Effect of Combined Probiotics and Zinc Supplementation on Immune Status of Pulmonary Tuberculosis Patients

Article (PDF Available)inPakistan Journal of Nutrition 15(7):680-685 · July 2016with 210 Reads 
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
DOI: 10.3923/pjn.2016.680.685
Cite this publication
Abstract
Patients with pulmonary tuberculosis generally malnourished due to side effect in anti-tuberculosis drugs, which altering gastrointestinal tract, it affects on recovery process, immune system and response. Probiotics and zinc are thought to have beneficial effects for nutritional status and immune response. This study was conducted to analyze the effect of combined probiotics and zinc on levels of lymphocytes, neutrophils lymphocyte count ratio (NLR) and monocytes in patients with pulmonary tuberculosis in Lung Health Center of Semarang. In a quasi-experimental study (quasi experiment) randomized design with pre-post test control group design, fifty four pulmonary tuberculosis patients were divided into 2 groups, the treatment group received a combination of probiotics and zinc, as well as a control group given a placebo, administration for 4 weeks. There were no differences in mean age, levels of lymphocytes and monocytes NLR at baseline (p>0.05). Increased levels of lymphocytes and decreased levels of monocytes and NLR after administration of the combination of probiotics and zinc (p<0.05). There was no significant relationship between nutriens intake with high levels of lymphocytes, NLR and monocytes (p>0.05). The most powerful effectiveness of the combination probiotics and zinc contained in the lymphocyte levels (12.8%). It is concluded that the combined probiotics and zinc over 4 weeks improve the immune system of patients with pulmonary tuberculosis measured by lymphocytes, NLR and monocytes.
Advertisement
  • ... Infeksi mengakibatkan inflamasi kronis, penurunan asupan, malabsorpsi nutrient, perubahan metabolisme tubuh dan radikal bebas, immunitas tubuh dan antioksidan tubuh menurun. 7,8 Obat-obat TBC berspektrum antibiotik kuat, menyebabkan kerusakan pada saluran pencernaan pada makroflora usus, penurunan penyerapan zat gizi, menurunnya respon imun tubuh yang disertai dengan penurunan status gizi dan nafsu makan penderita dan penyebab mual, muntah, diare, tidak nafsu makan, peningkatan suhu tubuh dan penurunan makroflora usus. 9 Pasien tuberculosis paru, mengalami penurunan status gizi disebabkan tingkat perilaku terhadap makanan dan kesehatan, khususnya kecukupan energi dan protein, lama menderita penyakit paru, serta pendapatan perkapita pasien. ...
    Article
    Latar belakang : Penyakit tuberkulosis (TBC) paru merupakan masalah kesehatan masyarakat global termasuk Indonesia. Penyakit tuberkulosis paru pada umumnya terjadi malnutrisi akibat efek samping obat anti tuberculosis, yang menyebabkan gangguan saluran cerna dan respon imunitas. Probiotik dan Selenium diduga memiliki efek menguntungkan respon imunitas dan status gizi pada pasien terinfeksi tuberculosisTujuan : Untuk menganalisis pengaruh pemberian suplementasi probiotik dan selenium terhadap NLR ( Neutrophill Ratio Lymphocyte ), Hemoglobin dan Albumin pada tikus wistar yang diinduksi Mycobacterium tuberculosis.Metode : Penelitian eksperimen dengan rancangan Randomized Post test Control Group Design. Dua puluh delapan tikus Wistar dibagi 4 kelompok, kelompok 1 : kelompok kontrol hanya diberikan OAT, kelompok 2 : probiotik + OAT, kelompok 3 : selenium + OAT serta kelompok 4 : probiotik dan selenium + OAT. Setelah diinduksi 14 hari, hewan diberikan perlakuan selama 28 hari. Analisis data menggunakan Anova, Post Hoc atau Kruskal Wallis, Mann Whitney pada tingkat kemaknaan p<0.05. Hasil : Terjadi penurunan kadar NLR, peningkatan kadar Hemoglobin dan Albumin pada tikus kelompok 1 (p<0.05), kelompok 2 (p<0.05) serta kelompok 3 (p<0.05). Efektifitas pemberian probiotik dan selenium paling kuat terdapat pada NLR, Hemoglobin dan AlbuminSimpulan : Suplementasi probiotik dan selenium selama 28 hari mampu meningkatkan sistem imunitas ( NRL ), Hemoglobin dan Albumin pada kelompok perlakuan lebih baik dibanding kelompok kontrol.