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Diagnoses from an On-Line Expert System for Chronic Pain Confirmed by Intra-Operative Findings

Authors:
Keywords: Intra-operative ndings, Expert system for chronic
pain, Back pain, Neck pain, Predicting organic pathology,
Misdiagnosis of chronic pain, Arm pain, Leg pain, On-line
diagnoses.
Introduction
A surgeon is often faced with multi-factorial challenges when
evaluating a patient with chronic pain problems. Chronic pain is
dened as a constant pain lasting 6 months or longer and often
causes psychological problems, which interferes with accurate
medical assessment [1]. X-ray studies, electromyelograms (EMG),
nerve conduction velocity studies and EMG may document an
organic basis of chronic back pain, but some pain problems cannot
be identied by objective tests, since there are many false negative
and false positive results on “objective” medical testing [2-5].
Physician prejudice against woman patients can result in a
signicantly less extensive evaluation of their complaints of
back pain [6]. Litigation may inuence symptoms and the type of
litigation may inuence outcomes [7,8]. For that reason, there is
a need to differentiate between “organic” (valid) and “functional”
(negative physical and laboratory examination) back, neck and
limb pain, before undertaking an extensive medical evaluation,
prescribing narcotic medication, or performing surgery [9]. Patients
often have difculty describing the location of their complaint of
pain. The combination of these factors leads to a misdiagnosis rate
of 40%-80% in chronic pain patients while for specic diagnoses;
this rate may reach as high as 97%, as is the case in the overuse of
the term bromyalgia [10-14]. In order to improve, surgery was
needed on 50%-80% of the misdiagnosed patients [10-13]. The
patient improvement, documented in published outcome studies,
establishes the benet of these surgeries [12,13,15].
The Diagnostic Paradigm and Treatment Algorithm is a 72 question
questionnaire, which asked about patient symptoms, with 2008
possible multiple choice answers, about conditions which improve
or worsen symptoms. It is available in English and Spanish over
the Internet at www.MarylandClinicalDiagnostics.com. It was
designed to evaluate 104 of the most common post-traumatic
injuries, resulting in chronic pain. Based on the diagnoses and
differential diagnoses, a Treatment Algorithm is generated. Results
are emailed back to physicians in 5 minutes after completion
of the test. The diagnoses from the Diagnostic Paradigm have a
96.3% correlation with diagnoses of Johns Hopkins Hospital staff
members [16].
*Corresponding author
Nelson Hendler, Former Assistant Professor of Neurosurgery, Johns
Hopkins University School of Medicine, University in Baltimore,
Maryland, US, Tel: 443-277-0306; E-mail: DocNelse@aol.com
Submitted: 03 Aug 2016; Accepted: 15 Aug 2016; Published: 19 Aug 2016
Journal of Anesthesia & Pain Medicine
Volume 1 | Issue 1 | 1 of 7
J Anesth Pain Med, 2016
Diagnoses from an On-Line Expert System for Chronic Pain Conrmed by Intra-
Operative Findings
Review Article
Alessandro Landi*1, Reginald Davis2, Nelson Hendler3 and Al-Rahim Abbasali Tailor4
Abstract
A number of researchers from Johns Hopkins Hospital report that 40%-80% of chronic pain patients are
misdiagnosed. Previous reports indicate an on-line questionnaire, The Diagnostic Paradigm and Treatment
Algorithm, provides diagnoses with a 96.3% correlation with diagnoses of Johns Hopkins Hospital staff members, in
patients with chronic back, neck or limb pain. This research was undertaken to determine if diagnoses generated by
the Diagnostic Paradigm and Treatment Algorithm could be conrmed by irrefutable indications of pathology, i.e.
intra-operative ndings. Prior to surgery, the Diagnostic Paradigm and Treatment Algorithm was administered to
ten patients. The Diagnostic Paradigm predicted 61/61 (100%) diagnoses which were conrmed intra-operatively.
The Diagnostic Paradigm had 71 false positive diagnoses, but these were part of the differential diagnoses of the
correct diagnoses. These differential diagnoses were rened by medical testing.
1Department of Neurology and Psychiatry, Division of
Neurosurgery, University of Rome.
2Assistant Professor of Neurosurgery, Johns Hopkins University
School of Medicine and Chief of Neurosurgery, Greater Baltimore
Medical Center.
3Former Assistant Professor of Neurosurgery, Johns Hopkins
University School of Medicine.
4Department of Neurological Surgery, Wexner Medical Center,
Ohio State University.
Volume 1 | Issue 1 | 2 of 7J Anesth Pain Med, 2016
The present study is designed to investigate the usefulness of the
Diagnostic Paradigm and Treatment Algorithm for predicting
the presence or absence of intra-operatively documented organic
pathological conditions in patients with chronic back, neck and/
or limb pain. Rather than compare “expert system” diagnosis
to clinical diagnosis, or abnormal medical tests, this research is
an attempt to determine if a properly designed “expert system”
questionnaire and Bayesian analysis of the answers gave diagnoses
which could identify the actual intra-operative ndings, using
predictive analytic techniques. In this fashion, diagnoses from the
“expert system” were conrmed by intra-operative ndings, which
is a much more powerful validation of the accuracy of diagnoses
of the expert system than previous comparisons.
The Diagnostic Paradigm and Treatment Algorithm
Clinical symptoms (what the patient reports to the doctor) in
medicine very often are the result of a convergence of medical
conditions. This means a single symptom, such as pain and
numbness in the last two ngers of a hand, may have multiple
origins, such as a C6-7 radiculopathy, ulnar nerve entrapment, or
thoracic outlet syndrome. Given a single clinical symptom, all
three diagnoses need to be considered, and are rank ordered from
most likely to least likely, as part of the diagnosis and differential
diagnosis. The cause of a single symptom can be rank ordered
based on clinical experience.
