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Effects of Turmeric ( Curcuma longa ) on Skin Health: A Systematic Review of the Clinical Evidence: Effects of Curcuma longa on Skin Health
Abstract
Turmeric (Curcuma longa), a commonly used spice throughout the world, has been shown to exhibit antiinflammatory, antimicrobial, antioxidant, and anti-neoplastic properties. Growing evidence shows that an active component of turmeric, curcumin, may be used medically to treat a variety of dermatologic diseases. This systematic review was conducted to examine the evidence for the use of both topical and ingested turmeric/curcumin to modulate skin health and function. The PubMed and Embase databases were systematically searched for clinical studies involving humans that examined the relationship between products containing turmeric, curcumin, and skin health. A total of 234 articles were uncovered, and a total of 18 studies met inclusion criteria. Nine studies evaluated the effects of ingestion, eight studies evaluated the effects of topical, and one study evaluated the effects of both ingested and topical application of turmeric/curcumin. Skin conditions examined include acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo. Ten studies noted statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups. Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health. However, currently published studies are limited and further studies will be essential to better evaluate efficacy and the mechanisms involved.
... The use of traditional practices for various health conditions is common practice in many households. In the context of provided data ( [16,33,34] and wound healing activities (Farhat et al., 2023) [8] . ...
... , it is evident that a significant majority (96.1%) used turmeric paste for wounds to stop the flow of blood and 83.6% used turmeric in milk for the treatment of cough and cold. Turmeric has known antiinflammatory, antimicrobial properties(Kumar et al., 2020; Trifan and Aprotosoaie, 2019;Vaughn et al. 2016) ...
... Animal studies have reported an increase in liver weight, discolored faces, and hyperplasia of the cecum and colon. [111,[113][114][115][116][117][118][120][121][122][123][124]. Oral use of turmeric may prevent Iron absorption. ...
... Curcumin can further interact with some medications, such as antiplatelet, camptothecin, mechlorethamine, doxorubicin, cyclophosphamide, celiprolol, midazolam, and tacrolimus [128]. It may also give rise to pharmacokinetic changes in cardiovascular medications, antibiotics, antidepressant agents, chemotherapeutic drugs, anticoagulants, and antihistamines [116,123]. ...
Turmeric is a medicinal herb with antioxidant and anti-inflammatory components that can affect metabolic parameters via various pathways, including the gut-brain axis. Although positive effects of turmeric on health have been reported, findings are conflicting. Accordingly, the current review aimed to provide an overview of the biochemical and biological characteristics of turmeric and examine the impacts of turmeric on cardio-metabolic risk factors with a special focus on its abilities to modulate gut microbiota. In the present comprehensive review, findings of systematic reviews/narrative reviews, clinical trials, animal, and in vitro studies on turmeric in the English language published between 2010 and March 2023 were summarized. Findings revealed that turmeric is a safe medicinal herb with mild gastrointestinal side effects in some cases. It can help improve the glycemic status, lipid profile, and blood pressure. However, food processing and fermentation can affect the bioavailability of its effective components, including curcumin. Several mechanisms, including those affecting intestinal microbiota diversity, intestinal permeability, inflammatory and oxidative pathways, are proposed for their positive effects on metabolic factors. However, due to high between-study heterogeneity, limited high-quality clinical trials, differences in the duration of the intervention, and the form of turmeric supplement, more studies on each metabolic parameter are needed to determine effective dosages and confirm its efficacy as a complementary therapy to modulate microbiota and cardio-metabolic parameters.
... Because of its acidic nature and antimicrobial properties, fighting skin breakouts like acne, pimples, and blackheads by cleaning dirt and oil from deep within. It further helps in tightening the skin pores to give you smooth skin [40]. Uses: Gives a soothing effect, hydrates the skin, treats acne, and prevents wrinkles and fine lines. ...
The face wash is used to cleanse the face without drying it out. It is also commonly known as a "cleanser". This product is found to be equally good for all skin types. A face wash is a mild cleanser that does the vital job of keeping skin clean, germ-free, smooth, and fresh and moisturizes the horny layer without any harshness to the skin. So that skin looks young and energetic. Various types of herbal ingredients can be used to manufacture face wash. The herbal face wash formulated by hydroalcoholic extract of turmeric, orange peel oil, and aloe vera is beneficial and has no side effects. The plants in this article have better antioxidant, antimicrobial, and anti-inflammatory properties. All herbal ingredients used in this formulation are easily available in the market of the surrounding area. Skin is part of the body and face skin is the most sensitive and important for human beings to appear good-looking. The herbal plant used in formulation has cosmetic and medicinal properties. The plants used in face wash like aloe vera, turmeric, etc. have properties for softening skin, removing acne as well as promoting healing. The herbal formulation was evaluated by different types of parameters like appearance, color, pH, viscosity, odor, solubility, etc. After formulation evaluation of the formulation is essential for measuring the safety and efficacy of the formulated product otherwise it may cause various harmful effects.
... Curcumin has powerful anti-inflammatory properties that have caught the attention of researchers, establishing it as a natural compound with potential therapeutic benefits for different inflammatory skin conditions, including AD [46][47][48]. In a recent study, topical formulations incorporating curcumin within a self-nanoemulsifying drug delivery system (SNEDDS) effectively reduced levels of TNF-α and IL-1β, as demonstrated in adult human epidermal cell experiments, making these preparations promising for treating inflammatory skin conditions, including AD [46]. ...
Atopic dermatitis is one of the most common inflammatory skin diseases, with an increasing incidence among both children and adults. The recurrent nature, often with the persistence of symptoms, and the polymorphism of the response to current therapies have led to increased research in the therapeutic area dedicated to this condition. The understanding of pathophysiological pathways has contributed to the development of innovative therapies, including biological therapies, JAK inhibitors, but also emerging technologies like nanotechnology-based drug delivery systems. These innovations promise enhanced efficacy, reduced side effects, and improved patient outcomes. The ongoing exploration of novel vehicles, formulations, and natural biopolymers, along with cutting-edge therapeutic agents like tapinarof and mesenchymal stem cells, highlights the potential for an even more precise and personalized management of AD in the future. Despite these advances, challenges persist, particularly in ensuring the long-term safety, accessibility, and broader application of these therapies, necessitating continued research and development.
... The scientific evidence has shown that topical application and its oral intake contribute to maintaining skin integrity because it accelerates wound healing (Zia et al. 2021;Akbik et al. 2014). Therefore, it is used for acne, atopic dermatitis, iatrogenic dermatitis, eczema, psoriasis, vitiligo, photoaging, and other skin disorders (Vaughn et al. 2016;Vollono et al. 2019). This natural pigment exerts protective effects against oxidative stress caused by ROS production, peroxidation of lipids, protein carbonylation, and mitochondrial permeability transition. ...
Main conclusion
This review highlights the potential of aromatic plants as natural antioxidants in cosmeceuticals to combat skin aging and promote health and rejuvenation.
Abstract
Aromatic plant extracts, essential oils, or their phytoconstituents have a long history of use in skincare, dating back centuries. Currently, these plant-based sources are extensively researched and utilized in the cosmeceutical industry to formulate products that enhance skin health and promote a youthful appearance. These plants’ diverse bioactivities and sensory properties make them ideal ingredients for developing anti-aging agents recommended for maintaining healthy skin through self-care routines, offering a natural alternative to synthetic products. Reactive oxygen species (ROS) accumulation in the dermis, attributed to intrinsic and extrinsic aging factors, particularly prolonged sun exposure, is identified as the primary cause of skin aging. Plant extracts enriched with antioxidant compounds including flavonoids, phenolics, tannins, stilbenes, terpenes, and steroids, are fundamental to counteract ROS-induced oxidative stress. Noteworthy effects observed from the use of these natural sources include photoprotective, senolytic, anti-inflammatory, anti-wrinkle, anti-acne, and anti-tyrosinase activities, encompassing benefits like photoprotection, wound healing, skin whitening, anti-pigmentation, tissue regeneration, among others. This review highlights several globally distributed aromatic plant species renowned for their benefits for skin, including Foeniculum vulgare Mill. (Apiaceae), Calendula officinalis L. and Matricaria chamomilla L. (Asteraceae), Thymus vulgaris L. (Lamiaceae), Litsea cubeba (Lour.) Pers. (Lauraceae), Althaea officinalis L. (Malvaceae), Malaleuca alternifolia (Maiden y Betche) Cheel (Myrtaceae), Cymbopogon citratus (DC.) Stapf (Poaceae), Rubus idaeus L. (Rosaceae), and Citrus sinensis L. Osbeck (Rutaceae), emphasizing their potential in skincare formulations and their role in promoting health and rejuvenation.
... Turmeric has been well-established in India and China for ages and has been confirmed to be a medicine used to cure diseases such as infections, depression, and stress. Curcumin, a lipophilic polyphenol compound, is the primary focus of turmeric's health benefits because it is derived from the herb's roots (Kocaadam & Şanlier, 2017;Vaughn et al., 2016). Curcumin is extracted from the turmeric plant using a solvent and crystallised for purity (Zam, 2018). ...
The microbiome of human beings, especially the gut microbiota, appears to be the most potent element of the human body responsible for health and disease. Various herbs and spices often used in cooking and exceptionally high in bioactive substances like polyphenols, terpenes, and flavonoids are getting more attention for their proposed effect on gut health. This study aims to examine the links between culinary herbs and spices and the gut microbiome and to review the latest research findings. Human microbiota has a variable number of bacteria, and the composition and properties of their microbiomes depend on diet, lifestyle, and environmental factors. The current literature demonstrates that phytochemicals in spices and herbs can modify gut microbiota, which may result in lower inflammation, better digestion, and prevention of non-communicable diseases. It has been proven with further studies that herbs such as cinnamon, ginger, turmeric and rosemary are beneficial for the intestines and have shown positive results in animal and human studies. In conclusion, adding culinary herbs and spices to the diet provides a straightforward but powerful means to preserve a healthy gut microbiota, and supports overall better health.
... T4O, a monomeric compound present in many plants' essential oils, has demonstrated significant antitumor, anti-inflammatory, and antibacterial effects [25]. T4O induces necrotic and apoptosis in murine mesothelioma and melanoma [26,27], and exerts a significant antiproliferative effect in colorectal, pancreatic, prostate, and gastric cancer cells [28]. ...
... Curcumin (diferuloyl-methane) is the active component of Turmeric and it has been shown to exhibit antiinflammatory, antimicrobial, antioxidant, antineoplastic properties, and even potential to improve mental illnesses. There was a statistically significant improvement in all symptoms assessed including erythema, scaling, thickening, and itching [9]. Cynodon dactylon has been used as an anti-inflammatory, anti-epileptic, diuretic, antiemetic and purifying agent [10]. ...
Background: Atopic dermatitis (eczema) is a common chronic or recurrent inflammatory skin disease affects 15-20% of children and 1-3% of adults worldwide. It is characterized by acute flare-ups of eczematous pruritic lesions over dry skin. Yoga and Naturopathy is a safe and cost-effective non pharmacological system which encompassing holistic approach in the prevention and treatment of diseases that is widely used to treat atopic dermatitis. Methods: Various bibliographic databases of previously published peer-reviewed research papers were explored and systematic data culminated in terms of various treatment strategies used for the management of Atopic Dermatitis. The prime focus is given towards system of Yoga and Naturopathy management. Results: A comprehensive review of 15 papers, including both research and review articles, was carried out to make the article readily understandable. The uniqueness, procedure, advantages of Yoga & Naturopathy interventions are discussed in detail. Results showed improvements in EASI and SCORAD scores. This shows the effectiveness of 4 weeks of YN interventions in reducing the severity of Atopic dermatitis. Conclusion: Although there are many modern and alternative treatment strategies available to treat Atopic Dermatitis the Yoga & Naturopathy system have been utilized and found effective; however, their stability and safety become the major impediments towards their successful positioning. This case report suggests that integrated yoga and naturopathy interventions have significant role in managing symptoms of patients with Atopic dermatitis.
... Turmeric is advantageous for skin health because of its antibacterial and anti-inflammatory effects. It is utilised in cosmetic items to lessen acne, ease skin irritations, and enhance skin tone [36]. ...
Due to its eco-friendly and sustainable character, the synthesis of metallic nanoparticles utilising biological resources has attracted much attention recently. To give a general overview of the biological production of copper nanoparticles (CuNPs), Curcuma Longa (Turmeric) is used as a reducing and stabilising agent in this literature study. The paper also emphasises the characterisation methods used to examine the synthesised nanoparticles, including UltraViolet-Visible Spectroscopy (UV-Vis), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). To comprehend their possible applications and related concerns, it also described how hazardous these copper nanoparticles (CuNPs) are.
