminotransferase (ALT), aspartate transaminase (AST), lipid peroxidation, triglycerides, cholesterol and glutathione did not change significantly, glucose and total protein levels reduced and presence of fatty cells in the liver [385] Rosa canina L. Fruit extract Hypoglycemic effect in normoglycemic plus glucose-hyperglycemic [386] Agrimony eupatoria L. Leaves extract Insulin releasing and insulin like activity [387] Rubus fruticosus Decrease in the blood glucose levels, reduction of serum lipids and liver enzymes [388] Prunus persica Leaves extract Reduction in blood glucose [389] Apocynaceae Gymnema sylvestre Gymnemic acid ...
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The present review focused on plant extracts or phytochemicals role in diabetes management has been tried by many researchers. I have attempted to compile a list of total 419 plant species belongs to 133 families have been used for in-vitro and in-vivo studies. The plant extract or phytochemicals have involved in decreasing or increasing or stimulating different mechanisms in reducing diabetes and they have been listed in tabular form. By this review, few molecules are used in diabetes management and they possess molecular mechanisms or involved in signal transduction to initiate the insulin production or utilization of blood glucose level bring down to normal stage. The researchers have used different parts of the plant extracts or individual phytochemicalsfor antidiabetic activities. This review brings the researcher data on antidiabetic activities of different plant extracts role in reducing of diabetic problems.
... The results indicated that the administration of rose hip aqueous extract in patients with type 2 diabetes for three successive months might result in the reduction of fasting blood glucose and serum total cholesterol/HDL-C without any side effect in patients (39). Moreover, a significant hypoglycemic effect at 250 mg/kg dose of ethanolic extract was observed in streptozotocin-induced diabetic rats (40). In another study, the intraperitoneal administration of hydroethanolic extract of rose hip with doses of 50-300 mg/kg to aloxan-induced diabetic rats, decreased serum levels of glucose, LDL-c, triglyceride, total cholesterol, urea, uric acid, creatinine and alkaline phosphatase (ALP), and at once increased serum HDL-c levels (41). ...
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Dog rose or Rosa canina L. is a perennial shrub that belongs to Rosacea family. It grows wild at the margin of forests, puddles of water, shrubberies and pastures. Rosa canina L. has been used for long years as a source of vitamins, medicinal supplements, and food throughout the world. It contains various vitamins (especially vitamin C) and other valuable compounds such as polyphenols, carotenoids, carbohydrates and fatty acids. The medicinal properties of rose hip in the symptomatic treatment of osteoarthritis, rheumatism and common cold are discussed in this paper. Moreover, there are evidences about anti-bacterial, anti-cancer, anti-diabetic and anti-obesity properties of this medicinal plant that have been reviewed in this article.
... The principal active constituent in the latter study was transtiliroside, a substance known to reduce blood glucose levels after glucose loading. Orhan et al. [102] administered an ethanol extract of rosehips (locally collected and dried R. canina) to rats during 7 days, and found a remarkable hypoglycemic effect in animals with induced diabetes. Andersson et al. [103] showed that a rosehip dietary supplementation (commercially available purée made of ground R. canina) reduced lipid accumulation in the liver of mice and lowered the total plasma cholesterol. ...
Article
Systematics and Genetics: Medicinal effects of rosehips are attributed mainly to dogroses, i.e. species in Rosa sect. Caninae. These are mostly pentaploid and have a unique meiosis with asymmetrical chromosome distribution. Offspring in reciprocal crosses differ widely since seedlings resemble the seed parent more than the pollen parent. Chemical Contents: Flesh (shells) of rosehips from dogroses contain high levels of antioxidants, mainly polyphenols and ascorbic acid, as well as carotenoids and vitamins B and E. The seeds are rich in polyunsaturated fatty acids and are used for skin treatment and cosmetics. Both shells and seeds, separately or together, are used for health-promoting food and food additives. Medicinal Effects: The most well-documented studies concern the positive effects on inflammatory processes, especially in patients suffering from osteoarthritis. The exact medicinal role of different rosehip compounds have not been investigated in detail, and the relative importance of fruit flesh versus seed is also not yet determined. Plant Production and Breeding: Rosehips are mainly harvested by hand from wild or naturalized dogrose bushes. Once the key compounds have been identified, commercial output of rosehips with predictable quality would be facilitated by careful optimization of plant material, cultivation conditions, and post-harvest and processing procedures. Some cultivars have been bred in Europe but breeding goals have not been clearly defined and commercial production is limited. Modern genomic tools have improved breeding programs in many crops but polyploidy and the canina meiosis present considerable challenges for research and breeding in dogroses.
... and β-caroten shows antioxidant activity and eliminates free radicals and oxidizing molecules from the organism which are involved in cancer development and possible damage of DNA [3]. In addition to all this potentials consummation of rosehip can help in: pain reduction [8,9], diabetic [10], and hyperlipidemic treatment [11]. It also demonstrates a neuroprotective, genoprotective [12], anti-obesity [13], skin-whitening [14], and antibiotic resistance reversal activity [15]. ...
