Once a game design has been created and production begins, a game development team’s two main activities are programming and content production. While a relatively small, experienced programming team can provide the necessary support for a state-of-the-art game, an art department and other departments have to produce the game content. In this chapter, we examine the production of content, including an analysis of what kinds of content exist in serious games, technical implications of the different kinds, and content production management. We also provide an introduction into procedural content generation, i.e., techniques to produce content algorithmically. Finally, we provide considerations for integrating serious content, and how the integration should be reflected in the organization of the overall game production.