... 1-3 For example, oral supplementation of turmeric/ curcumin products have been shown to improve disease severity in various dermatoses, partly via its antioxidative properties. 4 Carotenoids, such as astaxanthin-rich microalgae Haematococcus pluvialis extract, beta-carotene, and lycopene have also been shown to have antioxidative properties leading to photoprotective effects when taken orally. [5][6][7] The consumption of foods containing antioxidants such as almonds containing alpha-tocopherol 8 and carotenoid-rich mangos 9 have also been shown to improve measures of photoaging in postmenopausal women. ...
Purpose
The topical application of antioxidants has been shown to augment the skin’s innate antioxidant system and enhance photoprotection. A challenge of topical antioxidant formulation is stability and penetrability. The use of a targeted drug delivery system may improve the bioavailability and delivery of antioxidants. In this ex vivo study, we assessed the effects of the topical application of a liposome-encapsulated antioxidant complex versus a free antioxidant complex alone on skin photoaging parameters and penetrability in human skin explants.
Patients and Methods
Human organotypic skin explant cultures (hOSEC) were irradiated to mimic photoaging. The encapsulated antioxidant complex and free antioxidant complex were applied topically onto the irradiated hOSEC daily for 7 days. The two control groups were healthy untreated hOSEC and irradiated hOSEC. Photoprotective efficacy was measured with pro-inflammatory cytokine (IL-6 and IL-8) and matrix metalloproteinase 9 (MMP-9) secretion. Cell viability and metabolic activity were measured via resazurin assay. Tissue damage was evaluated via lactate dehydrogenase (LDH) cytotoxicity assay. Skin penetration of the encapsulated antioxidant complex was assessed via fluorescent dye and confocal microscopy.
Results
Compared to healthy skin, irradiated skin experienced increases in IL-6, IL-8 (p < 0.05), and MMP-9 (p < 0.05) secretion. After treatment with the encapsulated antioxidant complex, there was a 39.3% reduction in IL-6 secretion, 49.8% reduction in IL-8 (p < 0.05), and 38.5% reduction in MMP-9 (p < 0.05). After treatment with the free antioxidant complex, there were no significant differences in IL-6, IL-8, or MMP-9 secretion. Neither treatment group experienced significant LDH leakage or reductions in metabolic activity. Liposomes passed through the stratum corneum and into the epidermis.
Conclusion
The topical application of a liposome-encapsulated antioxidant complex containing ectoin, astaxanthin-rich microalgae Haematococcus pluvialis extract, and THDA improves penetrability and restored IL-6, IL-8, and MMP-9 levels in irradiated human skin explants, which was not seen in the comparator free antioxidant complex group.
... [17,18] Thus, the combination of Epsom salt, coconut oil, and Aloe vera might act by reducing the inflammatory response and protecting the skin from dehydration. In addition, topical application of turmeric was found to be beneficial for improving skin health by downregulating inflammatory makers [19] and exhibiting antimicrobial, antioxidant, and wound-healing properties. [20] Maternal diet can influence the quality of breast milk, which further influences infant's health, and behavior. ...
A 75-day-old male infant presented to the Naturopathy and Yoga Hospital by his mother with complaints of a dry, scaly, and itchy scalp, dry skin, and crying while passing stools for a month. He was diagnosed with atopic dermatitis (AD) using the Hanifin–Rajka criteria. The infant has been administered two topical applications on the entire body for ten days using Epsom salt (5 g) (magnesium sulfate) mixed with Aloe vera (15 g), turmeric powder (about 0.6 g) in warm coconut oil. Modifications in the mother’s diet were also advised. The case report shows remarkable changes in the symptoms with a reduction in the scaly patches on the scalp and rashes over the body. Following ten days of intervention, the baby stopped crying while passing stools. On follow-up, 30 days after the discharge, no relapses were reported, and the child was healthy. This case report shows the simple topical application of Epsom salt, coconut oil, Aloe vera , and turmeric combinations in the management of pediatric AD, inferring that, naturopathy interventions can be safe, and cost-effective in managing the AD in infants. However, further large-scale studies are warranted in this area for establishing safety, and efficacy and for large-scale applications in pediatric cases.
... Turmeric has been used in spices for cooking, and topically and orally in India as a home medication for its antioxidant, anti-inflammatory, anticarcinogenic, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antiulcer, and anticoagulant properties. [20] Allergic and pigmented contact dermatitis from turmeric in food, cosmetics, and occupational settings has been reported. [21,22] ACD with and without photo-aggravation from kumkum, which contains turmeric as a major ingredient or turmeric per se in the ritual thread, has been reported in Indian women. ...
Adverse cutaneous reactions, some of which are allergic in origin and of variable severity, occur from systemic
administration of medicaments, and others result from contact sensitivity from their topical use. Allergic contact
dermatitis (ACD) to topically applied medicaments, excipients or active ingredients, is encountered frequently in
clinical practice and should be suspected in all at-risk individuals. Although about one-third of all cases of ACD
are initiated or perpetuated by prescribed or non-prescribed topical preparations, the problem usually remains
underappreciated. e prevalence of hypersensitivity to these allergens varies across regions and periods of time
depending on the personal habits and health-seeking behavior of an individual, the interest of the clinician in the
feld of contact dermatitis, and the types of cases studied. Often promoted by social media influencers as a remedy
for all dermatological problems or cosmetics, the use of several home remedies and other over-the-counter antiaging and cosmetic products has increased exponentially in recent years. We, herein, briefly review some of the
commonly used products potentially causing ACD
... Curcumin / Curcuminoids is a polyphenolic molecule derived from turmeric (Curcuma longa) that has anti-inflammatory, antibacterial, antioxidant, and antineoplastic activities (Vaughn et al., 2016). Curcumin appears to be a therapeutic alternative for the treatment of vitiligo due to its antioxidant properties. ...
Vitiligo is a common skin disorder resulting from the breakdown of functional epidermal melanocytes. The global prevalence of vitiligo ranges from 0.5% to 2%, with higher rates reported in certain populations. Melanocytes, responsible for skin color, are destroyed in vitiligo condition leading to the appearance of smooth, white patches on the skin. The progression of vitiligo is influenced by various factors, including genetics, autoimmunity, psychosis, melanocyte self-destruction, trace element deficiency, oxidative stress, and other biochemical and environmental variables. Recent research has identified herbal plant extractions as potential agents for re-pigmentation and regeneration of normal skin color. Specific components of these herbal plants, such as furocoumarin, thymoquinone, flavonoids, curcuminoids, and glycyrrhizin, play crucial roles in promoting re-pigmentation. Combination therapies involving these herbal compounds have shown promise in increasing tyrosinase activity and reducing oxidative stress, which are two important aspects of vitiligo treatment. The review aims to comprehensively evaluate the efficacy of herbal plant therapies for melanocyte re-pigmentation in vitiligo patients. By analyzing the effectiveness of various herbal extracts and their active components, this study seeks to advance the understanding and potential application of herbal treatments for vitiligo. The findings from this review may contribute to the current knowledge on therapeutic options available for vitiligo patients.
... Curcumin is a brilliant yellow chemical component extracted from Curcuma longa L. (turmeric) plants of the Zingiberaceae family [1]. Turmeric has traditionally been used in herbal medicine to treat cutaneous and gastrointestinal irritation, weight loss, and improper digestion [2][3][4]. Curcumin, also known as diferuloylmethane, is a polyphenolic phytochemical component. Curcumin [1,7-Bis(4-hydroxy-3methoxyphenyl)-hepta-1,6-diene-3,4-dione] is an oil-soluble pigment with a molecular weight of 386.38 g/mol and a melting point of 175-180 °C. ...
Background: Psoriasis is a long-term chronic inflammatory, autoimmune and reoccur-ring skin condition. About 2% to 5% of the world's population is impacted by psoriasis. People affected by psoriasis are more prone to develop other health conditions including psoriatic arthritis, anxiety, depression and cardiovascular disorders. Long-term use of several synthetic medications used for their management has been showing typical severe side effects. Curcumin, a natural compound generated from the golden spice (Curcuma longa), has been recommended as a potential alternative for the management of psoriasis. Curcumin works at molecular level by binding with the various inflammatory receptors that play a key role in the initiation of psoriasis. Objective: The aim of this review is to report the use and discuss the mechanism of action of cur-cumin in the management of psoriasis and mutually overcome the side effects shown by the synthetic medications. Results: Through ample literature surveys, curcumin has been proposed as a safe and therapeutic option for psoriasis as compared to synthetic medications. Conclusion: As traditional herb curcumin appears as a beneficiary medicament because of its anti-oxidant, anti-inflammatory and immune-modulating activities proposing minimal side effects. Thereby ensuring its defensive mechanism against psoriasis.
... Curcumin, the major active component of turmeric has been demonstrated to possess a broad range of biological actions including antiinflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive, and hypocholesterolemic activities and improves skin tone [6,7,8]. The curcumin content in turmeric varies; ranging from 0.3% to 8.6% [9]. ...
Aims: Turmeric, with its active component curcumin, has garnered global attention for its medicinal benefits, including anti-inflammatory and antioxidant properties. This study aimed to analyse turmeric powder obtained from the Greater Accra Metropolis for nutrients and contaminants. Place and Duration of Study: Entrance Pharmaceuticals, Accra for 6 months. Methodology: 22 samples from 10 different processing sites and open markets were tested using physical and chemical methods. HPLC identified curcumin, ascorbic acid, riboflavin, thiamine, and pyridoxine levels. An independent t-test was done to compare concentrations of these nutrients in the powdered turmeric samples from the two sources. Results: Assessment showed no yellow lead salts but 9.1% were adulterated with chalk, and 91% contained metanil yellow. Curcumin (2014.95 vs. 567.79), riboflavin (21.60 vs. 1.75), thiamine (14.75 vs. 0.65 mg/mL), pyridoxine (9.35 vs. 0.65 mg/mL), and ascorbic acid (0.00 vs. 101.60 mg/mL) were significantly higher (p<0.05) in processed samples than open market ones. Samples without adulterants had higher curcumin and micronutrient levels. Conclusion: Strengthening monitoring programs is crucial to tackling food adulteration concerns.
... Various therapeutic uses of Curcuma longa have been recognized in traditional medicine since ancient times. Curcuma longa is often applied topically to treat inflammation and swelling, wound healing, and skin diseases (Vaughn et al. 2016;Kumar et al. 2023). In addition, it is consumed to cure digestive disorders such as indigestion, flatulence, and stomach ulcers (Dulbecco and Savarino 2013). ...
Hinduism has profound religious beliefs and cultural connections with many plants employed in various religious rituals to worship gods and goddesses. Most of these plants are believed to have curative properties for many ailments. In view of the Hindu population decline in Bangladesh during the last decades, there is a need to gather ethnopharmacological data on these sacred plants. This study focuses on documenting the therapeutic uses of plants significant to Hindu practices in southwestern Bangladesh. Through free listing interviews with 28 Hindu participants, medico-religious data on plants were collected using open-ended and semi-structured questionnaires. Results revealed 56 plant species from 32 botanical families as religiously sacred, with Aegle marmelos being most culturally significant. The study identified 89 diseases treated by these plants, with Curcuma longa being the most cited species, followed by Hibiscus rosa-sinensis. It introduced two new ethnomedicinal plant species, Oxystelma esculentum and Reinwardtia indica, previously unreported in Bangladesh. Additionally, new medicinal uses were uncovered, highlighting the intricate relationship between culture, religion, and traditional medicinal knowledge within the Bangladeshi Hindu community. This study represents the first attempt to compile a comprehensive list of plants utilized in Hindu religious practices in Bangladesh.
... During ancient times, turmeric was applied daily by women during bath but in this century in the midst of busy world this is not possible and due the staining property most of them are avoiding it but other than turmeric there are many herbs and essential oils which plays a key role in inhibition of hair growth. [4]. ...
Hair is one of the distinguishing characteristics of mammals, and it serves a variety of functions including protection from external forces, production of sebum, apocrine sweat, and pheromones. However, the unwanted hair growth is always a worrying aspect among teenage girls and women. The present study is the need of selecting herbal depilatories over chemical depilatories due to its high efficacy, safety and lesser side effects. The various types of hair removal process, herbs showing depilatory action and their composition for herbal cream are studied. According to statistics, the use of depilatories has been steadily expanding, and the global hair removal products market was valued at USO 2.2 billion in 2018, with a CAGR of 5.5 percent predicted from 2019 to 2025. Depilatories are the cosmetic preparation which is used to remove the hair from skin, in chemical depilatories the main active ingredients are salts of thioglycolic acids, sulphides and stannites which can produce rashes and side effects on long time usage, whereas herbal depilatories include active ingredients like Turmeric, Indian neetle, Neem, Tanner's cassia, Apple cider vinegar, Pawpaw extract etc. which are tremendously safe to use. Hence in this study we Review Article Shanker et al.; JPRI, 33(49B): 278-289, 2021; Article no.JPRI.75816 279 have been discussed about importance of few folklore herbal medicine and preparation methods of both chemical and herbal depilatories. Graphical Abstract
... Curcumin is a plant-derived substance that exhibits antiinflammatory, anti-bacterial, and antioxidant properties. Previous studies using curcumin for the treatment of MPB have shown significant improvements in hair growth and hair loss without any side-effects [57,85]. Additionally, curcumin analogs can block the activity of AR that plays a crucial role in MPB pathogenesis [86,87]. ...
