Todays fluctuated market context is mainly characterized by high product variety, variable volumes and short product life. Thus, assembly system design should be in such a way that it can face this variable issues within a short period of time at a low cost. In the context of global competition, it requires that products are with a short life-cycle and a high degree of customization. Therefore, the assembly system design should be able to adapt to the varying market demands. For this varying demand, there should be an alternative to the conventional assembly system. The Reconfigurable Assembly systems (RAS) are those type of assembly systems which can rapidly change their capacity as quantities that are assembled and functionality (product type, within a product family) in order to adapt the fluctuating and uncertainty in market demand. In the present scenario, some of the relevant research issues from design and operation in the area of RAS are identified in this paper. These research issues are identification of product family for RAS, design of modular products, design of optimum configuration for RAS, optimum design for assembly, identifying and quantifying design requirements, use of proper simulation tool for RAS, identification of quality problems, etc. Challenges and scopes in each area of these issues are identified.