The Diagnostic Paradigm was constructed in this fashion, so the
most likely cause for the symptom was considered the working
diagnosis, and in declining order, the other causes for the symptom
were considered. This type of thinking is called Bayesian logic,
and is the basis of the scoring and interpretation of the Diagnostic
Paradigm. The rank order of causes for a symptom was based on a
retrospective chart review of 10,000 charts over a 17 year period of
time. In this review, the origins of a single symptom were tabulated,
and assigned a weight, in terms of percentage of likelihood. This
leads to the diagnoses and differential diagnoses generated by the
Diagnostic Paradigm, followed by the percentage likelihood of a
cause for the symptom following each diagnosis or differential
diagnosis. This format has two consequences. All causes for a
single symptom are included, so no diagnosis is ever missed, and
the diagnoses and differential diagnoses are intentionally overly
inclusive.
In a prospective study to determine the accuracy of retrospectively
derived diagnoses, the diagnoses from the Diagnostic Paradigm
were found to have a 96.3% correlation with diagnoses of Johns
Hopkins Hospital staff members [16]. The output from the
Diagnostic Paradigm lists diagnoses and differential diagnoses,
rank ordered from most likely to least likely, and assigned
a “percentage of likelihood” of the diagnosis, based on the
number of symptoms a patient has divided by the total number
of symptoms a physicians would expect a patient to report for a
certain disorder. Diagnoses are clustered into 18 groups of similar
diagnoses, which are further differentiated by conducting the
medical testing recommended in the Treatment Algorithm. As
an example, if a patient had symptoms compatible with L4-L5
radiculopathy, the symptoms could be caused by a herniated disc at
L4-L5 compressing the nerve root, or by neural foraminal stenosis
of L4-L5. The two diagnoses would be clustered as part of a group
with similar clinical symptoms, which would require the same set
of diagnostics tests to differentiate the cause, i.e. 3D-CT, MRI,
facet block, root block, and provocative discogram. The ultimate
conrmation of the cause of the problem would be intra-operative
ndings.
Medical tests very often have false positive and false negative
results, which confounds the decision to perform surgery.
However, the real concern is not whether a patient has an
abnormal test. This real issue is the presence or absence of intra-
operative pathology, i.e. was the surgery warranted. Therefore,
a verbal test which could predict intra-operative ndings would
be a valuable screening tool for non-medical professionals, such
as psychologists, insurance carriers, or attorneys. It would help
them decide if extensive medical tests should be ordered, and the
Treatment Algorithm portion of the test provides the surgeon with
suggestions for interventional testing which is employed at Johns
Hopkins Hospital, in addition to the common tests, such as the
MRI of discs, in which the false negative rate could reach as high
as a 78% [17].
Methods
Patients
Ten patient charts were reviewed. These consecutively chosen
patients had been selected by the senior author for spinal surgery,
based on his clinical assessment and laboratory studies. Prior
to surgery, each of these ten patients were administered the
Diagnostic Paradigm and Treatment Algorithm, from www.
marylandclinicaldiagnostics.com.
Results
Analysis of Intra-Operative Findings
The operative note from each patient who received surgery was
blindly reviewed by a researcher who did not perform the surgery.
Findings were considered normal if pathology reports and intra-
operative notes indicated no pathology. Findings were considered
mild if pathology reports and/or intra-operative notes found
“mild scaring of a nerve root,” or “mild scarring of a peripheral
nerve” or “mild neural foraminal stenosis,” or “mild compression
of a vessel.” Likewise, if the reports or note contained the
word moderate or severe, then the pathology was considered
moderate or severe. Various surgeries were performed, including
fusions, laminectomies, discectomies, removal of arachnoiditis,
foraminotomy, and others.
Diagnostic Paradigm Diagnoses Intra-operative Findings
L5-S1 Herniated or Disupted Disc
Score=1.000000
L5-S1 Radiculopathy Score=0.937500 1 hard bony stenosis and a
soft stenosis
L4-L5 Radiculopathy Score=0.770833 1 ligamentum avum
hypertrophy.
Volume 1 | Issue 1 | 3 of 7J Anesth Pain Med, 2016
L4-L5 Herniated or Disrupted Disc
Score=0.750000
decompressed the dural
sac
L3-L4 Radiculopathy Score=0.650000 1
L3-L4 Herniated or Disrupted Disc
Score=0.500000
Lumbar Facet Syndrome L3-S1
Score=0.500000 1
Neural Foraminal Stenosis L1-S1
Score=0.500000 1opening of foramen of
L3,L4,L5 and S1 roots.
Lumbar Facet Syndrome L3-S1
Score=0.500000
Neural Foraminal Stenosis L1-S1
Score=0.500000 1
Retrolysthesis L1-S1 - Score=0.500000
L5-S1 Radiculopathy Score=0.946429 1 L5 and S1 roots are de-
compressed bilaterally
L5-S1 Herniated or Disupted Disc
Score=0.937500
Spinal Stenosis of the Lumbar Spine
Score=0.750000 1decompressed the dural
sac
L4-L5 Radiculopathy Score=0.730769 1 L4-L5 with an extensive
scar tissue
L4-L5 Herniated or Disrupted Disc
Score=0.687500
medial arthrectomy of
L4-L5-S1
Arachnoiditis L5-S1 Score=0.687500 1
L3-L4 Radiculopathy Score=0.678571
Lumbar Facet Syndrome L3-S1
Score=0.625000 1hyperthrophy of the facet
joints
Neural Foraminal Stenosis L1-S1
Score=0.625000 1opening of the right fora-
men of L5 and S1
Unstable Spinal Segment at L3-L4
Score=0.522727
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis
Unstable Lumbar Spinal Segment
Score=0.522727 1
Unstable Spinal Segment at L4-L5
Score=0.500000 1Stabilization with pedicu-
lar screws at L4- S1
Retrolysthesis L1-S1 - Score=0.500000
Unstable Spinal Segment at L5-S1
Score=0.500000 1 Posterolateral arthrodesis
L5-S1 Radiculopathy Score=0.946429 1 ligamentum avum
hypertrophy
L5-S1 Herniated or Disupted Disc
Score=0.916667
Neurolysis of the L5 right
root adherence.