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Rose hip (Rosa canina) fruits have been used in herbal remedies since ancient times. They are rich in a number of biologically active substances such as vitamins C, B1, B2, PP, K, vitamin E (in seeds), carotene (provitamin A), lycopene, pectin, flavonoids (campferol, quercetin, rutin), potassium, calcium, phosphorus salts. Rose hip seeds oil and residues are of special interest because of high content of linolenic acid. The aim of the current review was to describe the composition and properties of rosehip fruits and the effects of their supplementation to the feed of livestock animals, such as cattle, poultry and swine. Studies in animals prove positive effect in relation to both animal health and productivity in terms of quality and quantity, in cattle (milk and beef), pigs (pork yield and reproductive performance) and poultry (productive performance, egg quality).
... Rosa canina (RC) has traditionally been used to prevent and treat common colds, flu, digestive disturbances, and infections [46]. In Turkish folk medicine, the fruit is considered as the most promising remedy for hemorrhoids and diabetes mellitus [47]. Vitamin C, tocopherols, carotenoids, polyphenols, organic acids, sugars, and essential fatty acids are all found in rose hip, the pseudo-fruit of RC. ...
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Diabetes mellitus has long been seen as a substantial economic burden on patients, their families, and society. Impairment in blood sugar regulation has major health repercussions. Furthermore, untreated diabetes causes major chronic complications like blindness, renal failure, and heart failure, as well as an increase in associated mortality. New anti-diabetic medicines are being researched to help alleviate this issue. Conventional Anti-diabetic medications are beneficial, several synthetic drugs are available in the market to treat diabetes, but they are costly and come with inevitable adverse effects. Medicinal plants, on the other hand, may serve as an alternate source of anti-diabetic agents. According to the World Health Organization, 80 % of the population in underdeveloped nations still relies on traditional medicines or folk medicines, which are largely made from plants, for disease prevention or treatment. For instance, anti-proliferative, anti-viral, anti-inflammatory and anti-hyperglycemic effects. In order to find a natural anti-diabetic source that comes with less side effects, several studies have been conducted. The aim of this work is to review these studies and highlight the potential of plants when it comes to their anti-diabetic effect.
... fruits Reduce blood glucose level, regulate lipid metabolism by inhibiting fat accumulation (mainly visceral), decrease serum triglycerides, regeneration of pancreas β-cells, increase expression of insulin-dependent genes Gck and Ptp1b. Ninomiya et al. (2007), Orhan et al. (2009), Taghizadeh et al. (2016, Fattahi et al. (2017), Bahrami et al. (2020) Arctium spp. roots Decrease of blood glucose, increase of insulin synthesis, suppression of lipid synthesis by activating 5′-adenosine monophosphate activated protein kinase, regulated the expression of sterol regulatory elementbinding protein-1 and stearoyl-CoA desaturase. ...
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Background: Polyherbal mixtures called “medical species” are part of traditional and officinal medicine in Russia. This review aimed to analyze medical species used in Russia for the treatment of diabetes and related disorders. The information relevant to medical species, diabetes, and obesity was collected from local libraries, the online service E-library.ru, and Google Scholar. The prediction of the antidiabetic activity for the principal compounds identified in plants was performed using the free web resource PASS Online. Results: We collected and analyzed information about the compositions, specificities of use, and posology of 227 medical species. The medical species represent mixtures of 2–15 plants, while the most frequently mentioned in the literature are species comprising 3–6 plants. The top 10 plants among the 158 mentioned in the literature include Vaccinium myrtillus L., Phaseolus vulgaris L., Taraxacum campylodes G.E. Haglund., Urtica dioica L., Rosa spp., Hypericum spp ., Galega officinalis L., Mentha × piperita L., Arctium spp, and Fragaria vesca L. The leading binary combination found in medical species comprises the leaves of V. myrtillus and pericarp of P. vulgaris ; leaves of V. myrtillus and leaves of U. dioica ; and leaves of V. myrtillus and aerial parts of G. officinalis . In triple combinations, in addition to the above-mentioned components, the roots of T. campylodes are often used. These combinations can be regarded as basic mixtures. Other plants are added to improve the efficacy, treat associated disorders, improve gastrointestinal function, prevent allergic reactions, etc. Meanwhile, an increase in plants in the mixture necessitates advanced techniques for quality control. A feature of medical species in Russia is the addition of fresh juices, birch sap, seaweeds, and adaptogenic plants. Modern studies of the mechanisms of action and predicted activities of the principal compounds from medicinal plants support the rationality of polyherbal mixtures. Nevertheless, the mechanisms are not well studied and reported due to the limited number of compounds. Further investigations with calculations of synergistic or additive indices are important for strengthening the scientific fundamentals for the wider use of medical species in the therapy of diabetes. Two medical species, “Arfazetin” (7 medicinal plants) and “Myrphasinum” (12 medicinal plants), are approved for use in officinal medicine. The efficacy of these species was confirmed in several in vivo experiments and clinical trials. According to modern regulatory rules, additional experiments and clinical trials are required for more detailed investigations of the mechanisms of action and confirmation of efficacy. Conclusion: We believe that the scientifically based utilization of rich plant resources and knowledge of Russian herbal medicine can significantly contribute to the local economy as well as to the sectors seeking natural healing products.
