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University*of*St*Andrews1

School*of*Computer*Science1

Modelling the late effects of

cancer treatment on the ovary

Edinburgh Fertility 2016

Tom$Kelsey$

School*of*Computer*Science1

Overview

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Non-Growing Follicles

• Ovarian reserve

– Born with a population that declines until

menopause

– NGFs are selected for maturation

• Impossible to measure in vivo

– Using current technologies

• Populations are counted in vitro

– Typically histological examination of stained

tissue

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NGFs – Wallace & Kelsey 2010

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NGFs – Wallace & Kelsey 2010

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Ovarian Volume

• Indirect measure of ovarian reserve

• Possible to measure in vivo

– 2D & 3D ultrasound

• The assumption is that a large ovary

contains more NGFs than a small one

– Clearly true when comparing pre- and post-

menopausal ovaries

– We have no evidence for this assumption for

pre-menopausal ages

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Model Validation

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Using the models to assess infertility

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Effective Sterilising Doses

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Summary

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References

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ieHc@'"3'ieHc='8.)+/"0&R'Human$reproduc:on,$5,'

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Thank You

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