Spinal Stenosis of the Lumbar Spine
Score=0.750000 1
L4-L5 Radiculopathy Score=0.704545
Decompressive lami-
nectomy at L3-L4 and
L4-L5.
Arachnoiditis L5-S1 Score=0.687500 1
L4-L5 Herniated or Disrupted Disc
Score=0.666667 1Neurolysis of the dural
adherence
Unstable Spinal Segment at L3-L4
Score=0.550000
lumbar disc herniation at
L4-L5.
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis
s/Unstable Lumbar Spinal Segment
Score=0.550000
L3-L4 Radiculopathy Score=0.550000
Lumbar Facet Syndrome L3-S1
Score=0.541667
Unstable Spinal Segment at L4-L5
Score=0.522727
Unstable Spinal Segment at L5-S1
Score=0.522727
Retrolysthesis L1-S1 - Score=0.500000
L5-S1 Radiculopathy Score=1.000000 1
L5-S1 Herniated or Disupted Disc
Score=0.900000 1Neurolysis of the L5 right
root adherence
Spinal Stenosis of the Lumbar Spine
Score=0.750000 1 Microdiscectomy L5-S1.
L4-L5 Radiculopathy Score=0.727273 Neurolysis of the dural
adherence and scar tissue.
Arachnoiditis L5-S1 - Score=0.678571 1
L4-L5 Herniated or Disrupted Disc
Score=0.650000
Lumbar Facet Syndrome L3-S1
Score=0.625000
Neural Foraminal Stenosis L1-S1
Score=0.625000 1Severe foraminal stenosis
l5-s1
Unstable Spinal Segment at L3-L4
Score=0.562500
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis
Unstable Lumbar Spinal Segment
Score=0.562500
Unstable Spinal Segment at L4-L5
Score=0.538462 1Severe spinal l4-l5-s1
instability
Unstable Spinal Segment at L5-S1
Score=0.538462 1Stabilization with screws
and rods L4-L5-S1.
L3-L4 Radiculopathy Score=0.500000
Retrolysthesis L1-S1 - Score=0.500000
L5-S1 Herniated or Disupted Disc
Score=1.000000
Severe spinal l4-l5
instability
L5-S1 Radiculopathy Score=0.906250 1 Severe right lumbar disc
herniation l4-l5.
L4-L5 Radiculopathy Score=0.781250 Stabilization with screws
and rods L4-L5.
L4-L5 Herniated or Disrupted Disc
Score=0.750000 1
Decompressive lami-
nectomy of L4-L5 with
HARD stenosis.
Unstable Spinal Segment at L3-L4
Score=0.541667
Foraminotomy of L5 with
SEVERE FORAMINAL
STENOSIS.
Lumbar Facet Syndrome L3-S1
Score=0.541667
Microdiscectomy L4-L5
with removal
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis/
of a SEVERE lumbar disc
herniation.
Volume 1 | Issue 1 | 4 of 7J Anesth Pain Med, 2016
Unstable Lumbar Spinal Segment
Score=0.541667 1
Unstable Spinal Segment at L4-L5
Score=0.500000 1
L3-L4 Herniated or Disrupted Disc
Score=0.500000
L3-L4 Radiculopathy Score=0.500000
Retrolysthesis L1-S1 - Score=0.500000
Neural Foraminal Stenosis L1-S1
Score=0.500000 1
Unstable Spinal Segment at L5-S1
Score=0.500000
L5-S1 Radiculopathy Score=0.953125 1 Decompressive laminec-
tomy of L3-L4-L5
L5-S1 Herniated or Disupted Disc
Score=0.850000
SEVERE SPINAL STE-
NOSIS L3-L4-L5
L4-L5 Radiculopathy Score=0.750000 1
L3, L4 and L5 SEVERE
FORAMINAL STENO-
SIS
L4-L5 Herniated or Disrupted Disc
Score=0.600000
due to facet joint hyper-
trophy
Unstable Spinal Segment at L3-L4
Score=0.583333
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis/
Unstable Lumbar Spinal Segment
Score=0.583333
Unstable Spinal Segment at L4-L5
Score=0.550000
L3-L4 Radiculopathy Score=0.550000 1
Unstable Spinal Segment at L5-S1
Score=0.550000
Lumbar Facet Syndrome L3-S1
Score=0.500000 1
Retrolysthesis L1-S1 - Score=0.500000
Unstable Spinal Segment at L5-S1
Score=0.656250 1
L3, L4 & L5 SEVERE
FORAMINAL STENO-
SIS
Unstable Spinal Segment at L3-L4
Score=0.714286 1facet joint hypertrophy
L3. L4 L5
Unstable Spinal Segment at L4-L5
Score=0.656250 1 dural adherence.
