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Square Wave Voltammetric Determination of Rasagiline Mesylate on Hanging Mercury Drop Electrode and its application in Dosage Form and Biological Fluids

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Ibrahim Habib at National Research Center, Egypt
Ibrahim Habib
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Abstract

A new square wave voltammetric (SWV) method has been developed and validated for the determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4 x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The accuracy and precision of the method were within acceptable limits. The method was applied for determining the active ingredients in its tablets with % recoveries ± relative standard deviation of 95.46 ± 3.7 6 and in spiked human plasma with 94.3 ± 2.8 9%, respectively.
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Square Wave Voltammetric Determination of Rasagiline Mesylate on Hanging Mercury Drop Electrode and its application in Dosage Form and Biological Flui
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Int. J. Electrochem. Sci., 11 (2016) 4802 – 4811
International Journal of
ELECTROCHEMICAL
SCIENCE
www.electrochemsci.org
Square Wave Voltammetric Determination of Rasagiline
Mesylate on Hanging Mercury Drop Electrode and its
application in Dosage Form and Biological Fluids
Ibrahim H.I. Habib1, Mohamed Rizk2, Dalia Mohamed2, 3, Shereen Mowaka2, 4 and
Rasha Th. El-Eryan2, *
1 Microanalytical Chemistry Laboratory, Applied Organic Chemistry Department, National Research
Centre, Dokki, 12622, Giza, Egypt
2 Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11745, Cairo, Egypt.
3 Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, October
University for Modern Sciences and Arts, 11787, 6 October City, Egypt
4 Analytical Chemistry Department, Faculty of Pharmacy, British University in Egypt,
11837, El-Sherouk City, Egypt
*E-mail: rashaeleryan@hotmail.com
doi: 10.20964/2016.06.64
Received: 16 February 2016 / Accepted: 26 March 2016 / Published: 4 May 2016
A new square wave voltammetric (SWV) method has been developed and validated for the
determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic
behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as
different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation
potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4
x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits
of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The
accuracy and precision of the method were within acceptable limits. The method was applied for
determining the active ingredients in its tablets with % recoveries ± relative standard deviation of
95.46 ± 3.7 6 and in spiked human plasma with 94.3 ± 2.8 9%, respectively.
Keywords: Rasagiline mesylate; Square Wave Voltammetry; Hanging Mercury Drop Electrode;
acetylene group.
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