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Abstract

Yogic life style, a form of holistic mind-body medicine, is known to reduce stress and sympathetic tone6. Recent randomized controlled trial found holistic yoga program for 12 weeks to be significantly better than physical exercise in reducing Anti-Mullerian Hormone, Luteinizing Hormone and Testosterone, Modified Ferriman and Gallway (mFG) score for hirsutism and improving menstrual frequencies in PCOS patients. Yoga not only addresses the problems of PCOS but is likely to prevent the long term complications such as Cardio-vascular diseases, diabetes etc. Further, yoga, being holistic in its approach, is potentially more cost-effective and enduring. Hence yoga may be recommended as both a primary intervention and/or as adjunct to standard medical care for management of PCOS.
Clinical Roundup: Selected Treatment Options for
Polycystic Ovary Syndrome
To cite this article:
Alternative and Complementary Therapies. April 2013, 19(2): 101-106.
doi:10.1089/act.2013.19205.
Published in Volume: 19 Issue 2: April 16, 2013
Yoga for Polycystic Ovarian Syndrome
Poly Cystic Ovarian Syndrome (PCOS) is the most common female endocrine disorder with prevalence
estimates, ranging from 2.2 percent to as high as 26 percent1. It is believed that both genetic
predisposition and life style factors contribute to the etiology of PCOS2. Altered life style that includes
high calorie diet and lack of exercise resulting in obesity and insulin resistance which has been well
recognized as a exacerbating factor for PCOS3. Association between stress and PCOS has also been
documented 4. Adult women with PCOS have a 10-fold increased risk of developing type 2 diabetes, and
a 2-fold increased risk of the metabolic syndrome. There are studies suggesting that chronic stimulation
of sympathetic activity, a result of stressful life style, can induce dysregulation of the Hypothalamus-
Pituitary-Ovarian axis (HPO axis) in women with PCOS5.
Yogic life style, a form of holistic mind-body medicine, is known to reduce stress and sympathetic tone6.
Recent randomized controlled trial7 found holistic yoga program for 12 weeks to be significantly better
than physical exercise in reducing Anti-Mullerian Hormone, Luteinizing Hormone and Testosterone,
Modified Ferriman and Gallway (mFG) score for hirsutism and improving menstrual frequencies in
PCOS patients. Yoga not only addresses the problems of PCOS but is likely to prevent the long term
complications such as Cardio-vascular diseases, diabetes8 etc. Further, yoga, being holistic in its
approach, is potentially more cost-effective and enduring. Hence yoga may be recommended as both a
primary intervention and/or as adjunct to standard medical care for management of PCOS.
Following yogic practices are found to be useful in PCOS:
1. Physical postures (Asanas - 1 min each): a) Surya Namaskara (Sun Salutation) for 10 min; b)
prone asanas - Cobra Pose (Bhujangasana), Locust Pose (Salabhasana), Bow Pose
(Dhanurasana) ; c) standing asanas such as Triangle Pose (Trikonasana), Twisted Angle Pose
(Parsva -konasana), Spread Leg Intense Stretch (Prasarita padottanasana); d) supine asanas -
Inverted Pose (Viparita Karni), Shoulder Stand (Sarvangasana), Plough Pose (Halasana); e)
sitting asanas - sitting forward Stretch (Paschimottanasana), fixed angle Pose (Baddha-
konasana), Garland Pose (Malasana)
2. Breathing Techniques (Pranayama 2 min each): Sectional Breathing (Vibhagiya- Pranayama),
Forceful Exhalation (Kapala Bhati), Right Nostril Breathing (Suryanuloma Viloma) 2min,
Alternate nostril breathing (Nadi suddhi)
3. Guided relaxation (Savasana) for 10 min
4. OM Meditation (OM Dhyana) for 10 min
5. Group Lecture: Lectures, in the form of cognitive restructuring based on the spiritual philosophy
underlying yogic concepts, spiritual coping strategies etc.
REFERENCES
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2. Jahanfar S, Eden JA. Genetic and non-genetic theories on the etiology of polycystic ovary
syndrome. Gynecological Endocrinology. 1996;10(5):357-364.