L5-S1 Radiculopathy Score=1.000000 1 L3-L4-L5 WITH INSTA-
BILITY
L5-S1 Herniated or Disupted Disc
Score=0.850000 1
L3-L4 Radiculopathy Score=0.833333 1
L4-L5 Radiculopathy Score=0.750000 1
Lumbar Facet Syndrome L3-S1
Score=0.607143 1
L3-S1 Facet Break - Score=0.875000
Lumbar Facet Syndrome L3-S1
Score=0.607143 1
L5-S1 Radiculopathy Score=0.931818 1 SEVERE SPINAL STE-
NOSIS L4-L5
L5-S1 Herniated or Disupted Disc
Score=0.900000
Decompressive laminec-
tomy of L4-L5
L4-L5 Radiculopathy Score=0.750000 with HARD and SOFT
stenosis.
Spinal Stenosis of the Lumbar Spine
Score=0.750000 1 Foraminotomy of L5
Arachnoiditis L5-S1 - Score=0.666667 1 SEVERE FORAMINAL
STENOSIS
L4-L5 Herniated or Disrupted Disc
Score=0.650000
due to facet joint hyper-
trophy
Lumbar Facet Syndrome L3-S1
Score=0.583333 1Neurolysis of dural
adherence.
Unstable Spinal Segment at L3-L4
Score=0.562500
Unstable Spinal Segment at L4-L5
Score=0.562500
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis/
Unstable Lumbar Spinal Segment
Score=0.583333
Unstable Spinal Segment at L5-S1
Score=0.562500
L3-L4 Radiculopathy Score=0.500000
Retrolysthesis L1-S1 Score=0.500000
L3-S1 Facet Break Score=1.000000
Lumbar Facet Syndrome L3-S1
Score=0.583333 1
Retrolysthesis L1-S1 Score=0.500000
L5-S1 Radiculopathy Score=1.000000 1 SEVERE SPINAL STE-
NOSIS L4-L5
L5-S1 Herniated or Disupted Disc
Score=0.892857
Decompressive laminec-
tomy of L4-L5 with
Spinal Stenosis of the Lumbar Spine
Score=0.750000 1HARD and SOFT ste-
nosis.
L4-L5 Radiculopathy - Score=0.708333 1 Foraminotomy of L4
and L5
Arachnoiditis L5-S1 - Score=0.666667 1 SEVERE FORAMINAL
STENOSIS
L4-L5 Herniated or Disrupted Disc
Score=0.642857
due to facet joint hyper-
trophy
Lumbar Facet Syndrome L3-S1
Score=0.562500
Neurolysis of dural
adherence
Unstable Spinal Segment at L3-L4
Score=0.550000
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis/
Unstable Lumbar Spinal Segment
Score=0.583333
Unstable Spinal Segment at L4-L5
Score=0.531250
Unstable Spinal Segment at L5-S1
Score=0.531250
L3-L4 Radiculopathy Score=0.500000
Retrolysthesis L1-S1 - Score=0.500000
Volume 1 | Issue 1 | 5 of 7J Anesth Pain Med, 2016
Neural Foraminal Stenosis L1-S1
Score=0.500000 1
L3-S1 Facet Break - Score=0.875000
Lumbar Facet Syndrome L3-S1
Score=0.562500 1
Neural Foraminal Stenosis L1-S1
Score=0.500000 1
L5-S1 Radiculopathy Score=1.000000 extraforaminal disc herni-
ation l4-l5
L5-S1 Herniated or Disupted Disc
Score=0.900000
removal of medial articu-
lar mass of l4,
L4-L5 Radiculopathy Score=0.750000 1 removal of the hernia
which compress and
L3-L4 Radiculopathy Score=0.666667 disloged the l4 root out-
side the l4 right foramen,
L4-L5 Herniated or Disrupted Disc
Score=0.650000 1
stabilization with inter-
spinous fusion device
ASPEN
Unstable Spinal Segment at L3-L4
Score=0.625000
Unstable Spinal Segment at L4-L5
Score=0.625000 1
Spondylolysis/Spondylolythesis/Ante-
rio-Lysthesis/
Unstable Lumbar Spinal Segment
Score=0.583333 1
Unstable Spinal Segment at L5-S1
Score=0.625000 1
Retrolysthesis L1-S1 - Score=0.500000
TOTAL
Table 1: Lists the various surgeries for which intra-operative ndings
were reviewed.
Discussion
A number of decits exist with expert systems. In the absurd
extreme, if the computerized expert system lists all the possible
diagnoses, there is 100% sensitivity, but the specicity is very low.
Conversely, if the specicity is tightened to such a degree that the
computerized expert system always gets a specic diagnosis, but
misses other associated diagnoses, the sensitivity of the system is
reduced to a level of inaccuracy that approaches or exceeds the
lack of accuracy of current physician diagnostic skills and no
benet accrues from the use of the computerized expert system
[1-4].
After 30 years of work in this area, some authors feel only limited
progress has been made in expert systems [18]. Engelbrecht feels
that the quality of knowledge used to create the system, and the
availability of patient data are the two main problems confronting
any developer of an expert system, and advocates an electronic
medical record system to correct one component of the problem
[19]. Babic concurs with the value of the longitudinal collection
of clinical data, and data mining to develop expert systems [20].
The accuracy of any computer scored and interpreted expert
systems are a major issue. One of the major sources of error seems
to be the use of Boolean logic in programming the expert system.
The other problem is selecting too broad a topic of medicine, such
as “internal medicine.” As an example, think of the differential
diagnoses associated with the symptom of “fever.” Even if this is
broken down into “fever below 100 F,” fever between 100 and 102
F,” and fever greater than 102 F,” the task of determine a diagnosis
for a symptom such as fever becomes daunting.
