This article sets forth definitions for analysis, drivers and main issues in order to internalize sustainability principles in wine tourism. It analyzes current frameworks used to evaluate sustainability performance or guide implementation of sustainability programmes presented as assessments, labels, guides and/or certifications. They are classified here in three main groups: (1) general frameworks applied to sustainability criteria or environmental management and management processes; (2) frameworks focused on tourism, using a territorial scale; and (3) sustainable viticulture frameworks, programmes and certifications supported by national or regional initiatives. A cross-analysis of each category discusses the approach of the classical tripod (environmental, economical and social aspects), in addition to territorial aspects, in a cross-disciplinary perspective. Finally, it summarizes challenges and opportunities to wine tourism, highlighting the main issues in each dimension of sustainability and territorial aspects and detailing how tourism can act to reinforce sustainable viticulture programmes enhancing territorial aspects and wine sustainability.