Background
Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these variants to gene expression regulation has not been performed to the best of our knowledge.
Results
In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis and utilized single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. Through a transcriptome-wide association study and colocalization analysis, we identified 52, 75, and 144 MPB associations for T2, T3, and T4, respectively. To assess the causality of MPB genes, we performed a conditional and joint analysis, which revealed 10, 11, and 54 putative causality genes for T2, T3, and T4, respectively. Finally, we conducted drug repositioning and identified potential drug candidates that are connected to MPB-associated genes.
Conclusions
Overall, through an integrative analysis of gene expression and genotype data, we have identified robust MPB susceptibility genes that may help uncover the underlying molecular mechanisms and the novel drug candidates that may alleviate MPB.
... Kim et al (2020a) exemplified this by investigating the antiaging potential of Curcuma longa leaf extract (CLLE) using an SoC model constructed with human keratinocytes and fibroblasts (Figure 2). CLLE has been shown to exhibit anti-inflammatory and antioxidant properties and has been utilized as a natural product cosmetic ingredient (Vaughn et al, 2016). Their findings demonstrated a dosedependent increase in keratinocyte differentiation activity; stratum corneum thickness; and the expression of epidermal structural proteins, including FLG, involucrin, laminin a-5, and keratin 10. ...
... (Ram Kumar & Jain, 2010). There is preliminary evidence that oral and topical turmeric/curcumin supplements and products may have therapeutic advantages for skin health (Vaughn et al., 2016). Curcumin was discovered to have no antifungal activity by Apisariyakul et al. (1995). ...
... (Ram Kumar & Jain, 2010). There is preliminary evidence that oral and topical turmeric/curcumin supplements and products may have therapeutic advantages for skin health (Vaughn et al., 2016). Curcumin was discovered to have no antifungal activity by Apisariyakul et al. (1995). ...
... When curcumin's bioavailability is increased, it can be used to treat dermatological conditions, suppress the growth of tumors, treat HIV and cancer, and regulate the immune system and metabolism. 43 Researchers have synthesized and investigated the photostability of curcumin conjugated with PAMAM dendrimers. 44,45 An analysis of different generations of these conjugates must also be explored. ...
ABSTRACT: Curcumin (C21H20O6) is a polyphenol found in the plant
Curcuma longa. Even though it possesses many pharmacological effects,
owing to its limited intestinal absorption, solubility, and oral bioavailability,
it is more often used as a health supplement than as a lead chemical. The
poly(amido)amine (PAMAM) dendrimer (nanostructure) is utilized to
enhance the stability and targeted delivery of drugs. Recently, curcumin
was conjugated with the PAMAM dendrimer and analyzed for its
photostability. Further investigation into the physiochemical characteristics of different generations can facilitate curcumins’
targeted delivery for many diseases, including cancer. However, many of these conjugates’ physiochemical properties are not
available in databases since they have not been explored theoretically or experimentally. In this article, QSAR/QSPR (quantitative
structure−activity relationship/quantitative structure−property relationship) analysis of physiochemical properties was carried out
for component structures, which produced encouraging results. Hence, 16 discrete adriatic topological indices and their associated
entropy measures were evaluated to theoretically predict a few physiochemical properties of the conjugated structure. The
predictions will aid the chemist in drug designing.
... It is the primary therapeutic component of the turmeric plant and exhibits anti-oxidant, anti-inflammatory, antimicrobial, anticancer, antipsoriatic, and wound-healing activities. 2,3 Due to these therapeutic activities, Cur is used topically for skin aging, infections, acne, psoriasis, eczema, dermatitis-like inflammations, and skin cancer. Therefore, Cur was a friendly donation from BASF, Turkey. ...
Background
Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic turmerone (Tur), present in its rhizome. These compounds exhibit diverse therapeutic properties, including anti-inflammatory, antioxidant, and anti-tumor effects. However, the topical application of these compounds has a significant potential for inducing skin irritation. This study focuses on formulating solid lipid nanoparticle (SLN) carriers encapsulating both Cur and Tur for reduced irritation and enhanced stability.
Methods
SLN formulations were prepared by a method using homogenization followed by ultrasonication procedures and optimized by applying response surface methodology (RSM).
Results
The optimized SLN formulation demonstrated entrapment efficiencies, with 77.21 ± 4.28% for Cur and 75.12 ± 2.51% for Tur. A size distribution of 292.11 ± 9.43 nm was obtained, which was confirmed to be a spherical and uniform shape via environmental scanning electron microscopy (ESEM) images. The in vitro release study indicated cumulative releases of 71.32 ± 3.73% for Cur and 67.23 ± 1.64% for Tur after 24 hours under sink conditions. Physical stability tests confirmed the stability of formulation, allowing storage at 4°C for a minimum of 60 days. Notably, in vitro skin irritation studies, utilizing the reconstructed human epidermal model (EPI-200-SIT), revealed a significant reduction in irritation with the SLN containing Cur and Tur compared to nonencapsulated Cur and Tur.
Conclusion
These findings collectively endorse the optimized SLN formulation as a favorable delivery system for Cur and Tur in diverse topical uses, offering enhanced stability, controlled release and reduced irritation.
... 67 Curcumin's potential topical and systemic usage in the treating and preventing of skin aging has been investigated due to its recognized anti-inflammatory and antioxidant properties. 68 In a clinical study of 28 women, daily use of an herbal formula gel containing rosemary and turmeric extract (containing curcumin) for 4 weeks significantly improved skin elasticity and the subjects' overall self-assessment. 69 In addition, Curcumin's ability to stimulate collagen production is essential in terms of facial skin tone and appearance. ...
Background
Acne is a common skin issue that typically occurs during adolescence. It causes long‐lasting redness and swelling in the skin. An alternative approach to treating acne could involve using a cosmetic facial mask containing herbal ingredients such as Curcumin and Rosa Damascena extract for its antibacterial properties.
Aims
This study aims to create and try out a peel‐off mask gel made from Curcumin and R. Damascena extract. This gel is intended to have the ability to kill bacteria such as Staphylococcus aureus, Escherichia coli, and Propionibacterium acnes and remove dead cells from the skin surface.
Methods
The peel‐off mask was made using polyvinyl alcohol (PVA) in 8% and 10% as solidifier. The evaluation of peel‐off masks comprises the examination of physiochemical and mechanical aspects. Furthermore, their longevity, effectiveness, and antibacterial properties are also considered.
Results
The white color, pleasant smell, and soft texture were the defining features of the peel‐off gel mask. The changes in PVA affect the pH level, thickness, and how quickly the peel‐off mask dries. The stability test found that the peel‐off mask had no significant physical changes when exposed to freezing and thawing. However, there were some differences in color and separation when using the real‐time method. A prepared peel‐off mask containing 10% PVA and curcumin works best against P. acne. The amount of PVA in the formula affected the physical and chemical qualities, but it did not impact on the antibacterial abilities of the peel‐off mask gel. The best formula that gives the best results uses 10% PVA + curcumin.
Conclusions
Using the Curcumin and R. Damascena extract in the creation of the peel‐off mask gel ensures its efficacy and safety for skin application.
... Turmeric (Curcuma longa) is a dry tuber of a perennial herbaceous plant, classified as part of the ginger family. It is grown mainly in tropical and subtropical regions and has been widely used as a seasoning and treatment of food safety for various diseases [10,11]. Curcumin is an active ingredient extracted from Turmeric (Curcuma longa). ...
... It was shown that oral curcumin could be effective in preventing the recurrence of OLP lesions after treatment and initial control; in addition, the dose of curcumin is more important than the duration of the treatment [11]. Studies [23,33,36] have shown that curcumin with a dose of 2000 mg/day did not show a significant difference between the intervention and control groups, while curcumin with a dose of 6000 mg/day showed a significant improvement; this shows that curcumin, like many drugs, may have a dose-dependent effect. Curcumin in the prescribed dose is safe and effective in controlling the signs and symptoms of OLP and can reduce the need for drugs such as corticosteroids [6]. ...
Background and objectives
Oral lichen planus (OLP) is a relatively common chronic T-cell–mediated disease that can cause significant pain, particularly in its erosive or ulcerative forms. This study aimed to examine the therapeutic impact of curcumin on symptoms of OLP.
Materials and methods
This meta-analysis was performed according to the PRISMA guidelines. All related English documents indexed in electronic databases (including PubMed, Web of Science, Scopus, Embase, Wiley, Cochrane, and ProQuest databases [updated to August 15, 2023]) were retrieved. Data were double-extracted into a predefined worksheet, and quality analysis was performed using the Joanna Briggs Institute (JBI) scale. We carried out meta-analyses, and the random effects model was used to estimate the differences in erythema, lesion size, and pain between the curcumin control groups.
Results
The search identified 289 studies, of which 10 were found to meet the inclusion criteria. The overall findings of the meta-analysis revealed that curcumin did not have a significant effect on erythema of OLP (standardized mean difference [SMD] = -0.14; 95% CI, -0.68 to 0.40; P = 0.61; I² = 57.50%), lesion size of OLP (SMD = -0.15; 95% CI, -0.45 to 0.15; P = 0.33; I² = 28.42%), and pain of OLP (SMD = -0.38; 95% CI, -0.97 to 0.22; P = 0.22; I² = 86.60%). However, subgroup analysis based on treatment duration indicated that 2-week treatment duration was significantly associated with a reduction in OLP pain (n = 3; SMD = -1.21; 95% CI, -2.19 to -0.23; P = 0.01).
Conclusions
Curcumin had no significant effect on erythema, lesion size, and pain of OLP compared to the control groups. However, subgroup analysis revealed that curcumin was more effective in reducing pain in non-randomized trials and in trials with a treatment duration of 2 weeks.
Curcumin, known for its anti-inflammatory, antibacterial, anticarcinogenic, and antioxidant properties, faces challenges due to poor water solubility and low bioavailability as a BCS class II compound. The study investigates using a self-nanoemulsifying drug delivery system (SNEDDS) to enhance these properties, optimizing the formulation with the D-Optimal Mixture Design method. Sixteen formulas were prepared using oleic acid, Tween 80, and PEG 400. Each formula was characterized by particle size, % transmittance, emulsification time, and drug loading. The optimized formula, containing 10% oleic acid, 70% Tween 80, and 20% PEG 400, achieved a particle size of 80.167 nm, an emulsification time of 39.36 seconds, near 100% transmittance, and high drug loading.
Background
Oral potentially malignant disorders (OPMDs) not only harbour the risk of malignant transformation but can also affect patients’ quality of life owing to severe symptoms. Therefore, there is an urgent need for therapeutic strategies to improve patients’ quality of life. The objective of this meta-analysis was to comprehensively assess the efficacy of curcumin in the management of OPMDs.
Methods
PubMed, Embase, the Cochrane Library, and Web of Science were searched for clinical trials evaluating the efficacy of curcumin in the treatment of OPMDs from inception until March 2024. RevMan 5.4 software was used to perform statistical and subgroup analyses.
Results
Sixteen randomised controlled trials (1,089 patients) were selected. Curcumin exhibited comparable efficacy to conventional controls in alleviating pain (I ² = 98%, P = 0.49) and improving tongue protrusion (I ² = 94%, P = 0.51) in oral submucous fibrosis (OSF). Additionally, topical use of curcumin had an efficacy equivalent to that of conventional therapy in reducing pain (I ² = 83%, P = 0.31) and facilitating clinical remission (I ² = 67%, P = 0.38) of oral lichen planus (OLP).
Conclusion
The topical use of curcumin may palliate pain and promote clinical healing in OLP patients. Systemic curcumin can ameliorate the degree of pain and tongue protrusion in OSF. Therefore, our study suggests that curcumin could serve as an alternative treatment for managing OPMDs with lower medical toxicity than steroids, especially when steroids are not suitable. Further studies with larger sample sizes and adequate follow-up periods are required to validate our results.
