Social deficits are ubiquitous across childhood psychopathology, and impaired social functioning in childhood is associated with a multitude of negative outcomes throughout youth and into adulthood. In contrast, social competence, a key component of resilience, is associated with multiple positive outcomes. In this chapter, we discuss the nature of childhood resilience and how psychotherapeutic interventions may enhance resilience. The primary components of resilience, including proactive orientation, self-regulation, connections and attachments, special interests and talents, community, and proactive parenting, are reviewed. We then describe the Resilience Builder Program® (RBP®), a comprehensive resilience-based manualized group therapy for children and adolescents with prominent social competence deficits. Finally, we discuss efforts to evaluate the effectiveness of the RBP® in a private clinical practice, and we present pilot data in youth with ADHD, anxiety, and autism spectrum disorders.