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Effect of Natural Plant Extracts on Hair Loss Prevent in People with Alopecia
... Guava leaves have antioxidant action (Chen & Yen, 2007), antiageing properties (Edwin et al., 2007), antimicrobial effects (Buvaneswari, 2011). Reported pharmacological activities include diarrhoea (Ojewole et al., 2008), dysentery, gastrointestinal disorders (Lozoya et al., 2002), infantile enteritis caused by Rotavirus (Wei et al., 2000), diabetes (Cheng & Yang, 1983;Oh et al., 2005), obesity (Deguchi & Miyzaki, 2010), high cholesterol (Singh et al.,1993), bronchitis, laryngitis (Jaiarj, 1999), acne and skin infection (Qadan et al., 2005), wounds, boils, bites, soft tissue infectious site (Abubakar, 2009), hair loss (Sim et al., 2016), allergy (Han et al., 2011), asthma (Batick, 1984), epilepsy (Meckes et al., 1996), fever (Olajide et al., 1999), flu-H1N1, (Sriwilaijaroen et al., 2012), malaria (Nundkumar & Ojewole, 2002), periodontal diseases (Ravi & Divyashree, 2014), rheumatism (Ayensu, 1978). The leaves of Psidium guajava have anti-inflammatory and analgesic effects (Jewole et al., 2006), liver protective activity (Roy et al., 2006), antihypertensive and cardio protective (Sakanashi et al., 2003), anti-ulcer (Edwin et al., 2007), anti-stress (Lakshmi & Sudhakar, 2009), immuno-stimulatory activity (Laily et al., 2015); the anticancer effects of guava (breast, cervix, colon, mouth, prostate, stomach, thyroid) have variously been reported (Lee & Park, 2010;Chen et al., 2010). ...
Guava-Psidium guajava Linn. (Myrtaceae) is an evergreen tree cultivated for its precious fruit and high therapeutic properties of the whole plant. Guava is native to the Caribbean, Central America and South America. In 2011, guava was propagated by seed and it was analysed in 2018 at the University of Agronomic Sciences and Veterinary Medicine of Bucharest. The research pointed that in Romania guava, as container plant, can produce fruit every year, starting with the fourth year after sowing. The morphological analyses showed that the leaves of the main shoots varied in length between 11.1-12.5 cm, in width between 5.6-6.5 cm and the length of the petiole was between 0.7-1cm. The leaves of the suckers varied in length between 8.7-10.5 cm, in width between 4.1-5.3 cm and the length of the petiole was between 0.6-0.9 cm. The anatomical analyses of the leaf showed a dorsoventral mesophillum with a multiseriate upper epidermis. Biochemical analyses were done on fresh and dried leaves of 8 years old guava tree.
... Furthermore, the thickness and density of the hair were increased compared to baseline values. The study claimed natural plant extract could effectively prevent hair loss [117]. ...
Hair health is associated with personal distress and psychological well-being. Even though hair loss (alopecia) does not affect humans’ biological health, it affects an individual’s social well-being. So, treatment for hair problems and improving hair health are obligatory. Several pharmacological and cosmeceutical treatment procedures are available to manage hair loss and promote growth. Several factors associated with hair health include genetics, disease or disorder, drugs, lifestyle, chemical exposure, and unhealthy habits such as smoking, diet, and stress. Synthetic and chemical formulations have side effects, so people are moving towards natural compounds-based remedies for their hair problems. The history of using phytochemicals for hair health has been documented anciently. However, scientific studies on hair loss have accelerated in recent decades. The current review summarizes the type of alopecia, the factor affecting hair health, alopecia treatments, phytochemicals’ role in managing hair loss, and the mechanisms of hair growth-stimulating properties of phytochemicals. The literature survey suggested that phytochemicals are potent candidates for developing treatment procedures for different hair problems. Further detailed studies are needed to bring the scientific evidence to market.
... Prostaglandin analogue, calcitriol and miscellaneous, has been proposed and researched for prevention and treatment of CIA; nevertheless, the results have been unsatisfactory in several studies [9]. Recently, natural plant extracts containing sweet flag, have been found in the hair growth effect [10]. In addition, standardized Cinnamon bark extract was reported to prevent side effects of cancer chemotherapy, such as weight loss and alopecia [11]. ...