3. Holte J. Disturbances in insulin secretion and sensitivity in women with the polycystic
ovary syndrome. Baillieres Clin Endocrinol Metab. 1996;10:221-47.
4. Rasgon NL, Rao RC, Hwang S, et al. Depression in women with polycystic ovary
syndrome:clinical and biochemical correlates. J Affect Disord. 2003;74:299-304.
5. Diamanti-Kandarakis E. PCOS in adolescents. Best Practice & Research Clinical Obstetrics
& Gynaecology. 2009;24(2):173-83.
6. Sahajpal P, Ralte R. Impact of induced yogic relaxation training (IYRT) on stress level, self-
concept and quality of sleep among minority group individuals. J Indian Psychol.
2000;18:66-73.
7. Nidhi R, Padmalatha V, Nagarathna R, Amritanshu R.The effects of a holistic yoga program
on endocrine parameters in adolescents with polycystic ovarian syndrome. J Pediatr Adolesc
Gynecol. 2011 Aug;24(4):223-7.
8. Innes KE, Vincent HK. The influence of yoga-based programs on risk profiles in adults with type
2 diabetes mellitus: a systematic review. Evid Based Complement Alternat Med.2007; 4:469
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Hemant Bhargav, MBBS, MD (Y&R)*
*Corresponding author
Swami Vivekananda Yoga Anusandhana Samsthana
(S-VYASA)University
K.G. Nagar, Bengaluru, India
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Article
Full-text available
There is growing evidence that yoga may offer a safe and cost-effective intervention for Type 2 Diabetes mellitus (DM 2). However, systematic reviews are lacking. This article critically reviews the published literature regarding the effects of yoga-based programs on physiologic and anthropometric risk profiles and related clinical outcomes in adults with DM 2. We performed a comprehensive literature search using four computerized English and Indian scientific databases. The search was restricted to original studies (1970-2006) that evaluated the metabolic and clinical effects of yoga in adults with DM 2. Studies targeting clinical populations with cardiovascular disorders that included adults with comorbid DM were also evaluated. Data were extracted regarding study design, setting, target population, intervention, comparison group or condition, outcome assessment, data analysis and presentation, follow-up, and key results, and the quality of each study was evaluated according to specific predetermined criteria. We identified 25 eligible studies, including 15 uncontrolled trials, 6 non-randomized controlled trials and 4 randomized controlled trials (RCTs). Overall, these studies suggest beneficial changes in several risk indices, including glucose tolerance and insulin sensitivity, lipid profiles, anthropometric characteristics, blood pressure, oxidative stress, coagulation profiles, sympathetic activation and pulmonary function, as well as improvement in specific clinical outcomes. Yoga may improve risk profiles in adults with DM 2, and may have promise for the prevention and management of cardiovascular complications in this population. However, the limitations characterizing most studies preclude drawing firm conclusions. Additional high-quality RCTs are needed to confirm and further elucidate the effects of standardized yoga programs in populations with DM 2.
Article
Objectives: The objectives of this trial were to compare the effects of a holistic yoga program with the conventional exercise program in adolescent polycystic ovarian syndrome (PCOS). Design: This was a prospective, randomized, active controlled trial. Setting: Ninety (90) adolescent (15-18 years) girls from a residential college in Andhra Pradesh who satisfied the Rotterdam criteria were randomized into two groups. Intervention: The yoga group practiced a holistic yoga module, while the control group practiced a matching set of physical exercises (1 hour/day, for 12 weeks). Outcome measures: Anti-müllerian hormone (AMH-primary outcome), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, prolactin, body-mass index (BMI), hirsutism, and menstrual frequency were measured at inclusion and after 12 weeks. Results: Mann-Whitney test on difference score shows that changes in AMH (Y=-2.51, C=-0.49, p=0.006), LH, and LH/FSH ratio (LH: Y=-4.09, C=3.00, p=0.005; LH/FSH: Y=-1.17, C=0.49, p=0.015) were significantly different between the two intervention groups. Also, changes in testosterone (Y=-6.01, C=2.61, p=0.014) and Modified Ferriman and Gallway (mFG) score (Y=-1.14, C=+0.06, p=0.002) were significantly different between the two groups. On the other hand, changes in FSH and prolactin postintervention were nonsignificantly different between the two groups. Also, body weight and BMI showed nonsignificantly different changes between the two groups, while changes in menstrual frequency were significantly different between the two groups (Y=0.89, C=0.49, p=0.049). Conclusions: A holistic yoga program for 12 weeks is significantly better than physical exercise in reducing AMH, LH, and testosterone, mFG score for hirsutism, and improving menstrual frequency with nonsignificant changes in body weight, FSH, and prolactin in adolescent PCOS.
