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Pharmaceutical formulation for the production of rapidly disintegrating tablets
Abstract
Pharmaceutical formulation in the form of agglomerates comprising
A) an excipient content composed of
a) 60-97% by weight of sugar or sugar alcohols,
b) 1-25% by weight of a disintegrant, selected from the group consisting of croscarmellose, sodium carboxymethylstarch and L-hydroxypropoylcellulose,
c) 1-15% by weight of water-insoluble, film-forming polymers
d) 0-15% by weight of water-soluble polymers and
e) 0-15% by weight of further pharmaceutically customary excipients the total of the components a) to e) being 100% by weight.
... In turn, the polyvinyl acetate polymer used in varnishes with complex of casein phosphopeptide and amorphous calcium phosphate (CPP-ACP) shows very good solubility in aqueous solutions, which can directly affect the dynamics of fluoride ion release. 31 Alcohol, undergoing rapid evaporation after exposure to air, leaves free volume, which causes easier contact of the varnish with water and accelerates the release of fluoride. 32 The active agents of the first generation of varnishes are usually in the form of neutral or acidified 5% NaF containing 2.26% fluoride ions (22,600 ppm of fluoride), 1% difluorosilane containing 0.1% fluoride ions (1,000 ppm of fluoride) or 6% NaF combined with 6% CaF 2 (56,300 ppm of fluoride). ...
In dentistry, fluoride compounds play a very important role in the development of teeth hard tissue. They have been modifying the development of the carious process for many years in accordance with the principles of minimally invasive therapy. Studies have confirmed their effectiveness in the prevention and treatment of carious lesions and erosion of deciduous and permanent teeth, as well as in the dentin hypersensitivity treatment. Typically, each varnish consists of 3 basic components, i.e., a resin usually in the form of mastic, shellac and/or rosin, an alcohol-based organic solvent (usually ethanol) and active agents. In the first-generation varnishes, the active agent is fluorine compounds, most often in the form of 5% NaF, while in second-generation varnishes, the composition is further enriched with calcium and phosphorus compounds in the form of CPP-ACP/CPP-ACPF, ACP, TCP, fTCP, CSPS, TMP, CXP, or CaGP. This influences the bioavailability of fluoride in the oral environment by increasing both its release from the product and its subsequent accumulation in enamel and plaque, promotes more efficient closure of dentinal tubules, and facilitates pH buffering in the oral cavity.
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