... Suruç ve çevresinde geleneksel olarak kullanılan bazı bitkilerin laboratuvar çalıĢmalarında farklı aktiviteler gösterdiği kayıt altına alınmıĢtır. Bu bitkilerden, Rosa canina meyvesinin antidiyabetik, antienflamatuar, antinosiseptif ve antioksidan etki gösterdiği [28][29], Foeniculum vulgare, Rhus coriaria L. Rosmarinus officinalis L., Salvia ssp., antioksidan etki gösterdiği [30][31], Urtica dioica L. immünomodülatör, antifungal antidiyabetik, antimikrobiyal, antiülser and antianaljezik aktivite gösterdiği [32][33][34][35], Helichrysum türleri antienflamatuar ve antinosiseptif aktivite gösterdiği [36], Malva türleri ise antioksidan ve antiülserojenik aktivite gösterdiği [37][38] rapor edilmiĢtir. ...
... . creatinine, gentamicin, kidney, rat, ureaOrhan et al., 2009;Yi et al., 2007 Downloaded from nbr.khu.ac.ir at 6:29 +0430 on Wednesday June 2nd 2021[ DOI: 10.52547/nbr.7.2.177 ] Downloaded from nbr.khu.ac.ir at 6:29 +0430 on Wednesday June 2nd 2021 [ DOI: 10.52547/nbr.7.2.177 ] ‫ﮐﺮاﺗﯿﻨﯿﻦ‬ ‫و‬ ‫اوره‬ ‫ﺳﻄﺢ‬ ‫ﺷﺪﻧﺪ،‬ ‫ﺗﯿﻤﺎر‬ ‫ﺑﺪن‬ ‫وزن‬ ‫ﮐﯿﻠﻮﮔﺮم‬ ‫ﻫﺮ‬ ‫ازاي‬ ‫)ﺷﮑﻞ‬ ‫اﺳﺖ‬ ‫ﮐﻨﺘﺮل‬ ‫ﮔﺮوه‬ ‫در‬ ‫آن‬ ‫ﻣﯿﺰان‬ ‫ﺣﺪود‬ ‫در‬ ‫ﺧﻮن‬ 1 ‫ﺗﻮﻟﯿﺪ‬ ‫اداﻣﻪ‬ ‫در‬ ‫و‬ ( ‫آﺳﯿﺐ‬ ‫درﻧﺘﯿﺠﻪ‬ ‫و‬ ‫اﮐﺴﯿﺪاﺗﯿﻮ‬ ‫اﺳﺘﺮس‬ ‫ﻣﯽ‬ ‫ﺳﻠﻮﻟﯽ‬ ‫ﻫﺎي‬ ‫درواﻗﻊ‬ ‫ﺷﻮد.‬ Downloaded from nbr.khu.ac.ir at 6:29 +0430 on Wednesday June 2nd 2021 [ DOI: 10.52547/nbr.7.2.177 ] ‫ﮐﻮﻫﯽ‬ ‫ﻧﺴﺘﺮن‬ ‫ﻣﯿﻮه‬ ‫ﻋﺼﺎره‬ ‫ﮐﺮاﺗﯿﻨﯿﻦ.‬ ...
... Previous study on fruits of R canina demonstrated that this medicinal plant possesses hypoglycemic effect in animal model of diabetes mellitus. 27 One of the main causes of diabetes mellitus is defined as deficiency of pancreatic b-cell viability and performance. The finding of current study exhibited that enhancement of pancreatic b-cell proliferation plays a pivotal role in managing diabetes mellitus and its complications by this medicinal plant. ...
Article
Rosa canina fruits have been used traditionally for the treatment of diabetes mellitus and its complications. The aim of current study was to evaluate the in vitro mechanism of action of R canina in managing diabetes mellitus. Cell proliferation and cytotoxicity assay were performed on pancreatic β-cells, βTC6. The protective activity of the extract on streptozotocin-induced death in βTC6 cells was studied. The effect of R canina on the metabolism of glucose in HepG2, a hepatocellular carcinoma cell line, was evaluated. The effect of the extract on glucose diffusion across the dialysis membrane, which is a comfortable model for assessing cellular glucose absorption, was evaluated. The results obtained from current study confirmed that R canina extract can act as a growth factor for pancreatic β-cell line providing a novel mechanism for the observed antidiabetic effect of this natural agent. Further preclinical studies are necessary to evaluate the perfect mechanism of action of R canina in diabetes mellitus.
... The safety and efficacy of each herb in above mentioned combination is evident by their use in folk medicine through time by traditional healer (Hashempur et al. 2015;Zarshenas et al. 2014). The antidiabetic effect has been reported in experimental model of diabetes for C. spinosa (Eddouks et al. 2004), R. canina (Orhan et al. 2009), S. securigera (Porchezhian and Ansari 2001), S. marianum (Sheela et al. 2013), U. dioica, (Farzami et al. 2003). T. foenum-graecum (Ajabnoor and Tilmisany 1988) and V. arctostaphylos (Feshani et al. 2011). ...
