The rapid growth in remote healthcare services and biomedical demands has seen novel developments in wireless body area networks (WBANs). The WBAN can be seen as an integration of intelligent networks, which permits devices and sensors to work together to obtain a series of critical physiological parameters, such as blood flow velocity and heartbeat frequency. Analysis of WBAN radio frequency communication systems is the key factor and the critical research challenge that determines system performance, such as achievable transmission distance, data rate and so forth. The human head is an area of particular potential in WBAN design that is worthy of attracting more attention than its limited literature to date. This paper is primarily focused on the one of the most detailed comprehensive multi-modal imaging-based anatomical human head models. This is a multimodal imaging-based detailed anatomical model, denoted by the acronym MIDA, this features 153 structures at a high resolution of up to 500 mu m, including numerous distinct muscles, bones and skull layers in the license-free 2.4 GHz industrial, scientific, and medical (ISM) band. It presents and compares a set of advanced simulation methods and then proposes a path loss simulation flat phantom, semi-empirical path loss models for typical homogeneous tissues and the anatomical human head MIDA model. The bit error rate (BER) performances of the MIDA model fading channel using binary phase shift keying (BPSK) and pulse-amplitude modulation (PAM) are obtained. Furthermore, achievable transmission distances for several data rates for predetermined acceptable BERs are accomplished. The results show that PAM promises longer transmission distances than BPSK when using both high and low data rates. The proposed communication systems can be applied to optimize implantation communication system scenarios and biotelemetry applications.