This Handbook of Ubuntu, Inequality and Sustainable Development interrogates the multiple inequalities that subsist in our world today and explores the extent to which the concept of Ubuntu, emerging from Africa but with the potential to be applied in diverse contexts beyond the continent, holds promise for mitigation and resolution. The handbook responds to the United Nations (UN) Sustainable Development Goals (SDGs) Agenda 2030, particularly SDG 10, which strives to “Reduce inequality within and among countries.” Among its targets is: “By 2030, empower and promote the social, economic and political inclusion of all, irrespective of age, sex, disability, race, ethnicity, origin, religion or economic or other status.” In addition, it speaks of the need to give voice to developing countries, as well as to promote “orderly, safe, regular and responsible migration of people” and “encourage official development assistance and financial flows….” (See https://www.unwomen.org/en/news/in-focus/women-and-the-sdgs/sdg-10-reduced-inequalities, accessed 13 January 2023). Contributors to this handbook acknowledge the intrinsic connectedness of the SDGs, as they recognize the inequalities that relate to gender (SDG 5), climate change and the environment (SDG 13), as well as the struggle against poverty (SDG 1). They reflect on how Ubuntu can be a strategic resource in pursuit of these goals. Cognisant of the urgency of securing peace and strong institutions (SDG 16), they also seek to apply insights from Ubuntu to promote peacebuilding and sustainable development. This introductory chapter seeks to provide the ethos, motivation and orientation of the handbook. It outlines the global context of inequality, summarizes the trends in the study and application of Ubuntu and draws attention to some of the major areas where the values and principles of Ubuntu are urgently required. The chapter also provides an overview of the critiques of Ubuntu, admitting that no concept, including one as progressive and relevant as Ubuntu, should escape detailed analysis and scrutiny. It also summarizes the chapters in this handbook.