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Background: Capparis spinosa, Rosa canina, Securidaca securigera, Silybum marianum, Urtica dioica, Trigonella foenum-graecum and Vaccinium arctostaphylos are used traditionally as an herbal combination for treatment of diabetic patients in Iran. Despite the clinical evidence supporting their use in solitary form, no controlled human study has determined the efficacy and safety of their combination in treatment of diabetic patients. Methods: A total 150 type II diabetic patients of both sexes under the oral anti-hyperglycemic drugs treatment (maximum 10 mg glyburide and 1000 mg metformin daily) were randomly assigned to three groups. The patients in each group received either herbal combination or placebo or metformin capsule daily for three months, without any change in their previous oral anti-hyperglycemic drugs dosage. Herbal combination, placebo and metformin capsules matched by shape and color were prepared in the Institute of Medicinal Plants Karaj, Iran. To assess the efficacy and safety of the treatments, the patients fasting plasma glucose, HbA1c, lipid profile, liver enzymes and renal function were determined at the beginning of the study and after three months. Results: Results showed that after three months, the fasting plasma glucose, HbA1c and cholesterol levels in herbal combination were decreased significantly as compared to placebo group (20% and 12% respectively) and also compared to base line (25% and 15% respectively). The herbal combination was as effective as metformin in reduction of FPG (p = 0.001, p = 0.001) and HbA1c (p = 0.028 and p = 0.050 respectively) compared to placebo. No notable hepatic, renal and gastrointestinal side effects were observed in the trial groups. Conclusion: The results suggest that traditional herbal combination may safely improve glycemic control in type II diabetic patients with no significant adverse effect.
... The rosehip fruits were estimated mainly by the contents of ascorbic acid (vitamin C), tanning substances and pectin. The fruits can accumulate up to 1000-4000 mg.g -2 ascorbic acid and 4,5-6,8% tanning substances [3,14,16]. The chemical composition of the fruits analyzed was comparable with the literary data and the contents of the other components in other representatives of the same family. ...
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The active acidity of the yoghurt was monitored during both periods of preparation and storage. At the end of the storage period (14 days), the active acidity reached pH 4,2 ÷ 4,3. For the same period, the vitamin C content was the highest in sample 2 and varied from 13,65 ÷ 13,12 mg.g-2. The dry matter content in the yoghurt obtained was determined. Higher values of dry matter were observed in samples 2 and 3, with values varying from 12,60 % to 13,4 %. The higher values of the dry matter content in the product were due to the pectin type substances extracted during the extraction process. The pectin substances extracted into the milk stabilized the coagulum, improved the taste and the nutritious value of the yoghurt obtained. The total number of viable bacteria in the yoghurts obtained was determined and they were found to increase during the storage period. The highest total number of viable lactic acid bacteria was observed for Sample 2 - 3,6.108 CFU.g-2 which is about 10 times more than these in Sample 1 (reference).
... The uses of R. canina were recorded to be for gastric diseases and colds, in our research area. It has been reported that R. canina L. showed antinociceptive, antioxidant and antiinflammatory activity, and anti-diabetic effects (Özcan, 2003;Deliorman et al., 2007;Orhan et al., 2009). Urtica dioica L. is used in Ulukışla and neighbouring places to treat cancers, bronchitis and kidney stones. ...
Article
This study aimed to identify wild plants collected for medicinal purposes by the local people of Ulukişla County, located in the Central Anatolia Region of Turkey and to establish the uses and local names of these plants.A field study was carried out over a period of approximately 2 years (2002-2003). During this period, 59 vascular plant specimens were collected. Demographic characteristics of participants, local plant names, plant parts used and preparation methods of the plants were investigated and recorded. Within the scope of the study, the plant species were collected; herbarium materials were prepared; and the plant specimens were named. In addition, the relative importance value of the species was determined and was calculated for the medicinal plants included in the study.A total of 59 medical plants belonging to 27 families were identified in the region. The most common families were Lamiaceae, Rosaceae, Asteraceae, Poaceae and Apiaceae.This study identified not only the wild plants collected for medical purposes by local people of Ulukişla County in the Central Anatolia Region, but also the uses and local names of these plants. Comparison of the data obtained in this study from the plants growing in Ulukişla with the experimental data obtained in previous laboratory studies showed mostly the same ethnobotanical usages. The plant flora of Ulukişla is threatened by such factors as grazing, expansion of new agricultural lands, and unsustainable picking of plants to generate income. Steps should be taken immediately to ensure the inclusion of relevant flora within conservation designations.
... Compound 9 was identified as kaempferol-3-O-␤-D-(6 -Ep-coumaroyl) glucopyranoside (tiliroside). Tiliroside is widely produced by Malvaceae sensu lato and has demonstrated many pharmacological properties, such as vasorelaxant, antioxidant, hypolipidemic, antinociceptive and anti-inflammatory activities (Barbosa et al., 2007;Orhan et al., 2009;Zhang et al., 2015). ...