Those expert systems that seem to have the best results are the
ones that focus on a narrow and highly specialized area of
medicine. One questionnaire consists of 60 questions, to cover
32 rheumatologic diseases, for 358 patients [21]. The correlation
rate was 74.4%, and an error rate of 25.6%, with the 44% of the
errors attributed to “information decits of the computer using
standardized questions,” [21]. However, a later version called
“RHEUMA” was used prospectively in 51 outpatients, and
achieved a 90% correlation with clinical experts [22]. Several
groups have approached the diagnosis of jaundice. ICTERUS
produced a 70% accuracy rate while ‘Jaundice’ also had a 70%
overall accuracy rate [23,24]. An expert system for vertigo was
reported, and it generated and accuracy rate of 65%, [25]. This
later was reported as OtoNeurological Expert (ONE), which
generated the exact same results reported in the earlier article [26].
There was a 76% agreement for diagnosis of depression, between
an expert system and a clinician [27]. When a Computer Assisted
Diagnostic Interview (CADI) was used to diagnosis a broad range
of psychiatric disorders, there was an 85.7% agreement level with
three clinicians [28]. In a review of twenty charts by a computerized
analysis of treatment for hypertension, using Hyper Critic, a panel
of 18 family practitioners felt the treatment suggested by the
computer system was erroneous or possibly erroneous 16% of the
time [28]. The panel accepted Hyper Critics critiques equally as
benecial as critiques from 8 human reviewers [29]. Others have
developed a “to do” list to remind and alert treating physicians
about tests they should order, based on input into electronic patient
records [30]. In the narrow area of managing lipid levels, there
was a 93% agreement between management advice given by the
expert system, and the specialist, after interpretation of laboratory
and clinical data [31]. However, physicians have a 65% level of
accepting comments from expert systems regarding diagnosis of
a patient, and are resistant to comments about prescriptions for
patients, with only a 35% acceptance level [32]. Therefore, there
may be more resistance from untrained physician to the use of the
diagnostic studies recommended by the Report of the Diagnostic
Paradigm, than there might be to accepting the diagnoses generated
by the Report of the Diagnostic Paradigm. This premise needs to
be tested in future research.
The rationale for the output of the Diagnostic Paradigm was
to have a high degree of sensitivity, i.e. to be as inclusive as
possible with diagnoses and differential diagnoses, and then use
the recommended diagnostic studies and laboratory tests in the
Treatment Algorithm to increase the specicity of the diagnoses.
This led to generating a large number of false positive results,
which then would require renement using objective testing. In
Volume 1 | Issue 1 | 6 of 7J Anesth Pain Med, 2016
this fashion, the chance of missing a possible diagnosis is reduced.
Moreover, 100% of the false positive results were within the same
cluster of diagnostic considerations or the Diagnostic Group as the
diagnosis which predicted a positive intra-operative nding. As an
example, L4-5 retrolysthesis, in the absence of neural foraminal
stenosis, and L3-S1 facet syndrome will have very similar clinical
manifestations, which would be impossible to differentiate on
the basis of symptoms alone, i.e. worse pain in the lower back
when leaning backwards, and improvement with exion, and can
be differentiated only by testing recommended in the Treatment
Algorithm.
Many of the recommended diagnostic studies from the Treatment
Algorithm are not commonly used in community medical centers,
but have been used for years by major teaching hospitals in the
United States. A classic example of this is the wide spread use
of the MRI for detecting disc damage in the cervical and lumbar
spine. However, in 98 patients with no complaint of back pain,
the MRI has a 29% false positive rate, i.e. the MRI says there is
pathology in a disc, in patients who are asymptomatic and a 69%-
79% false negative rate, i.e. the MRI says there is no abnormality,
in patients who are symptomatic, and have positive provocative
discogram [33-35]. The value of the provocative discogram is
clearly demonstrated by the groundbreaking work by Bogduk,
who clearly demonstrated pain bers in the posterior portion of
the annulus of an inter-vertebral disc, which can be damaged, and
produce pain, without any anatomical distortion of the disc [36].
He terms this condition “internal disc disruption” [37]. Central to
understanding the value of the provocative discogram the concept
that pain is a physiological condition, not an anatomical event.
While the use of an MRI can detect only anatomical distortions,
the use of the provocative discogram, which is a physiological
test, is more reliable for diagnosing chronic pain. The same
rationale applies to the use of other physiological tests, used to
make diagnoses in chronic pain patients, such as root blocks,
nerve blocks, facet blocks, peripheral nerve blocks, bone scans,
gallium scans, Indium 111 scans, neurometer studies, EMG/nerve
conduction velocity studies, somatosensory evoked potentials,
and exion-extension X-rays with oblique’s. This is why the
majority of the recommended tests in the Treatment Algorithm are
physiological ones.
Additionally, there were 61 pathological conditions found intra-
operatively by the senior author on the 10 patients included
in the study, or 6.1 diagnoses per patient on the average. This
indicates the complex nature of the type of patients included in
the study. The higher than normal level of medical diagnoses is
further complicated by the average IQ of 93 found in workers
compensation patients with active cases, which comprised 35% of
the Mensana Clinic population as well as 6% of the population that
was functionally illiterate [10,11]. Therefore, 41% of the patient
population would have some difculty reading and understanding
a written questionnaire. Since patients do not accurately complete
paper and pencil questionnaires, this results in faulty information
being conveyed and analyzed. This underscores the necessity of
developing an input methodology that forces the patient to complete
the questionnaire properly, such as an automated entry mechanism,
that notes inconsistencies, i.e. if a patient marks he has pain in the
leg, then he must complete the section on the symptoms of pain,
or else the system will not let the patient continue. Conversely, if
a patient does not mark that he has leg pain in the verbal section
of the tests, and then completes the symptoms in the pictorial
section of the test, he should be instructed to return to the verbal
section. This potential source of errors has been addressed in a
computerized version of the Diagnostic Paradigm and Treatment
Algorithm, which is now available over the Internet, at www.
mensanadiagnostics.com.