Background:
Acne is a chronic inflammatory and immune-mediated disease of the pilosebaceous unit (the skin structure consisting of a hair follicle and its associated sebaceous gland). It is characterised by non-inflammatory lesions (open and closed comedones) and inflammatory lesions (papules, pustules, nodules, and cysts). Lesions may be present on the face, thorax, and back, with variable severity. Acne exhibits a global distribution and has a growing prevalence. Acne vulgaris is the most common form. Acne gives rise to complications such as scars and can seriously affect people's mental health, especially those with severe acne. Acne has a huge impact on the quality of life and self-esteem of those affected.
Objectives:
To synthesise the existing evidence on the efficacy and safety of non-systemic pharmacological interventions and non-pharmacological interventions (physical therapy and complementary therapies) in the treatment of acne vulgaris and related skin complications.
Methods:
We searched the Cochrane Database of Systematic Reviews, Epistemonikos, MEDLINE, and Embase to 2 December 2021, and checked the reference lists of included reviews. At least two authors were responsible for screening, data extraction, and critical appraisal. We excluded reviews with high risk of bias as assessed with the ROBIS tool. We evaluated the overall certainty of the evidence according to GRADE (as carried out by the authors of the included reviews or ourselves). We provide comprehensive evidence from the review data, including summary of findings tables, summary of results tables, and evidence maps.
Main results:
We retrieved and assessed a total of 733 records; however, only six reviews (five Cochrane reviews and one non-Cochrane review) with low risk of bias met the overview inclusion criteria. The six reviews involved 40,910 people with acne from 275 trials and 1316 people with acne scars from 37 trials. The age of the participants ranged from 10 to 59 years, with an average age range from 18 to 30 years. Four reviews included original trials involving only female participants and three reviews included original trials with only male participants. Main results for clinically important comparisons: Benzoyl peroxide versus placebo or no treatment: In two trials involving 1012 participants over 12 weeks, benzoyl peroxide may reduce the total (mean difference (MD) -16.14, 95% confidence interval (CI) -26.51 to -5.78), inflammatory (MD -6.12, 95% CI -11.02 to -1.22), and non-inflammatory lesion counts (MD -9.69, 95% CI -15.08 to -4.29) when compared to placebo (long-term treatment), but the evidence is very uncertain (very low-certainty evidence). Two trials including 1073 participants (time point: 10 and 12 weeks) suggested benzoyl peroxide may have little to no effect in improving participants' global self-assessment compared to placebo (long-term treatment), but the evidence is very uncertain (risk ratio (RR) 1.44, 95% CI 0.94 to 2.22; very low-certainty evidence). Very low-certainty evidence suggested that benzoyl peroxide may improve investigators' global assessment (RR 1.77, 95% CI 1.37 to 2.28; 6 trials, 4110 participants, long-term treatment (12 weeks)) compared to placebo. Thirteen trials including 4287 participants over 10 to 12 weeks suggested benzoyl peroxide may increase the risk of a less serious adverse event compared to placebo (long-term treatment), but the evidence is very uncertain (RR 1.46, 95% CI 1.01 to 2.11; very low-certainty evidence). Benzoyl peroxide versus topical retinoids: Benzoyl peroxide may increase the percentage change in total lesion count compared to adapalene (long-term treatment), but the evidence is very uncertain (MD 10.8, 95% CI 3.38 to 18.22; 1 trial, 205 participants, 12 weeks; very low-certainty evidence). When compared to adapalene, benzoyl peroxide may have little to no effect on the following outcomes (long-term treatment): percentage change in inflammatory lesion counts (MD -7.7, 95% CI -16.46 to 1.06; 1 trial, 142 participants, 11 weeks; very low-certainty evidence), percentage change in non-inflammatory lesion counts (MD -3.9, 95% CI -13.31 to 5.51; 1 trial, 142 participants, 11 weeks; very low-certainty evidence), participant's global self-assessment (RR 0.96, 95% CI 0.86 to 1.06; 4 trials, 1123 participants, 11 to 12 weeks; low-certainty evidence), investigators' global assessment (RR 1.16, 95% CI 0.98 to 1.37; 3 trials, 1965 participants, 12 weeks; low-certainty evidence), and incidence of a less serious adverse event (RR 0.77, 95% CI 0.48 to 1.25, 1573 participants, 5 trials, 11 to 12 weeks; very low-certainty evidence). Benzoyl peroxide versus topical antibiotics: When compared to clindamycin, benzoyl peroxide may have little to no effect on the following outcomes (long-term treatment): total lesion counts (MD -3.50, 95% CI -7.54 to 0.54; 1 trial, 641 participants, 12 weeks; very low-certainty evidence), inflammatory lesion counts (MD -1.20, 95% CI -2.99 to 0.59; 1 trial, 641 participants, 12 weeks; very low-certainty evidence), non-inflammatory lesion counts (MD -2.4, 95% CI -5.3 to 0.5; 1 trial, 641 participants, 12 weeks; very low-certainty evidence), participant's global self-assessment (RR 0.95, 95% CI 0.68 to 1.34; 1 trial, 240 participants, 10 weeks; low-certainty evidence), investigator's global assessment (RR 1.10, 95% CI 0.83 to 1.45; 2 trials, 2277 participants, 12 weeks; very low-certainty evidence), and incidence of a less serious adverse event (RR 1.27, 95% CI 0.98 to 1.64; 5 trials, 2842 participants, 10 to 12 weeks; low-certainty evidence). For these clinically important comparisons, no review collected data for the following outcomes: frequency of participants experiencing at least one serious adverse event or quality of life. No review collected data for the following comparisons: topical antibiotics versus placebo or no treatment, topical retinoids versus placebo or no treatment, or topical retinoids versus topical antibiotics.
Authors' conclusions:
This overview summarises the evidence for topical therapy, phototherapy, and complementary therapy for acne and acne scars. We found no high-certainty evidence for the effects of any therapy included. Randomised controlled trials and systematic reviews related to acne and acne scars had limitations (low methodological quality). We could not summarise the evidence for topical retinoids and topical antibiotics due to insufficient high-quality systematic reviews. Future research should consider pooled analysis of data on new emerging drugs for acne treatment (e.g. clascoterone) and focus more on acne complications.
Pigmentation is the process in which the skin pigments are entirely gets tanned and turns into black color. Exposure to ultraviolet radiation is produce selective effects for vitamin D synthesis, which causes melanin synthesis and pigmentation. Skin pigmentation is nowadays becoming a major problem. Due to this we used depigmenting agents which makes skin fairer. In present study we used the herbal materials which are having the anti-inflammatory and anti-oxidant activity which helps to reduce pigmentation. So, to overcome from the skin pigmentation we made the herbal cream which having a such type ingredients that which helps to reduce pigmentation and makes skin fair. For reduction of pigmentation, we formulated herbal cream by using Papaya Pulp, Aloe Vera, Pomegranate Peel Powder as well as Orange Peel Powder. These ingredients can reduce pigmentation by inhibiting tyrosine which is responsible for melanin secretion. The daily use of our herbal cream can reduce melanin quickly.
Many people simply recognise turmeric; the golden-coloured powder as a spice, experimental and clinical research, has however, shown that the remedies of various diseases are also attributable to it, especially to its most potent bioactive curcuminoid, curcumin. Curcumin possesses antioxidant, antidiabetic, anti-inflammatory, antimicrobial, anticoagulant, cardiovascular, and central nervous system effects, but its utilization was before now limited due to its poor bioavailability and easy elimination. The development of adjuvants like piperine and other nano-formulations currently helps to overcome this limitation, and curcumin, now less limited, finds applications in diverse fields, including the medical, cosmetic, food, and agricultural industries. Other curcuminods, such as bisdemethoxycurcumin and demethoxycurcumin, are also present within the plant. This review aims to provide a look into the entire plant, beginning with its cultivation, processing, diseases, botanical details, bioactive compounds and their consequent activities, benefits from its bacterial fermentation, clinical applications on human subjects, as well as its utilization in the food, cosmetic, medical, and agricultural industries.
Thalassemia is an inherited genetic disorder of hemoglobin that affects a large population worldwide, and it is estimated that between 50,000 and 60,000 infants with thalassemia are born each year. The most common treatment for thalassemia is blood transfusion, which leads to iron overload. This in itself is a serious clinical condition, and is commonly managed with iron chelation therapy. However, iron chelators can cause various skin complications, including hyperpigmentation, skin rash, itching, and photosensitivity. These skin side effects can impact patients’ quality of life. Therefore, this article provides a comprehensive overview of skin complications caused by iron chelators, along with a proposed comprehensive approach to their management in patients with beta-thalassemia. Key strategies include patient education, regular skin assessment, sun protection measures, symptomatic relief with topical corticosteroids and antihistamines, and consideration of treatment modification if severe complications occur. Collaboration between hematologists and dermatologists, along with psychological support and regular follow-up, is an essential component of this multidisciplinary approach. By implementing these strategies, healthcare providers can optimize skin care for patients with beta-thalassemia treated with iron chelators and improve their quality of life.
Traditional herbal medicines (THM) are used by almost 75%-80% of the people in Bangladesh to treat various types of skin diseases. This review includes ethnobotanical data as well as relevant scientific studies on plants used in traditional medicine in Bangladesh to treat various types of skin disorders like inflammatory skin disorders, viral infections, bacterial infections, fungal infections, parasitic infections, pigmentation disorders, skin cancers, trauma and other skin disease conditions. Using specified key phrases, information on the traditional herbal medicinal plants of Bangladesh that are effective against various skin ailments was collated from several electronic databases such as PubMed, Google Scholar, Web of Science, Scopus, ScienceDirect, Springer and others. A total of 45 relevant publications were investigated, providing complete information on 221 distinct herbal plant species belonging to 73 families utilised by the diverse peoples of Bangladesh for the treatment of skin problems. The most often utilised plant organ in this study was leaves, followed by roots, fruits, entire plants, barks, seeds, stems, rhizomes and flowers. The Asteraceae family has the most species, whereas in terms of plant habit, herbs have the most species. Azadirachta indica, Curcuma longa, Vitex negundo, Aegle marmelos, Allium sativum and Lawsonia inermis are the most commonly utilised species. This research might be used as a beginning point for a systematic search for natural herbal remedies to treat skin diseases in Bangladesh's flora.
Turmeric is growing in India since ancient times mainly for its culinary and medicinal properties, particularly in Ayurveda. Various property of this spice has extended its use as a component of food additive and other natural dies, also as a clinical component in the cosmetic and pharmaceutical industries and many other uses. A recent pandemic, COVID-19, also further valued the health benefits in the form of an immunity booster. The USA is the largest consumer of Indian turmeric, imported 22 percent of the total exported value, and followed by Bangladesh (18%), Iran (6%), and UAE (5%) in the last year. Some of the other importing countries are Malaysia, UK, Morocco, Germany and Japan. This opportunity can be utilized further by introducing some new innovative products and recipes. Secondary data used in the present study. Objectives: To study the growth of area, production and productivity of Turmeric in India, To analyse the growth of area, production and productivity of Turmeric in India during pre and post-liberalisation period viz. Pre-Economic liberalization (1950-51 to 1990-91) and Post-Economic liberalization (1991-92 to 2021-22). From the study analysis, Annual growth of area is estimated that-4.03 in 1990-91. The positive AGR value of turmeric showed that 20 in 1961-62. The minimum production of turmeric found that-32 (In ' 000 MT) in the year 1972-73 and the maximum of turmeric production is 51(In ' 000 MT) in 1978-79 period respectively. The mean value of turmeric production analysed with 3.83 during the study. Standard deviation of production valuation showed 19.64 and the CV value is estimated that 512.99. The minimum of turmeric productivity showed 2 (In MT/Hectare) from 1961-62 to 1983-84 and maximum is 4 (In MT/Hectare) in 1989-90 respectively. The mean value of productivity is 2.30. Post-liberalisation period better growth in production of turmeric form 1950 to 2021-22. The productivity of turmeric AGR revealed that-21.62 in 1990-91 and 0 .00 level in 2021-22. Productivity of turmeric showed not good better level during the study periods.
Excessive alcohol intake will aggravate the health risk between the liver and intestine and affect the multi-directional information exchange of metabolites between host cells and microbial communities. Because of the side effects of clinical drugs, people tend to explore the intervention value of natural drugs on diseases. As a flavor substance, spices have been proven to have medicinal value, but they are still rare in treating hepatointestinal diseases caused by alcohol. This paper summarized the metabolic transformation of alcohol in the liver and intestine and summarized the potential value of various perfume active substances in improving liver and intestine diseases caused by alcohol. It is also found that bioactive substances in spices can exert antioxidant activity in the liver and intestine environment and reduce the oxidative stress caused by diseases. These substances can interfere with fatty acid synthesis, promote sugar and lipid metabolism, and reduce liver injury caused by steatosis. They can effectively regulate the balance of intestinal flora, promote the production of SCFAs, and restore the intestinal microenvironment.