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The species Waltheria viscosissima A.St.–Hil, Malvaceae, which is known as ‘malva-branca’, is traditionally used in the Brazilian northeast for the treatment of coughs. This research looks towards reporting the isolation of phytoconstituents of W. viscosissima, as well as the quantification of its phenolics, total flavonoid content, and free radical scavenging potential, along with an evaluation of its larvicidal activity against Aedes aegypti larvae. Chromatographic techniques were used to isolate the compounds and a structural elucidation was performed by 1D and 2D NMR. The quantification of total phenolics and flavonoids and the DPPH˙ radical scavenging activity was determined through spectrophotometric methods. Consequently, the phytochemical investigation led to the identification of fourteen compounds from the aerial parts of the W. viscosissima: steroids, triterpenes, alkaloids, and eight flavonoids previously reported in the literature. The quantification of compounds showed that the aerial parts extract possessed high concentration of flavonoids, while the roots extract were rich in other phenolic compounds. At the DPPH˙ free radical scavenging assay, the roots extract presented EC50 = 77.32 ± 4.37 µg/ml and the aerial parts extracts showed EC50 = 118.10 ± 1.21 µg/ml. W. viscosissima roots extract showed the most potent larvicidal activity against Ae. aegypti (LC50 = 4.78 mg/ml), with the potential of being used in effective and economically viable preparations that can be catered for domestic use towards controlling the vector insect of severe diseases, such as dengue and Zika. Keywords: Sterculiaceae, Phytochemical study, Antioxidant activity, Larvicidal assay, Aedes aegypti
... In this study, the ethanolic extract of Rosa canin L a cause in gaining weight in rats diabetic. The results of this study are in accordance with Orhan et al., (2009) which showed that R.canina L increased the body weight of diabetic rats. ...
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Medicinal plants play a main role in the management of diabetes mellitus especially in expanding countries where resources are few. Rosa canina L. is a medicinal plant largely used in common folk medicine. The aim of present research is studying effects of Rosa canina extract on amounts of serum biochemical factors in diabetic male rats. In this experiment, 32 male Wistar rats were obtained and randomly divided into four groups (n=8). These groups received normal saline (10mg/kg), RC fruit extract (250 mg/kg) and RC fr uit extract (500mg/kg) as oral gavages every day for a period of four weeks, respectively. glucose, cholesterol and triglyceride levels in the serum were determined at the end of the period. The results showed that glucose, cholesterol and triglyceride concentrations were significantly increased in the diabetic group. The levels of glucose, cholesterol and triglyceride significantly decreased in the treatment groups in comparison with the diabetic control group (p<0.05). The changes of glucose,triglyceride in treatment groups showed no significant differences. In contrast the cholesterol differences in groups receiving extract was significant in comparison with the normal saline group.
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Plant extracts have been reported to have contributed to the increase of nutritional values which are important to the human health. Investigations were carried out to evaluate the phytochemicals content and antioxidant activity of Rosa kordesii petal extracts in different solvents. Methanol, water and n-hexane were used as solvent. Under an observational analytic study revealed the presences of alkaloids, flavonoids, phenols, carbohydrate, resins, saponins, steroids, tannins, anthracenosides and coumerins as phytochemicals in the extracts. The order of phenolic contents was as follows: aqueous extract; 461.93±3.24, methanolic extract; 349.59±3.62; and n-hexane extract; 42.42±1.71mg GAE/g residue whereas total flavonoid contents were found to be 78.11±2.00, 168.22±2.29 and 45±2.00 mg of catechin/g of extract, respectively. Antioxidant activity of each extract was carried out by total antioxidant capacity test, DPPH, ABTS and ferric reducing antioxidant power (FRAP) assay by using ascorbic acid as standard. Methanolic extract was found to be the most effective in all assays, except total antioxidant capacity test with IC50 of 21.93μg/ml (DPPH Assay) and 10.38μg/ml (ABTS Assay). The antioxidant activities were positively associated with the total phenolic and flavonoid contents of the extracts. Further study on different solvent extracts of Rosa kordesii would be carried out to elucidate the active principles for its outmost activity.
