Tumor-specific frequencies and ocular melanoma

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Specific kilohertz frequencies in the environment from variable frequency drives on electric motors at a liquid natural gas compressor and storage station on a natural gas pipeline seem to be associated with the development of a very rare cancer, ocular melanoma, at a high school and in individuals living or working in a neighborhood near the plant. Primary neutral-to-earth oscilloscope voltage waveforms and spectra measured near the high school were nearly identical to the ground voltage 2.3 miles away at the gas pipeline. Peak frequencies of 7440 and 19,980 Hz were found at both places. The electric utility practice of using the earth as a conduit for return currents facilitated this exposure.

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... Comment on " Milham & Stetzer (2016) Electrocution & microwave cooking are obvious biological actions of electromagnetic energy that are generally accepted by most people. This acceptance is not under contention because the intensities of the energy are large, and the actions are easily manifest. ...
... Thus, the report by Milham & Stetzer (2016), correlating appearance of a specific cancer type, ocular melanoma, with low-frequency currents associated with the return of electricity to the generating station via terrestrial ground returns from electrically energized equipment at a nearby industrial plant, should be seriously investigated as a hereto-fore unknown potential human cancer-causing agent. Unlike the requirement mandated in many European countries for wired return-current connections back to electricity-generating substations, the wiring codes in the US allow for ground-based return of the current, which is less expensive to build, but it creates the exposure situation described in the report. ...
The epidemiology of cutaneous malignant melanoma (CMM) has a number of facets that do not fit with sunlight and ultraviolet light as the primary etiologic agents. Indoor workers have higher incidence and mortality rates of CMM than outdoor workers; CMM occurs in body locations never exposed to sunlight; CMM incidence is increasing in spite of use of UV blocking agents and small changes in solar radiation. Installation of two new fluorescent lights in the milking parlor holding area of a Minnesota dairy farm in 2015 caused an immediate drop in milk production. This lead to measurement of body amperage in humans exposed to modern non-incandescent lighting. People exposed to old and new fluorescent lights, light emitting diodes (LED) and compact fluorescent lights (CFL) had body amperage levels above those considered carcinogenic. We hypothesize that modern electric lighting is a significant health hazard, a carcinogen, and is causing increasing CMM incidence in indoor office workers and tanning bed users. These lights generate dirty electricity (high frequency voltage transients), radio frequency (RF) radiation, and increase body amperage, all of which have been shown to be carcinogenic. This could explain the failure of ultraviolet blockers to stem the malignant melanoma pandemic. Tanning beds and non-incandescent lighting could be made safe by incorporating a grounded Faraday cage which allows passage of ultraviolet and visible light frequencies and blocks other frequencies. Modern electric lighting should be fabricated to be electrically clean.
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There is clinical evidence that very low and safe levels of amplitude-modulated electromagnetic fields administered via an intrabuccal spoon-shaped probe may elicit therapeutic responses in patients with cancer. However, there is no known mechanism explaining the anti-proliferative effect of very low intensity electromagnetic fields. To understand the mechanism of this novel approach, hepatocellular carcinoma (HCC) cells were exposed to 27.12 MHz radiofrequency electromagnetic fields using in vitro exposure systems designed to replicate in vivo conditions. Cancer cells were exposed to tumour-specific modulation frequencies, previously identified by biofeedback methods in patients with a diagnosis of cancer. Control modulation frequencies consisted of randomly chosen modulation frequencies within the same 100 Hz-21 kHz range as cancer-specific frequencies. The growth of HCC and breast cancer cells was significantly decreased by HCC-specific and breast cancer-specific modulation frequencies, respectively. However, the same frequencies did not affect proliferation of nonmalignant hepatocytes or breast epithelial cells. Inhibition of HCC cell proliferation was associated with downregulation of XCL2 and PLP2. Furthermore, HCC-specific modulation frequencies disrupted the mitotic spindle. These findings uncover a novel mechanism controlling the growth of cancer cells at specific modulation frequencies without affecting normal tissues, which may have broad implications in oncology.
