The editors invited this article, and the subsequent four response pieces, as a contribution to the debate on knowledge production in Africa and African studies, which was a critical issue in the late colonial and post-independence African universities, and which has continued to be a concern of leading African scholars in the decades since. Here the contributors examine questions regarding the political economy of knowledge production in universities in postcolonial Africa, reflecting on historical and contemporary challenges. What factors undermine knowledge production in Africa? What roles can African universities play in 'decolonizing knowledge production' on the continent.