Article
The aim of this study was to determine and compare the fatty acid (FA) composition of the monogalactosyldiacylglycerol (MGDG) fraction, obtained from rose pericarps and seeds, as well as Litozin® powder. In this work two Rosa species, growing wild in Poland, namely Rosa canina and Rosa rugosa, were investigated. MGDG was eluted from the lipid extract using different solvents: (CHCl 3 , (CH 3 ) 2 CO, CH 3 OH) and its presence was observed only in the acetone-soluble fraction. MGDG was isolated and purified by means of medium-pressure liquid chromatography (MPLC) and preparative TLC. It is worth noting that the MPLC method was used for the first time to fractionate and isolate the MGDG fraction from the lipid extract. The carbohydrate part of MGDG was determined after acidic hydrolysis on a TLC plate. Only the spot with R f value corresponding to galactose (R f 0.33) was observed. The FA composition of MGDG from the rose seeds, rose pericarps, and Litozin® was determined by gas-liquid chromatography (GLC). The results are presented in Table 1. The FA composition of MGDG found in pericarps was similar for both rose species. Comparison of the FA composition of MGDG from the seeds of both species has also revealed no significant differences. However, there were some differences in the FA composition of MGDG between pericarps and seeds of the analyzed species. We have identified 13 FA in the pericarps and 10 FA in the seeds of both analyzed species. The FA composition of MGDG of the pericarps consisted mostly of fatty acids with chain length from 10 to 18 carbons. It is interesting that long-chain FA (24:0 and 24:1) have been observed only in the seeds of both species. Our investigation has revealed that unsaturated FA were dominant in the pericarps of both species (93.745–94.856%). The major unsaturated FA of MGDG from the pericarps of Rosa canina and Rosa rugosa were those with chain length of 18 C (93.886% and 92.795%, respectively), while the content of unsaturated FA with chain length of 16 and 17C was less than 1%. The dominant FA of MGDG from the pericarps of both species was linolenic acid (18:3 n-3), and the percentage of the compound was 74.486% of MGDG FA from R. canina and 86.057% of MGDG FA from R. rugosa. The analysis has also revealed high amounts of 18:2 n-6 FA, especially in MGDG from R. canina pericarps (17.330%).
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Plants have been the main source of medicines since ancient times. Practically all human societies have utilized plants not only as sources of nutrition but also as therapy against diseases and ailments. Plants contain various phytochemicals and these phytochemicals can play an important role in reducing occurrences of many diseases by boosting up various organ functions of the human body, by acting as antioxidants and by supplying necessary nutrients. In the present review, an attempt has been made to document the botanical, phytochemical, pharmacological and toxicological information on Melia azedarach, a medicinal plant used in the indigenous system of medicine for therapeutic purpose. M. azedarach has been shown to possess various pharmacological activities like antinephrolithiasis, antiulcer, antibacterial, hepatoprotective, antioxidant, antifertility, anthelmintic, antipyretic, anti-parasitic and cytotoxic activities etc. A review of the relevant scientific literature on the M. azedarach L. showed that this plant contains many phytochemical constituents including alkaloids, terpenoids, saponins, glycosides, phenolic compounds, flavonoids and rutins. The present review is an effort to screen a detail updated survey of the literature on its phytochemical and pharmacological appraisals which have been or still are being learned.
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In this study we have investigated rosehip fruit productivity and total acidity in response to rainfall for 2007-2010 period of time. The annual average rainfall had a value of 765.6 mm and 98.6 mm during the growing season, the maximum being recorded in June 2010 (226.5 mm) and the minimum in April 2009 (8.4 mm). Evolution of average weight during the four years studied, remained the same at all resorts, small weight differences were observed between 2007 and 2008. Average weight resorts and between resorts ranged from values between 210-170 g. Rosehip fruits are of interest for the food, cosmetics and health industries. From the point of view of phytotherapy it is important to determine the content of vitamin C but also other organic acids (e.g., citric acid, malic acid - commonly used in food processing as an acidity regulator and antioxidant). Total titratable acidity provides information on organic acid content in fruits of rosehip preserved by drying. Total acidity value in 2009 ranged between 2.1 and 3.5 g malic acid. The average value for 2009 was 3.063 g malic acid. Determination of titratable acidity in 2010 showed values that ranged around the mean of 2.46 g malic acid.
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Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, nephropathy and neuropathy which are collectively known as diabetic complications and are the principal actors in co-morbidity and eventual mortality often associated with diabetes. The ability of therapeutic compounds including medicinal plants to restore glycemic balance or homeostasis in hyperglycemic condition is an index of their antidiabetic function and relevance. Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds. Notably, alloxan is far less expensive and more readily available than streptozotocin. On this ground, one will logically expect a preference for use of alloxan in experimental diabetes studies. Surprisingly, a sub meta-analysis of randomly selected studies conducted within the last one and half decade revealed otherwise. This observation necessitated the review of alloxan as a diabetogenic agent in animal studies.
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The present study was designed to investigate the hypoglycemic and hypolipidemic effects of the water extract (WE) and crude polysaccharides (CPs) obtained from the tuberous root of Liriope spicata (Thund.) var. prolifera Y. T. Ma, which is widely used in prescriptions of traditional Chinese medicine for the treatment of diabetes mellitus. WE and CPs were administered orally at different doses (200 and 100 mg/kg body weight) to normal and streptozotocin (STZ)-induced type 2 diabetic male BABL/c mice, respectively. The fasting blood glucose (FBG), lipids and insulin in serum were estimated and an oral glucose tolerance test (OGTT) was performed for the evaluation of hypoglycemic and hypolipidemic effects. Both doses of WE and CPs did not show any appreciable effect on FBG in normal mice. However, they caused a marked decrease of FBG and a significant improvement on glucose tolerance and insulin resistance in STZ-induced type 2 diabetic mice. In addition, while lowering total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) cholesterol levels, WE and CPs elevated the relative high density lipoprotein (HDL) cholesterol level (HDL/TC) in serum. Compared to WE, the hypoglycemic and hypolipidemic effects of CPs were more marked. The results suggest that WE and CPs may have hypoglycemic and hypolipidemic potential for the type 2 diabetes and support the traditional use of the tuberous root of Liriope spicata var. prolifera as a hypoglycemic agent.