Article
Polycystic ovary syndrome (PCOS), a heterogeneous syndrome of unknown aetiology, is the leading cause of anovulation, hirsutism and infertility in women. This multifactorial syndrome emerges at puberty and has cardiovascular and metabolic sequelae through menopause. The common features of normal puberty, namely menstrual irregularities and insulin resistance, obscure the diagnosis of adolescent PCOS, while there are no established diagnostic criteria for PCOS in this age group. The clinical implications of PCOS diagnosis in adolescents remain unclear. Experts in the field still ponder whether PCOS should be managed at such a young age with a view to hindering the long-term sequelae of the syndrome.
Article
Insulin resistance, defined as a diminished effect of a given dose of insulin on glucose homeostasis, is a highly prevalent feature of women with PCOS. Insulin resistance in PCOS is closely associated with an increase in truncal—abdominal fat mass, elevated free fatty acid levels, increased androgens, particularly free testosterone through reduced SHBG levels, and anovulation. The causes for insulin resistance in PCOS are still unknown. One line of evidence suggests that an increase in truncal—abdominal fat mass and subsequently increased free fatty acid levels induce insulin resistance in women with PCOS. Increased effects of corticosteroids and a relative reduction in oestrogen and progesterone seem to be involved in the aberrant body fat distribution. Conversely, there are also results supporting primary, genetic target cell defects as a cause of insulin resistance in PCOS. An explanation for these seemingly contradictory results could be that the group of women with PCOS is heterogeneous with respect to the primary event in carbohydrate/insulin disturbances.
Article
Polycystic ovary syndrome (PCOS) is a common endocrine disorder; the precise cause of it remains elusive. This review summarizes the genetic and non-genetic theories that have been postulated to explain the etiology of this enigmatic condition.
Article
We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS). Thirty-two women with PCOS completed the Center for Epidemiological Studies-Depression Rating Scale (CES-D). Clinical and biochemical characteristics were assessed. Sixteen women had CES-D scores indicative of depression. Depression was associated with greater insulin resistance (P=0.02) and higher body mass index (P=0.05). Women receiving oral contraceptives for the treatment of PCOS were less depressed than patients not receiving treatment (P=0.03). Possible selection bias, use of a screening tool alone without further diagnostic evaluation of depression, small samples size and lack of direct comparison with an age matched control group, should be considered in interpretation of these results. Findings suggest a high prevalence of depression among women with PCOS, and an association between depression and PCOS markers.
Article
The objective was to determine the prevalence and metabolic parameters of polycystic ovary syndrome (PCOS) in southern China. The study was observational with a parallel study. Participants were studied in a medical examination center. A population of 915 women of reproductive age was investigated at the time of their annual physical examination to determine the prevalence of PCOS in unselected women from southern China. Our results demonstrated a 2.2% (20/915) prevalence of PCOS. Women with PCOS had higher levels of luteinizing hormone and higher luteinizing hormone/follicle-stimulating hormone ratios than those in the other groups. Women with PCOS had higher fasting insulin levels and lower fasting glucose/fasting insulin ratios than women in any of the other groups. Some clinical and biochemical characteristics were apparent in PCOS patients in our population, and ethnic differences may be considered when studying the clinical and metabolic features of PCOS in China.
Impact of induced yogic relaxation training (IYRT) on stress level, selfconcept and quality of sleep among minority group individuals
  • P Sahajpal
  • R Ralte
Sahajpal P, Ralte R. Impact of induced yogic relaxation training (IYRT) on stress level, selfconcept and quality of sleep among minority group individuals. J Indian Psychol. 2000;18:66-73.