Article

Initial Experience in Irreversible Electroporation of Unresectable Pancreatic Cancer

Authors:
  • Saint Savvas General Oncology Hospital of Athens
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Abstract

Aims: Irreversible electroporation (IRE) is a novel non thermal ablative modality. We present our experience in the treatment of locally advanced unresectable pancreatic adenocarcinoma Methods: We retrospectively reviewed a case series of 5 patients who underwent IRE between October 2013 and August 2014. Four out of five patients have been previously treated with chemotherapy. Three patients had CT guided IRE and two patients had open US guided IRE as an adjunct to surgical bypass. The radiological response has been evaluated according to the modified RECIST criteria. Results: Three men and two women with a median age of 58 years (range 45–63) were treated. Median tumour size was 37 mm (range 24–60). One patient who had an open procedure including a metal stent removal died from multi organ failure. One patient developed Grade III cholangitis following percutaneous IRE and was managed conservatively. With a median follow up of 8 months (range 5–15), 3 patients are alive with stable disease and 1 chemotherapy naïve patient died from disseminated disease. Conclusions: Irreversible electroporation is a viable option in the management of locally advanced pancreatic cancer, provided there is available expertise. Pre-treated patients who respond to chemotherapy and are amenable to percutaneous ablation seem to be the most suitable candidates.

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