For maintaining healthy, attractive appearance hair has the vital role. Hair problems are common and can diminish self-esteem and selfconfidence of a person. Many forms of hair problems, baldness, alopecia, hair fall, gray hair, dryness, and most common dandruff require clinical care by a health care professional. Hair is sensitive to changes in the environment, diet, and overall health. Identifying these changes and resorting to the wisdom of Ayurveda for their coping mechanisms can help maintain good hair health. Ayurveda formulations always have attracted considerable attention because of their good activity and comparatively lesser side effects with synthetic drugs. This review gives knowledge regarding the beneficial effects and recent progress of medicinal plants for the treatment of hair disorders.
Background
Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these variants to gene expression regulation has not been performed to the best of our knowledge.
Results
In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis and utilized single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. Through a transcriptome-wide association study and colocalization analysis, we identified 52, 75, and 144 MPB associations for T2, T3, and T4, respectively. To assess the causality of MPB genes, we performed a conditional and joint analysis, which revealed 10, 11, and 54 putative causality genes for T2, T3, and T4, respectively. Finally, we conducted drug repositioning and identified potential drug candidates that are connected to MPB-associated genes.
Conclusions
Overall, through an integrative analysis of gene expression and genotype data, we have identified robust MPB susceptibility genes that may help uncover the underlying molecular mechanisms and the novel drug candidates that may alleviate MPB.
The body's most delicate organ is the skin. It is well fact that daily skin exposure causes a variety of issues, including pigmentation, acne, pimples, and sunburn markings. These days, acne is the most prevalent skin condition. Acne is a follicular skin disorder characterized by inflammatory and non-inflammatory lesions and scarring that mostly affects the Pilosebaceous unit of the face, neck, and trunk. Approximately 80-95% of people in their pubertal years, 20-45% of adults, and less than 25% of women experienced skin disorders including acne, black spots, etc. Adult female acne can affect women even after they turn 25. For a very long time, there have been a lot of topical and systematic treatments for Acne vulgaris that use synthetic components. Because synthetic medications have a high risk of side effects and can be used in both internal and exterior therapy, Natural treatments are thought to be a safer and more effective option for treating acne vulgaris. The use of phytochemicals and medicinal plants to treat skin conditions, such as acne vulgaris, has grown in popularity during the last few decades. A relevant approach is the use of natural medicine as an alternative and supplemental therapy. This study's primary goal was to systematically evaluate the safety and effectiveness of natural medicinal herbs and phytochemicals in the
Diesel particulate matter is one of the most dangerous environmental stressors affecting human health. Many plant-derived compounds with antioxidant and anti-inflammatory properties have been proposed to protect the skin from pollution damage. Curcumin (CUR) has a plethora of pharmacological activities, including anticancer, antimicrobial, anti-inflammatory and antioxidant. However, it has low bioavailability due to its difficult absorption and rapid metabolism and elimination. CUR encapsulation in nanotechnological systems and its combination with biopotentiators such as piperine (PIP) can improve its pharmacokinetics, stability and activity. In this study, ethosomes (ETs) were investigated for CUR and PIP delivery to protect the skin from damage induced by diesel particulate matter. ETs were produced by different strategies and characterized for their size distribution by photon correlation spectroscopy, for their morphology by transmission electron microscopy, and for their drug encapsulation efficiency by high-performance liquid chromatography. Franz cells enabled us to evaluate in vitro the drug diffusion from ETs. The results highlighted that ETs can promote the skin permeation of curcumin. The studies carried out on their antioxidant activity demonstrated an increase in the antioxidant power of CUR using a combination of CUR and PIP separately loaded in ETs, suggesting their possible application for the prevention of skin damage due to exogenous stressors. Ex vivo studies on human skin explants have shown the suitability of drug-loaded ETs to prevent the structural damage to the skin induced by diesel engine exhaust exposure.
Supplementation of micronutrients is considered to be crucial in the reinforcement of the skin’s barrier. In this paper, 14 nutritional compounds commonly used in food or pharmaceutic industries were analyzed in terms of influencing skin conditions. The major objective of this paper was to provide a narrative review of the available literature regarding several chosen compounds that are currently widely recommended as supplements that aim to maintain proper and healthy skin conditions. We conducted a review of the literature from PubMed, Scopus, and Web of Science until September 2023 without any other restrictions regarding the year of the publication. Ultimately, we reviewed 238 articles, including them in this review. Each of the reviewed compounds, including vitamin A, vitamin C, vitamin D, vitamin E, curcumin, chlorella, Omega-3, biotin,Ppolypodium leucotomos, Simmondsia chinesis, gamma oryzanol, olive leaf extract, spirulina, and astaxanthin, was observed to present some possible effects with promising benefits for a skin condition, i.e., photoprotective radiation. Adding them to the diet or daily routine might have a positive influence on some skin inflammatory diseases such as atopic dermatitis or psoriasis. Further, UV radiation protection facilitated by some supplements and their impact on human cells might be helpful during chemotherapy or in preventing melanoma development. Further research is needed because of the lack of clear consensus regarding the doses of the described compounds that could provide desirable effects on the skin.
Feridas crônicas representam um ônus para o Sistema Único de Saúde, e a curcumina emerge como uma opção custo-efetiva no seu tratamento. O objetivo do estudo é analisar as evidências do uso da curcumina, isoladamente ou em combinação com outros ativos medicinais ou agentes biofísicos na cicatrização de feridas crônicas em adultos. Trata-se de uma revisão narrativa de abril a setembro de 2023, empregando estratégias de busca estruturada baseadas em PICO e MeSH Terms relacionados à "curcumin," "chronic wounds," e "wound healing". Foram incluídos estudos sem restrição de ano de publicação, com participantes com idade superior a 18 anos e que apresentassem feridas crônicas. Foram incluídos estudos em português, espanhol ou inglês. Dos 525 artigos identificados, seis atenderam aos critérios de inclusão. O estudo destaca resultados promissores da curcumina na cicatrização de feridas crônicas, principalmente em pacientes diabéticos. Contudo, ressalta-se a necessidade de mais estudos clínicos sobre a temática.
The increasing prevalence of tanning as a skincare concern, due to factors such as pollution, stress, UV radiation, and lifestyle, has prompted the need for the development of organic anti-tan formulations. The current study aims to synthesize an organic anti-tan substance and evaluate its various properties for both stability and effectiveness. It is well-known that the skin's natural defense mechanism against UV damage is the development of melanin, a dark brown pigment, to protect the skin from burning. Historically, plants have been utilized to meet the basic requirements for healthy and beautiful skin.
However, conventional cosmetics often contain toxic ingredients that can lead to regenerative issues and increased growth hazards, with studies suggesting that the more products utilized, the higher the potential for harmful concentrations in the body. Therefore, it is recommended to avoid cosmetics altogether. However, if use is deemed necessary, the use of natural or organic cosmetics is suggested. This project aims to create and assess a polyherbal face and body pack for cosmetic use, utilizing only natural ingredients.
Systematic reviews and meta-analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta-analyses suggest preliminary or satisfactory clinical evidence for agnus castus (Vitex agnus castus) for premenstrual complaints, flaxseed (Linum usitatissimum) for hypertension, feverfew (Tanacetum partenium) for migraine prevention, ginger (Zingiber officinalis) for pregnancy-induced nausea, ginseng (Panax ginseng) for improving fasting glucose levels as well as phytoestrogens and St John's wort (Hypericum perforatum) for the relief of some symptoms in menopause. However, firm conclusions of efficacy cannot be generally drawn. On the other hand, inconclusive evidence of efficacy or contradictory results have been reported for Aloe vera in the treatment of psoriasis, cranberry (Vaccinium macrocarpon) in cystitis prevention, ginkgo (Ginkgo biloba) for tinnitus and intermittent claudication, echinacea (Echinacea spp.) for the prevention of common cold and pomegranate (Punica granatum) for the prevention/treatment of cardiovascular diseases. A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications. Nevertheless, potentially serious adverse events, including herb-drug interactions, have been described. This suggests the need to be vigilant when using herbal remedies, particularly in specific conditions, such as during pregnancy and in the paediatric population. Copyright © 2016 John Wiley & Sons, Ltd.
Objective:
The study objective was to assess the effectiveness of a turmeric- and sandal wood oil-containing cream [Vicco(®) turmeric cream (VTC); Vicco Laboratories, Parel, India] on radiodermatitis in patients with head and neck cancer undergoing radiotherapy.
Methods:
A total of 50 patients with head and neck cancer requiring >60 Gy of curative radiotherapy/chemoradiotherapy were enrolled in the study. The volunteers were randomly divided into two groups of 25 patients. Group 1 was assigned to a topical application of Johnson's(®) baby oil (Johnson & Johnson Ltd, Baddi, India) and Group 2 for VTC. Prophylactic application of the cream was initiated on Day 1 and continued every day until 2 weeks after the end of treatment. Both agents were symmetrically applied within the irradiated field five times a day, and the acute skin reactions were assessed twice weekly in accordance with the Radiation Therapy Oncology Group scores by an investigator who was unaware of the details.
Results:
The incidence of radiodermatitis increased with the exposure to radiation and was the highest in both groups at Week 7. However, a significant reduction in grades of dermatitis were seen in cohorts applying VTC at all time points, including 2 weeks post radiotherapy (p < 0.015 to p < 0.001). The occurrence of Grade 3 dermatitis was lower in the cohorts using VTC and was statistically significant (p < 0.01). Additionally, follow-up observations 2 weeks after the completion of radiotherapy also showed a reduced degree of radiodermatitis in cohorts applying VTC, which was significant (p = 0.015).
Conclusion:
VTC is shown to be effective in preventing radiodermatitis and needs to be validated in larger double-blind trials.
Advances in knowledge:
For the first time, this study shows that the turmeric- and sandal oil-based cream was effective in preventing radiation-induced dermatitis.
Uremic pruritus as a symptom that affects hemodialysis (HD) patients can decrease the quality of life and increase morbidity in these patients. The aim of this study was to evaluate the effects of turmeric on uremic pruritus in HD patients.
This was a double-blind placebo-controlled trial conducted on 100 HD patients suffering from pruritus. Patients (mean age 53.3 ± 15.8 years) were randomized into two groups: turmeric and placebo. The pruritus score and biochemical determinants including high-sensitivity C-reactive protein (hs-CRP) were compared before and at the end of the study between the two groups.
The mean decrease in hs-CRP was significantly higher in the turmeric than the placebo group (-0.8 ± 2.6 vs. 0.4 ± 8.7 mg/l, p = 0.012). Also reduction of pruritus scores was greater in the turmeric than the placebo group (13.6 ± 2.6 vs. 7.2 ± 2.6, p = 0.001). No side effect was observed during the study due to the use of turmeric.
This study demonstrates the possible efficacy of turmeric in decreasing hs-CRP and uremic pruritus in end stage renal disease patients. Future studies are needed to further evaluate the efficacy and safety of turmeric.
The aim of the present study was to evaluate the improvement of diabetic microangiopathy in patients suffering from this condition since at least five years, and whose disease was managed without insulin.
Curcumin, the orange pigment of turmeric, has recently received increasing attention because of its antioxidant properties, mediated by both direct oxygen radical quenching and by induction of anti-oxidant responses via Nrf2 activation. This aspect, combined with the beneficial effects on endothelial function and on tissue and plasma inflammatory status, makes curcumin potentially useful for the management of diabetic microangiopathy. To further evaluate this, Meriva, a lecithinized formulation of curcumin, was administered at the dosage of two tablets/day (1 g Meriva/day) to 25 diabetic patients for four weeks. A comparable group of subjects followed the best possible management for this type of patients.
All subjects in the treatment and control group completed the follow-up period; there were no dropouts. In the treatment group, at four weeks, microcirculatory and clinical evaluations indicated a decrease in skin flux (P<0.05) at the surface of the foot, a finding diagnostic of an improvement in microangiopathy, the flux being generally increased in patients affected by diabetic microangiopathy. Also, a significant decrease in the edema score (P<0.05) and a corresponding improvement in the venoarteriolar response (P<0.05) were observed. The PO2 increased at four weeks (P<0.05), as expected from a better oxygen diffusion into the skin due to the decreased edema. These findings were present in all subjects using Meriva, while no clinical or microcirculatory effects were observed in the control group.
Meriva was, in general, well tolerated, and these preliminary findings suggest the usefulness of this curcumin formulation for the management of diabetic microangiopathy, opening a window of opportunities to be evaluated in more prolonged and larger studies. The molecular mechanisms involved in the beneficial effects of curcumin on microcirculation and edema are also worth investigation.
