Article

Effects of Ethanol on the Transport of β-Estradiol in Hairless Mouse Skin

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Abstract

This paper describes the striking effects of ethanol on the transport of β-estradiol in hairless mouse skin. Three sets of two-chamber diffusion cell experiments were conducted: 1) ethanol/saline in the donor chamber and saline in the receiver chamber, 2) saline in the donor and ethanol/saline in the receiver chamber, and 3) with ethanol/saline in both chambers. The results were shown to deviate enormously from the classical lipid barrier model. A new model, based on diffusion across a binary solvent mixture, was used to analyze the data. A good agreement was observed between experimental data and theoretical results.

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