We describe a model in which guilt and shame associate with reactions to wrongdoing among perpetrators of interpersonal harm. Individuals who reported wronging another person (N = 410) completed measures of perceived transgression severity, guilt and shame, and possible reactions to perpetration of wrongdoing (i.e., forgiving, punishing, and excusing oneself). Guilt positively predicted forgiving ... [Show full abstract] and punishing oneself, and negatively predicted excusing oneself of blame. Shame, in contrast, negatively predicted forgiving oneself and positively predicted punishing and excusing oneself. The observed patterns of associations between guilt and shame with perpetrators’ reactions to wrongdoing provide further support for the dual-process model of self-forgiveness. Implications for future basic and applied investigations are discussed.