Skin is among the first and most heavily damaged organs upon sulphur mustard (SM) exposure. Pruritus is the most common chronic skin complication of SM, which adversely affects the quality of life (QoL). However, current therapies for the management of SM-induced pruritus are very limited and associated with side effects. The present trial investigated the efficacy of curcumin in the alleviation of SM-induced chronic pruritic symptoms. A total of ninety-six male Iranian veterans (age 37-59 years) were randomised to receive either curcumin (1 g/d, n 46) or placebo (n 50) for 4 weeks. Serum concentrations of substance P and activities of antioxidant enzymes were measured at baseline and at the end of the trial. Assessment of pruritus severity was performed using the pruritus score, visual analogue scale (VAS) and scoring atopic dermatitis (SCORAD) index. QoL was evaluated using the Dermatology Life Quality Index (DLQI) questionnaire. Serum concentrations of substance P (P < 0·001) as well as activities of superoxide dismutase (P = 0·02), glutathione peroxidase (P = 0·006) and catalase (P < 0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group. Curcumin supplementation was also associated with significant reductions in measures of pruritus severity including the pruritus score (P < 0·001), VAS score (P < 0·001), overall (P < 0·001) and objective SCORAD (P = 0·009), and DLQI's first question (P < 0·001). None of these measures was significantly changed in the placebo group. As for the QoL, although DLQI scores decreased in both groups (P < 0·001 and P = 0·003 in the curcumin and placebo groups, respectively), the magnitude of reduction was significantly greater in the curcumin group (P < 0·001). In conclusion, curcumin may be regarded as a natural, safe, widely available and inexpensive treatment for the management of SM-induced chronic pruritus.
To date, we are unaware of a review that has investigated common cosmeceutical ingredients in order to answer the three specific questions proposed by the father of cosmeceuticals, Dr. Albert Kligman. It is the goal of this review to gather all the published scientific data on five common cosmeceutical ingredients, answer the three major questions about the scientific rationale for their use, and ascertain how much we really know about consumers' favorite cosmeceutical ingredients.Most of the research concerning cosmeceutical retinoid ingredients is based upon the effects of retinoic acid on the skin. Clinical trials concerning retinol and retinaldehyde are scant and lacking in statistical evaluation for significance. There is research substantiating the effects of kinetin in plants and also in-vitro antioxidant effects. However, proof of anti-aging activity remains elusive, and the clinical efficacy of kinetin is based on limited data. Niacinamide is the ingredient investigated that most closely upholds the "Kligman standards" of cosmeceutical-ingredient analysis. With the available scientific evidence on topical niacinamide, clinicians are able to adequately answer questions about permeability, mechanism, and clinical effect. Both green tea and soy have been popularized commercially based on their antioxidant effects, yet there is a paucity of clinical studies concerning their efficacy as topical anti-aging agents. It may be that soy and green tea are better at preventing the signs and symptoms of skin aging than actually reversing them. Since cosmeceutical products are claiming to therapeutically affect the structure and function of the skin, it is rational and necessary to hold them to specified scientific standards that substantiate efficacy claims.
The cytoskeletal protein, FtsZ plays a pivotal role in prokaryotic cell division and is present in majority of the bacterial species. In recent years, inhibitors of FtsZ have been identified that may function as lead compounds for the development of novel antimicrobials. It has been found that curcumin, the main bioactive component of Curcuma longa, inhibits Bacillus subtilis and Escherichia coli growth by inhibiting FtsZ assembly. Though it is experimentally established that curcumin inhibits FtsZ polymerization, the binding site of curcumin in FtsZ is not known. In this study, interaction of curcumin with catalytic core domain of E. coli and B. subtilis FtsZ was investigated using computational docking.
It has been suggested that the quality of clinical trials should be assessed by blinded raters to limit the risk of introducing bias into meta-analyses and systematic reviews, and into the peer-review process. There is very little evidence in the literature to substantiate this. This study describes the development of an instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research and its use to determine the effect of rater blinding on the assessments of quality. A multidisciplinary panel of six judges produced an initial version of the instrument. Fourteen raters from three different backgrounds assessed the quality of 36 research reports in pain research, selected from three different samples. Seven were allocated randomly to perform the assessments under blind conditions. The final version of the instrument included three items. These items were scored consistently by all the raters regardless of background and could discriminate between reports from the different samples. Blind assessments produced significantly lower and more consistent scores than open assessments. The implications of this finding for systematic reviews, meta-analytic research and the peer-review process are discussed.
The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall-bladder.
To compare the effect of 20 mg curcumin or placebo on the gall-bladder volume of healthy volunteers.
A randomized, double blind and crossover design study was carried out in 12 healthy volunteers (seven males and five females). Ultrasonography examination was carried out serially to measure the gall-bladder volume. The data obtained was analysed by paired Student's t-test.
The fasting gall-bladder volumes of 15.74 +/- 4.29 mL on curcumin and 15.98 +/- 4.08 mL on placebo were similar (P > 0.20). The gall-bladder volume was reduced within the period after curcumin administration. The percentage of gall-bladder volume reduction at 0.5, 1.0, 1.5 and 2.0 h after 20 mg curcumin administration were 11.8 +/- 6.9, 16.8 +/- 7.4, 22.0 +/- 8.5 and 29. 3 +/- 8.3%, respectively, which was statistically significant compared to placebo.
On the basis of the present findings, it appears that curcumin induces contraction of the human gall-bladder.
Curcumin (diferuloylmethane), a yellow substance from the root of the plant Curcuma longa Linn., has been demonstrated to inhibit carcinogenesis of murine skin, stomach, intestine and liver. However, the toxicology, pharmacokinetics and biologically effective dose of curcumin in humans have not been reported. This prospective phase-I study evaluated these issues of curcumin in patients with one of the following five high-risk conditions: 1) recently resected urinary bladder cancer; 2) arsenic Bowen's disease of the skin; 3) uterine cervical intraepithelial neoplasm (CIN); 4) oral leucoplakia; and 5) intestinal metaplasia of the stomach. Curcumin was taken orally for 3 months. Biopsy of the lesion sites was done immediately before and 3 months after starting curcumin treament. The starting dose was 500 mg/day. If no toxicity > or = grade II was noted in at least 3 successive patients, the dose was then escalated to another level in the order of 1,000, 2,000, 4,000, 8,000, and 12,000 mg/day. The concentration of curcumin in serum and urine was determined by high pressure liquid chromatography (HPLC). A total of 25 patients were enrolled in this study. There was no treatment-related toxicity up to 8,000 mg/day. Beyond 8,000 mg/day, the bulky volume of the drug was unacceptable to the patients. The serum concentration of curcumin usually peaked at 1 to 2 hours after oral intake of crucumin and gradually declined within 12 hours. The average peak serum concentrations after taking 4,000 mg, 6,000 mg and 8,000 mg of curcumin were 0.51 +/- 0.11 microM, 0.63 +/- 0.06 microM and 1.77 +/- 1.87 microM, respectively. Urinary excretion of curcumin was undetectable. One of 4 patients with CIN and 1 of 7 patients with oral leucoplakia proceeded to develop frank malignancies in spite of curcumin treatment. In contrast, histologic improvement of precancerous lesions was seen in 1 out of 2 patients with recently resected bladder cancer, 2 out of 7 patients of oral leucoplakia, 1 out of 6 patients of intestinal metaplasia of the stomach, I out of 4 patients with CIN and 2 out of 6 patients with Bowen's disease. In conclusion, this study demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months. Our results also suggest a biologic effect of curcumin in the chemoprevention of cancer.
Recently, there have been considerable efforts to search for naturally occurring substances that can inhibit, reverse, or retard the multi-stage carcinogenesis. A wide array of phenolic substances derived from edible and medicinal plants have been reported to possess anticarcinogenic and antimutagenic activities and in many cases, the chemopreventive activities of phytochemicals are associated with their anti-inflammatory and/or antioxidative properties. Panax ginseng C.A. Meyer cultivated in Korea has been widely used in traditional herbal medicine for the treatment of various diseases. Certain fractions or purified ingredients of ginseng have been shown to exert anticarcinogenic and antimutagenic activities. Our previous studies have revealed that the methanol extract of heat-processed Panax ginseng C.A. Meyer attenuates the lipid peroxidation in rat brain homogenates and is also capable of scavenging superoxide generated by xanthine- xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of the same extract onto shaven backs of female ICR mice also suppressed TPA-induced skin tumor promotion. Likewise, topical application of ginsenoside Rg3, one of the constituents of heat-treated ginseng, significantly inhibited TPA-induced mouse epidermal ornithine decarboxylase activity and skin tumor promotion. Expression of cyclooxygenase-2 (COX-2) in TPA-stimulated mouse skin was markedly suppressed by Rg3 pretreatment. In addition, Rg3 inhibited TPA-stimulated activation of NF-kappaB and extracellular-regulated protein kinase (ERK), one of the mitogen-activated protein (MAP) kinase in mouse skin and also in cultured human breast epithelial cells (MCF-10A).
Curcumin, derived from the rhizome curcuma longa, is one of the primary ingredients in turmeric and curry powders that are used as spices in Middle Eastern and Asian countries, especially on the Indian subcontinent. More recently, laboratory studies have demonstrated that dietary curcumin exhibits various biological activities and significantly inhibits colon tumorigenesis and tumor size in animals. Curcumin displays both anti-inflammatory and antioxidant properties, giving it the potential to be considered in the development of cancer preventive strategies and applications in clinical research. Experimental studies have shown the biological activities of the compound, but much more information on pharmacokinetics, bioavailability, and food content are needed. Whether the amount of curcumin in turmeric and curry powders is sufficient to suggest effects on biological activities and cancer risk is unknown. To determine and compare the quantitative amounts of curcumin that are present in several brands of turmeric and curry powders, a high performance liquid chromatography technique was used to analyze 28 spice products described as turmeric or curry powders and two negative controls. Pure turmeric powder had the highest curcumin concentration, averaging 3.14% by weight. The curry powder samples, with one exception, had relatively small amounts of curcumin present, and the variability in content was great. The curcumin content of these seasoning products that are consumed as a component of the diet should be considered in evaluating baseline tissue concentration and response to curcumin supplementation, which is under study in chemoprevention trials.
Lipid peroxidation has been implicated in a variety of diseases. 4-Hydroxy-2-nonenal (HNE), a major oxidation by-product, is cytotoxic, mutagenic, and genotoxic, being involved in disease pathogenesis. Naturally occurring pharmacologically active small molecules are very attractive as natural nonsteroidal anti-inflammatory agents. Interest has greatly increased recently in the pharmacotherapeutic potential of curcumin, the yellow pigment found in the rhizomes of the perennial herb Curcuma longa (turmeric). Curcumin is efficacious against colon cancer, cystic fibrosis, and a variety of other disorders. Curcumin's full pharmacological potential is limited owing to its extremely limited water solubility. We report here that the water solubility of curcumin could be increased from 0.6 microg/ml to 7.4 microg/ml (12-fold increase) by the use of heat. Spectrophotometric (400-700 nm) and mass spectrometric profiling of the heat-extracted curcumin displays no significant heat-mediated disintegration of curcumin. Using an enzyme-linked immunosorbent assay that employed HNE modification of solid-phase antigen, we found that the heat-solubilized curcumin inhibited HNE-protein modification by 80%. Thus, inhibition of HNE modification may be a mechanism by which curcumin exerts its effect. We also report a simple assay to detect curcumin spectrophotometrically. Curcumin was solubilized in methanol and serially diluted in methanol to obtain a set of standards that were then read for optical density at 405 nm. Curcumin in the heat-solubilized samples was determined from this standard. Heat-solubilized curcumin should be considered in clinical trials involving curcumin, especially in the face of frustrating results obtained regarding curcumin-mediated correction of cystic fibrosis defects.
The global popularity of herbal supplements and the promise they hold in treating various disease states have caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. This volume focuses on presenting current scientific evidence of biomolecular effects of selected herbs and their relation to clinical outcome and promotion of human health. This book also addresses the ethical challenges of using herbal medicine and its integration into modern, evidence-based medicine.
Drawing from the work of leading international researchers in different fields, this book contains an in-depth scientific examination of effects of individual herbs, as well as their use in the treatment of important diseases such as cancer, cardiovascular disease, dermatologic disorders, neurodegenerative disease, and diabetes. Due to the strong associations among oxidative stress, ageing, and disease, the powerful antioxidant properties of herbs and spices are also examined. The herbs featured are some of the most widely used remedies and cover a wide range, including flowering herbs, fruits and berries, roots and rhizomes, and fungi.
To help bring a new level of quality control to the production of herbal extracts, the use of mass spectrometry and chemometric fingerprinting technology in the authentication of herbs is also presented. As the need for effective, affordable health promotion and treatment increases, especially in the growing ageing population, there is demand for rigorous scientific examination of herbal medicines. This timely and comprehensive volume addresses this need and is an important text for medical professionals and researchers, as well as those interested in herbal or complementary medicine.