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In this study, in vitro inhibitory effects of 55 extracts or fractions obtained from 10 plant species on interleukin-1 (IL-1alpha, IL-1beta) and tumor necrosis factor (TNF-alpha) biosynthesis were studied. The following plant materials from Turkish folk medicine for the treatment of various diseases which are thought to be inflammatory in nature e.g. rheumatism, fever, infections, edemas or related inflammatory diseases were selected as the subject of this study: Cistus laurifolius leaves, Clematis flammna flowering herbs, Crataegus orientalis roots, Daphne oleoides ssp. oleoides whole plant, Ecbalium elaterium roots, Rosa canina roots, Rubus discolor roots, Rubus hirtus roots, Sambucus ebulus flowers and leaves, Sambucus nigra flowers and leaves. All plants showed inhibitory activity against at least one of these models in various percentages depending upon the concentration, thus supporting the folkloric utilization. Daphne oleoides was found to be the most active plant against the test models.
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We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of beta-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of beta-lactams from the extract, tellimagrandin I and rugosin B. Tellimagrandin I was very effective regarding the reduction of the minimum inhibitory concentration, and rugosin B showed some effect. Tellimagrandin I showed a weak bactericidal action when added together with oxacillin. Judging from the fractional inhibitory concentration index, the effect of tellimagrandin I and oxacillin was synergistic. Tellimagrandin I also significantly reduced the minimum inhibitory concentration of tetracycline in some strains of methicillin-resistant Staphylococcus aureus.
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Based on ethnopharmacological and taxonomic information, seeds of 21 Scottish plant species from 14 different families were obtained from authentic seed suppliers. Their n-hexane, dichloromethane and methanol extracts were assessed for antibacterial activity against 11 pathogenic bacterial species. Methanol extracts of 11 plant species showed significant antibacterial activity. Malva moschata and Prunus padus were active against five bacterial species, Reseda lutea against four, Centaurium erythraea and Crithmum maritimum against three, Calluna vulgaris against two, and Armeria maritima, Centaurea scabiosa, Daucus carota, Rosa canina and Stellaria holostea against one bacterial species. C. erythraea and P. padus were also active against methicillin resistant Staphylococcus aureus.
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Research was performed to experimentally evaluate the antioxidant capacity of different plant products sold by herbalists (ginger, dog rose, ginseng and camomile) and of several types of tea (ordinary tea, green tea, detheinated tea, lemon and peach flavoured tea) using a superoxide dismutase (SOD) biosensor recently developed by the present authors. Measurements were carried out by comparing biosensor response to the superoxide radical produced in solution using the xanthine-xanthine oxidase system, both in the presence and absence of the antioxidant sample considered. Precision of antioxidant capacity measures for herbal products and for non diluted samples was good, generally with a R.S.D.%< or =10% and a LOD value about 0.1 for relative antioxidant capacity. Also a "pool" of polyphenols from different tea samples was measured using a tyrosinase biosensor (LOD approximately 2 microM).
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Corilagin and tellimagrandin I are polyphenols isolated from the extract of Arctostaphylos uvaursi and Rosa canina L. (rose red), respectively. We have reported that corilagin and tellimagrandin I remarkably reduced the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus(MRSA). In this study, we investigated the effect of corilagin and tellimagrandin I on the penicillin binding protein 2 '(2a) (PBP2 '(PBP2a)) which mainly confers the resistance to beta-lactam antibiotics in MRSA. These compounds when added to the culture medium were found to decrease production of the PBP2 '(PBP2a) slightly. Using BOCILLIN FL, a fluorescent-labeled benzyl penicillin, we found that PBP2 '(PBP2a) in MRSA cells that were grown in medium containing corilagin or tellimagrandin I almost completely lost the ability to bind BOCILLIN FL. The binding activity of PBP2 and PBP3 were also reduced to some extent by these compounds. These results indicate that inactivation of PBPs, especially of PBP2 '(PBP2a), by corilagin or tellimagrandin I is the major reason for the remarkable reduction in the resistance level of beta-lactams in MRSA. Corilagin or tellimagrandin I suppressed the activity of beta-lactamase to some extent.
