... Also, other P. protegens strains synthesize metabolites with antifungal activity, such as 2,4-DAPG (DAPG) [23,[55][56][57], pyocyanin [56,58], pyrrolnitrin (PR) [18,56], pyoluteorin (PL) [56,57], orfamide A [41,56,59], rhizoxin A [56,60], cyanide acid (HCN) [56,61], and chitinases [41,42,62]. For example, in addition to its plant-growth-promoting abilities, P. protegens CHA0 isolated from roots of the tobacco plant can inhibit the oomycete Pythium ultimatum, Fusarium oxysporum basidiomycete, and even some herbivorous insects [26,[63][64][65][66]. Also, P. protegens Pf-5 is a strain that is closely phylogenomically related with P. protegens E1BL2 and also inhibits the growth of phytopathogenic fungi through the production of DAPG, PR, PL, HCN, and rhizoxin [67]. Although no antifungal activities have been reported with P. protegens EMM-1, this strain isolated from the maize rhizosphere of Rojo Criollo landrace inhibits the growth of Pseudomonas putida, Pseudomonas syringae, and Ralstonia solanacearum phytopathogenic bacteria and Klebsiella pneumoniae, Burkholderia cepacia complex, and Streptococcus beta-hemolytic clinical pathogenic bacteria [68,69]. ...