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and characterizing new probiotic strains (23, 46). Beyond
extending the clinical substantiation of existing probiotics
and introducing novel strains, the ability to have one’s oral
microbiome individually characterized to the genus level by
providing a saliva sample is easily attainable (47). Thinking
ahead, this personal microbiome prole could eventually
be accompanied by a list of potential probiotic strains
specically targeting the resident pathogenic bacteria.
Beyond that, look for saliva to become the new blood, in
the context of biomarkers. Aside from the ease of sample
collection, biomarkers in the blood are often present in
microgram quantities, while the same biomarkers are often
present in saliva at nanogram or even picogram levels.
This sort of laboratory testing is already commercially
The main challenges will likely come from identifying
probiotics that do not pose any safety concerns, the ability
to colonize on one or more surfaces in the oral cavity, being
sufciently stable over time, and their compatibility with
multiple delivery formats. Adequate consumer education
regarding the need and benets of orally-targeted probiotics
is imperative. Finally, the uidity of worldwide regulatory
agencies and their statutes is unpredictable and merits
The oral microbiome is a major contributor to our oral health,
which in turn is closely linked to systemic health, the ability
to ward off disease, and a person’s overall quality of life.
A concerted effort to achieve regular exercise, high quality
nutrition, and good oral hygiene habits to promote our oral
health should be cornerstones of a healthy lifestyle. Good
oral hygiene includes proper diet, correct tooth brushing
techniques, use of dental oss, regular dental visits, and
regular teeth cleaning by a qualied dental hygienist. As we
have discussed, the use of selected orally-targeted probiotics
now offers a highly complementary approach to good oral
hygiene that promises to deliver the next generation of oral
and throat healthcare.
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Agro FOOD Industry Hi Tech - vol. 27(3) - May/June 2016