The purpose of an “expert system” is to improve the level of the
reliability and accuracy of diagnosis, and enhance medical care.
While the Diagnostic Paradigm is a rst step to help diagnosis
chronic pain patients, further research is needed to rene the value
of the Diagnosis Paradigm. Work needs to be done by reducing the
number of False Positive results, and by expanding the number
of diagnoses covered by Diagnostic Paradigm. Moreover, the
Treatment Algorithm can be further rened to make testing more
specic. Finally, the Diagnostic Paradigm needs testing at other
medical centers for further validation with other clinicians.
References
1. Hendler N (1982) The four stages of pain. Diagnosis and
Treatment of Chronic Pain. Wright-PSG Publishing Co: 1-8.
2. Hendler N, Uematesu S, Long D (1982) Thermographic
validation of physical complaints in ‘psychogenic pain’
patients. Psychosomatics 23: 283-287.
3. Hender N, Zinreich J, Kozikowski J (1993) Three-dimensional
CT validation of physical complaints in “psychogenic pain”
patients. Psychosomatics 34 :90-96.
4. Uematsu S, Hendler N, Hungerford D, Long D, Ono N (1981)
Thermography and electromyography in the differential
diagnosis of chronic pain syndromes and reex sympathetic
dystrophy. Electromyogr Clin Neurophysiol 21: 165-182.
5. Brown BR Jr (1978) Diagnosis and therapy of common
myofascial syndromes. JAMA 239: 646-648.
6. Armitage KJ, Schneiderman LJ, Bass RA (1979) Response of
physicians to medical complaints in men and women. JAMA
241: 2186-2187.
7. Daus AT, Freeman WW, Wilson J (1984) Psychological
variable and treatment outcome of compensation and auto
accident patients in a multidisciplinary chronic spinal pain
clinic. Orthop Rev 13: 596-605.
8. Talo S, Hendler N, Brodie J (1989) Effects of active
and completed litigation on treatment results: workers’
compensation patients compared with other litigation patients.
J Occup Med 31: 265-269.
9. Southwick SM, White AA (1983) The use of psychological
tests in the evaluation of low-back pain. J Bone Joint Surg Am
65: 560-565.
10. Hendler N, Kozikowski J (1993) Overlooked Physical
Diagnoses in Chronic Pain Patients Involved in Litigation.
Psychosomatics 34: 494-501.
11. Hendler N, Bergson C, Morrison C (1996) Overlooked
Volume 1 | Issue 1 | 7 of 7J Anesth Pain Med, 2016
physical diagnoses in chronic pain patients involved in
litigation, Part 2. The addition of MRI, nerve blocks, 3-D CT,
and qualitative ow meter. Psychosomatics 37: 509-517.
12. Long D, Davis R, Speed W, Hendler N (2006) Fusion For
Occult Post-Traumatic Cervical Facet Injury. Neurosurg 16:
129-135.
13. Dellon AL, Andonian E, Rosson GD (2009) CRPS of the
upper or lower extremity: surgical treatment outcomes. J
Brachial Plex Peripher Nerve Inj 4: 1.
14. Hendler N, Murphy ME, Romano T (2010) Chronic Pain Due
to Thoracic Syndrome, Acromo-Clavicular Joint Syndrome,
Disrupted Disc, Nerve Entrapments, Facet Syndrome, and
Other Disorders Misdiagnosed as Fibromyalgia: 10-13.
15. Hendler N (1988) Validating and Treating the Complaint of
Chronic Back Pain: The Mensana Clinic Approach. Clinical
Neurosurgery 35: 385-397.
16. Hendler N, Berzoksky C, Davis RJ (2007) Comparison of
Clinical Diagnoses Versus Computerized Test Diagnoses
Using the Mensana Clinic Diagnostic Paradigm (Expert
System) for Diagnosing Chronic Pain in the Neck, Back and
Limbs. Pan Arab Journal of Neurosurgery: 8-17.
17. Sandhu HS, Sanchez-Caso LP, Parvataneni HK, Cammisa
FP Jr, Girardi FP, et al. (2000) Association between ndings
of provocative discography and vertebral endplate signal
changes as seen on MRI. J Spinal Disord 13: 438-443.
18. Metaxiotis KS, Samouilidis JE (2000) Expert systems in
medicine: academic exercise or practical tool? J Med Eng
Technol 24: 68-72.
19. Engelbrecht R (1997) [Expert systems for medicine--functions
and developments]. Zentralbl Gynakol 119: 428-434.
20. Babic A (1999) Knowledge discovery for advanced clinical
data management and analysis. Stud Health Technol Inform
68: 409-413.
21. Schewe S, Herzer P, Krüger K (1990) Prospective application
of an expert system for the medical history of joint pain. Klin
Wochenschr 68: 466-471.
22. Schewe S, Schreiber MA (1993) Stepwise development of a
clinical expert system in rheumatology. Clin Investig 71: 139-
144.
23. Molino G, Marzuoli M, Molino F, Battista S, Bar F, et al.
(2000) Validation of ICTERUS, a knowledge-based expert
system for Jaundice diagnosis. Methods Inf Med 39: 311-318.