Decursin, a pyranocoumarin compound from the root of Angelica gigas Nakai as a main constituent, has been reported to have various biological activities, including anti-inflammatory, anticancer, and antioxidant effects. This study aimed to predict and confirm the pharmacological relevance of Decursin on chemotherapy-induced alopecia (CIA) with the underlying molecular mechanisms. Decursin-targeted genes were compared with the gene set of alopecia and investigated through functional enrichment analysis. CIA was induced in C57BL/6J mice by injection of cyclophosphamide, and 1, 10, and 100 μM of Decursin were topically treated to depilated dorsal skin. KGF⁺ expression was detected in the dorsal skin tissues. Based on the predicted results, caspase, PIK3/AKT, and MAPKs protein expressions by Decursin were analyzed in the TNF-α-induced keratinocytes. The Decursin network had 60.20% overlapped genes with the network of alopecia. Biological processes, such as cellular response to chemical stimulus, apoptosis, PI3K-AKT signaling pathway, and MAPK signaling pathway, were derived from the Decursin network. In the Decursin-treated skin, there was morphological hair growth and histological restoration of hair follicles in the CIA mice. The KGF⁺ fluorescence and protein expressions were significantly increased by Decursin treatment. In addition, caspase-3, -7, and -8 expressions, induced by TNF-α, were dose-dependently decreased along with the inhibition of PI3K, AKT, ERK, and p38 expressions in Decursin-treated keratinocytes. These findings indicated that Decursin would be a potent therapeutic option for hair loss, in response to chemotherapy.
Ligusticum chuanxiong Hort (LC; Umbelliferae) is an effective medical plant, which has been extensively applied for many years to treat various diseases with other Chinese herbal medicines. Although a considerable amount of scientific research was reported on LC in the last decade, it is currently scattered across various publications. The present review comprises the chemical and pharmacological research on LC in the last decade.
The objective of this review is to bring together most of the scientific research available on LC and evaluate its effects and mechanisms.
The information for 82 cases included in this review was compiled using major databases such as Medline, Elsevier, Springer, Pubmed, and Scholar.
The compounds contained in LC can be divided into five kinds, essential oil (EO), alkaloids, phenolic acids, phthalide lactones, and other constituents. A great deal of pharmacological research has been done, which mainly focuses on cardiovascular and cerebrovascular effects, antioxidation, neuroprotection, antifibrosis, antinociception, antiinflammation, and antineoplastic activity.
A large number of pharmacological and chemical studies during the last 10 years have demonstrated the vast medicinal potential of LC. It is still very clear that LC is a plant with widespread use now and also with extraordinary potential for the future. The documents strongly support the view that LC has beneficial therapeutic properties and indicates its potential as an effective adaptogenic herbal remedy.
Hair growth problems can affect human physical and mental health and are of particular relevance during the aging process. In an effort to resolve such problems, we attempted to find plants having hair growth regulation activity and thus collected plant extracts from Tunisia for bioprospecting purposes. Among them, we investigated the Erica multiflora extract to evaluate the hair growth promotion activity by using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay and cell cycle assay on human dermal papilla cells in vitro and an administration assay on mouse dorsal skin in vivo. The results showed that the Erica multiflora extract promotes dermal papilla cell growth and cell cycle with high activity, and induced hair growth in vivo by induction of anagen phase from telogen phase.
The adult hair follicle dermal papilla (DP) and dermal sheath (DS) cells are developmentally active cell populations with a proven role in adult hair follicle-cycling activity and unique inductive powers. In stem cell biology, the hair follicle epithelium has recently been the subject of a great deal of investigation, but up to now, the follicle dermis has been largely overlooked as a source of stem cells. Following the sporadic appearance of muscle, lipid and bone-type cells in discretely isolated follicle DP and DS cell primary cultures, we demonstrated that cultured papilla and sheath cell lines were capable of being directed to lipid and bone differentiation. Subsequently, for the first time, we produced clonal DP and DS lines that had extended proliferative capabilities. Dye exclusion has been reported to be an identifying feature of stem cells; therefore, clonal papilla and sheath lines with differing capacity to exclude rhodamine 123 were cultured in medium known to induce adipocyte and osteocyte differentiation. Both DS- and DP-derived clones showed the capacity to make lipid and to produce calcified material; however, different clones had varied behaviour and there was no obvious correlation between their stem cell capabilities and dye exclusion or selected gene expression markers. As a highly accessible source, capable of being discretely isolated, the follicle has important potentially as a stem cell source for tissue engineering and cell therapy purposes. It will also be interesting to compare follicle dermal stem cell properties with the broader stem cell capabilities discovered in skin dermis and investigate whether, as we believe, the follicle is a key dermal stem cell niche. Finally, the discovery of stem cells in the dermis may have implications for certain pathologies in which abnormal differentiation occurs in the skin.
The study aimed to evaluate the antinociceptive and antiinflammatory activity of pine (Pinus densiflora) pollen in mice. The antinociceptive activity was determined using acetic acid-induced abdominal constriction and formalin-induced licking, and the hot plate test. Antiinflammatory effects were evaluated using carrageenan- and formalin-induced paw edema, and arachidonic acid-induced ear edema in mice. The ethanol extract of pine pollen (100 and 200 mg/kg, p.o.) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mouse writhing induced by acetic acid and an elevation of the pain threshold in the hot plate test in mice. The pine pollen extract also produced a significant inhibition of carrageenan- and formalin-induced paw edema as well as arachidonic acid-induced ear edema in mice. The inhibitions were similar to those produced by aminopyrine and indomethacin, p.o. The different polyphenols found in pine pollen could account for the antinociceptive and antiinflammatory actions. The results obtained indicate that the extract possesses analgesic and antiinflammatory effects.