Botanical extracts and single compounds are increasingly used in cosmetics but also in over-the-counter drugs and food supplements. The focus of the present review is on controlled clinical trials with botanicals in the treatment of acne, inflammatory skin diseases, skin infections, UV-induced skin damage, skin cancer, alopecia, vitiligo, and wounds. Studies with botanical cosmetics and drugs are discussed, as well as studies with botanical food supplements. Experimental research on botanicals was considered to a limited extent when it seemed promising for clinical use in the near future. In acne therapy, Mahonia, tea tree oil, and Saccharomyces may have the potential to become standard treatments. Mahonia, Hypericum, Glycyrrhiza and some traditional Chinese medicines appear promising for atopic dermatitis. Some plant-derived substances like dithranol and methoxsalen (8-methoxypsoralen) [in combination with UVA] are already accepted as standard treatments in psoriasis; Mahonia and Capsicum (capsaicin) are the next candidates suggested by present evidence. Oral administration and topical application of antioxidant plant extracts (green and black tea, carotenoids, coffee, and many flavonoids from fruits and vegetables) can protect skin from UV-induced erythema, early aging, and irradiation-induced cancer. Hair loss and vitiligo are also traditional fields of application for botanicals. According to the number and quality of clinical trials with botanicals, the best evidence exists for the treatment of inflammatory skin diseases, i.e. atopic dermatitis and psoriasis. However, many more controlled clinical studies are needed to determine the efficacy and risks of plant-derived products in dermatology. Safety aspects, especially related to sensitization and photodermatitis, have to be taken into account. Therefore, clinicians should not only be informed of the beneficial effects but also the specific adverse effects of botanicals used for dermatologic disorders and cosmetic purposes.
Human studies of curcumin extract on lipid-lowering effect have not been completely investigated and have had controversy results. This study tested the effect of daily curcumin extract for 12 weeks on weight, glucose, and lipid profiles in patients with metabolic syndrome. Sixty-five patients were randomized into two groups; 33 patients taking curcumin extract capsule (630 mg thrice daily) and 32 patients taking a placebo capsule thrice daily for 12 weeks. At 12 weeks after the curcumin extract consumption, the level of high-density lipoprotein cholesterol (HDL-C) significantly increased from 40.96 ± 8.59 to 43.76 ± 2.79 mg/dL (p < 0.05), and the level of low-density lipoprotein cholesterol (LDL) was significantly reduced (120.55 ± 36.81 to 106.51 ± 25.02 mg/dL, p < 0.05). The triglyceride-lowering effect, a reduction of 65 mg/dL, was also found in this study. In subgroups analysis, the consumption of curcumin may have a lowering cholesterol effect in male patients and an increasing HDL-C effect in female patients, both of which result in a decrease of T-Chol/HDL-C ratio. The intake of the curcumin extract of 1890 mg/day for 12 weeks was associated with lipid-lowering effect but did not improve weight and glucose homeostasis in the patients with metabolic syndrome. Daily curcumin consumption may be an alternative choice to modify cholesterol-related parameters, especially in metabolic syndrome patients. Copyright © 2014 John Wiley & Sons, Ltd.
This study aimed to assess the possible beneficial effects of curcumin capsules as lipid-lowering effects and as a permeability glycoprotein (P-gp) inhibitor on the pharmacokinetics and pharmacodynamics of glyburide and as a P-gp substrate with glyburide in patients with type-2 diabetes mellitus. Open-label, randomized control trial was carried out for 11 days on eight type-2 diabetic patients on glyburide therapy. On the first day of the study, following the administration of 5 mg of glyburide, blood samples were collected from the patients at various time intervals ranging from 0.5 to 24 h. Blood sampling was repeated on the 11th day of the study, after treating the patients with curcumin for ten consecutive days. Glyburide concentrations changed at the second hour, Cmax was unchanged, the glucose levels were decreased, Area Under first Movement Curre (AUMC) was increased, and no patient has experienced the hypoglycaemia. The low-density lipoprotein, very-low-density lipoprotein and triglycerides were decreased significantly, and the high-density lipoprotein content increased. The co-administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control. The lipid lowering and antidiabetic properties of the curcumin show as a potential future drug molecule. Copyright © 2014 John Wiley & Sons, Ltd.
Curcuminoids are bioactive polyphenolics with potent antiinflammatory properties. Although several lines of in vitro and preclinical evidence suggest potent anticancer effects of curcuminoids, clinical findings have not been conclusive. The present randomized double-blind placebo-controlled trial aimed to evaluate the efficacy of curcuminoids as adjuvant therapy in cancer patients. Eighty subjects with solid tumors who were under standard chemotherapy regimens were randomly assigned to a bioavailability-boosted curcuminoids preparation (180 mg/day; n = 40) or matched placebo (n = 40) for a period of 8 weeks. Efficacy measures were changes in the health-related quality of life (QoL) score (evaluated using the University of Washington index) and serum levels of a panel of mediators implicated in systemic inflammation including interleukins 6 (IL-6) and 8 (IL-8), TNF-α, transforming growth factor-β (TGFβ), high-sensitivity C-reactive protein (hs-CRP), calcitonin gene-related peptide (CGRP), substance P and monocyte chemotactic protein-1 (MCP-1). Curcuminoid supplementation was associated with a significantly greater improvement in QoL compared with placebo (p < 0.001). Consistently, the magnitude of reductions in TNF-α (p < 0.001), TGFβ (p < 0.001), IL-6 (p = 0.061), substance P (p = 0.005), hs-CRP (p < 0.001), CGRP (p < 0.001) and MCP-1 (p < 0.001) were all significantly greater in the curcuminoids versus placebo group. In contrast, the extent of reduction in serum IL-8 was significantly greater with placebo versus curcuminoids (p = 0.012). Quality of life variations were associated with changes in serum TGFβ levels in both correlation and regression analyses. Adjuvant therapy with a bioavailable curcuminoid preparation can significantly improve QoL and suppress systemic inflammation in patients with solid tumors who are under treatment with standard chemotherapy protocols. Copyright © 2014 John Wiley & Sons, Ltd.
Background: Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and cardiovascular disease (CVD). In this context, C-reactive protein (CRP) has been identified as a strong predictor and independent risk factor of CVD. Curcuminoids are multifunctional natural product with promising cardioprotective and anti-inflammatory properties. Curcuminoids have been suggested to lower circulating levels of CRP, but clinical findings have not been consistent. Objectives: To pool the published results of clinical trials on the impact of supplementation with curcuminoids on circulating levels of CRP. Methods: PubMed/MEDLINE and SCOPUS databases were searched for clinical trials reporting circulating CRP changes in individuals receiving curcuminoids. Effect sizes with 95% confidence intervals (CI) were calculated using a random-effects model. Inter-study heterogeneity was assessed using Cochran's Q and I(2) tests. Sensitivity analyses were conducted using leave-one-out method. Results: Six trials comprising 172 subjects in the curcuminoids group and 170 subjects in the placebo group fulfilled the eligibility criteria and included in the meta-analysis. Compared with placebo, supplementation with curcuminoids was associated with a significant reduction in circulating CRP levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004). This significant effect was maintained in subgroups of trials that used bioavailability-improved preparations of curcuminoids and had supplementation duration of ≥4 weeks, but not in the subgroups without these characteristics. Conclusions: Supplementation with curcuminoids may reduce circulating CRP levels. This effect appears to depend on the bioavailability of curcuminoids preparations and also duration of supplementation. Future well-designed and long-term trials are warranted to verify this effect of curcuminoids. Copyright © 2013 John Wiley & Sons, Ltd.
Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies. The objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in patients with major depressive disorder (MDD). Herein, 60 patients diagnosed with MDD were randomized in a 1:1:1 ratio for six weeks observer-masked treatment with fluoxetine (20 mg) and curcumin (1000 mg) individually or their combination. The primary efficacy variable was response rates according to Hamilton Depression Rating Scale, 17-item version (HAM-D17 ). The secondary efficacy variable was the mean change in HAM-D17 score after six weeks. We observed that curcumin was well tolerated by all the patients. The proportion of responders as measured by the HAM-D17 scale was higher in the combination group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups; however, these data were not statistically significant (P = 0.58). Interestingly, the mean change in HAM-D17 score at the end of six weeks was comparable in all three groups (P = 0.77). This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders. Copyright © 2013 John Wiley & Sons, Ltd.
Radiation dermatitis occurs in approximately 95% of patients receiving radiotherapy (RT) for breast cancer. We conducted a randomized, double-blind, placebo-controlled clinical trial to assess the ability of curcumin to reduce radiation dermatitis severity in 30 breast cancer patients. Eligible patients were adult females with noninflammatory breast cancer or carcinoma in situ prescribed RT without concurrent chemotherapy. Randomized patients took 2.0 grams of curcumin or placebo orally three times per day (i.e., 6.0 grams daily) throughout their course of RT. Weekly assessments included Radiation Dermatitis Severity (RDS) score, presence of moist desquamation, redness measurement, McGill Pain Questionnaire-Short Form and Symptom Inventory questionnaire. The 30 evaluable patients were primarily white (90%) and had a mean age of 58.1 years. Standard pooled variances t test showed that curcumin reduced RDS at end of treatment compared to placebo (mean RDS = 2.6 vs. 3.4; P = 0.008). Fisher's exact test revealed that fewer curcumin-treated patients had moist desquamation (28.6% vs. 87.5%; P = 0.002). No significant differences were observed between arms for demographics, compliance, radiation skin dose, redness, pain or symptoms. In conclusion, oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients.
Background:
Chronic cutaneous complications such as pruritus are among the very frequent complaints of sulphur mustard (SM)-exposed patients. The present trial investigated the impact of curcumin on serum inflammatory biomarkers and their association with pruritus severity and quality of life (QoL).
Methods:
This was a randomized, double-blind trial among 96 male Iranian veterans (age 37-59 y) who were suffering from chronic SM-induced pruritic skin lesions. Patients were randomly assigned to curcumin (1 g/d, n = 46) or placebo (n = 50) for four weeks. Serum concentrations of interleukins 6 (IL-6) and 8 (IL-8) together with high-sensitivity C-reactive protein (hs-CRP) and calcitonin gene-related peptide (CGRP) were measured at baseline and at the end of the trial. Assessment of pruritus severity was performed using the pruritus score and QoL using the Dermatology Life Quality Index (DLQI).
Results:
Serum IL-8 and hs-CRP were significantly reduced in both groups but the magnitude of reduction was greater in the curcumin group (P < 0.001). Serum CGRP was only decreased in the curcumin group (P < 0.001). No significant change was observed in serum IL-6. There were significant correlations between CGRP and IL-6 changes (P = 0.011) and between DLQI and IL-8 changes (P = 0.026) in the curcumin group. In the curcumin group, changes in serum IL-8 concentrations were found as the significant predictor of DLQI scores (P = 0.026) but none of the independent variables could predict pruritus scores.
Conclusions:
Curcumin supplementation effectively mitigates inflammation in patients suffering from chronic SM-induced cutaneous complications. This anti-inflammatory effect might account for the observed pruritus alleviation and QoL improvement by this phytochemical.
Curcumin (CUR), a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of CUR in inflammatory disorders, cardiovascular disease, cancer, Alzheimer's disease and neurological disorders have been shown. However, the clinical application of CUR is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based delivery approaches have been used to enhance the oral bioavailability, biological activity or tissue-targeting ability of CUR. This article reviews potential novel drug delivery systems for CUR including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanosuspensions, nanoemulsions, complexes and dendrimer/dimer, which provide promising results for CUR to improve its biological activities.
Summary To determine whether abnormal activity of a calmodulin-containing enzyme which catalyses phosphorylation reactions may play a pathogenetic role in psoriasis, the presence and activity of phosphorylase kinase (PK) in human epidermis were determined in patients with untreated/active psoriasis (n=10), treated/resolving psoriasis (n= 10), and non-psoriatic controls (n= 10). Biopsies were taken from involved and uninvolved skin for PK, organic phosphorus, and inorganic phosphate estimation, and light and electron microscopy. The enzyme was present in involved and uninvolved skin of every patient in the study. PK activity (units/mg protein) was significantly higher in active psoriasis than in resolving psoriasis and controls. PK activity correlated directly with organic phosphorus levels, and inversely with the extent of cellular glycogenolysis measured by the depletion of glycogen granules within the keratinocytes. The study demonstrates that PK is present in both psoriatic and normal epidermis, with significantly higher levels in active psoriasis. Furthermore, higher levels of PK activity, glycogenolysis and phosphorylation are associated with increased clinical psoriatic activity. We conclude that PK, a calmodulin-containing enzyme, is involved in regulating calcium-dependent phosphorylation events in human epidermis, and disturbance of its activity may play a key role in the clinical manifestations of psoriasis.