24. Cammà C, Garofalo G, Almasio P, Tinè F, Craxì A, et al.
(1991) A performance evaluation of the expert system
‘Jaundice’ in comparison with that of three hepatologists. J
Hepatol 13: 279-285.
25. Kentala E, Auramo Y, Juhola M, Pyykkö I (1998) Comparison
between diagnoses of human experts and a neurotologic expert
system. Ann Otol Rhinol Laryngol 107: 135-140.
26. Kentala EL, Laurikkala JP, Viikki K, Auramo Y, Juhola M, et
al. (2001) Experiences of otoneurological expert system for
vertigo. Scand Audiol Suppl : 90-91.
27. Cawthorpe D (2001) An evaluation of a computer-based
psychiatric assessment: evidence for expanded use.
Cyberpsychol Behav 4: 503-510.
28. Miller PR, Dasher R, Collins R, Grifths P, Brown F (2001)
Inpatient Diagnostic Assessments: 1. Accuracy of Structured
vs. Unstructured Interviews. Psychiatry Res. 105: 255-264.
29. van der Lei J, van der Does E, Man in ‘t Veld AJ, Musen MA,
van Bemmel JH (1993) Response of general practitioners
to computer-generated critiques of hypertension therapy.
Methods Inf Med 32: 146-153.
30. Silverman BG, Andonyadis C, Morales A (1998) Web-based
health care agents; the case of reminders and todos, too
(R2Do2). Artif Intell Med 14: 295-316.
31. Sinnott MM, Carr B, Markey J, Brosnan P, Boran G, et al.
(1993) Knowledge Based Lipid Management System for
General Practitioners. Clin Chim Acta 222: 71-77.
32. Kuilboer MM, van der Lei J, de Jongste JC, Overbeek SE,
Ponsioen B, et al. (1998) Simulating an integrated critiquing
system. J Am Med Inform Assoc 5: 194-202.
33. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT,
Malkasian D, et al. (1994) Magnetic resonance imaging of the
lumbar spine in people without back pain. N Engl J Med 331:
69-73.
34. Braithwaite I, White J, Saifuddin A, Renton P, Taylor BA
(1998) Vertebral end-plate (Modic) changes on lumbar
spine MRI: correlation with pain reproduction at lumbar
discography. Eur Spine J 7: 363-368.
35. Sandhu HS, Sanchez-Caso LP, Parvataneni HK, Cammisa
FP Jr, Girardi FP, et al. (2000) Association between ndings
of provocative discography and vertebral endplate signal
changes as seen on MRI. J Spinal Disord 13: 438-443.
36. Carragee EJ, Chen Y, Tanner CM, Truong T, Lau E, et al.
(2000) Provocative discography in patients after limited
lumbar discectomy: A controlled, randomized study of pain
response in symptomatic and asymptomatic subjects. Spine
25: 3065-3071.
37. Bogduk, McGuirk (2002) Pain Research and Clinical
Management. Elsevier 13: 119-122.
Copyright: ©2016 Hendler N. is is an open-access article distributed
under the terms of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium,
provided the original author and source are credited.
... To address the high rate of misdiagnoses in chronic pain patients, a group of physicians from Johns Hopkins Hospital developed a Diagnostic Paradigm for Chronic Pain which duplicates diagnoses of Johns Hopkins doctors 96% of the time (15). Using the accurate diagnoses generated by this Internet based questionnaire allowed surgeons to predict what they would find intra-operatively 100% of the time (16). Subsequently, physicians from Johns Hopkins Hospital and University of Rome developed a Headache Diagnostic Paradigm which duplicated their diagnoses 94% of the time (5). ...
... These diagnoses have a 96% correlation with diagnoses of Johns Hopkins Hospital doctors (15). Based on the correct diagnosis, the Treatment Algorithm recommends the correct test to use, which are the tests used at Johns Hopkins Hospital, and often not in common use (3) The efficacy of this technique has been documented by the ability of the Diagnostic Paradigm and Treatment Algorithm to predict intra-operative finding with 100% accuracy (16), as well as outcome studies documenting consistent patient improvement after they have properly diagnosed and correctly tested and treating by following the recommendations of the Diagnostic Paradigm and Treatment Algorithm (31,32,33). Using the Diagnostic Paradigm and Treatment Algorithm to serve as a basis for duplicating a consistent evaluation method has a number of advantages. ...
... Using the Diagnostic Paradigm and Treatment Algorithm to serve as a basis for duplicating a consistent evaluation method has a number of advantages. The Diagnostic Paradigm and Treatment algorithm provides a method of obtaining a thorough history, without interruption of the patient, in a language the patient could understand (English or Spanish) with 100% inter-rater reliability, since all physicians would use the test for diagnostic evaluations, which would not take any physician time to obtain, and takes only 5 minutes of staff time to administer, is far cheaper than the $140,000 needed for one on one training, produces a diagnosis with a 96% correlation with diagnoses of Johns Hopkins Hospital physicians, and has published outcome studies documenting the efficacy of this expert system (16,31,32,33). This seems to be an ideal "expert system" for use by anaesthesiologist, and other specialists. ...
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... To address the high rate of misdiagnoses in chronic pain patients, a group of physicians from Johns Hopkins Hospital developed a Diagnostic Paradigm for Chronic Pain which duplicates diagnoses of Johns Hopkins doctors 96% of the time (15). Using the accurate diagnoses generated by this Internet based questionnaire allowed surgeons to predict what they would find intra-operatively 100% of the time (16). Subsequently, physicians from Johns Hopkins Hospital and University of Rome developed a Headache Diagnostic Paradigm which duplicated their diagnoses 94% of the time (5). ...
