On this Post Antibiotic era, the General Public and Researchers are keen eyes on finding solutions for treating their ailments and research purposes (respectively) through Traditional systems of Medicine. With the emergence of newer infections and allergens day by day, treatment options are often short lived and the need for finding out new drugs is need of the hour. Scientists reports that, world healthcare system could face a serious Antibiotic resistance in the forthcoming centuries. Hence, in spite of newer strains of microbes and newer antibiotics to cope up with them, it is always advised to improve the overall Immune power of the individuals especially from their childhood itself. In that way, ‘Urai mathirai’, a Poly Herbal Siddha formulation promises to be a very good immune booster, prevents contagious diseases besides effective against Maantham (Indigestion), Kanai (Primary complex), chronic cough and fever. This pill is provided to numerous children attending the OPD of all Government Siddha Hospitals and PHCs thereby ensuring the boosting up of the immune status of the individuals. This review paper deals with all the aspects of ‘Urai Mathirai’, its ingredients and their supremacy as both Prophylactic and Therapeutic agents. To conclude, ‘Urai mathirai’ has the greater ability to cure diseases ranging from Pediatrics to Geriatrics.