Phosphorylase kinase (PhK), also known as adenosine triphosphate (ATP)-phosphorylase b phosphotransferase, integrates multiple calcium/calmodulin-dependent signalling pathways, including those involved in cell migration and cell proliferation, while coupling these pathways to glycogenolysis and ATP-dependent phosphorylation, thus ensuring continuing energy supply for these activities.
Our laboratory recently reported correlation of elevated PhK activity with psoriatic activity. This study further evaluates the significance of drug-induced suppression of PhK activity on psoriatic activity.
PhK activity was assayed in four groups, each with 10 patients: (i) active untreated psoriasis; (ii) resolving psoriasis treated by calcipotriol (Dovonex(R), Bristol Myers Squibb, Princeton, NJ, U.S.A. ), a vitamin D3 analogue and an indirect inhibitor of PhK; (iii) curcumin (diferuloylmethane), a selective PhK inhibitor; and (iv) 10 normal non-psoriatic subjects.
PhK activity in units mg-1 protein was highest in active untreated psoriasis (1204 +/- 804.3; mean +/- SD), lower in the calcipotriol-treated group (550.7 +/- 192. 9), lower in curcumin-treated group (207.2 +/- 97.6), and lowest in normal skin (105.4 +/- 44.6). One-way analysis of variance performed on log-transformed PhK activity measure showed significant differences among the four groups, F3,36 = 48.79, P < 0.0001. Decreased PhK activity in curcumin-and calcipotriol-treated psoriasis was associated with corresponding decreases in keratinocyte transferrin receptor (TRR) expression, severity of parakeratosis and density of epidermal CD8+ T cells.
Our results demonstrate that drug-induced suppression of PhK activity is associated with resolution of psoriatic activity as assessed by clinical, histological and immunohistochemical criteria, and support the hypothesis that effective antipsoriatic activity may be achieved through modulation of PhK activity.
To summarize long-term open-label use of curcuminoids and experience of side-effects in 53 patients with the autoimmune condition oral lichen planus (OLP) who had previously participated in randomized controlled trials (RCTs) of curcuminoids at UCSF.
This descriptive retrospective cohort study conducted in 2009 collected information from clinic charts and patient interview on the over-the-counter (OTC) use of curcuminoids during a 1-5 year follow-up period. Of the 53 eligible patients, 33 had previously participated in a RCT (2003-2004) that evaluated a dose of 2000mg/day of curcuminoids and which was ended early for futility and 20 had participated in a RCT (2007-2008) that evaluated a dose of 6000mg/day which demonstrated its efficacy. At the last study visit of each of the 2 RCTs all participants were given current published information about curcuminoids, and some went on to take OTC curcuminoids.
Follow-up data was available on 43 participants [25/33 (75%) from the first and 19/20 (95%) from the second RCT]. 18/25 (72%) participants from the first trial took OTC curcuminoids after completion of the trial period. The mean total daily dose was 2137.5mg (SD=793, range 500-3000mg) and mean duration of curcuminoids use was 30 months (SD=27.5). The total follow-up time after completion of the RCT for the 18 participants was mean 68.2 months (SD 5.9). 10/18 (56%) reported that curcuminoids controlled OLP symptoms, and the mean duration of use among these patients was 35.8 months (SD 27.4). 8/18 (44%) were unsure whether curcuminoids helped and the mean duration of use was 21.0 months (SD 27.3). 2 of 18 patients (11%) reported a side-effect (SE) of diarrhea. 19/19 (100%) patients from the second trial took OTC curcuminoids after completion of the trial period. The mean total daily dose was 5058mg (SD=1445, range 1000-6000mg) and mean duration of curcuminoids use 9.6 months (SD=8.04). The total follow-up time after completion of the RCT for the 19 participants was mean 15.8 months (SD 4.8). 12/19 (63%) reported that curcuminoids controlled OLP symptoms, and the mean duration of use was 14.1 months (SD 6.7). 2/19 (11%) reported lack of improvement with a daily dose of 1500mg and 2500mg for 3 months each. 5/19 (26%) were unsure whether curcuminoids helped and the mean duration of use was 1.5 months (1.2 SD). Six of these 19 patients (32%) reported SEs, three had abdominal discomfort, two diarrhea and one slight urgency in defecation on the capsule but not the tablet formulation. The SEs resolved with dose reduction to 4500mg/day in one and 3000mg/day in two patients, while two patients [2/19 (11%)] discontinued curcuminoids due to the SE.
A total of 22/37 (60%) of patients reported a reduction of symptoms with curcuminoids, 13/37 (35%) were unsure and 2/37 (5%) reported that it did not help in reduction of symptoms. Side-effects included abdominal discomfort and diarrhea, however occurrence was dose-related, and complaints were mild.
1. Curcumin is the active ingredient of the dietary spice turmeric and has been consumed for medicinal purposes for thousands of years. Modern science has shown that curcumin modulates various signalling molecules, including inflammatory molecules, transcription factors, enzymes, protein kinases, protein reductases, carrier proteins, cell survival proteins, drug resistance proteins, adhesion molecules, growth factors, receptors, cell cycle regulatory proteins, chemokines, DNA, RNA and metal ions.
2. Because of this polyphenol’s potential to modulate multiple signalling molecules, it has been reported to possess pleiotropic activities. First demonstrated to have antibacterial activity in 1949, curcumin has since been shown to have anti-inflammatory, anti-oxidant, pro-apoptotic, chemopreventive, chemotherapeutic, antiproliferative, wound healing, antinociceptive, antiparasitic and antimalarial properties as well. Animal studies have suggested that curcumin may be active against a wide range of human diseases, including diabetes, obesity, neurological and psychiatric disorders and cancer, as well as chronic illnesses affecting the eyes, lungs, liver, kidneys and gastrointestinal and cardiovascular systems.
3. Although many clinical trials evaluating the safety and efficacy of curcumin against human ailments have already been completed, others are still ongoing. Moreover, curcumin is used as a supplement in several countries, including India, Japan, the US, Thailand, China, Korea, Turkey, South Africa, Nepal and Pakistan. Although inexpensive, apparently well tolerated and potentially active, curcumin has not been approved for the treatment of any human disease.
4. In the present article, we discuss the discovery and key biological activities of curcumin, with a particular emphasis on its activities at the molecular and cellular levels, as well as in animals and humans.
Curcuminoids are components of turmeric (Curcuma longa) that possess anti-inflammatory properties.
We sought to study the efficacy of curcuminoids in controlling the signs and symptoms of oral lichen planus, at doses of 6000 mg/d (3 divided doses), and their safety at this dose.
Twenty consecutive, eligible patients who consented were enrolled into this randomized, double-blind, placebo-controlled clinical trial in 2007 through 2008. Measurement of symptoms and signs of oral lichen planus using the Numerical Rating Scale (NRS) and the Modified Oral Mucositis Index (MOMI), respectively; complete blood counts; liver enzymes; C-reactive protein; and interleukin-6 levels was done at baseline and day 14. Two-sided P values are reported.
In the placebo group, the percentage changes from baseline in NRS (median [interquartile range] = 0.00 [-29 to 16.7], P > .99), erythema (0.00 [-10 to 16.7], P = .98), ulceration (0.00 [0.00 to 26.7], P = .63), and total MOMI scores (-3.2 [-13 to 9.09], P = .95) were not statistically significant, whereas they were statistically significant in the curcuminoids group: NRS (-22 [-33 to -14], P = .0078); erythema (-17 [-29 to -8.3], P = .0078), ulceration (-14 [-60 to 0.00], P = .063), MOMI (-24 [-38 to -11], P = .0039). The curcuminoids group showed a greater reduction in clinical signs and symptoms as compared with the placebo group, measured by percentage change in erythema (P = .05) and total MOMI score (P = .03), and proportion showing improvement in NRS (0.8 vs 0.3, P = .02) and total MOMI score (0.9 vs 0.5, P = .05). Adverse effects were uncommon in both groups.
The small sample size resulted in limited power, particularly for multivariate analyses.
Curcuminoids at doses of 6000 mg/d in 3 divided doses are well tolerated and may prove efficacious in controlling signs and symptoms of oral lichen planus.
Background:
Several botanically derived agents are available for the treatment of male-pattern baldness.
Objective:
The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5α-reductase and 5% minoxidil in the treatment of androgenetic alopecia.
Methods:
Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding.
Results:
There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study.
Conclusion:
In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth.
The aim of this study was to compare the efficacy of targeted narrowband UVB phototherapy plus topical tetrahydrocurcuminoid with that of targeted narrowband UVB monotherapy for induction of repigmentation in vitiligo.
The 308-nm excimer laser and targeted narrowband UVB phototherapy have recently been shown to be effective in repigmenting vitiligo. Studies have suggested that the combination of the 308-nm excimer laser and various topical treatments is more effective than UV monotherapy in the treatment of vitiligo.
Ten subjects with focal or generalized vitiligo were enrolled in this study. Two similar lesions were treated with either targeted narrowband UVB plus topical tetrahydrocurcuminoid cream or targeted UVB alone. The UV treatments were carried out twice a week for 12 weeks. The degree of repigmentation, documented by monthly digital photography, was assessed by a blinded dermatologist.
On completion of the study, statistically significant repigmentation, compared with baseline, occurred in both treatment groups. The overall degree of repigmentation was slightly better in the combination group at 8 and 12 weeks (p = 0.078 and 0.158 respectively). Adverse effects were minor and well tolerated.
Targeted narrowband UVB phototherapy plus topical tetrahydrocurcuminoid cream was slightly more effective than targeted narrowband UVB monotherapy for vitiligo located in UV-sensitive areas. However, the differences in degrees of repigmentation did not reach statistically significant levels.
Botanical extracts and single compounds are increasingly used in cosmetics but also in over-the-counter drugs and food supplements. The focus of the present review is on controlled clinical trials with botanicals in the treatment of acne, inflammatory skin diseases, skin infections, UV-induced skin damage, skin cancer, alopecia, vitiligo, and wounds. Studies with botanical cosmetics and drugs are discussed, as well as studies with botanical food supplements. Experimental research on botanicals was considered to a limited extent when it seemed promising for clinical use in the near future. In acne therapy, Mahonia, tea tree oil, and Saccharomyces may have the potential to become standard treatments. Mahonia, Hypericum, Glycyrrhiza and some traditional Chinese medicines appear promising for atopic dermatitis. Some plant-derived substances like dithranol and methoxsalen (8-methoxypsoralen) [in combination with UVA] are already accepted as standard treatments in psoriasis; Mahonia and Capsicum (capsaicin) are the next candidates suggested by present evidence. Oral administration and topical application of antioxidant plant extracts (green and black tea, carotenoids, coffee, and many flavonoids from fruits and vegetables) can protect skin from UV-induced erythema, early aging, and irradiation-induced cancer. Hair loss and vitiligo are also traditional fields of application for botanicals. According to the number and quality of clinical trials with botanicals, the best evidence exists for the treatment of inflammatory skin diseases, i.e. atopic dermatitis and psoriasis. However, many more controlled clinical studies are needed to determine the efficacy and risks of plant-derived products in dermatology. Safety aspects, especially related to sensitization and photodermatitis, have to be taken into account. Therefore, clinicians should not only be informed of the beneficial effects but also the specific adverse effects of botanicals used for dermatologic disorders and cosmetic purposes.
To evaluate the efficacy and safety of a topical application of Herbavate cream (Troikaa Pharmaceuticals Ltd, Ahmedabad, India), a polyherbal formulation in the management of outpatients with eczema.
This was an open label design.
One hundred and fifty (150) outpatients with a clinical diagnosis of eczema and meeting the eligibility criteria used topical Herbavate twice daily for 4 weeks. Change in symptom score for eczema (erythema, scaling, thickening, and itching) was assessed weekly using a 4-point score. The trial was carried out at Civil Hospital, Ahmedabad, Seth V.S. Hospital, Ahmedabad, and Stanley Medical College, Chennai.
The primary outcome measure was a change in symptom score at 4 weeks as compared to baseline scores. The secondary outcome measure was a weekly change in symptom score as compared to the previous visit. Local tolerance was judged by development of side effects at site of application. Results: Clinical improvement in symptom score at the end of study as compared to baseline was significant for all symptoms assessed (p < 0.001). Significant reduction in symptoms scores was observed from end of week 1. Local tolerance was good, with only 5 patients reporting side effects that improved with continued use. No patient withdrew due to side effects.
Herbavate, a topical polyherbal formulation, appears to an attractive alternate option for the management of outpatients with eczema.