Public Utility Commissions (PUC) in several states adopted 0.5volt rms (root mean squared) or 1.0milliampere as the actionable limit for utilities to respond to complaints of uncontrolled voltage. This study clearly shows that the actionable level should be reduced to 10mV p-p (peak-to-peak), which is 140 times less than the current standard. Dairy farmer complaints that animal behavior and milk production were affected by electrical shocks below adopted standards were investigated on 12 farms in Wisconsin, Michigan, and Minnesota. Milk production per cow was determined from daily tank-weight pickup and number of cows milked. Number of transient events, transients, voltage p-p, waveform phase angle degree, sags, and sag-Vrms were measured from event recorders plugged into milk house wall outlets. Data from 1705 cows and 939 data points were analyzed by multiherd least-squares multiple regression and SAS-ANOVA statistical programs. In five herds for 517days, milk/cow/day decreased -0.0281kg/transient event as transient events increased from 0 to 122/day (P<0.02). Negative effects on milk/cow/day from event recorder measurements were significant for eight independent electrical variables. Step-potential voltage and frequency of earth currents were measured by oscilloscope from metal plates grouted into the floor of milking stalls. Milk decreased as number of 3rd, 5th, 7th, 21st, 28th, and 42nd harmonics and the sum of triplen harmonics (3rd, 9th, 15th, 21st, 27th, 33rd, and 39th) increased/day (P<0.003). Event recorder transient events were positively correlated with oscilloscope average V p-p event readings. Steps/min counted from videotapes of a dancing cow with no contact to metal in the barnyard were correlated with non-sinusoidal 8.1 to 14.6mV p-p impulses recorded by oscilloscope for 5min from EKG patches on legs. PUC standards and use of 500-Ohm resistors in test circuits underestimate effects of non-sinusoidal, higher frequency voltage/current common on rural power lines.
Three cases of male breast cancer were diagnosed among a small group of men who worked in a basement office of a multi-story office building. This office was adjacent to an electrical switchgear room which generated high magnetic fields in their work space. The risk of male breast cancer in this group was increased about 100-fold (observe three cases, expect 0.03 cases; P < 0.00001). Since 1991, 15 epidemiologic studies have associated male breast cancer with exposure to electromagnetic field. Am. J. Ind. Med. 46:86–87, 2004. © 2004 Wiley-Liss, Inc.
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independence and it consistent high standards, have made BJC one of the world's premier general cancer journals. Its increasing popularity is reflected by a steadily rising impact factor.
To determine trends in incidence, treatment, and survival with primary uveal melanoma in the United States over a 36-year period from 1973 to 2008. Systematic review of existing databases. A total of 4070 patients with primary uveal melanoma (International Classification of Disease for Oncology [ICD-O-2] codes C69.3 [choroid], C69.4 [ciliary body and iris], and C69.2 [retina]) derived from the Surveillance, Epidemiology, and End Results (SEER) program database in the United States from 1973 to 2008. The significance of trends in age-adjusted incidence, treatment, and 5-year relative survival rates were determined using chi-square testing and 95% confidence intervals (CIs). Age-adjusted incidence, form of treatment (surgery, radiation, or both), and 5-year relative survival rates. There were 4070 cases of uveal melanoma representing 3.1% of all recorded cases of melanoma. The majority of cases (98.3%) were reported by hospital inpatient/outpatient clinics. Histopathologic confirmation was available in 2804 cases (72.1% for all years). The mean age-adjusted incidence of uveal melanoma in the United States was 5.1 per million (95% CI, 4.8-5.3). The majority of cases (97.8%) occurred in the white population. There was a statistically significant variation of age-adjusted incidence between sexes (male = 5.8, 95% CI, 5.5-6.2; and female = 4.4, 95% CI, 4.2-4.7). A decreasing trend was observed in patients treated with surgery alone (93.8% for 1973-1975 vs. 28.3% for 2006-2008), whereas a corresponding increase was seen in those treated with radiation (1.8% for 1973-1975 vs. 62.5% for 2006-2008). No change in the 5-year relative survival rate (81.6%) was observed from 1973 to 2008. The age-adjusted incidence of uveal melanoma (5.1 per million) has remained unchanged from 1973 to 2008. Despite a shift toward more conservative treatments, survival has not improved during this time period.