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Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation)
Abstract
We demonstrate a new non-invasive method to assess the functional condition of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. Motion of retinal tissue, that is induced by expansion of the vessels therein, is measured with an accuracy of about 10 nm. The pulse shape of arterial and venous pulsation, their temporal delay as well as the frequency dependent pulse propagation through the capillary bed are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.
... However, fully coherent high-speed tomography not only visualizes dynamic processes with diffraction limited resolution, but will also provide new contrast mechanisms that rely on fast and small changes of scattering properties or of optical pathlengths. Hence FF-SS-OCT can contribute to numerous areas, e.g., measure tissue responses to photocoagulation, 33 detect heart-beat-induced pressure waves in order to probe vascular status, 34,35 or obtain data for optophysiology. 36 ...
Research and medicine rely on non-invasive optical techniques to image living tissue with high resolution in space and time. But so far a single data acquisition could not provide entirely diffraction-limited tomographic volumes of rapidly moving or changing targets, which additionally becomes increasingly difficult in the presence of aberrations, e.g., when imaging retina in vivo. We show, that a simple interferometric setup based on parallelized optical coherence tomography acquires volumetric data with 10 billion voxels per second, exceeding previous imaging speeds by an order of magnitude. This allows us to computationally obtain and correct defocus and aberrations resulting in entirely diffraction-limited volumes. As demonstration, we imaged living human retina with clearly visible nerve fiber layer, small capillary networks, and photoreceptor cells, but the technique is also applicable to obtain phase-sensitive volumes of other scattering structures at unprecedented acquisition speeds.
... However, fully coherent high-speed tomography not only visualizes dynamic processes with diffraction limited resolution, but will also provide new contrast mechanisms that rely on fast and small changes of scattering properties or of optical pathlengths. Hence FF-SS-OCT can contribute to numerous areas, e.g., measure tissue responses to photocoagulation, 33 detect heart-beat-induced pressure waves in order to probe vascular status, 34,35 or obtain data for optophysiology. 36 ...
Research and medicine rely on non-invasive optical techniques to image living tissue with high resolution in space and time. But so far a single data acquisition could not provide entirely diffraction-limited tomographic volumes of rapidly moving or changing targets, which additionally becomes increasingly difficult in the presence of aberrations, e.g., when imaging retina in vivo. We show, that a simple interferometric setup based on parallelized optical coherence tomography acquires volumetric data with 10 billion voxels per second, exceeding previous imaging speeds by an order of magnitude. This allows us to computationally obtain and correct defocus and aberrations resulting in entirely diffraction-limited volumes. As demonstration, we imaged living human retina with clearly visible nerve fiber layer, small capillary networks, and photoreceptor cells, but the technique is also applicable to obtain phase-sensitive volumes of other scattering structures at unprecedented acquisition speeds.
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