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In this study, we evaluated the anti-hyperglycemic effect of a polysaccharides fraction from American ginseng berry extract in diabetic ob/ob mice. All animals received daily intraperitoneal injections of polysaccharides at 150 mg/kg body wt. (n = 5), polysaccharides at 50 mg/kg body wt. (n = 5), or vehicle (n = 5) for 10 consecutive days. On Day 5, as compared to the vehicle-treated mice (230.5 +/- 13.5 mg/dl, mean +/- S.E), mice from both treated groups showed significantly lower fasting blood glucose levels (187.4 +/- 20.5 mg/dl and 187.4 +/- 17.1 mg/dl), respectively (both P < 0.05). On Day 10, compared to the vehicle group (240.1 +/- 12.3 mg/dl), the 50 mg/kg dose group were at 188.4 +/- 12.6 mg/dl (P < 0.05), and the 150 mg/kg dose group were normoglycemic (148.8 +/- 17.6 mg/dl, P < 0.01). Those ob/ob mice treated with vehicle did not, however, show significant changes in fasting blood glucose levels. Data from the intraperitoneal glucose tolerance test (IPGTT) showed that, compared to Day 0, there was a significant improvement in glucose tolerance in animals who received the 50 and 150 mg/kg polysaccharide doses, and the area under the curve (AUC) decreased 15.5% (P < 0.05) and 28.2% (P < 0.01), respectively. Interestingly, after cessation of polysaccharide treatment, the fasting blood glucose levels stayed lower, and returned to control concentration on Day 30. We also observed that the polysaccharides fraction did not affect body weight changes in ob/ob mice. Our data suggest that the polysaccharides fraction from American ginseng berry extract has a potential clinical utility in treating diabetic patients.
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Hypoglycemic effect of Gentiana olivieri Griseb. (Gentianaceae) flowering herbs on oral administration were studied using in vivo models in normal, glucose-hyperglycemic and streptozotocin-induced diabetic rats. Through in vivo bioassay-guided fractionation processes isoorientin, a known C-glycosylflavone, was isolated from the ethylacetate fraction by silica gel column chromatography as the main active ingredient from the plant. Isoorientin exhibited significant hypoglycemic and antihyperlipidemic effects at 15 mg/kg b.w.dose. Isoorientin concentration of the extracts and fractions were determined by HPLC in order to establish a correlation between the hypoglycaemic activity.
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To examine the effects of Astragalus polysaccharide (APS), a component of an aqueous extract of Astragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor (IR) signal transduction, and its potential role in the amelioration of insulin resistance. Ten-week-old fat-fed streptozotocin (STZ)-treated rats, an animal model of type II diabetes mellitus (TIIDM), were treated with APS (400 mg/kg p.o.) for 5 weeks. Insulin sensitivity was identified by the insulin-tolerance test. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle and liver were performed by immunoprecipitation or Western blotting. PTP1B activity was measured by an assay kit. The diabetic rats responded to APS with a significant decrease in body weight, plasma glucose, and improved insulin sensitivity. The activity and expression of PTP1B were elevated in the skeletal muscle and liver of TIIDM rats. Thus the insulin signaling in target tissues was diminished. APS reduced both PTP1B protein level and activity in the muscle, but not in the liver of TIIDM rats. Insulin-induced tyrosine phosphorylation of the IR beta-subunit and insulin receptor substrate-1 (IRS-1) were increased in the muscle, but not in the liver of APS-treated TIIDM rats. There was no change in the activity or expression of PTP1B in APS-treated normal rats, and blood insulin levels did not change in TIIDM rats after treatment with APS. APS enables insulin-sensitizing and hypoglycemic activity at least in part by decreasing the elevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats.
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The acute hypoglycaemic effect of water and ethanolic extracts of three Viscum album subspecies, ssp. album, ssp. austriacum, ssp. abietis, were investigated in normoglycaemic and streptozotozocin-induced diabetic rats. Blood glucose level was measured according to glucose oxidase method. The antioxidant activity of these extracts was also studied in the liver, kidney and heart tissues of streptozotocin-induced diabetic rats after subacute administration. In order to determine antioxidant activity of extracts, tissue MDA and GSH levels were measured by using spectrophotometric methods. All results were compared with the diabetic control groups. The findings obtained in the experiments demonstrated that European mistletoe (Viscum album L.) subspecies possess potent antihyperglycaemic and antioxidant activity depending on host plant.
Article
Fruit from Lycium barbarum L. in the family Solanaceae is well-known in traditional Chinese herbal medicine. Lycium barbarum polysaccharides (LBP) have been identified as one of the active ingredients responsible for its biological activities. We isolated polysaccharides from dried Lycium barbarum fruits by boiling water extraction. In the study, 50 animals were divided into two groups: a nondiabetic control (n=10) and a diabetic group (n=40). Diabetes was induced by a single injection of streptozotocin (50mg/kg BW; Sigma, USA) freshly dissolved in a 0.1 mol/L citrate buffer (pH 4.5) into the intraperitonium. The normal control rats and the untreated diabetic control rats were only injected with the citrate buffer. Treated diabetic rats were administrated with LBP in drinking water through oral gavage for 30 days. At the end of experiment, oxidative indice in blood, liver and kidney of all groups were examined. The results show that administration of LBP can restore abnormal oxidative indice near normal levels. Therefore, we may assume that LBP is effective in the protection of liver and kidney tissue from the damage of STZ-induced diabetic rats and that the LBP may be of use as a antihyperglycemia agent.