... These diagnoses have a 96% correlation with diagnoses of Johns Hopkins Hospital doctors (15). Based on the correct diagnosis, the Treatment Algorithm recommends the correct test to use, which are the tests used at Johns Hopkins Hospital, and often not in common use (3) The efficacy of this technique has been documented by the ability of the Diagnostic Paradigm and Treatment Algorithm to predict intra-operative finding with 100% accuracy (16), as well as outcome studies documenting consistent patient improvement after they have properly diagnosed and correctly tested and treating by following the recommendations of the Diagnostic Paradigm and Treatment Algorithm (31,32,33). Using the Diagnostic Paradigm and Treatment Algorithm to serve as a basis for duplicating a consistent evaluation method has a number of advantages. ...
... Using the Diagnostic Paradigm and Treatment Algorithm to serve as a basis for duplicating a consistent evaluation method has a number of advantages. The Diagnostic Paradigm and Treatment algorithm provides a method of obtaining a thorough history, without interruption of the patient, in a language the patient could understand (English or Spanish) with 100% inter-rater reliability, since all physicians would use the test for diagnostic evaluations, which would not take any physician time to obtain, and takes only 5 minutes of staff time to administer, is far cheaper than the $140,000 needed for one on one training, produces a diagnosis with a 96% correlation with diagnoses of Johns Hopkins Hospital physicians, and has published outcome studies documenting the efficacy of this expert system (16,31,32,33). This seems to be an ideal "expert system" for use by anaesthesiologist, and other specialists. ...
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Full-text available
Research by Johns Hopkins Hospital physicians found that 40%-95% of chronic pain patients were not properly diagnosed. By using an on-line diagnostic test which gives diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors, several physician groups reported an increase use of interventional testing up to 192% of the time.
... At his initial evaluation, he received the Pain Validity Test, which predicted that he would have a 95% chance of having a medical test abnormality on the correct medical testing 24,25 . He also took the Diagnostic Paradigm which provides diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors 26 , and can predict intra-operative findings with 100% accuracy 27 . The Diagnostic Paradigm found that the patient had internal disc disruption at C4-5 and C5-6, and anteriolysthesis of C5 on C6. ...
... Cost of correct diagnosis with surgery for 3 months 24,25 . She also took the Diagnostic Paradigm which provides diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors 26 , and can predict intra-operative findings with 100% accuracy 27 . The Diagnostic Paradigm found that the patient had internal disc disruption at L4-5. ...
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... At her initial evaluation, she received the Pain Validity Test, which predicted that she would have a 95% chance of having a medical test abnormality on the correct medical testing 24,25 . She also took the Diagnostic Paradigm which provides diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors 26 , and can predict intra-operative findings with 100% accuracy 27 . The Diagnostic Paradigm found that the patient had internal disc disruption at L4-5. ...
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Provocative discography is a controversial diagnostic tool for pathologic discs. Modic has identified vertebral endplate signal changes on magnetic resonance imaging (MRI) that are thought to signify advanced discogenic degeneration. These two distinct diagnostic tools are examined to determine if there is association between them. Fifty-three consecutive patients who underwent both investigations were retrospectively reviewed. In discs that had negative T1 MRI findings, 28.2% of patients had concordant pain and 17.3% had discordant pain. In discs with positive T1 MRI findings, 34.8% of patients had concordant pain and 17.4% had discordant pain. 79.5% and 74.4% of levels with patient concordant pain on discography had no endplate changes on T1-and T2-weighted MR images, respectively (compared with 84.5% and 81.7%, respectively, for levels with no patient pain on discography). Our data showed no significant relationship between these distinct diagnostic tools. Further investigation of their relative roles in this application is recommended.
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Workups by physicians in response to five common complaints in a sample of 104 men and women--52 married couples--were evaluated by chart audit. For the total group of complaints, back pain, headache, dizziness, chest pain, and fatigue, the physicians' workups were significantly more extensive for men than they were for women. These data tend to support the argument that male physicians take medical illness more seriously in men than in women.
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PHYSICIANS commonly are faced with cervical and lumbar pain problems from antecedent trauma, muscular tension, or postural abnormalities. The common denominator of these conditions is skeletal muscle and ligamentous strain. Pain originating from lesions in these structures, regardless of anatomic localization, has been termed "primary myofascial syndrome." Paramount to the diagnosis of myofascial syndrome is the absence of demonstrable neurologic or orthopedic deficits. In fact, this constellation of pain problems frequently mimics conditions such as herniated cervical and lumbar disks, facet syndromes, fractured transverse processes, thoracic outflow syndrome, and spondylolisthesis. Obviously, therapy for these latter diagnoses is different from that for primary myofascial syndrome, and attention should be given to ruling out such surgically correctable lesions by evaluation of past history, adequate physical examination, and appropriate laboratory and roentgenographic studies. More than 500 cases of primary myofascial syndrome have been diagnosed and treated in the past six years at the
Article
An expert system with 60 questions about medical history was developed for 32 rheumatologic diseases: 358 outpatients with joint complaints have been examined. The final diagnosis (result of symptoms, signs, and findings) was compared with the computer diagnoses and with the independently assumed diagnoses of the physician. The only source of information available to the physician was the medical history. Misinterpretation of the computer diagnoses occurred in 25.6% of cases compared with 21.5% of the physician. The final clinical diagnosis remained uncertain in 32.6% of cases. The error frequency of the expert system was influenced by the underlying disease, the certainty of the assumed diagnosis by the physician, the user experience in rheumatology, the number of questions asked, and the time of application before or after the doctor-patient contact. Of the errors 44% were produced because of information deficits of the computer using standardized questions. The information of the physician in the diagnostic process is quite different to that of the computer.